Article
Multidisciplinary Sciences
Mohammad Khedri, Mostafa Keshavarz Moraveji
Summary: This study investigated the self-assembly of polymeric nanoparticles for drug delivery systems and successfully loaded an antitumor drug onto a targeting ligand. The results revealed a correlation between polymer molecular weight and particle stability, and confirmed the improvement of drug delivery to receptors and cancerous cells by the targeting ligand.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Natalia Veronica, Paul Wan Sia Heng, Celine Valeria Liew
Summary: This review provides an overview of the applications of alginate in solid dosage form formulations, with a focus on its role in oral sustained release formulations. The mechanisms of drug release from alginate matrices, as well as the influence of alginate properties and formulation components on drug release, are discussed. In addition, modifications of alginate to improve its ability to regulate drug release are also explored.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Biochemistry & Molecular Biology
Nathaniel Wright, Tim Wu, Yadong Wang
Summary: In this study, a three-layer microneedle for controlled release of three different molecules is designed. The microneedles, efficiently generated through micromolding, have good mechanical integrity and effectively penetrate the skin. The three layers in the microneedles release the cargo in a three-phase manner.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Ana Mateos-Maroto, Laura Fernandez-Pena, Irene Abelenda-Nunez, Francisco Ortega, Ramon G. Rubio, Eduardo Guzman
Summary: This review provides an updated perspective on the various applications of polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method in the biomedical field, emphasizing the significant advantages offered by the LbL method for fabricating platforms for different disease detection and treatment.
Article
Pharmacology & Pharmacy
Kerr D. G. Samson, Eleonore C. L. Bolle, Mariah Sarwat, Tim R. Dargaville, Ferry P. W. Melchels
Summary: This study focused on developing an osmotically triggered delayed delivery device to improve the efficiency of single-administration vaccine delivery systems. Factors controlling the release delay were characterized, with adjustments in material permeability and device wall thickness shown to be advantageous for maintaining reproducibility. The photo-cured poly(epsilon-caprolactone) network showed full degradability in vitro and no cytotoxicity after direct contact with dermal fibroblasts for 11 days, supporting further development of flexible biomaterials for in vivo vaccine booster delivery.
Article
Chemistry, Physical
Ewelina Juszczyk, Piotr Kulinowski, Ewelina Baran, Artur Birczynski, Jolanta Klaja, Dorota Majda, Encarna Garcia-Montoya, Wladyslaw P. Weglarz, Przemyslaw Dorozynski
Summary: The study demonstrated the unique hydration patterns of polymer-based matrices, showing features such as internal locking, lamellar regions, water resolution, and water penetration. These patterns were influenced by matrix composition and molecular properties of constituents.
Article
Pharmacology & Pharmacy
J. G. B. De Marchi, R. Ce, G. Onzi, A. C. S. Alves, N. Santarem, A. Cordeiro da Silva, A. R. Pohlmann, S. S. Guterres, A. J. Ribeiro
Summary: This study aims to improve the absorption of nanoparticle formulation by functionalizing its surface with immunoglobulin G. The functionalized nanoparticles showed adequate size and good entrapment efficiency, and led to a desirable increase in insulin release time. Interactions of nanoparticle components were proven through differential scanning calorimetry, infrared spectroscopy, and paper chromatography.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Jinqiang Wang, Zejun Wang, Guojun Chen, Yanfang Wang, Tianyuan Ci, Hongjun Li, Xiangsheng Liu, Daojia Zhou, Anna R. Kahkoska, Zhuxian Zhou, Huan Meng, John B. Buse, Zhen Gu
Summary: This study introduces a glucose-responsive cationic polymer for constructing polymer-insulin complexes, which shows potential for glucose-stimulated insulin delivery. The effects of different parameters on the insulin release kinetics were studied to evaluate the blood glucose regulation ability in type 1 diabetic mice.
