Article
Cardiac & Cardiovascular Systems
Josep Gomez-Lara, Loreto Oyarzabal, Luis Ortega-Paz, Salvatore Brugaletta, Rafael Romaguera, Neus Salvatella, Gerard Roura, Fernando Rivero, Lara Fuentes, Fernando Alfonso, Imanol Otaegui, Bert Vandeloo, Beatriz Vaquerizo, Manel Sabate, Josep Comin-Colet, Joan-Antoni Gomez-Hospital
Summary: This study investigated the impact of different stents on endothelial function, finding variations in vasomotor responses and neointimal healing between devices, but no significant differences in endothelial dysfunction issues.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Yaokun Liu, Bo Zheng, Bin Zhang, Robert Ndondo-lay, Fangfang Nie, Naijie Tang, Yongsheng Miao, Jianping Li, Yong Huo
Summary: This study evaluated the safety and efficacy of Biomagic rapamycin-eluting bioabsorbable scaffold (BVS) in non-atherosclerotic porcine coronary arteries using quantitative coronary angiography, optical coherence tomography, histomorphometry, and pharmacokinetics. The results showed that Biomagic demonstrated comparable long-term safety to Firebird2 in porcine coronary arteries with mild to moderate inflammation. Although Biomagic was associated with greater percent stenosis relative to Firebird2 within 36 months, expansile remodeling was observed after 12 months in Biomagic with significantly greater lumen area at >= 36 months. Scaffold resorption is considered complete at 36 months.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Masato Nakamura, Kazushige Kadota, Yoshihisa Nakagawa, Kengo Tanabe, Yoshiaki Ito, Tetsuya Amano, Yuichiro Maekawa, Akihiko Takahashi, Nobuo Shiode, Yoritaka Otsuka, Tomohiro Kawasaki, Yutaka Hikichi, Junya Shite, Ken Kozuma, Raisuke Iijima, Yoshitaka Murakami
Summary: This randomized comparison study showed that ultrathin-strut drug-eluting stents were noninferior to thin-strut drug-eluting stents in terms of target lesion failure at 1 year, indicating that differences in strut thickness among DES have little impact on clinical outcomes when implanted with intravascular imaging guidance.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Multidisciplinary Sciences
Jinzhou Zhu, Xiyuan Zhang, Jialin Niu, Yongjuan Shi, Zhengbin Zhu, Daopeng Dai, Chenxin Chen, Jia Pei, Guangyin Yuan, Ruiyan Zhang
Summary: A drug-eluting bioresorbable stent (BRS) has been developed as an alternative to the standard drug-eluting stent (DES) due to concerns over the rigid constraint of DES. A new patented Mg-Nd-Zn-Zr alloy (JDBM) was developed to reduce the rapid degradation rate of Mg-based BRSs. In vitro and in vivo experiments showed that a PDLLA/RAPA coated JDBM BRS demonstrated low risks and maintained mechanical integrity after 6 months, with similar efficacy to standard DES.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Wei Xu, Makoto Sasaki, Takuro Niidome
Summary: Drug-eluting stents (DESs) are commonly used for the treatment of coronary artery disease. The evolution of the drug-eluting layer on the stent's surface is crucial for its functionality. Using biodegradable polymers is an attractive approach as it reduces the risk of late thrombosis after stent implantation. Understanding drug-release behavior from these polymers is important for improving the safety and efficacy of stent treatments.
