期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 13, 期 4, 页码 5179-5194出版社
MDPI AG
DOI: 10.3390/ijms13045179
关键词
vaccine; antigen delivery system; bacteriophage fd
资金
- FIRB-Merit [RBNE08LN4P_002]
- [MIUR-PON01_00117]
Peptides displayed on the surface of filamentous bacteriophage fd are able to induce humoral as well as cell-mediated immune responses, which makes phage particles an attractive antigen delivery system to design new vaccines. The immune response induced by phage-displayed peptides can be enhanced by targeting phage particles to the professional antigen presenting cells, utilizing a single-chain antibody fragment that binds dendritic cell receptor DEC-205. Here, we review recent advances in the use of filamentous phage fd as a platform for peptide vaccines, with a special focus on the use of phage fd as an antigen delivery platform for peptide vaccines in Alzheimer's Disease and cancer.
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