Article
Gastroenterology & Hepatology
Shekhar Singh Jadaun, Rohit Mehtani, Ana Hasnain, Sushant Bhatia, Vikash Moond, Mukesh Kumar, Vikash Kuhad, Shweta Singh, Shaleen Agarwal, Subhash Gupta, Sanjiv Saigal
Summary: This retrospective study analyzed the outcomes of living donor liver transplant (LDLT) in primary sclerosing cholangitis (PSC) at a tertiary liver transplant center in north India. The study found that LDLT in PSC can achieve good long-term outcomes, but there is a risk of PSC recurrence in approximately one-fifth of patients.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Immunology
Emanual Maverakis, Alexander A. Merleev, Dayoung Park, Muchena J. Kailemia, Gege Xu, L. Renee Ruhaak, Kyoungmi Kim, Qiuting Hong, Qiongyu Li, Patrick Leung, William Liakos, Yu-Jui Yvonne Wan, Christopher L. Bowlus, Alina I. Marusina, Nelvish N. Lal, Yixuan Xie, Guillaume Luxardi, Carlito B. Lebrilla
Summary: The study utilized MRM mass spectrometry to characterize glycan alterations associated with PBC and PSC, resulting in multi-analyte diagnostic models capable of accurately distinguishing the diseases. Additionally, the research investigated how environmental factors, such as bile acids, can influence glycosylation and potentially lead to the generation of altered selfantigens as immune targets.
CLINICAL IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Annarosa Floreani, Sara De Martin
Summary: PSC is a chronic cholestatic liver disease with no effective treatment currently available. There is controversy over the use of UDCA in PSC treatment. Novel pharmacological strategies targeting bile composition, immunomodulation, gut microbiome, and fibrosis are emerging, suggesting potential for personalized combination therapies for successful PSC treatment.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Yaqin Zhang, Ziying Jiao, Mingwei Chen, Bing Shen, Zongwen Shuai
Summary: Primary biliary cholangitis (PBC) is an autoimmune-mediated liver disease characterized by progressive damage and destruction of bile duct epithelial cells. Non-coding RNA plays a crucial role in the pathogenesis and biological processes of PBC and can serve as potential biomarkers for diagnosis and treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Gastroenterology & Hepatology
Frederik Nevens, Michael Trauner, Michael P. Manns
Summary: The discovery of nuclear receptors and transporters has contributed to the development of new drugs for the treatment of cholestatic liver diseases, particularly in the field of second-line therapies for PBC. These new drugs can target cholestasis, fibrogenesis, immune-mediated action, and symptom relief. Obeticholic acid is currently the only approved second-line therapy for PBC, while other drugs in late-stage clinical development include peroxisome proliferator-activated receptor agonists, norursodeoxycholic acid, and NADPH oxidase 1/4 inhibitors.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuki Yamashita, Takeji Umemura, Takefumi Kimura, Satoru Joshita, Junko Hirohara, Toshiaki Nakano, Atsumasa Komori, Atsushi Tanaka
Summary: This study showed that baseline ALBI grade is a simple non-invasive predictor for prognosis in PBC, and it is significantly associated with histological stage and disease progression. ALBI score/grade can be used to assess liver function and predict mortality and the need for liver transplantation in PBC patients.
Article
Nutrition & Dietetics
Maryam Ebadi, Elora Rider, Catherine Tsai, Sarah Wang, Ellina Lytvyak, Andrew Mason, Aldo J. Montano-Loza
Summary: This study aimed to investigate the association between severe vitamin D deficiency and disease progression, hepatobiliary malignancies, liver-related mortality, and the need for liver transplantation in primary sclerosing cholangitis (PSC). The results showed that severe vitamin D deficiency was related to an increased risk of hepatobiliary malignancies, and a severe deficiency at diagnosis and persistent deficiencies over time were independently associated with poor clinical liver outcomes.
Article
Gastroenterology & Hepatology
Eric F. Martin
Summary: The number of liver transplantation for primary biliary cholangitis (PBC) has decreased over the years, but it remains an important and curative option for progressive PBC patients. Recent studies from the Global PBC Study Group have provided valuable insights into the changes in PBC before and after liver transplantation.