Article
Cardiac & Cardiovascular Systems
Petr Tousek, Tomas Lazarak, Ivo Varvarovsky, Marketa Novackova, Marek Neuberg, Viktor Kocka
Summary: The PRAGUE-22 study investigated the efficacy of Magmaris stents compared to Xience stents in patients with acute coronary syndrome. The study found that implantation of Magmaris stents was associated with a greater extent of late lumen loss compared to Xience stents at the 12-month follow-up. This suggests that permanent, everolimus-eluting metallic stents may have better outcomes in this patient population.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Medicine, General & Internal
Kyoung-Woo Seo, Hyoung-Mo Yang, Junghan Yoon, Hyo-Soo Kim, Kiyuk Chang, Hong-Seok Lim, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Seung-Hwan Lee, Sung Gyun Ahn, Young Jin Youn, Jun-Won Lee, Bon-Kwon Koo, Kyung Woo Park, Han-Mo Yang, Jung-Kyu Han, Wook-Sung Chung, Hun-Jun Park, Byung-Hee Hwang, Eun-Ho Choo, Gyu-Chul Oh, Seung-Jea Tahk
Summary: The study evaluated the 5-year clinical outcomes of the Genoss DES, a Korean-made sirolimus-eluting coronary stent with abluminal biodegradable polymer, and found comparable rates of major adverse cardiac events with the Promus Element stent. The results confirm the reliability and effectiveness of the Genoss DES stent.
Article
Cardiac & Cardiovascular Systems
D. Chen, R. Gadeley, A. Wang, N. Jepson
Summary: This case report presents a rare but potentially lethal complication of coronary artery perforation during PCI with Absorb BVS implantation. The report highlights the technical challenges associated with managing this life-threatening complication.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Dong-Ru Ho, Shih-Horng Su, Pey-Jium Chang, Wei-Yu Lin, Yun-Ching Huang, Jian-Hui Lin, Kuo-Tsai Huang, Wai-Nga Chan, Chih-Shou Chen
Summary: This study investigated the effect of mTOR inhibitor drug-eluting biodegradable stent on thermal-injury-related ureteral stricture in rabbits. The results showed that the treatment significantly attenuated urinary tract obstruction induced by thermal injury and reduced the level of fibrosis proteins. It also suggested that inhibiting mTOR may result in changes in the fibrotic process by modifying fibrosis signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Riccardo Improta, Paola Scarparo, Jeroen Wilschut, Quinten Wolff, Joost Daemen, Wijnand K. Den Dekker, Felix Zijlstra, Nicolas M. Van Mieghem, Roberto Diletti
Summary: The study compared stent recoil of dp-ZES and bp-SES in chronic total occlusions and found that the ultra-thin strut bp-SES was a predictor of high absolute and high relative focal stent recoil.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Tobias Lenz, Tobias Koch, Michael Joner, Erion Xhepa, Jens Wiebe, J. J. Coughlan, Alp Aytekin, Tareq Ibrahim, Massimiliano Fusaro, Salvatore Cassese, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Sebastian Kufner
Summary: This study compared the 10-year clinical outcomes of patients with and without diabetes mellitus after treatment with new-generation drug-eluting stents. The results showed that patients with diabetes mellitus had significantly higher rates of major adverse cardiac events compared to those without diabetes mellitus.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Ae-Young Her, Eun-Seok Shin, Sunwon Kim, Bitna Kim, Tae-Hyun Kim, Chang-Bae Sohn, Byung Joo Choi, Yongwhi Park, Jung Rae Cho, Young-Hoon Jeong
Summary: This study investigated the clinical impact of drug-coated balloon (DCB) treatment in patients with diabetes mellitus (DM) and multivessel coronary artery disease (CAD), and found that DCB treatment reduced the risk of major adverse cardiovascular events (MACE) in patients with DM, but not in those without DM.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Engineering, Biomedical
