Article
Engineering, Environmental
Peter R. Tentscher, Beate Escher, Rita Schlichting, Maria Koenig, Nadine Bramaz, Kristin Schirmer, Urs von Gunten
Summary: The study found that both para-benzoquinones and hydroquinones can induce oxidative stress response, and they can react rapidly with components of the incubation medium. However, they do not activate defense against genotoxicity or DNA repair activity.
Article
Biochemistry & Molecular Biology
Galina N. Chelomina, Sergey P. Kukla, Viktor P. Chelomin, Pham N. Doanh
Summary: Parasite infection can lead to DNA damage, potentially involving oxidative stress and cancer development; these research findings are important for understanding the pathogenesis mechanisms of parasitic diseases.
Article
Biochemistry & Molecular Biology
Mahsa Karbaschi, Yunhee Ji, Mubarak A. Mujawar, Mario Mendoza, Juan S. Marquez, Apurva Sonawane, Pratikkumar Shah, Chris Ross, Shekhar Bhansali, Marcus S. Cooke
Summary: This article describes the development of an automated device for high throughput sample processing in a comet assay, which reliably assesses DNA damage in individual eukaryotic cells. The device performs as well as manual methods but with the advantages of decreased human involvement and assay run time, making it a valuable approach for high throughput DNA damage assessment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Merle M. Nicolai, Barbara Witt, Sharleen Friese, Vivien Michaelis, Lisa Holz-Armstrong, Maximilian Martin, Franziska Ebert, Tanja Schwerdtle, Julia Bornhorst
Summary: This study characterizes the adverse effects of manganese on genome integrity in dopaminergic-like neurons. The results show that manganese exposure leads to DNA damage and an enhanced DNA damage response, as well as significant alteration of the neuronal network.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Ghada Tagorti, Bulent Kaya
Summary: This review further explores the genotoxic potential of microplastics, particularly their impact on aquatic organisms and human cells, revealing their association with reactive oxygen production, inflammatory responses, and DNA repair interference. Additionally, with lifestyle changes during the COVID-19 pandemic, the outbreak may enhance the genotoxic risk of MPs through increased human exposure and disruption of defense systems.
Article
Chemistry, Multidisciplinary
Sneh M. Toprani, Dimitrios Bitounis, Qiansheng Huang, Nathalia Oliveira, Kee Woei Ng, Chor Yong Tay, Zachary D. Nagel, Philip Demokritou
Summary: The potential genotoxic effects of engineered nanomaterials (ENMs) on DNA repair pathways have been investigated using a fluorescence multiplex-host-cell reactivation (FM-HCR) assay. Results showed that some ENMs may enhance DNA repair capacity while others suppress it. This method can be a valuable part of a multitier, in vitro hazard assessment of ENMs, providing insights into the interplay between ENM properties, DNA repair efficiency, and genomic stability.
Review
Environmental Sciences
Ivana Durovcova, Stanislav Kyzek, Jana Fabova, Jana Makukova, Eliska Galova, Andrea Sevcovicova
Summary: This review aims to summarize the genotoxic effects of BPA on organisms across all taxa. BPA can induce DNA damage through multiple mechanisms and has adverse effects on organisms in various ecosystems.
ENVIRONMENTAL POLLUTION
(2022)
Article
Multidisciplinary Sciences
Emine Yalcin, Kultigin Cavusoglu
Summary: This study investigated the toxic effects of potassium bromate on Allium cepa L. and tested the reducing effects of grape seed extract (GSE). The results showed that potassium bromate exposure caused decreases in physiological parameters and abnormalities in cell genetic indicators, disrupting the antioxidant/oxidant balance. GSE administration reduced the toxic effects of potassium bromate and improved the examined parameters.
SCIENTIFIC REPORTS
(2022)
Review
Environmental Sciences
Rupa Rani, Abhidha Kela, Geeta Dhaniya, Kamini Arya, Amit K. Tripathi, Rajesh Ahirwar
Summary: Specific miRNAs have been identified as early warning biomarkers for health effects associated with exposure to PAHs in exposed populations, and they can serve as indicators of early health effects in response to chronic environmental exposure to PAHs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Wei Zhao, Zhongjie Liu, Jiaming Luo, Changqing Ma, Luying Lai, Zhengyuan Xia, Shiyuan Xu
Summary: The study indicates that PARP-1 plays a key role in repairing oxidative DNA damage induced by bupivacaine, with interactions with XPD protein contributing to DNA integrity maintenance.
Article
Environmental Sciences
Sonalin Rath, Surajit Das
Summary: Bacteria thriving in the mangrove ecosystem play a significant role in elemental cycles, but their performance is influenced by climate change and environmental stressors. This study investigates the genotoxic effect of such stressors on mangrove bacteria and their adaptation strategies. The results show cellular injuries and DNA damage in response to stressors, with different bacterial strains exhibiting varying levels of tolerance and adaptive mechanisms.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biotechnology & Applied Microbiology
Ying He, Haotian Ding, Xingya Xia, Wenyi Qi, Huaisong Wang, Wenyuan Liu, Feng Zheng
Summary: This study used a collection of GFP-fused yeast cells to evaluate the genotoxicity of nitrosamine compounds, showing that they can cause extensive DNA damage and activate multiple repair pathways. The evaluation criteria based on total protein expression levels correlate well with the mammalian carcinogenicity data TD50, suggesting that the yeast cell collection could serve as a potential reliable criterion for evaluating the carcinogenicity of compounds. The assay based on DNA damage pathway integration is highly sensitive and can be used as a supplementary method for evaluating trace potentially genotoxic impurities in actual production.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Environmental Sciences
Javed Ahmad, Rubina Yasmeen, Mohammad Irfan, Asma A. Al-Huqail, Mohammad Irfan Qureshi
Summary: Traces of arsenic in vegetables and crops cultivated in arsenic-polluted soils are a global concern due to its carcinogenic properties and harmful effects on the food chain. This study focused on the accumulation and defense mechanisms of fenugreek plants exposed to arsenic stress. The findings showed increased oxidative stress and DNA damage at higher arsenic concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Merle M. Nicolai, Ann-Kathrin Weishaupt, Jessica Baesler, Vanessa Brinkmann, Anna Wellenberg, Nicola Winkelbeiner, Anna Gremme, Michael Aschner, Gerhard Fritz, Tanja Schwerdtle, Julia Bornhorst
Summary: Although manganese is an essential trace element, overexposure can lead to toxicity and neurological dysfunction. This study investigated the mode of action of manganese toxicity on genomic integrity, focusing on DNA damage and repair mechanisms using Caenorhabditis elegans as a model organism. The results suggest that excessive manganese exposure can decrease genomic integrity and activate base excision repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ireneusz Litwin, Seweryn Mucha, Ewa Pilarczyk, Robert Wysocki, Ewa Maciaszczyk-Dziubinska
Summary: In this study, it was found that trivalent antimony can cause various forms of DNA damage, including replication and oxidative DNA damage, and affect the activation of DNA damage checkpoints and formation of recombination repair centers in the model organism Saccharomyces cerevisiae.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)