期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 13, 期 11, 页码 14956-14961出版社
MDPI
DOI: 10.3390/ijms131114956
关键词
Myostatin (MSTN); single nucleotide polymorphisms (SNPs); common carp (Cyprinus carpio L.); growth traits; association analysis
资金
- Ministry of Science and Technology [2010CB126305]
- Minstry of Agriculture [2011-G12]
- State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20]
Myostatin (MSTN) is a member of the transforming growth factor-beta superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in selected common carp individuals from wild populations, and two SNPs in intron 2 (c.371 + 749A > G, c.371 + 781T > C) and two synonymous SNPs in exon 3 (c.42A > G, c.72C > T) were identified. Genotyping by direct sequencing of polymerase chain reaction (PCR) products for these four SNPs were performed in 162 individuals from a commercial hatchery population. Association analysis showed that two SNPs in exon 3 were significantly associated with body weight (BW) and condition factor (K), and haplotype analyses revealed that haplotype H7H8 showed better growth performance. Our results demonstrated that some of the SNPs in MSTN may have positive effects on growth traits and suggested that MSTN could be a candidate gene for growth and marker-assisted selection in common carp.
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