Article
Biochemistry & Molecular Biology
Qiaohong Xu, Fang Cui, Xiaodong Li, Nan Wang, Yingrui Gao, Shiping Yin, Fangdi Hu
Summary: Dangshen, a medicinal and edible plant, has been found to have protective effects on gastric mucosa. It can improve chronic non-atrophic gastritis by enhancing antioxidant capacity, suppressing inflammatory responses, and reducing cell apoptosis. This study reveals the potential value of Dangshen in the treatment of gastric diseases.
Article
Environmental Sciences
Hui Yang, Yuting Chen, Minjuan Zeng, Haipeng Wu, Xiangli Zou, Tiantian Fang, Lu Zhai, Hairong Liang, Hao Luo, Gaiqin Tian, Qizhan Liu, Huanwen Tang
Summary: This study found that LINC01480, a long non-coding RNA, plays a critical role in the damage caused by benzene and its metabolite. It inhibits apoptosis by regulating the PI3K/AKT pathway and may become a potential target for therapeutic intervention of benzene-induced toxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Integrative & Complementary Medicine
Shuhan Wang, Qixiao Cui, Xiaoyu Chen, Xuejie Zhu, Kehao Lin, Qiusheng Zheng, Yuliang Wang, Defang Li
Summary: This study found that Ailanthone has inhibitory effects on human tongue squamous cell carcinoma (TSCC) and can induce apoptosis, cell cycle arrest, and downregulate the PI3K/Akt signaling pathway. These findings suggest the potential therapeutic application of Ailanthone for human TSCC.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Environmental Sciences
Yulong Wang, Jia Xu, Saud Alarifi, Huanjun Wang
Summary: Thyroid cancer, particularly papillary thyroid cancers, is common in populations with high iodine intake. Signaling molecules like PI3K, AKT, and MAP kinase play significant roles in cancer progression and are potential targets for cancer treatment. Natural compounds derived from plants, such as the diterpenoid compound kirenol studied in this research, show promising anticancer properties and could be used as a therapeutic modality for thyroid cancer.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biology
Neslihan Tekin Karacaer, Baris Kerimoglu, Talat Baran, Mehtap Tarhan, Ayfer Mentes, Kamile Ozturk
Summary: The investigation focused on reporting the fabrication, characterization, cytotoxicity, and apoptotic assessment of two new platinum based compounds on human leukemia cells. The results demonstrated dose-dependent cytotoxic effects and modulation of apoptotic gene expressions in the treated cells, suggesting the potential of these newly synthesized platinum compounds as anticancer drugs.
Article
Oncology
Fei Peng, Weisong Cai, Jianping Li, Haohuan Li
Summary: This study demonstrates that ClC-5 downregulation induces apoptosis in osteosarcoma cells via the activation of the mitochondria-dependent apoptotic pathway. Lowering intracellular Cl- concentration increases cell viability, while knockdown of ClC-5 promotes apoptosis and disrupts cell survival in osteosarcoma. The interaction between ClC-5 and Bax, along with the promotion of Bax translocation, plays a crucial role in this apoptotic process.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Tapas Patra, Keith Meyer, Ratna B. Ray, Tatsuo Kanda, Ranjit Ray
Summary: The combination of Akt inhibitor and mTORC1/2 dual inhibitor has been shown to effectively induce apoptotic cell death in p53 mutant HCC cells by activating FOXO3a. This treatment strategy may offer therapeutic advantages for HCC patients with p53 mutations.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Shoaib Alam, Taj Mohammad, Rayees A. Padder, Md. Imtaiyaz Hassan, Mohammad Husain
Summary: This study explored the apoptotic potential of natural compounds targeting Bax and Bcl2 using in-silico and in-vitro methods. Thymoquinone and quercetin showed good binding affinities towards Bax and Bcl2, leading to stable complexes maintained by various noncovalent interactions. In vitro experiments demonstrated their impressive apoptotic induction potential and ability to sensitize NSCLS cells towards apoptosis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Andrology
Dong Xing, Yuanyuan Liu, Dalin Sun, Dandan Wang, Yihan Jin, Bin Cai, Baofang Jin
Summary: This study found that Yangjing capsule could promote testosterone production and inhibit cell apoptosis in Leydig cells by triggering the SET/PI3K/Akt pathway. The results showed that YC-medicated serum significantly increased the expression levels of key molecules and testosterone production, while suppressing apoptosis in MLTC-1 cells. In vivo experiments also confirmed the effects of YC extract on steroidogenesis and apoptosis suppression in mouse testis.
Article
Biochemistry & Molecular Biology
Sucharat Tungsukruthai, Onrapak Reamtong, Sittiruk Roytrakul, Suchada Sukrong, Chanida Vinayanwattikun, Pithi Chanvorachote
Summary: The study demonstrates that the polyphenol stilbene compound PE5 can inhibit the growth of lung cancer cells by promoting autophagic cell death, offering a potential new approach to cancer treatment. Cell death induced by PE5 is accompanied by autophagy induction and is mediated by targeting the AKT/mTOR and Bcl-2 pathways to induce ACD.
Article
Biochemistry & Molecular Biology
Te-Chun Hsia, Shu-Fen Peng, Fu-Shin Chueh, Kung-Wen Lu, Jiun-Long Yang, An-Cheng Huang, Fei-Ting Hsu, Rick Sai-Chuen Wu
Summary: This study demonstrates that BDMC possesses potent anticancer activity on human glioblastoma cells, inhibiting tumor cell proliferation and inducing apoptosis. In a mouse model, BDMC treatment significantly suppresses tumor growth without inducing systemic toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Mieko Matsuyama, Joseph T. Ortega, Yuri Fedorov, Jonah Scott-McKean, Jeannie Muller-Greven, Matthias Buck, Drew Adams, Beata Jastrzebska, William Greenlee, Shigemi Matsuyama
Summary: In this study, a cytoprotective small molecule (CSM) named M109S was identified through a cell-based screening. M109S protected retinal cells and inhibited mitochondrial-dependent apoptosis by interacting with Bax and affecting cellular metabolism.
Article
Cell Biology
Qin Zhang, Li Chen, Mengxi Gao, Shubin Wang, Lingzhen Meng, Liru Guo
Summary: In this study, it was found that kaempferol has anti-hepatocellular carcinoma activity by inhibiting cell proliferation, promoting apoptosis, and regulating the expression levels of apoptosis-related proteins in HepG2 cells.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Alicia Garrido, Leticia Perez-Sisques, Cristina Simonet, Genis Campoy-Campos, Julia Solana-Balaguer, Nuria Martin-Flores, Manel Fernandez, Marta Soto, Donina Obiang, Ana Camara, Francesc Valldeoriola, Esteban Munoz, Yaroslau Compta, Esther Perez-Navarro, Jordi Alberch, Eduardo Tolosa, Maria-Jose Marti, Mario Ezquerra, Cristina Malagelada, Ruben Fernandez-Santiago
Summary: The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). It was found that there were specific increases of P-Ser-473-AKT levels in all G2019S carriers, either L2PD or L2NMC, absent in iPD.
ANNALS OF NEUROLOGY
(2022)
Review
Oncology
Victoria Zaitceva, Gelina S. Kopeina, Boris Zhivotovsky
Summary: Anastasis is a phenomenon where cells reverse death process and continue to grow even after being disturbed and damaged. Researchers examine the mechanisms of cell death reversal, development of anastasis, detection methods, and the role of signaling from different intracellular compartments in stimulating anastasis.