Article
Chemistry, Multidisciplinary
David A. Mahvi, Jenny Korunes-Miller, Catalina Bordeianu, Ngoc-Quynh Chu, Abraham D. Geller, Robbie Sabatelle, Samantha Berry, Yin P. Hung, Yolonda L. Colson, Mark W. Grinstaff, Chandrajit P. Raut
Summary: An implantable biodegradable polymer film has been developed for the controlled and extended local delivery of paclitaxel, which has shown significant improvements in survival and recurrence in three different sarcoma models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Chenlong Li, Huimin Zhou, Jingjiang Sun, Deshuo Wang, Jun Chang, Qingfu Wang, Yanan Li, Wei Zhao
Summary: F-19 MRI-assisted drug delivery allows for real-time monitoring and tracking of drug transportation. Amphiphilic block copolymers containing hydrophilic polyethylene glycol and F-19-containing hydrophobic segments were synthesized, with the photolysis behavior of the copolymers controlled using o-nitrobenzyl oxygen. Increasing the hydrophobic chain length enhanced drug loading capacity and photoresponsivity, while reducing chain mobility and FMRI-F-19 signal. Nanoparticles with a PTFEA polymerization degree of 10 exhibited detectable FMRI-F-19 signals and sufficient drug loading capacity (loading efficiency = 10%, cumulative release = 49%), providing a promising smart theranostic platform for F-19 MRI.
Review
Pharmacology & Pharmacy
Suzana Goncalves Carvalho, Amanda Leticia Polli Silvestre, Aline Martins dos Santos, Bruno Fonseca-Santos, Winner Duque Rodrigues, Maria Palmira Daflon Gremiao, Marlus Chorilli, Janaina Cecilia Oliveira Villanova
Summary: One of the challenges in veterinary pharmacotherapy is the limited availability of drugs and dosage forms due to interspecies variability. Polymer-based drug delivery systems show promise in overcoming limitations in bioavailability, efficacy, and safety for animals. This article provides an overview of major polymer-based drug delivery systems for veterinary use, discussing various delivery systems and mechanisms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Athina Liaskoni, Ricky D. Wildman, Clive J. Roberts
Summary: Extrusion-based 3D printing was used to manufacture sustained drug release PCL implants. Different drug loading formulations were printed without solvents or excipients, and analyzed using SEM, DSC, XRD, ATR-FTIR, and Raman spectroscopy. The implants demonstrated sustained drug release efficiency and the Korsmeyer-Peppas model was suggested as the best fit for drug release profiles. This work highlights the potential of hot-melt extrusion-based 3D printing for customizable drug-eluting implants.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Anna Puiggali-Jou, Jesus Ordono, Luis J. del Valle, Soledad Perez-Amodio, Elisabeth Engel, Carlos Aleman
Summary: Different approaches were examined for controlled release of L-lactate, with the method of loading L-lactate at the outer PLA layers showing significant influence on the release regulation process. This method can achieve prolonged and sustained release of L-lactate. The biocompatibility and suitability of the engineered films for cardiac tissue engineering has been confirmed.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Yan Jie Neriah Tan, Wai Pong Yong, Han Rou Low, Jaspreet Singh Kochhar, Jayant Khanolkar, Teng Shuen Ernest Lim, Yajuan Sun, Jonathan Zhi En Wong, Siowling Soh
Summary: Medicine should be personalized based on individual differences, and can be achieved by using 3D printing to customize drug tablets with specific dosages, release durations, and combinations of drugs. The method involves printing a template and fabricating the drug tablet according to the template, allowing for customizable tablets with a simple structure and efficient constant release profile.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Nathan Koch, Olivier Jennotte, Celine Toussaint, Anna Lechanteur, Brigitte Evrard
Summary: The current study aimed to select the optimal lipid solid dispersion for cannabidiol by screening different lipid excipients and inorganic carriers. The selected dispersion was found to enhance the solubility of cannabidiol and showed good tableting properties. The Design of Experiments revealed that the percentage of dispersion and compression forces were the main influencing factors. It was also highlighted that there are certain limitations in manufacturing tablets with lipid materials.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Oncology
Parijat Pandey, Hitesh Chopra, Deepak Kaushik, Ravinder Verma, Deepika Purohit, Jatin Parashar, Vineet Mittal, Md. Habibur Rahman, Saurabh Bhatia, Pradeep Kumar, Tanima Bhattacharya, Priti Tagde, Ahmed Al-Harrasi