CLINICS IN LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Michael Praktiknjo, Taotao Zhou, Maximiliane Krusken, Torid Jacob, Alois M. Sprinkart, Sebastian Nowak, Markus Kimmann, Leona Dold, Johannes Chang, Christian Jansen, Christian P. Strassburg, Julian Luetkens, Tobias J. Weismuller
Summary: This study found that intramuscular fat fraction (IMFF) is associated with transplant-free survival in patients with primary sclerosing cholangitis (PSC). IMFF may serve as an indicator for identifying patients in urgent need of liver transplantation.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Kristoffer Kjaergaard, Kim Frisch, Michael Sorensen, Ole Lajord Munk, Alan Frederick Hofmann, Jacob Horsager, Anna Christina Schacht, Mary Erickson, David Shapiro, Susanne Keiding
Summary: The study demonstrated that OCA increased the hepatic transport of conjugated bile acids in PBC patients, reducing the time hepatocytes are exposed to potentially toxic bile acids.
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Saraswathi Lakkasani, Gowthami Sai Kogilathota Jagirdhar, Murad Qirem, Scott W. Digiacomo, Srinivasa Pantula
Summary: Primary sclerosing cholangitis (PSC) is a liver disease characterized by inflammation and fibrosis in the bile ducts, often associated with inflammatory bowel disease. PSC poses a risk for various types of cancer and there is currently no effective medical treatment available. In rare cases, PSC can overlap with autoimmune hepatitis (AIH), emphasizing the need for comprehensive evaluation and appropriate treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Diletta Overi, Guido Carpino, Laura Cristoferi, Paolo Onori, Lindsey Kennedy, Heather Francis, Nicola Zucchini, Cristina Rigamonti, Mauro Vigano, Annarosa Floreani, Daphne D'Amato, Alessio Gerussi, Rosanna Venere, Gianfranco Alpini, Shannon Glaser, Domenico Alvaro, Pietro Invernizzi, Eugenio Gaudio, Vincenzo Cardinale, Marco Carbone
Summary: Extensive ductular reaction is associated with disease stage, liver fibrosis, treatment response, and prognosis in patients with primary biliary cholangitis (PBC). The establishment of ductular-canalicular junctions and fibrogenetic cell activation are observed in PBC patients with reactive ductules. Ursodeoxycholic acid treatment reduces ductular reaction and fibrosis and increases ductular-canalicular junctions in a mouse model of intrahepatic cholestasis.
Review
Medicine, General & Internal
Alex Smith, Benjamin Giles, Richard J. Aspinall
Summary: Recent years have witnessed significant progress in our understanding and management of primary biliary cholangitis. Large multicentre studies have provided extensive data on the natural course of the disease, facilitating the identification of high-risk patients and the development of new medications. Recent guidelines underscore the importance of risk stratification, targeted symptom management, and early initiation of second-line therapies.
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2022)
Article
Surgery
Wisam Sbeit, Tawfik Khoury, Eran Goldin, Mahmud Mahamid
Summary: The study found that fully-covered metal stent (FCMS) was a safe and effective treatment option for patients with Primary Sclerosing Cholangitis (PSC) related refractory Dominant Strictures (DS).
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Gastroenterology & Hepatology
Michal Prokopic, Ulrich Beuers
Summary: PSC is a rare liver disease characterized by bile duct abnormalities leading to liver fibrosis and potential cholangiocarcinoma. The exact pathogenesis is still unclear, with strong association with inflammatory bowel disease. Current medical treatments have not been proven effective, with liver transplantation remaining the most viable option for late-stage disease.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Magd A. Kotb, Hesham Nabeh Elmahdy, Nour El Deen Mahmoud Khalifa, Mohamed Hamed Nasr El-Deen, Mohamed Amr N. Lotfi
Article
Urology & Nephrology
Neveen A. Soliman, Marwa M. Nabhan, Safaa M. Abdelrahman, Hanan Abdelaziz, Rasha Helmy, Khaled Ghanim, Hafez M. Bazaraa, Ahmed M. Badr, Omar A. Tolba, Magd A. Kotb, Khaled M. Eweeda, Alaa Fayez
