期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 12, 期 7, 页码 4237-4249出版社
MDPI AG
DOI: 10.3390/ijms12074237
关键词
camptothecin; dextran; supercritical antisolvent; tumor-targeted; nanoparticle
资金
- State Forestry Administration of China [2010-4-20]
- Special Fund for Forestry Scientific Research in the Public Interest [2010040072]
- Fundamental Research Funds for the Central Universities [DL09BB08]
In this study, folic-dextran-camptothecin (Fa-DEX-CPT) tumor-targeted nanoparticles were produced with a supercritical antisolvent (SAS) technique by using dimethyl sulfoxide (DMSO) as a solvent and carbon dioxide as an antisolvent. A factorial design was used to reveal the effect of various process parameters on the mean particle size (MPS) and morphology of the particles formed. Under the optimum operation conditions, Fa-DEX-CPT nanoparticles with a MPS of 182.21 nm were obtained. Drug encapsulation efficiency and loading efficiency were 62.13% and 36.12%, respectively. It was found that the concentrations of the camptothecin (CPT) and dextran solution had a major influence upon morphology and shape of the final product. In addition, the samples were characterized by Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) with the purpose of developing a suitable targeted drug delivery system for cancer chemotherapy.
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