Article
Engineering, Biomedical
Jianhua He, Wenli Zhang, Xiaoju Zhou, Fengfei Xu, Jiahui Zou, Qiqi Zhang, Yi Zhao, Hongliang He, Hu Yang, Jianping Liu
Summary: Nanoparticle-based therapeutics show potential for treating atherosclerosis, but the complex plaque microenvironment hinders their targeting ability. In this study, we developed reactive oxygen species (ROS)-responsive and size-reducible nanoassemblies to overcome this barrier. These nanoassemblies specifically accumulated in atherosclerotic plaque, rapidly disassembled in response to excess ROS, and released smaller nanoparticles for deeper penetration and targeted drug delivery. In vivo studies demonstrated that the nanoassemblies reduced plaque size, lipid deposition, macrophage content, and local inflammatory factor levels, while also alleviating systemic inflammation. Overall, the ROS-responsive and size-reducible nanoassemblies exhibit enhanced targeting ability and provide an effective approach for atherosclerosis therapy.
BIOACTIVE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Matheus Mulling dos Santos, Alessandro de Souza Prestes, Gabriel Teixeira de Macedo, Sabrina Antunes Ferreira, Joao Luis Souza Vargas, Luana Caroline Schuler, Andreza Fabro de Bem, Nilda de Vargas Barbosa
Summary: Syzigium cumini leaf extract (ScExt) has shown to protect macrophages from oxLDL-mediated toxicity by preventing overproduction of reactive oxygen/nitrogen species and foam cell formation induced by oxLDL. These protective effects make ScExt a promising antioxidant for future trials in atherosclerosis prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medical Laboratory Technology
Anvarsadat Kianmehr, Durdi Qujeq, Abouzar Bagheri, Abdolkarim Mahrooz
Summary: Vascular endothelial cells respond to physicochemical stimuli, with oxidized low-density lipoprotein contributing to atherosclerosis. MicroRNAs play a role in cellular homeostasis under stress and can serve as therapeutic targets and biomarkers.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nadezhda Barvitenko, Elisaveta Skverchinskaya, Alfons Lawen, Elena Matteucci, Carlota Saldanha, Giuseppe Uras, Alessia Manca, Muhammad Aslam, Antonella Pantaleo
Summary: ROS are recognized as important signaling messengers in endothelial cells, with potential positive effects on pro-survival pathways downstream of G(i)-protein-coupled receptors. However, the role of ROS in stabilizing the endothelial barrier remains uncertain.
Article
Immunology
Linfang Zhang, Xiujuan Xia, Hao Wu, Xuanyou Liu, Qiang Zhu, Meifang Wang, Hong Hao, Yuqi Cui, De-Pei Li, Shi-You Chen, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: H. pylori infection impairs endothelial function in male mice through exosome-mediated ROS formation, while female mice show no change in endothelial function. This effect is achieved by increasing ROS production in the blood vessels.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Ali Mahdi, Tigist Wodaje, Oskar Kovamees, John Tengbom, Allan Zhao, Tong Jiao, Marcus Henricsson, Jiangning Yang, Zhichao Zhou, Anni Nieminen, Malin Levin, Aida Collado, Jonas Brinck, John Pernow
Summary: This study demonstrates that red blood cells (FH-RBCs) from patients with familial hypercholesterolemia (FH) and elevated low-density lipoprotein cholesterol (LDL-c) levels induce endothelial dysfunction, which is associated with an increased risk of premature atherosclerosis. This is mainly achieved through increased levels of arginase 1 and reactive oxygen species (ROS).