NEPHROLOGIE & THERAPEUTIQUE
(2017)
Article
Multidisciplinary Sciences
Magd A. Kotb, Inas Abd El Satar, Ahmed M. Badr, Nancy H. Anis, Hoda Abd El Rahman Ismail, Alaa F. Hamza, Hesham M. Abdelkader
JOURNAL OF ADVANCED RESEARCH
(2017)
Article
Multidisciplinary Sciences
Magd A. Kotb, Lobna Mansour, Christine William Shaker Basanti, Wael El Garf, Ghada I. Z. Ali, Sally T. Mostafa El Sorogy, Inas E. M. Kamel, Naglaa M. Kamal
JOURNAL OF ADVANCED RESEARCH
(2018)
Article
Pediatrics
Magd A. Kotb, Alaa F. Hamza, Hesham Abd El Kader, Magda El Monayeri, Dalia S. Mosallam, Nazira Ali, Christine William Shaker Basanti, Hafez Bazaraa, Hany Abdelrahman, Marwa M. Nabhan, Hend Abd El Baky, Sally T. Mostafa El Sorogy, Inas E. M. Kamel, Hoda Ismail, Yasmin Ramadan, Safaa M. Abd El Rahman, Neveen A. Soliman
PEDIATRIC TRANSPLANTATION
(2019)
Article
Medicine, General & Internal
Magd Ahmed Kotb, Dalia Mosallam, Christine William Shaker Basanti, Sally Talaat Mostafa El Sorogy, Ahmed M. Badr, Hend El Hosainy Abd El Baky, Iman Hassan Draz
Article
Hematology
Fatina I. Fadel, Magd A. Kotb, Mohamed A. Abdel Mawla, Rasha M. Hasanin, Amr Mohamed Salem, Mohamed Gamal Fathallah, Khalda Sayed Amr, Hoda Abdalla Ahmed, Doaa M. Salah
Summary: Primary hyperoxaluria type 1 (PH1) is a rare disease characterized by overproduction of oxalate, presenting with radiopaque renal stones or obstructive uropathy. Clinical presentation varies by age of onset, with infantile onset being the most aggressive form. Aggressive hemodialysis through arteriovenous fistula is necessary for adequate dialysis, while peritoneal dialysis is challenged by infection.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Editorial Material
Pediatrics
Magd Ahmed Kotb, Satoshi Ieiri, Sherif Mohamed Shehata
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Magd A. Kotb, Lubna A. Fawaz, Rania A. Zeitoun, Yomna M. Shaalan, Nazira Aly, Hesham Abd El Kader, Gamal El Tagy, Haytham Esmat, Alaa F. Hamza, Hend Abd El Baky
Summary: This study examined the factors related to poor bone health in pediatric liver transplant recipients. The use of steroids, weight, platelets, and hemoglobin were found to be significantly associated with poor bone health. The findings highlight the importance of assessing and improving bone health in children following liver transplantation.
Review
Medicine, General & Internal
Magd A. Kotb, Ahmed Kotb, Sahar Talaat, Sherif M. Shehata, Nabil El Dessouki, Ahmed A. ElHaddad, Gamal El Tagy, Haytham Esmat, Sameh Shehata, Mohamed Hashim, Hanan A. Kotb, Hanan Zekry, Hesham M. Abd Elkader, Sherif Kaddah, Hend E. Abd El Baky, Nabil Lotfi
Summary: Kotb disease BA is a liver disease caused by congenital aflatoxicosis, leading to severe liver tissue damage and impaired liver regeneration. It is characterized by inflammation, fibrosis, bile duct proliferation, cirrhosis, and disruption of detoxification genes, requiring prompt diagnosis and intervention.
Article
Engineering, Biomedical
Magd Ahmed Kotb, Hesham Nabih Elmahdy, Hadeel Mohamed Seif El Dein, Fatma Zahraa Mostafa, Mohammed Ahmed Refaey, Khaled Waleed Younis Rjoob, Iman H. Draz, Christine William Shaker Basanti
MEDICAL DEVICES-EVIDENCE AND RESEARCH
(2020)
Proceedings Paper
Computer Science, Artificial Intelligence
Magd Ahmed Kotb, Hesham Nabih Elmandy, Fatma El Zahraa Mostafa, Christine William Shaker, Mohamed Ahmed Refaey, Khaled Waleed Younis Rjoob
INTELLIGENT COMPUTING, VOL 2
(2019)
Article
Gastroenterology & Hepatology
Magd A. Kotb, Iman Draz, Christine W. S. Basanti, Sally T. M. El Sorogy, Hesham M. Abd Elkader, Haytham Esmat, Hend Abd El Baky, Dalia Sayed Mosallam
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
(2019)
Review
Medicine, General & Internal
Magd A. Kotb, Lobna Mansour, Radwa A. Shamma
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2019)
Article
Computer Science, Theory & Methods
Magd Ahmed Kotb, Mona El Falaki, Hesham Nabih Elmahdy, Christine William Shaker, Fatma El Zahraa Mostafa, Mohamed Ahmed Refaey, Khaled W. Y. Rjoob
INTERNATIONAL JOURNAL OF ADVANCED COMPUTER SCIENCE AND APPLICATIONS
(2016)