期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 11, 页码 22117-22131出版社
MDPI
DOI: 10.3390/ijms141122117
关键词
Csr network; Rsm network; global regulation; RNA-binding protein; sRNAs; post-transcriptional regulation
资金
- FNRS [FRSM 3.4621.12]
- Interuniversity Attraction Poles Programme
- Belgian Science Policy Office (MICRODEV)
- Fonds Jean Brachet
- Fondation David and Alice Van Buuren
- FRIA
Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr) network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators. CsrA binds to mRNA targets and regulates translation either negatively or positively. Binding to small non-coding RNAs controls activity of this protein. Expression of these regulators is tightly regulated at the level of transcription and stability by various global regulators (RNAses, two-component systems, alarmone). We discuss the implications of these complex regulations in bacterial adaptation.
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