Lin-Lin Liu, Juan Qin, Chu-Hui Zeng, Rui-Jie Du, Tao Pan, Jia-Jie Ji, Li-Gong Lu, Lei Chen, Dong-Fang Liu, Jian Yang, Shi-Cheng He, Hai-Dong Zhu, Gao-Jun Teng
Summary: A biodegradable composite stent with a drug-loaded polymer coating was designed and tested in this study. The stent exhibited increased radial force and continuous drug release as it degraded. The results showed that it has the potential to be a safe and effective approach for benign esophageal stricture.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Jung-Hoon Park, Jieun Park, Yejong Park, Jeon Min Kang, Dae Sung Ryu, Jeongsu Kyung, Jong Keon Jang, Changmo Hwang, In Kyong Shim, Ho-Young Song, Su-Geun Yang, Song Cheol Kim
Summary: The study investigated the efficacy and safety of an acetazolamide-eluting biodegradable tubular stent for preventing self-digestion and inflammatory diseases caused by pancreatic juice leakage in a porcine model. Results showed that the stent significantly suppressed intra-abdominal inflammatory diseases and prevented late stricture formation at the anastomotic site.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Jian-Feng Zheng, Zi-Wei Xi, Yang Li, Jia-Nan Li, Hong Qiu, Xiao-Ying Hu, Tong Luo, Chao Wu, Xin Wang, Lai-Feng Song, Li Li, Hai-Ping Qi, Gui Zhang, Li Qin, Wan-Qian Zhang, Xiao-Li Shi, Shu-Han Wang, De-Yuan Zhang, Bo Xu, Run-Lin Gao
Summary: This study investigated the long-term biocompatibility, safety, and degradation of the ultrathin nitrided iron bioresorbable scaffold. The results showed that the efficacy and safety of the nitrided iron scaffold were comparable with those of the Vision stent within 52 weeks after implantation. Furthermore, a large number of struts were almost completely absorbed in situ at 7 years follow-up.
BIOACTIVE MATERIALS
(2022)
Review
Cardiac & Cardiovascular Systems
Vincenzo Tufaro, Patrick Washington Serruys, Lorenz Raber, Martin Richard Bennett, Ryo Torii, Sophie Zhaotao Gu, Yoshinobu Onuma, Anthony Mathur, Andreas Baumbach, Christos Vasileios Bourantas
Summary: Intravascular imaging plays an important role in assessing the effectiveness of drug therapies targeting atherosclerosis. Serial intravascular ultrasound, optical coherence tomography, or near-infrared spectroscopy-intravascular ultrasound studies allow for evaluation of the impact of different treatments on plaque burden and morphology. However, established intravascular imaging surrogate endpoints have limited efficacy in predicting the prognostic value of these therapies, necessitating the development of alternative imaging endpoints based on multimodality/hybrid intravascular imaging.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Shigetaka Kageyama, Neil O'Leary, Mohammed S. El-Kurdi, Jochen Reinoehl, Eric Solien, Richard W. Bianco, Mirko Doss, Bart Meuris, Renu Virmani, Martijn Cox, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study demonstrates the feasibility and effectiveness of a novel biorestorative graft in an ovine coronary artery bypass graft model, suggesting its potential as an alternative to saphenous vein grafts. These findings could pave the way for the first-in-man trial of using this new material for coronary artery bypass graft patients who struggle with harvesting SVGs.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Letter
Cardiac & Cardiovascular Systems
Jordi Sans-Rosello, Hector M. Garcia-Garcia
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Guy F. A. F. Prado, Pablo J. Blanco, Carlos A. Bulant, Gonzalo D. Ares, Jose Mariani, Adriano Caixeta, Breno O. Almeida, Stefano Garzon, Fabio A. Pinton, Emanuele Barbato, Flavio L. Ribichini, Gabor G. Toth, Felix Mahfoud, William Wijns, Hector M. Garcia-Garcia, Pedro A. Lemos
