Mechanobiology of Platelets: Techniques to Study the Role of Fluid Flow and Platelet Retraction Forces at the Micro- and Nano-Scale

Well plate microfluidic system for investigation of dynamic platelet behavior under variable shear loads

(2011) Carolyn G. Conant et al.   BIOTECHNOLOGY AND BIOENGINEERING

Biological AFM: where we come from - where we are - where we may go

(2011) Ignacio Casuso et al.   JOURNAL OF MOLECULAR RECOGNITION

Calibrated micropost arrays for biomechanical characterisation of cardiomyocytes

(2011) K. Kim et al.   Micro & Nano Letters

Microfluidic devices for modeling cell–cell and particle–cell interactions in the microvasculature

(2011) Balabhaskar Prabhakarpandian et al.   MICROVASCULAR RESEARCH

Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity

(2011) Michael T Yang et al.   Nature Protocols

Cell-ECM traction force modulates endogenous tension at cell-cell contacts

(2011) V. Maruthamuthu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Morphology of Platelet Aggregates Formed on Collagen Under Laminar Blood Flow

(2010) T. Colace et al.   ANNALS OF BIOMEDICAL ENGINEERING

Quantitative Analysis of Human Platelet Adhesions Under a Small-Scale Flow Device

(2010) Katsuko S. Furukawa et al.   ARTIFICIAL ORGANS

Mesenchymal Stem Cell Mechanics from the Attached to the Suspended State

(2010) John M. Maloney et al.   BIOPHYSICAL JOURNAL

Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D

(2010) K. M. Wannemacher et al.   BLOOD

The kinetics of  IIb 3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy

(2010) M. Stolla et al.   BLOOD

Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes

(2010) Zhijun Liu et al.   Cellular and Molecular Bioengineering

Shear-Mediated Platelet Adhesion Analysis in Less Than 100 μ L of Blood: Toward a POC Platelet Diagnostic

(2010) Nigel J Kent et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions

(2010) S. F. Maloney et al.   Integrative Biology

Platelet retraction force measurements using flexible post force sensors

(2010) Xin M. Liang et al.   LAB ON A CHIP

Mechanics and contraction dynamics of single platelets and implications for clot stiffening

(2010) Wilbur A. Lam et al.   NATURE MATERIALS

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of physiologically relevant dynamic shear stress on platelet and endothelial cell activation

(2010) Wei Yin et al.   THROMBOSIS RESEARCH

Shear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ibα shedding

(2009) Hong Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Microfluidic Technology in Vascular Research

(2009) A. D. van der Meer et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Dynamics of platelet thrombus formation

(2009) S. P. JACKSON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

(2009) Francisco Javier Tovar-Lopez et al.   LAB ON A CHIP

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

Loss of high-molecular-weight von Willebrand factor multimers mainly affects platelet aggregation in patients with aortic stenosis

(2009) Roza Badr Eslam et al.   THROMBOSIS AND HAEMOSTASIS

Early evaluation of acute traumatic coagulopathy by thrombelastography

(2009) Roger C. Carroll et al.   Translational Research

Synthetic microvascular networks for quantitative analysis of particle adhesion

(2008) Balabhaskar Prabhakarpandian et al.   BIOMEDICAL MICRODEVICES

Mechanical Forces Induced by the Transendothelial Migration of Human Neutrophils

(2008) Aleksandr Rabodzey et al.   BIOPHYSICAL JOURNAL

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth

(2008) A. Ono et al.   BLOOD

Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients

(2008) A. Levrat et al.   BRITISH JOURNAL OF ANAESTHESIA

Catch-Bond Mechanism of Force-Enhanced Adhesion: Counterintuitive, Elusive, but … Widespread?

(2008) Evgeni V. Sokurenko et al.   Cell Host & Microbe

Single-cell force spectroscopy

(2008) J. Helenius et al.   JOURNAL OF CELL SCIENCE

Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates

(2008) K. B. NEEVES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microfluidic devices for studies of shear-dependent platelet adhesion

(2008) Edgar Gutierrez et al.   LAB ON A CHIP

A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood

(2008) Keith B. Neeves et al.   LAB ON A CHIP

Magnetic microposts for mechanical stimulation of biological cells: Fabrication, characterization, and analysis

(2008) Nathan J. Sniadecki et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Traction forces and rigidity sensing regulate cell functions

(2008) Marion Ghibaudo et al.   Soft Matter

Emergence of Patterned Stem Cell Differentiation Within Multicellular Structures

(2008) Sami Alom Ruiz et al.   STEM CELLS

Toward Physiological Conditions for Cell Analyses: Forces of Heart Muscle Cells Suspended Between Elastic Micropillars

(2007) A. Kajzar et al.   BIOPHYSICAL JOURNAL