Review
Pediatrics
Marissa J. DeFreitas, Chryso P. Katsoufis, Merline Benny, Karen Young, Shathiyah Kulandavelu, Hyunyoung Ahn, Anna Sfakianaki, Carolyn L. Abitbol
Summary: Oxidative stress during pregnancy can lead to complications and adverse fetal programming, with antioxidant therapies potentially preventing disease progression.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Robert Puls, Clarissa von Haefen, Christoph Buehrer, Stefanie Endesfelder
Summary: The risk of oxidative stress is unavoidable in preterm infants and increases the risk of neonatal morbidities. Premature infants often require sedation and analgesia, and the commonly used opioids and benzodiazepines are associated with adverse effects. Impairment of cerebellar functions during cognitive development could be a crucial factor in neurodevelopmental disorders of prematurity. Recent studies have focused on dexmedetomidine (DEX), which has been associated with potential neuroprotective properties and is used as an off-label application in neonatal units. Exposure to high oxygen concentrations caused oxidative stress in the immature rat cerebellum, but pretreatment with DEX significantly reduced the damage and facilitated a faster recovery, confirming its neuroprotective effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kutilda Soontarapornchai, Charles L. Cai, Taimur Ahmad, Jacob V. Aranda, Ivan Hand, Kay D. Beharry
Summary: The study found that caffeine can provide neuroprotection under normoxic conditions, reducing oxidative stress, increasing myelination, and increasing Golgi bodies. However, different oxygen environments may alter and modify the pharmacodynamic actions of caffeine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Richard Simon Machado, Leonardo Tenfen, Larissa Joaquim, Everton Venicius Rosa Lanzzarin, Gabriela Costa Bernardes, Sandra Regina Bonfante, Khiany Mathias, Erica Biehl, Solange de Souza Stork, Tais Denicol, Mariana Pacheco de Oliveira, Mariella Reinol da Silva, Lucineia Gainski Danielsk, Rafaella Willig de Quadros, Gislaine Tezza Rezin, Silvia Resende Terra, Jairo Nunes Balsini, Fernanda Frederico Gava, Fabricia Petronilho
Summary: This study evaluated oxidative stress and mitochondrial dysfunction in the brain of rats exposed to different levels of hyperoxia. The results showed that exposure to high levels of oxygen led to increased oxidative stress and mitochondrial dysfunction in the brain structures of rats.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Senqiu Qiao, Yue Sun, Yangyang Jiang, Xiaoming Chen, Jingzeng Cai, Qi Liu, Ziwei Zhang
Summary: This study found that oxidative stress is the main mechanism behind nickel neurotoxicity. Nickel induced oxidative stress damage and autophagy in the mouse brain, but melatonin was able to intervene and protect the nervous system.
Article
Biochemistry & Molecular Biology
Suzan Attia Mawed, Carlotta Marini, Mahmoud Alagawany, Mayada R. Farag, Rasha M. Reda, Mohamed T. El-Saadony, Walaa M. Elhady, Gian E. Magi, Alessandro Di Cerbo, Wafaa G. El-Nagar
Summary: This study elucidated the ultrastructure changes in the ovary in response to exposure to zinc oxide nanoparticles (ZnO-NPs) and explored the role of autophagy and apoptosis in the fertility of female zebrafish. The results showed that ZnO-NPs induced cytotoxicity, oxidative stress, and necroptosis, leading to a reduction in the fecundity of female zebrafish.
Article
Neurosciences
Shuhui Dai, Yuan Feng, Chuanhao Lu, Hongchen Zhang, Wenke Ma, Wenyu Xie, Xiuquan Wu, Peng Luo, Lei Zhang, Fei Fei, Zhou Fei, Xia Li
Summary: Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude sickness. Autophagy plays a critical role in ischemic brain injury, but its role in hypobaric hypoxia remains unknown. This study demonstrates that acute exposure to hypobaric hypoxia impairs autophagic activity in the mouse brain, leading to oxidative stress, neuronal loss, and brain damage. This research also suggests that the protein dynamin2 potentially regulates autophagic flux, and enhancing autophagic activity can attenuate the negative effects of hypobaric hypoxia.