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Ruo-Lan Li, Ling-Yu Wang, Hu-Xinyue Duan, Die Qian, Qing Zhang, Li-Sha He, Xue-Ping Li
Summary: As the common pathological basis of various cardiovascular diseases, the morbidity and mortality of atherosclerosis (AS) have increased in recent years. Among the development of AS, endothelial dysfunction plays a particularly important role. Flavonoids derived from herbal medicines can prevent endothelial dysfunction by inhibiting oxidative stress, and quercetin and naringenin show superior protective effects for AS treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiujuan Xia, Linfang Zhang, Hao Wu, Feng Chen, Xuanyou Liu, Huifang Xu, Yuqi Cui, Qiang Zhu, Meifang Wang, Hong Hao, De-Pei Li, William P. Fay, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: This study found that CagA(+) H. pylori effectively colonizes gastric mucosa and impairs endothelial function, leading to increased atherosclerosis through exosomes-mediated ROS formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sivanan Sivasinprasasn, Naruemon Wikan, Jiraporn Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus
Summary: The study revealed that the combined application of PAVA and RSV can inhibit ox-LDL-induced inflammatory responses, decrease activation of NF-KB/NLRP3 pathway, reduce recruitment of monocytes, and ameliorate impairment of cell-cell junctions, offering a novel mechanism for the treatment of cardiovascular diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Song Xue, Hanfei Tang, Gefei Zhao, Chao Fang, Yang Shen, Dong Yan, Ye Yuan, Weiguo Fu, Zhenyu Shi, Xiao Tang, Daqiao Guo
Summary: The study revealed that CCL8 may promote atherosclerosis by inducing endothelial permeability increase. The NOX2/ROS signaling pathway may be the underlying mechanism for this effect. This research contributes to a deeper understanding of the connection between chemokines and atherosclerosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Hui Jiang, Yongwen Zhou, Seyed M. Nabavi, Amirhossein Sahebkar, Peter J. Little, Suowen Xu, Jianping Weng, Jianjun Ge
Summary: Atherosclerosis is an immuno-metabolic disease involving chronic inflammation, oxidative stress, epigenetics, and metabolic dysfunction. Oxidation of low-density lipoprotein (LDL) is a primary modification in atherosclerosis, leading to pathophysiological changes and plaque formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Layal El-Hajjar, Judy Hindieh, Rana Andraos, Marwan El-Sabban, Jalil Daher
Summary: Cardiovascular disease caused by atherosclerosis is a major cause of death worldwide. This study explores the role of oxidized LDL and the LOX-1 scavenger receptor in endothelial dysfunction and inflammation, providing insight into the pathways involved in atherosclerosis progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hitomi Ohinata, Takashi Obama, Tomohiko Makiyama, Yuichi Watanabe, Hiroyuki Itabe
Summary: This study found that high-density lipoproteins (HDL) partially decreased neutrophil extracellular trap (NET) formation induced by copper-oxidized low-density lipoprotein (oxLDL). It was also discovered that oxidized phosphatidylcholines and lysophosphatidylcholine in oxLDL promoted NET formation, which could be completely blocked by native HDL. Furthermore, an electronegative subfraction of LDL, LDL(-), was found to promote NET formation. These findings suggest that plasma lipoproteins and their oxidative modifications play multiple roles in promoting NET formation, and HDL acts as a suppressor of this response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yixin Xu, Haoran Bu, Yufan Jiang, Xiaoqing Zhuo, Ke Hu, Zhihua Si, Yong Chen, Qiwei Liu, Xianwei Gong, Haihui Sun, Qingyi Zhu, Lianqun Cui, Xiaochun Ma, Yuqi Cui
Summary: The antioxidant N-acetyl cysteine (NAC) has been found to have protective effects against the development of atherosclerosis, particularly when potentiated by ambient fine particulate matter (PM) in individuals with hyperlipidemia. NAC treatment was shown to decrease levels of oxidized LDL, reactive oxygen species, and inflammatory cytokines in the blood, while maintaining circulating endothelial progenitor cells. These effects ultimately led to a reduction in atherosclerotic plaque formation, demonstrating the potential of NAC in preventing PM-potentiated atherosclerosis.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Pharmacology & Pharmacy
