Article
Plant Sciences
Yu Jiao-Yan, Liu Qing-Qing, Li Xi, Zhao Mei, Sun Ting, Hu Na, Jiang Wei, Zhang Rui-Tao, Yang Peng, Yang Qi
Summary: Oxymatrine (OMT) has protective effects on neurological function and reduces blood-brain barrier permeability. OMT protects against ischemia-reperfusion injury through modulation of cellular damage and tight junction protein expression levels.
Article
Biochemistry & Molecular Biology
Jin Yu, Hong Zhu, Mark S. Kindy, Saeid Taheri
Summary: This study demonstrates that suppression of CYP2E1 can alleviate I/R injury and protect BBB integrity by reducing oxidative stress and inflammation. CYP2E1 KO mice showed lower lesion volume and neurological deficits after I/R, with decreased oxidative stress and inflammatory responses.
Article
Medicine, Research & Experimental
Wei Chu, Xuemei Sun, Xiaoxiao Zhu, Yu Chen Zhao, Jingcheng Zhang, Qin Kong, Lanlan Zhou
Summary: The study showed that the glycoprotein (GP) Ib antagonist anfibatide (ANF) mitigated blood-brain barrier (BBB) disruption after cerebral ischemia/reperfusion (CI/R) injury through activation of the Epac signaling pathway. ANF treatment improved tight junction protein expression, suppressed actin rearrangement, reduced brain tissue permeability, and alleviated brain edema. Additionally, ANF upregulated Epac1 protein expression in the ischemic cerebral cortex, demonstrating its protective effects on BBB integrity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Francesco Girolamo, Yow-Pin Lim, Daniela Virgintino, Barbara S. S. Stonestreet, Xiaodi F. F. Chen
Summary: Microvasculature development is affected by hypoxia-ischemia (HI) and hypoxia (H) in neonates, leading to brain injury. Inter-alpha inhibitor proteins (IAIPs) have been found to mitigate brain injury in neonatal rats exposed to HI, but their effects on the microvasculature have not been investigated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Bharath Chelluboina, Anil K. Chokkalla, Suresh L. Mehta, Kahlilia C. Morris-Blanco, Saivenkateshkomal Bathula, Sneha Sankar, Jin Soo Park, Raghu Vemuganti
Summary: The study found that TNC knockdown following a stroke can significantly reduce TNC protein expression, improve motor function deficits, decrease infarct volume, BBB damage, and inflammation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Zhizhun Mo, Zhongyi Zeng, Yuxiang Liu, Linsheng Zeng, Jiansong Fang, Yinzhong Ma
Summary: Stroke is a leading cause of death and survivors often suffer from severe neurological and motor deficits. The Wnt signaling pathway has been found to play a key role in the pathogenesis of stroke and reactivating this pathway can have significant therapeutic effects. A comprehensive understanding of the role of Wnt signaling in different cell types can help evaluate its potential value for stroke treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Caifeng Gu, Weichun Mo, Kunlun Wang, Mingqiang Gao, Junfeng Chen, Feng Zhang, Jie Shen
Summary: Ischemia/reperfusion (I/R) damage induced by stroke poses a serious hazard to human life, while the mechanism of blood-brain barrier (BBB) dysfunction is still unknown. Researchers found that cerebral I/R damage increased infarct volume and BBB permeability in a rat model of stroke. They also discovered that miR-370-3p regulates BBB permeability by targeting MAPK1.
Review
Clinical Neurology
Pan Huang
Summary: Arachidonic Acid (AA) is the precursor of cerebrovascular active substances in the human body, and its metabolites are closely associated with the pathogenesis of cerebrovascular diseases. In recent years, the cytochrome P450 (CYP) metabolic pathway of AA has become a research hotspot, which is regulated by soluble epoxide hydrolase (sEH). 1-trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl) urea (TPPU) is a novel sEH inhibitor that exerts cerebrovascular protective activity. This article reviews the mechanism of TPPU's protective effect on ischemic stroke disease.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Xuehui Fan, Hongping Chen, Chen Xu, Yingju Wang, Pengqi Yin, Meng Li, Zhanbin Tang, Fangchao Jiang, Wan Wei, Jihe Song, Guozhong Li, Di Zhong
Summary: S1PR3 is involved in the regulation of blood-brain barrier damage after cerebral ischemia/reperfusion. S1PR3 is expected to be an indicator and predictor of cerebral ischemia, and drugs targeting S1PR3 may also provide new ideas for clinical medications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xue Yang, Jia Liang, Mengjie Jia, Tianhui Yang, Xinyang Deng, Pan Wang, Lili Ren, Shuang Gao, Zhongfu Zuo, Dan Pei, Jing Bi, Peng Wang
Summary: The study showed that B3galt2 protects mice against ischemic stroke by modulating the TGF-beta signaling pathway, reducing infarct volume, and improving neurological function. The damage to the BBB is closely related to the neuroprotective effects after cerebral ischemia.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Neurosciences
Oak Z. Chi, Antonio Chiricolo, Xia Liu, Nikhil Patel, Estela Jacinto, Harvey R. Weiss
Summary: The study demonstrated that inhibition of SGK1 can reduce BBB disruption following cerebral ischemia-reperfusion and decrease infarct size. The SGK1 inhibitor GSK650394 decreased BBB disruption, reduced cortical infarct size, and lowered NDRG1 phosphorylation and MMP2 protein levels in the ischemic-reperfused cortex.
NEUROSCIENCE LETTERS
(2021)
Article
Medicine, Research & Experimental
Yu Long, Songyu Liu, Jinyan Wan, Yulu Zhang, Dan Li, Shuang Yu, Ai Shi, Nan Li, Fei He
Summary: This study investigated the effect of BO-BA-LP on improving blood-brain barrier integrity. The results showed that BO-BA-LP could increase the ability of BA to penetrate the cell membrane, leading to increased concentrations of BA in plasma and brain tissues. BO-BA-LP also improved neurological function and histopathology in CIRI mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Miao Zeng, Ruifeng Zhang, Qiuyue Yang, Lin Guo, Xiaolu Zhang, Bin Yu, Jiali Gan, Zhen Yang, Huhu Li, Yu Wang, Xijuan Jiang, Bin Lu
Summary: This review summarizes the mechanisms of various saponins in relieving cerebral ischemia-reperfusion injury (CIRI) and provides valuable information for researchers to design and develop new drugs using saponins to treat CIRI-related conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Patrick Lyden, Alastair Buchan, Johannes Boltze, Marc Fisher
Summary: Despite years of research, ischemic stroke remains a major public health concern, and STAIR XI workshop addressed challenges such as redefining neuroprotection paradigm, using tissue window for patient selection, and proposing target window for therapies targeting elements of the neurovascular unit at different times.
Article
Biochemistry & Molecular Biology
Fei Li, Fangfang Zhou, Binbin Yang
Summary: The study showed that overexpression of miR-152-3p improved neurological deficits and protected blood-brain barrier integrity in rats with middle cerebral artery occlusion (MCAO). In an in vitro model, the level of miR-152-3p decreased significantly in bEnd.3 cells after oxygen-glucose deprivation/reperfusion insult. Overexpression of miR-152-3p in bEnd.3 cells protected against OGD/R-induced microvascular hyperpermeability. The protective effect of miR-152-3p was associated with reduced endothelial apoptosis through negative modulation of the MAP3K2/JNK/c-Jun pathway.
NEUROCHEMICAL RESEARCH
(2023)