NEUROSCIENCE BULLETIN
(2023)
Article
Marine & Freshwater Biology
Yu Wang, Hongjing Zhao, Yachen Liu, Menghao Guo, Ye Tian, Puyi Huang, Mingwei Xing
Summary: This study investigated the brain damage caused by arsenite exposure in common carp and the protective effects of zinc ion supplementation. Results showed that zinc ion coadministration effectively alleviated oxidative damage, tight junction injuries, nerve conduction depletion, and apoptotic and autophagic cell death induced by arsenite in the brain.
AQUATIC TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daolin Tang, Rui Kang
Summary: Over the past decade, research has focused on understanding oxidative cell death, particularly the transition from oxytosis to ferroptosis. Oxytosis, a form of nerve cell death induced by glutamate, was associated with intracellular glutathione depletion and inhibition of cystine uptake. The term ferroptosis was coined during a compound screening in 2012 and is induced by inhibitors of system xc(-) and GPX4. This article reviews the significant findings, models, and mechanisms of ferroptosis, and discusses its implications in various pathological conditions.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Daniele Mancardi, Sara Ottolenghi, Umberto Attanasio, Carlo Gabriele Tocchetti, Rita Paroni, Pasquale Pagliaro, Michele Samaja
Summary: Oxygen levels play a crucial role in regulating cellular processes and can affect cell death. Oscillating oxygen levels, rather than permanent low levels, are considered the most detrimental factor. The heart and brain are particularly sensitive to alterations in oxygen levels, and the interaction between oxygen and other gases such as nitric oxide is important in ischemic organs. Understanding the effects of oxygen dysregulation is also crucial for iron metabolism.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Oncology
Elisabeth Taucher, Iurii Mykoliuk, Melanie Fediuk, Freyja-Maria Smolle-Juettner
Summary: This article provides an overview of the connection between oxidative stress, autophagy, and cancer. Autophagy is a crucial cellular repair mechanism that is linked to various diseases, including cancer. Reactive oxygen and nitrogen species induce oxidative stress, which can trigger autophagy during nutrient deprivation. Researchers are increasingly focusing on identifying novel therapeutic targets in the autophagy process.
Article
Biochemistry & Molecular Biology
Sandra L. Grimm, Rachel E. Stading, Matthew J. Robertson, Tanmay Gandhi, Chenlian Fu, Weiwu Jiang, Guobin Xia, Krithika Lingappan, Cristian Coarfa, Bhagavatula Moorthy
Summary: Oxygen supplementation is crucial for premature infants and COVID-19 patients, but it can also cause long-term pulmonary injury due to inflammation, with xenobiotic-metabolizing CYP enzymes playing a crucial role.
Article
Multidisciplinary Sciences
Yu-Hsuan Cheng, Hung-Keng Li, Chien-An Yao, Jing-Ying Huang, Yi-Ting Sung, Shiu-Dong Chung, Chiang-Ting Chien
Summary: Negative air ions have antioxidant and anti-inflammatory effects, protecting against lung injury and promoting wound healing in diabetic rats.