Summary: This study investigated the relationship between the spatial geometry of coronary arteries and the severity and composition of coronary artery disease (CAD) using computational methods. The results showed that three-dimensional geometric indexes were associated with the degree and composition of atherosclerosis in coronary arteries, and this association remained significant even after adjusting for clinical characteristics.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Sneha S. Jain, Ditian Li, Ovidiu Dressler, Lak Kotinkaduwa, Patrick W. Serruys, A. Pieter Kappetein, Joseph F. Sabik, Marie-Claude Morice, John Puskas, David E. Kandzari, Dimitri Karmpaliotis, Nicholas J. Lembo, W. Morris Brown, Adrian P. Banning, Gregg W. Stone
Summary: This study assessed the association between periprocedural major adverse events (MAE) and subsequent mortality after percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery revascularization. The study found that nonfatal periprocedural MAE strongly predicted both early and late mortality after both PCI and CABG.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Xinlei Wu, Mick P. L. Renkens, Laura Kerkmeijer, Mattia Lunardi, Jiayue Huang, Daixin Ding, Neil O'Leary, Robbert J. de Winter, Yoshinobu Onuma, Patrick W. Serruys, Joanna Wykrzykowska, Shengxian Tu, William Wijns
Summary: This study presents a computational model for assessing superficial wall strain (SWS) of de-novo coronary stenoses treated with bioresorbable scaffold (BRS) or drug-eluting stent (DES). The model utilizes angiography data to evaluate the mechanical status of arteries in-vivo, providing valuable information for predicting cardiovascular outcomes.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Pruthvi C. Revaiah, Yoshinobu Onuma, Patrick W. Serruys
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Astronomy & Astrophysics
S. Samuroff, R. Mandelbaum, J. Blazek, A. Campos, N. MacCrann, G. Zacharegkas, A. Amon, J. Prat, S. Singh, J. Elvin-Poole, A. J. Ross, A. Alarcon, E. Baxter, K. Bechtol, M. R. Becker, G. M. Bernstein, A. Carnero Rosell, M. Carrasco Kind, R. Cawthon, C. Chang, R. Chen, A. Choi, M. Crocce, C. Davis, J. DeRose, S. Dodelson, C. Doux, A. Drlica-Wagner, K. Eckert, S. Everett, A. Ferte, M. Gatti, G. Giannini, D. Gruen, R. A. Gruendl, I Harrison, K. Herner, E. M. Huff, M. Jarvis, N. Kuropatkin, P-F Leget, P. Lemos, J. McCullough, J. Myles, A. Navarro-Alsina, S. Pandey, A. Porredon, M. Raveri, M. Rodriguez-Monroy, R. P. Rollins, A. Roodman, G. Rossi, E. S. Rykoff, C. Sanchez, L. F. Secco, I Sevilla-Noarbe, E. Sheldon, T. Shin, M. A. Troxel, I Tutusaus, N. Weaverdyck, B. Yanny, B. Yin, Y. Zhang, J. Zuntz, M. Aguena, O. Alves, J. Annis, D. Bacon, E. Bertin, S. Bocquet, D. Brooks, D. L. Burke, J. Carretero, M. Costanzi, L. N. da Costa, M. E. S. Pereira, J. De Vicente, S. Desai, H. T. Diehl, J. P. Dietrich, P. Doel, I Ferrero, B. Flaugher, J. Frieman, J. Garcia-Bellido, S. R. Hinton, D. L. Hollowood, K. Honscheid, D. J. James, K. Kuehn, O. Lahav, J. L. Marshall, P. Melchior, J. Mena-Fernandez, F. Menanteau, R. Miquel, J. Newman, A. Palmese, A. Pieres, A. A. Plazas Malagon, E. Sanchez, V Scarpine, M. Smith, E. Suchyta, M. E. C. Swanson, G. Tarle, C. To
Summary: We directly constrain galaxy intrinsic alignments (IAs) using data from Dark Energy Survey Year 3 (DES Y3), Extended Baryon Oscillation Spectroscopic Survey (eBOSS), and Baryon Oscillation Spectroscopic Survey (BOSS). Our measurements incorporate different types of galaxies at various redshifts and fit a model that includes lensing, magnification, and photometric redshift error. We detect IAs in each sample and observe a detectable dependence on color between broadly defined red samples. It is likely that future measurements will require a more sophisticated approach to account for the effects of color and luminosity on the IA signal.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Hesham El Zomor, Hendrik Wienemann, Matti Adam, Tanja Rudolph, Ahmed Elkoumy, Mahmoud Abdelshafy, Pruthvi Chenniganahosahalli Revaiah, Patrick W. Serruys, Osama Soliman
