Review
Biochemistry & Molecular Biology
Yong Chool Boo
Summary: Arbutin, a compound of hydroquinone and D-glucose, has been studied for over 30 years for its skin lightening action. Research has focused on its mechanism of action, efficacy, safety, and potential synergies with other compounds. Studies also suggest that arbutin's antioxidant properties may contribute to its skin depigmenting effects. Future research may lead to advanced skin lightening and protecting cosmetic products.
Article
Agriculture, Multidisciplinary
Yi-Chi Chen, Yang-Yang Liu, Liqiang Chen, Dong-Mei Tang, Yunli Zhao, Xiao-Dong Luo
Summary: In this study, 14 alkaloids were isolated from Plumula Nelumbinis and investigated for their antimelanogenic effects. Two compounds, compound 4 and compound 12, showed significant reduction in melanogenesis and inhibition of tyrosinase activity. Mechanistically, these compounds exerted their effects by inhibiting key proteins involved in melanin production. These findings highlight the potential use of Plumula Nelumbinis containing compound 4 and compound 12 as functional foods for treating hyperpigmentation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Carla Atallah, Celine Viennet, Sophie Robin, Sami Ibazizen, Helene Greige-Gerges, Catherine Charcosset
Summary: This study evaluated the depigmenting activity and skin penetration of liposome formulations encapsulating cysteamine hydrochloride. The results showed that liposomes improved the stability and penetration of cysteamine hydrochloride in the skin.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biology
Pradtana Choosuwan, Jantana Praiboon, Korawinwich Boonpisuttinant, Anirut Klomjit, Narongrit Muangmai, Rapeeporn Ruangchuay, Anong Chirapart
Summary: This study evaluated the effects of ethanolic extracts from twelve seaweeds on tyrosinase inhibition and melanin synthesis. The results showed that the ethanolic extracts of Caulerpa racemosa, Ulva intestinalis, and Lobophora challengeriae had inhibitory effects on melanin production and intracellular tyrosinase levels. These seaweeds can be potential sources of natural tyrosinase inhibitors for therapeutic or cosmetic applications in the future.
Review
Pharmacology & Pharmacy
Samaneh Zolghadri, Mohammad Beygi, Tasneem F. Mohammad, Mahdi Alijanianzadeh, Thanigaimalai Pillaiyar, Pablo Garcia-Molina, Francisco Garcia-Canovas, Jose Munoz-Munoz, Ali Akbar Saboury
Summary: Hyperpigmentation is a common and distressing dermatologic condition. Inhibition of tyrosinase is considered a logical approach to prevent the accumulation of melanin in the skin. Non-hydroquinone lightening agents and nano-based strategies have been developed as alternatives for treating hyperpigmentation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Microbiology
Muthuraj Rudrappa, M. Santosh Kumar, Raju Suresh Kumar, Abdulrahman I. Almansour, Karthikeyan Perumal, Sreenivasa Nayaka
Summary: In this study, a melanin-producing actinomycete strain was isolated from soil and characterized using various techniques. The results demonstrate the significant value of the melanin pigment in industrial and biomedical applications.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Dermatology
Sirima Boonjing, Varisa Pongrakhananon, Wantanee Sittiwong, Kuntarat Arunrungvichian, Rawiwan Maniratanachote, Paninee Chetprayoon
Summary: Through a series of experiments, we identified two compounds with anti-pigmentation activity and an interaction with tyrosinase. These findings provide an alternative approach for the development of skin-whitening products that do not require animal testing.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amin Mahmood Thawabteh, Alaa Jibreen, Donia Karaman, Ala Thawabteh, Rafik Karaman
Summary: Human skin pigmentation and melanin synthesis are highly variable and influenced by genetics, UV exposure, and certain drugs. Skin conditions that cause pigmentary abnormalities can impact patients' physical appearance, psychological health, and social functioning. Hyperpigmentation and hypopigmentation are the major classifications of skin pigmentation. The most common clinical skin pigmentation disorders include albinism, melasma, vitiligo, Addison's disease, and post-inflammatory hyperpigmentation. Treatment options for pigmentation problems include anti-inflammatory medications, antioxidants, and tyrosinase inhibitors. This review article discusses the different types of pigmentation problems, their causes, and treatments, as well as the clinically tested plants, marine species, and medications available for treating skin diseases.
Article
Dermatology
Seung-Min Oh, Ye Eun Lee, Min Ji Ko, Ji Hwoon Baek, Min Kyung Shin
Summary: This study analyzed melanin pigmentation images to observe facial pigmentary demarcation lines (FPDLs) and suggest facial hyperpigmentation types for normal individuals. Four groups of FPDLs were observed, with the dark spot type being the most common. The photoaging type was more common among subjects over 40s, while the PIH type was more common in younger subjects.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mubashir Hassan, Saba Shahzadi, Andrzej Kloczkowski
Summary: This review focuses on the exploration of different chemical derivatives used as anti-melanogenic compounds, including natural compounds from plants and synthetic compounds inspired by these natural products. These compounds have shown potential as tyrosinase inhibitors with different therapeutic effects and may lead to the development of effective agents against melanogenesis in various industries.
Article
Biochemistry & Molecular Biology
Tahereh Shojazadeh, Leila Zolghadr, Saeed JafarKhani, Sajjad Gharaghani, Alireza Farasat, Hossein Piri, Nematollah Gheibi
Summary: Arachidonic acid (AA) inhibits tyrosinase activity and leads to changes in enzyme structure and thermodynamic stability. The interaction between AA and tyrosinase supports the advantages of this fatty acid for preventing medical hyperpigmentation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biotechnology & Applied Microbiology
Khadijeh Khezri, Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Akbar Hedayatizadeh-Omran
Summary: This study successfully prepared and characterised kojic acid nanostructured lipid carriers (KA-NLCs), with the optimized formulation KA-NLC3 showing stable drug release and enhanced percutaneous delivery for cosmetic applications.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Geology
Valentina Rossi, Samuel M. Webb, Maria McNamara
Summary: Studies have shown that in some fossils, melanosome chemistry may be altered by diagenesis, leading to the loss of original chemical composition; experiments have also confirmed that melanosome metal chemistry can change in copper-rich media; these results provide an experimental basis for interpreting the chemistry of fossil melanosomes.
Article
Food Science & Technology
Mohammed Shariful Azam, Jae-Il Kim, Chang Geun Choi, Jinkyung Choi, Bonggi Lee, Hyeung-Rak Kim
Summary: Research showed that SHQA ameliorated hyperpigmentation in α-MSH-stimulated B16F10 cells through multiple mechanisms, including inhibiting the expression of TYR and TRP1, reducing cAMP levels, activating the ERK1/2 signaling pathway, and promoting the degradation of MITF protein.
Review
Biochemistry & Molecular Biology
Anna Gryn-Rynko, Beata Sperkowska, Michal S. Majewski
Summary: The article focuses on the search for novel plant-derived anti-tyrosinase inhibitors from the Morus genus and their structure-activity relationships, providing crucial information for the cosmetics and medical industries.