Summary: Cancer remains a leading cause of death worldwide, and while there are treatment options available, their adverse effects often outweigh their therapeutic benefits. Nanotechnology shows promise in addressing these issues, but further development is needed. Stimuli-responsive nanomedicine, dendrimers, micelles, and lipid-based nano-formulations have been explored for their efficacy in cancer treatment. This review paper highlights significant patents granted/applied globally that utilize nanotechnology for cancer treatment, with focus on enhancing the ADME profile of therapeutic molecules.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Sunaina Indermun, Pradeep Kumar, Mershen Govender, Yahya E. E. Choonara
Summary: Tyrosine kinase inhibitors (TKIs) are effective drug molecules for treating various cancers. Nanomedicinal interventions and approaches can enhance the efficacy of TKIs by providing carrying capacities and potentially targeting tumor-specific environments and cellular compartments. Different nanosystems have been developed for TKI delivery in cancer treatment, with each having their own preparation methods and physicochemical properties. This review discusses the applicability of nano-interventions for combination therapies, dose reduction, and improved treatment outcomes, highlighting the efficacy of developed nanosystems against different cancer cell lines and models.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Polymer Science
Sindy P. Ndlovu, Thierry Y. Fonkui, Pradeep Kumar, Yahya E. Choonara, Derek T. Ndinteh, Blessing A. Aderibigbe
Summary: A major challenge in treating burn wounds is bacteria invasion which prolongs the wound healing process. To address the issue of skin tears caused by removal of wound dressings, researchers designed dissolvable wound dressings that can be easily removed without causing tears, while also exhibiting desirable antibacterial activity and absorption capability.
Article
Pharmacology & Pharmacy
Mumuni Sumaila, Pradeep Kumar, Philemon Ubanako, Samson A. Adeyemi, Yahya E. Choonara
Summary: This research reports the design and characterization of rifampicin (RIF) and isoniazid (INH) loaded hybrid lipid-polysaccharide nanoparticles using the solvent injection method, and demonstrated the influence of conjugated mannosyl residue on macrophage targeting and intracellular drug delivery capacity.
CURRENT DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Samson A. A. Adeyemi, Zardad Az-Zamakhshariy, Yahya E. E. Choonara
Summary: This study focused on a new approach to achieve site-specific stimuli-responsive delivery of solid lipid nanoparticles (SLNs) loaded within thermo-sonic nano-organogel (TNO) variants for treating cervical cancer. The results showed that SLNs released 5-FU from TNO under external thermal and ultrasound stimuli, achieving rate-modulated drug release. This method has potential applications in the treatment of cervical cancer.
Article
Engineering, Biomedical
Hillary Mndlovu, Lisa C. du Toit, Pradeep Kumar, Yahya E. Choonara
Summary: This study developed scaffolds using polymers and peptides for wound healing and skin tissue regeneration. The scaffolds showed improved mechanical properties through crosslinking with tannic acid and transformed physicochemical and morphological features through the use of RGD. The superior performance of these scaffolds in promoting wound healing and tissue regeneration was demonstrated.
BIOMEDICAL MATERIALS
(2023)
Article
Polymer Science
X. Nqoro, S. A. Adeyemi, P. Ubanako, D. T. Ndinteh, P. Kumar, Y. E. Choonara, B. A. Aderibigbe
Summary: Wound management is crucial for saving lives, and using appropriate wound dressing is essential. Alginate-based topical gels loaded with essential oils, magnetite nanoparticles, and tranexamic acid were prepared. The gel formulations showed desired properties and demonstrated significant wound healing, antibacterial, and blood clotting potential. These formulations have the potential to be effective wound dressings for treating bleeding and infected wounds.
Article
Polymer Science
Thashree Marimuthu, Zainul Sidat, Pradeep Kumar, Yahya E. Choonara
Summary: This study compares the effectiveness of an ionic liquid (IL) agent, [HMIM]Cl, as a plasticizer in comparison to current industry standards. The results show that [HMIM]Cl is a more effective plasticizer than the tested standards, even at concentrations as low as 20-30% w/w. Additionally, the combination of [HMIM]Cl with a standard plasticizer demonstrates remarkable plasticizing capability and long-term stability.