Zizheng Suo, Yanzhi Liu, Yueyi Li, Cong Xu, Yuhan Liu, Mingming Gao, Jinghui Dong
Summary: Vitamin D not only affects calcium and phosphorus homeostasis but also regulates about 3% of human gene transcription. It has protective effects on cardiovascular disease and hypertension by modulating COX-1 and COX-2 expression to maintain normal vascular function.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Oncology
Xiaoli Peng, Hui Chang, Yeyun Gu, Junli Chen, Long Yi, Qi Xie, Jundong Zhu, Qianyong Zhang, Mantian Mi
CANCER PREVENTION RESEARCH
(2015)
Article
Food Science & Technology
Yong Zhang, Ming-liang Chen, Yong Zhou, Long Yi, Yan-xiang Gao, Li Ran, Shi-hui Chen, Ting Zhang, Xi Zhou, Dan Zou, Bin Wu, Ying Wu, Hui Chang, Jun-dong Zhu, Qian-yong Zhang, Man-tian Mi
MOLECULAR NUTRITION & FOOD RESEARCH
(2015)
Article
Multidisciplinary Sciences
Junli Chen, Hui Chang, Xiaoli Peng, Yeyun Gu, Long Yi, Qianyong Zhang, Jundong Zhu, Mantian Mi
SCIENTIFIC REPORTS
(2016)
Article
Sport Sciences
Dan Zou, Ka Chen, Peng Liu, Hui Chang, Jundong Zhu, Mantian Mi
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2014)
Review
Nutrition & Dietetics
Hui Chang, Lin Lei, Yun Zhou, Fayin Ye, Guohua Zhao
Article
Nutrition & Dietetics
Jie Zeng, Kun Wang, Fayin Ye, Lin Lei, Yun Zhou, Jia Chen, Guohua Zhao, Hui Chang
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2019)
Review
Oncology
Jie Zeng, Yi Gu, Hongjuan Fu, Chang Liu, Yixin Zou, Hui Chang
CLINICAL BREAST CANCER
(2020)
Review
Gastroenterology & Hepatology
Hongjuan Fu, Jie Zeng, Chang Liu, Yi Gu, Yixin Zou, Hui Chang
Summary: High intake of folate may be associated with a decreased risk of pancreatic cancer, especially in case-control studies. However, this association was not observed in cohort studies. Dose-response meta-analysis showed a marginal association between an increment of folate intake and the risk of pancreatic cancer.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Chemistry, Medicinal
Jie Zeng, Zhihui Deng, Yixin Zou, Chang Liu, Hongjuan Fu, Yi Gu, Hui Chang
Summary: The study demonstrated that TF can decrease serum lipid levels, increase the activity of antioxidant enzymes, and inhibit atherosclerotic plaque formation in mice. In vitro, TF was shown to protect endothelial cells from oxidative damage.
PHYTOTHERAPY RESEARCH
(2021)
Review
Oncology
Yi Gu, Jie Zeng, Yixin Zou, Chang Liu, Hongjuan Fu, Hui Chang
Summary: High folate intake is associated with a decreased risk of urothelial carcinoma, particularly invasive UC, but further research is needed to confirm this association.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Review
Oncology
Jianbo He, Hongjuan Fu, Cancan Li, Zhihui Deng, Hui Chang
Summary: Epidemiological studies on the association between vitamin B-12 and gastric cancer risk have reported inconsistent findings. A systematic review and meta-analysis found no significant association between vitamin B-12 intake and gastric cancer risk overall. However, high intake of vitamin B-12 may decrease the risk in Helicobacter pylori-negative individuals but increase the risk in Hp-positive populations. Excessive vitamin B-12 intake may also increase the risk of non-cardia gastric cancer. The association between vitamin B-12 intake and gastric cancer risk differs between smokers and nonsmokers.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Plant Sciences
Jianbo He, Hongjuan Fu, Cancan Li, Zhihui Deng, Hui Chang
Summary: Eriodictyol has a chemopreventive effect on breast carcinogenesis in vitro and in vivo through targeting circ_0007503 and inhibiting the PI3K/Akt pathway.
Review
Oncology
Cong Li, Jianbo He, Hongjuan Fu, Hui Chang
Summary: A meta-analysis of 12 studies shows that high intake of vitamin B-6 may reduce the risk of gastric cancer. However, this association is only observed in case-control studies, not in cohort studies. Furthermore, the association is confirmed in the United States but not in Europe or other regions.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Jianting Li, Lin Lei, Fayin Ye, Yun Zhou, Hui Chang, Guohua Zhao
Article
Oncology
Xiaoli Peng, Hui Chang, Junli Chen, Qianyong Zhang, Xiaoping Yu, Mantian Mi