Article
Biochemistry & Molecular Biology
Xiao-Qing Li, Yi Wang, Shu-Jie Yang, Yu Liu, Xiang Ma, Lu Liu, Si-Hong Li, Dong Niu, Xing Duan
Summary: Maternal diabetes has negative effects on oocyte quality, but melatonin supplementation can protect oocytes from these damages and improve oocyte quality in assisted reproductive technologies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Huan Liu, Shiqing He, Jianpeng Wang, Chong Li, Yongshi Liao, Qin Zou, Rui Chen
Summary: Tetrandrine ameliorates traumatic brain injury (TBI) by regulating autophagy to reduce ferroptosis, providing a new therapeutic strategy for TBI. The experimental results show that tetrandrine improves neurological function, reduces cerebral edema, promotes autophagy, and inhibits ferroptosis on days 1, 3, and 7 after TBI.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Widuri Kho, Clarissa von Haefen, Nadine Paeschke, Fatme Nasser, Stefanie Endesfelder, Marco Sifringer, Adrian Gonzalez-Lopez, Nadine Lanzke, Claudia D. Spies
Summary: Dexmedetomidine can prevent cognitive impairments caused by neuroinflammation, possibly through modulation of macroautophagy and miRNA expression.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Article
Developmental Biology
Samipa Pudasaini, Vivien Friedrich, Christoph Buehrer, Stefanie Endesfelder, Till Scheuer, Thomas Schmitz
Summary: The myelination of axons in the neonatal brain is a complex process primarily achieved by oligodendroglial cells expressing GABA receptors. Inhibition of GABA(A) and GABA(B) receptors revealed that GABA(B) receptor antagonization may increase oligodendroglial proliferation and lead to deficits in myelin expression. These findings suggest a potential role of GABA(B) receptor activity in modulating oligodendroglial development.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Article
Cell Biology
Karin M. Kirschner, Simon Kelterborn, Herrmann Stehr, Johanna L. T. Penzlin, Charlotte L. J. Jacobi, Stefanie Endesfelder, Miriam Sieg, Jochen Kruppa, Christof Dame, Lina K. Sciesielski
Summary: This study investigated the adaptation of the oxygen sensing system and its targets, the hypoxia-inducible factor-regulated genes (HRGs), in the developing lung. The results showed that the composition of the HIF-PHD system changed from intrauterine to neonatal phases. Understanding the interplay of the oxygen sensing system components during lung development may help counteract prematurity-associated diseases.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Pediatrics
Josephine Herz, Ivo Bendix, Ursula Felderhoff-Mueser
Summary: Perinatal brain injury is the leading cause of neurological mortality and morbidity in childhood, with various noxious stimuli contributing to the pathogenesis; Neuroinflammation plays an important role in perinatal brain injury, affecting the evolution of cell damage and repair activities; Different immune cell subsets, as well as sex differences and maturational stage, are critical factors in understanding perinatal brain injury.
PEDIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Lucia Beckmann, Stefanie Obst, Nicole Labusek, Hanna Abberger, Christian Koester, Ludger Klein-Hitpass, Sven Schumann, Christoph Kleinschnitz, Dirk M. Hermann, Ursula Felderhoff-Mueser, Ivo Bendix, Wiebke Hansen, Josephine Herz
Summary: Clinical and experimental studies suggest sexual dimorphism in neonatal brain injury and therapy responses caused by hypoxia-ischemia (HI). This study found that regulatory T cells (Tregs) from neonatal female mice provide neuroprotection, while Tregs from male mice increase secondary neurodegeneration, which may be associated with intrinsic transcriptional differences between sexes. There is an urgent need for sex-stratified clinical and preclinical analyses.
Article
Cell Biology
Vivien Giszas, Evelyn Strauss, Christoph Buehrer, Stefanie Endesfelder
Summary: This study demonstrates that oxidative stress induced by high oxygen can damage neurogenesis in rat pups and that caffeine can enhance the reversal of cellular neuronal damage. However, important transcripts for migration and differentiation of postmitotic granular cells are irreversibly reduced by hyperoxia and cannot be rescued by caffeine.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Cell Biology
Stefanie Obst, Josephine Herz, Miguel A. Alejandre Alcazar, Stefanie Endesfelder, Marius A. Moebius, Mario Ruediger, Ursula Felderhoff-Muser, Ivo Bendix
Summary: This article summarizes the recent findings on the mechanisms of hyperoxia-induced neonatal lung and brain injury, and discusses the potential common pathophysiological pathways connecting these two organ systems. The article also emphasizes the promises and needs of currently suggested therapies, including pharmacological and regenerative cell-based treatments.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Rebekka Vogtmann, Lilo Valerie Burk, Meray Serdar, Rainer Kimmig, Ivo Bendix, Alexandra Gellhaus
Summary: Preeclampsia (PE) is a pregnancy disorder characterized by decreased blood vessel formation and reduced placental perfusion, leading to fetal growth restriction and preterm birth. This study used a transgenic mouse model to investigate the disrupted fetal brain development in PE and its association with placental hypoxia and cerebrovascular adaptation.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Endocrinology & Metabolism
Lisa Middendorf, Alexandra Gellhaus, Antonella Iannaccone, Angela Koeninger, Anne-Kathrin Dathe, Ivo Bendix, Beatrix Reisch, Ursula Felderhoff-Mueser, Britta Huening
Summary: The sFlt-1/PlGF ratio does not predict the motor optimality score (MOS-R) in preterm infants, but low birth weight, which is correlated with an elevated ratio, has a negative effect on MOS-R outcome.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Julia Heise, Thomas Schmitz, Christoph Buehrer, Stefanie Endesfelder
Summary: High-risk preterm infants are at risk of cognitive developmental deficits due to oxygen toxicity. Caffeine has a neuroprotective effect and can counteract the negative effects of oxygen insult on neuronal maturation in the hippocampus. Interestingly, caffeine inhibits the transcription of neuronal mediators in normoxia.
