期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 11, 期 6, 页码 2291-2305出版社
MDPI
DOI: 10.3390/ijms11062291
关键词
FGF; FGFR; NCAM; FGFR agonist; neuroprotective effect
资金
- Danish Medical Research Council
- Danish Natural Science Research Council
- Lundbeck Foundation
- Danish Cancer Society
- European Union [LSHM-CT-2005-512012]
Fibroblast growth factor receptors (FGFRs) interact with their cognate ligands, FGFs, and with a number of cell adhesion molecules (CAMs), such as the neural cell adhesion molecule (NCAM), mediating a wide range of events during the development and maintenance of the nervous system. Determination of protein structure, in silico modeling and biological studies have recently resulted in the identification of FGFR binding peptides derived from various FGFs and NCAM mimicking the effects of these molecules with regard to their neuritogenic and neuroprotective properties. This review focuses on recently developed functional peptide agonists of FGFR with possible therapeutic potential.
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