Review
Pharmacology & Pharmacy
Maan Singh, Harsh Barua, Vaskuri G. S. Sainaga Jyothi, Madhukiran R. Dhondale, Amritha G. Nambiar, Ashish K. Agrawal, Pradeep Kumar, Nalini R. Shastri, Dinesh Kumar
Summary: Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and stability can be effectively improved through the cocrystallization process with suitable coformers. Carboxylic acid-based coformers, such as fumaric acid, oxalic acid, succinic acid, and citric acid, are commonly used and have proven to be effective in API cocrystal formation. This review summarizes the role of coformers in enhancing the physicochemical and pharmaceutical properties of APIs and discusses the patentability and regulatory issues related to pharmaceutical cocrystals.
Article
Biochemistry & Molecular Biology
Divesha Essa, Pierre P. D. Kondiah, Pradeep Kumar, Yahya E. E. Choonara
Summary: In this study, quercetin-loaded PLGA nanoparticles were prepared and optimized. It was found that coating with chitosan increased the cellular uptake of the nanoparticles and folic acid targeting provided selective toxicity and enhanced uptake in LnCap prostate cancer cells. The targeted nano-system exhibited sustained, pH-dependent quercetin release, higher cytotoxicity, and cellular uptake in LnCap cells compared to non-targeted nano-system.
Review
Biochemistry & Molecular Biology
Divya Thirumal, Rakesh K. Sindhu, Shuchi Goyal, Aayush Sehgal, Ashok Kumar, Marianesan Arockia Babu, Pradeep Kumar
Summary: Psoriasis is an inflammatory skin condition that causes various diseases and significantly affects patients' quality of life. It not only impairs the skin but also affects other parts of the body. Many variables can directly or indirectly impact the etiology of psoriasis. Psoriasis affects approximately 2% of the world's population, and significant progress has been made in understanding and treating alternative forms of psoriasis.
Article
Pharmacology & Pharmacy
Sibusiso Alven, Philemon Ubanako, Samson A. Adeyemi, Derek T. Ndinteh, Yahya E. Choonara, Blessing Atim Aderibigbe
Summary: This study reported the efficacy of carboxymethyl cellulose-based topical gels loaded with a combination of essential oils and silver nanoparticles as potential wound dressings for bacterial-infected wounds. The gels displayed promising antibacterial activity and excellent wound closure in vitro, indicating their potential clinical applications.
THERAPEUTIC DELIVERY
(2023)
Review
Pharmacology & Pharmacy
Pavan Walvekar, Pradeep Kumar, Yahya E. Choonara
Summary: Bolus vaccines are often administered multiple times due to inadequate activation of T and B lymphocytes. Recent research focuses on developing long-acting vaccine delivery systems that can enhance antigen presentation in lymph nodes and achieve robust immune responses. Various polymers and lipids have been explored to develop effective biomaterial-based vaccine strategies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Nanoscience & Nanotechnology
Lindokuhle M. Ngema, Samson A. Adeyemi, Thashree Marimuthu, Philemon N. Ubanako, Wilfred Ngwa, Yahya E. Choonara
Summary: A design for targeted paclitaxel (PTX) delivery nanosystem using superparamagnetic iron oxide nanoparticles (SPIONs) decorated with anti-vascular endothelial growth factor peptide, HRH, was established. The formulated CLA-coated PTX-SPIONs@HRH showed significant tumor targetability and antiangiogenic activity. The nanosystem demonstrated high PTX loading efficiency, sustained release, and dose-dependent anti-proliferative activity in lung adenocarcinoma cells. In addition, it effectively reduced VEGF-A secretion and induced tumor regression in a lung tumor xenograft mouse model. The nanosystem also prolonged the circulation time and enhanced the half-life of PTX. The results suggest that CLA-coated PTX-SPIONs@HRH could be a potential effective treatment for non-small-cell lung carcinoma as a nanomedicine.
ACS APPLIED BIO MATERIALS
(2023)