Article
Biochemistry & Molecular Biology
Robert Puls, Clarissa von Haefen, Christoph Buehrer, Stefanie Endesfelder
Summary: The risk of oxidative stress is unavoidable in preterm infants and increases the risk of neonatal morbidities. Premature infants often require sedation and analgesia, and the commonly used opioids and benzodiazepines are associated with adverse effects. Impairment of cerebellar functions during cognitive development could be a crucial factor in neurodevelopmental disorders of prematurity. Recent studies have focused on dexmedetomidine (DEX), which has been associated with potential neuroprotective properties and is used as an off-label application in neonatal units. Exposure to high oxygen concentrations caused oxidative stress in the immature rat cerebellum, but pretreatment with DEX significantly reduced the damage and facilitated a faster recovery, confirming its neuroprotective effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rebekka Vogtmann, Mian Bao, Monia Vanessa Dewan, Alina Riedel, Rainer Kimmig, Ursula Felderhoff-Mueser, Ivo Bendix, Torsten Ploesch, Alexandra Gellhaus
Summary: Fetal adaptations to harmful intrauterine environments due to pregnancy disorders such as preeclampsia (PE) can negatively program the offspring's metabolism, resulting in long-term metabolic changes. In this study, researchers examined the consequences of sFLT1 overexpression in transgenic mice with PE/FGR on the offspring's metabolic phenotype. The results showed that sFLT1 overexpression led to growth-restricted fetuses with altered liver development and metabolic gene expression. The postnatal follow-up revealed increased weight gain and abnormal hormone levels in male PE offspring, suggesting adverse metabolic pre-programming specifically targeting males.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Moritz Borger, Clarissa von Haefen, Christoph Buehrer, Stefanie Endesfelder
Summary: Preterm birth is a risk factor for cardiometabolic disease. Pharmacological intervention using Dexmedetomidine (DEX) can protect cardiomyocytes from oxidative stress. DEX inhibits the transcription of oxidative stress marker GCLC and modulates the activation of the Hippo pathway.
Article
Immunology
Nicole Labusek, Yanis Mouloud, Christian Koester, Eva Diesterbeck, Tobias Tertel, Constanze Wiek, Helmut Hanenberg, Peter A. Horn, Ursula Felderhoff-Mueser, Ivo Bendix, Bernd Giebel, Josephine Herz
Summary: By comparing the neuroprotective effects of EVs derived from primary MSCs and ciMSCs in a mouse model of brain injury, we found that ciMSC-EVs can effectively reduce neuroinflammation and promote neuroregeneration, showing similar neuroprotective effects as primary MSC-EVs. This suggests that ciMSCs are an ideal cell source for the scaled manufacturing of EV-based therapeutics to treat neonatal and possibly also adult brain injury, overcoming the heterogeneity issue of MSCs.
INFLAMMATION AND REGENERATION
(2023)