Article
Food Science & Technology
Qinyuan He, Qiutong Zheng, Yanping Liu, Yilong Miao, Yumeng Zhang, Ting Xu, Shufen Bai, Xia Zhao, Xiaojun Yang, Zhice Xu
Summary: This study suggests that a high-salt diet may impair female fertility in mice by weakening oocyte quality. The underlying mechanisms involve the inhibition of oocyte autophagy and apoptosis, as well as the disruption of mitochondrial function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Environmental Sciences
Rui Cheng, Zhiming Zhang, Chunhua Zhan, Tianlong Qin, Li Wang, Xuezhen Zhang
Summary: This study found that exposure to selenite inhibited the ovarian development and oocyte maturation in female zebrafish, resulting in reduced egg production. It also induced oocyte apoptosis and disrupted the hormone levels and oxidative stress response in the ovary. Furthermore, maternal exposure to selenite led to offspring apoptosis and altered the transcription of genes related to endoplasmic reticulum stress.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Kang-Na Wei, Xin-Jie Wang, Zhao-Cheng Zeng, Ruo-Ting Gu, Shu-Zi Deng, Jiang Jiang, Chang-Long Xu, Wei Li, Hai-Long Wang
Summary: The study revealed the toxic effects of PFOS on mouse oocyte maturation, including reduced polar body extrusion rate and symmetrical cell division. PFOS caused abnormal cytoskeleton in oocytes, inhibited meiotic progression, and disrupted oocyte quality and histone modifications.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Reproductive Biology
Lihua Cao, Ting Yang, Shihai Huang, Xuedan Yun, Hanqi Hou, Ting Wang, Deshun Shi, Xiangping Li
Summary: ZO-1 and ZO-2 are involved in maintaining epithelial polarity, gene transcription, cell proliferation, and tumor cell metastasis. Their expression patterns during porcine oocyte maturation are similar, and downregulation of ZO-1 and ZO-2 affects the maturation of porcine oocytes and early embryonic development.
Article
Pharmacology & Pharmacy
Hyo-Gu Kang, Pil-Soo Jeong, Min Ju Kim, Ye Eun Joo, Min-Ah Gwon, Se-Been Jeon, Bong-Seok Song, Sun-Uk Kim, Sanghoon Lee, Bo-Woong Sim
Summary: Exposure to arsenic has negative effects on porcine oocyte maturation, including meiotic defects and embryo developmental arrest, which are achieved through mitochondrial dysfunction and apoptosis induced by oxidative stress.
Review
Biochemistry & Molecular Biology
Cai-feng Fei, Li-quan Zhou
Summary: Reproductive diseases, particularly infertility, are a widespread issue globally. The review highlights the impact of genetic mutations in various developmental regulators on infertility in young female patients. Categorizing these factors and comparing phenotypic differences between human and mouse models provide valuable insights for clinical diagnosis and treatment.
Article
Cell Biology
Dong Niu, Kun-Lin Chen, Yi Wang, Xiao-Qing Li, Lu Liu, Xiang Ma, Xing Duan
Summary: It has been found that exposure to HES can adversely affect oocyte quality, resulting in impaired oocyte maturation and abnormalities in mitochondrial function. Mitochondrial dysfunction and disruption in mitochondrial fission and fusion dynamics are believed to be major contributors to the reduced oocyte quality after HES exposure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Jian-Zhou Shang, Shi-Ru Li, Xiao-Qing Li, Yu-Ting Zhou, Xiang Ma, Lu Liu, Dong Niu, Xing Duan
Summary: Exposure to Simazine reduces oocyte maturation competence and embryonic developmental capacity, disrupts microtubule stability and actin polymerization, leading to mitochondrial dysfunction and apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Ida Hallberg, Sara Persson, Matts Olovsson, Marc-Andre Sirard, Pauliina Damdimopoulou, Joelle Ruegg, Ylva C. B. Sjunnesson
Summary: Exposure to PFOS during oocyte maturation in cows resulted in delayed embryo development, altered gene expression and DNA methylation patterns, which may impact female fertility. The effects were more pronounced at higher exposure concentrations.
Article
Cell Biology
Yu Li, Yilong Miao, Jingyue Chen, Bo Xiong
Summary: Inhibition of SIRT6 in porcine oocytes led to meiotic defects including impaired polar body extrusion and cumulus cell expansion, disrupted spindle/chromosome structure and actin dynamics, as well as defective cytoplasmic maturation with disturbed distribution of cortical granules and ovastacin content. Transcriptome analysis revealed altered expression of genes related to oocyte meiosis, oxidative phosphorylation, and cellular senescence, indicating that SIRT6 inhibition may induce meiotic defects through excessive ROS-induced early apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wu-Sheng Sun, Hoon Jang, Mi-Ryung Park, Keon Bong Oh, Haesun Lee, Seongsoo Hwang, Li-Jie Xu, In-Sul Hwang, Jeong-Woong Lee
Summary: The study suggests that N-acetyl-L-cysteine (NAC) supplementation during in vitro culture has beneficial effects on bovine oocytes and embryos by reducing intracellular reactive oxygen species (ROS) and promoting intracellular glutathione levels. NAC also influences early embryonic development with both dose-dependent and stage-specific effects, leading to improved developmental rates and reduced apoptosis.
Review
Cell Biology
Yu Wu, Mo Li, Mo Yang
Summary: Post-translational modifications such as phosphorylation, ubiquitination, SUMOylation, and PARylation play crucial roles in regulating mammalian oocyte maturation and embryo development by modulating processes like chromosome condensation, protein degradation, and cell cycle progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Maitha M. Alhajeri, Rayyah R. Alkhanjari, Rawad Hodeify, Ali Khraibi, Hamdan Hamdan
Summary: One of the primary reasons for the complexity of multicellular organisms is the highly complex intracellular and intercellular communication system, which involves neurotransmitters and neuropeptides. Dysregulation of neurotransmitter signaling has been associated with various pathologies. The connection between neuronal signaling and physiological changes during oocyte maturation and fertilization is still not fully explored.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Joohyeong Lee, Eunhye Kim, Seon-Ung Hwang, Lian Cai, Mirae Kim, Hyerin Choi, Dongjin Oh, Eunsong Lee, Sang-Hwan Hyun
Summary: The study showed that treatment with glucuronic acid and N-acetyl-D-glucosamine during porcine oocyte in vitro maturation can enhance oocyte diameter, perivitelline space thickness, reduce reactive oxygen species levels, improve gene expression, and enhance cortical granule reaction. This treatment also led to higher blastocyst rates in both chemically defined and complex media, indicating beneficial effects on early embryonic development after parthenogenesis and somatic cell nuclear transfer.
Article
Reproductive Biology
Jing Xu, Mary B. Zelinski
Summary: In vitro follicle development (IVFD) is a valuable model for understanding folliculogenesis, screening ovarian toxicity, and preserving fertility and species. This review discusses the culture systems used in IVFD across various species and the improvements made in follicle growth and oocyte maturation through optimization of culture conditions. The evaluation of oocyte quality following IVFD, including epigenetic and genetic profile, maturation, embryonic development, and pregnancy outcomes, is summarized. The review also highlights the limitations and knowledge gaps in IVFD for proper oocyte development. This information contributes to the goal of producing competent oocytes with genetic integrity for successful embryonic development and healthy offspring.
BIOLOGY OF REPRODUCTION
(2022)