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shinichiro Masuda, Patrick W. Serruys, Shigetaka Kageyama, Nozomi Kotoku, Kai Ninomiya, Scot Garg, Alan Soo, Marie-Angele Morel, John D. Puskas, Jagat Narula, Ulrich Schneider, Torsten Doenst, Kaoru Tanaka, Johan de Mey, Mark La Meir, Antonio L. Bartorelli, Saima Mushtaq, Giulio Pompilio, Daniele Andreini, Yoshinobu Onuma
Summary: This study compared treatment recommendations based on the SYNTAX score 2020 derived from coronary computed tomography angiography (CCTA) and invasive coronary angiography (ICA). The results showed moderate to substantial agreement between the anatomical SYNTAX scores derived from CCTA and ICA, suggesting that CCTA could be used as an alternative to ICA when making decisions regarding the modality of revascularization.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Nozomi Kotoku, Daixin Ding, Kai Ninomiya, Neil O' Leary, William Wijns, Shengxian Tu, Nicolo Piazza, Yoshinobu Onuma, Patrick W. Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kai Ninomiya, Patrick Serruys, Shinichiro Masuda, Jiayue Huang, Ding Daixin, Nozomi Kotoku, Shigetaka Kageyama, Manish Doshi, William Wijns, Shengxian Tu, Faisal Sharif, Bernardo Cortese, Sandeep Basavarajaiah, Bernhard Reimers, Antonio Colombo, Yoshinobu Onuma
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Yoshinobu Onuma, Shinichiro Masuda, Takashi Muramatsu, Yuki Ishibashi, Ken Kozuma, Hideyuki Kawashima, Gaku Nakazawa, Kuniaki Takahashi, Kengo Tanabe, Norihiro Kogame, Masato Nakamura, Taku Asano, Takayuki Okamura, Yosuke Miyazaki, Hiroki Tateishi, Yukio Ozaki, Shimpei Nakatani, Yuki Katagiri, Yoshihiro Morino, Kai Ninomiya, Shigetaka Kageyama, Nozomi Kotoku, Patricia O. Guimaraes, Pedro A. Lemos, Patrick W. Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Eric K. W. Poon, Xinlei Wu, Jouke Dijkstra, Neil O'Leary, Ryo Torii, Johan H. C. Reiber, Christos V. Bourantas, Peter Barlis, Yoshinobu Onuma, Patrick W. Serruys
Summary: The study aims to compare the differences in endothelial shear stress (ESS) obtained using different image reconstruction methods in patients' vessels treated with bioresorbable scaffolds. The results show that using 3D-quantitative coronary angiography for simple image reconstruction underestimates the minimum stent area and stent length compared to the optical coherence tomography method, and angiography-derived ESS tends to overestimate ESS.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Patricia O. Guimaraes, Marcelo Franken, Caio A. M. Tavares, Fabio S. Silveira, Murillo O. Antunes, Ricardo R. Bergo, Rodrigo M. Joaquim, Jessica C. S. Hirai, Pedro B. Andrade, Fabio G. Pitta, Jose Mariani, Bruno R. Nascimento, Marcos S. Silveira, Tiberio A. O. Costa, Frederico T. C. Dall'Orto, Renato G. Serpa, Fernanda B. A. Sampaio, Louis N. Ohe, Fernanda M. Mangione, Remo H. M. Furtado, Rogerio Sarmento-Leite, Frederico Monfardini, Silvia R. L. Assis, Jose C. Nicolau, Andrei C. Sposito, Renato D. Lopes, Yoshinobu Onuma, Marco Valgimigli, Dominick J. Angiolillo, Patrick W. Serruys, Otavio Berwanger, Fernando Bacal, Pedro A. Lemos
Summary: This study aims to compare the efficacy and safety of immediate aspirin-free single antiplatelet therapy (SAPT) with dual antiplatelet therapy (DAPT) in patients with acute coronary syndromes (ACS) following percutaneous coronary intervention (PCI). It will provide important insights on the efficacy and safety of withdrawing aspirin in the early phase of ACS.
