Review
Endocrinology & Metabolism
Emma K. Rautenberg, Yassin Hamzaoui, Dawn K. Coletta
Summary: Type 2 diabetes (T2D) and obesity present major challenges in public health. Understanding the molecular mechanisms contributing to these metabolic disorders, particularly insulin resistance, is crucial. Impaired mitochondria structure and function are common features in insulin-resistant individuals with T2D or obesity, potentially due to epigenetic regulation of mitochondrial and nuclear-encoded genes. Investigating mitochondrial abnormalities is important for gaining insights into the pathogenesis of diabetes and obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Khurshid Ahmad, Sibhghatulla Shaikh, Jeong Ho Lim, Syed Sayeed Ahmad, Hee Jin Chun, Eun Ju Lee, Inho Choi
Summary: This review discusses the role of skeletal muscle (SM) in insulin resistance and type 2 diabetes (T2D), as well as the pharmacological targets and potential modulators/inhibitors associated with SM metabolism. The review highlights the importance of SM in metabolic disorders and the therapeutic potential of natural compounds in targeting SM-associated T2D targets.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Manuela Moriggi, Sara Belloli, Pietro Barbacini, Valentina Murtaj, Enrica Torretta, Linda Chaabane, Tamara Canu, Silvia Penati, Maria Luisa Malosio, Antonio Esposito, Cecilia Gelfi, Rosa Maria Moresco, Daniele Capitanio
Summary: The study revealed gender-specific responses to obesity in mice, with males showing various metabolic alterations while females exhibited activation of compensatory mechanisms. Bioinformatics analysis identified upstream molecules regulating pathways differently in males and females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chiedozie Kenneth Ugwoke, Erika Cvetko, Nejc Umek
Summary: There is a close relationship between microvascular dysfunction and insulin resistance in obesity, with changes in skeletal muscle microcirculation leading to impaired insulin function and disturbed glucose homeostasis. Various molecular mechanisms and potential pharmacological treatments have been identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Christopher Livelo, Yiming Guo, Girish C. Melkani
Summary: Nearly 50% of adults will suffer from obesity in the U.S. by 2030, which can lead to high economic and healthcare burdens, elevated mortality rates, and reduced health span. Recent studies have shown that time-restricted feeding/eating (TRF; TRE in humans) may be an effective alternative therapy for obesity. It has been found that TRF can modulate skeletal muscle function, metabolism, and structure, offering potential insights for future research on TRF as a solution to obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Vinaya Simha, Ian R. Lanza, Surendra Dasari, Katherine A. Klaus, Nathan Le Brasseur, Ivan Vuckovic, Marcello C. Laurenti, Claudio Cobelli, John D. Port, K. Sreekumaran Nair
Summary: Familial partial lipodystrophy (FPL) is characterized by muscle hypertrophy and insulin resistance. However, FPL patients do not show increased muscle strength despite their muscularity, and experience earlier fatigue during exercise. This is accompanied by impaired mitochondrial function and altered gene expression, which may explain the metabolic abnormalities and skeletal muscle dysfunction in FPL patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Thomas M. Barber, Ioannis Kyrou, Harpal S. Randeva, Martin O. Weickert
Summary: Obesity leads to the development of insulin resistance, which in turn causes various metabolic consequences. Insulin resistance is associated with multiple complex pathogenic pathways, including chronic inflammation and mitochondrial dysfunction. Lifestyle optimization, such as regular physical activity, improved diet, and sufficient sleep, can effectively reverse insulin resistance without medication intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Olivier Reynaud, Jennifer Wang, Marie-Belle Ayoub, Jean-Philippe Leduc-Gaudet, Dominique Mayaki, Maude Dulac, Sabah N. A. Hussain, Raynald Bergeron, Gilles Gouspillou
Summary: Obesity is a major risk factor for developing health problems, such as insulin resistance and type 2 diabetes. This study investigated the protective effects of Parkin overexpression against obesity-induced mitochondrial dysfunction. The results suggest that Parkin overexpression positively impacts muscle and mitochondrial health, challenging the belief that intrinsic mitochondrial dysfunction is involved in the development of insulin resistance caused by high-fat feeding.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bruno Luiz da Silva Pieri, Matheus Scarpatto Rodrigues, Hemelin Resende Farias, Gustavo de Bem Silveira, Victoria de Souza Gomes da Cunha Ribeiro, Paulo Cesar Lock Silveira, Claudio Teodoro De Souza
Summary: Insulin resistance is the link between obesity and type 2 diabetes mellitus, and oxidative stress may play a role in this process. This study found that NAC supplementation improved insulin resistance and blood glucose levels by reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Avinash Kumar, Nicole Welch, Saurabh Mishra, Annette Bellar, Rafaella Nasciemento Silva, Ling Li, Shashi Shekhar Singh, Mary Sharkoff, Alexis Kerr, Aruna Kumar Chelluboyina, Jinendiran Sekar, Amy H. Attaway, Charles Hoppel, Belinda Willard, Gangarao Davuluri, Srinivasan Dasarathy
Summary: The dysregulated metabolism of ammonia causes reversible mitochondrial dysfunction and induces skeletal muscle senescence through transcriptional and translational perturbations. Multiomics analysis showed the impacts of ammonia lowering on mitochondrial function and protein expression. Dysregulated ammonia metabolism led to reversible defects in electron transport chain complexes and senescence-related molecular changes in skeletal muscle.
Article
Endocrinology & Metabolism
Francois Marchildon, Jingyi Chi, Sean O'Connor, Hilary Bediako, Paul Cohen
Summary: This study found that PRDM16 is required for the activation of beige fat in myostatin null mice, but the activation of beige fat is not necessary for the protection from obesity, glucose intolerance, insulin resistance, and hepatic steatosis in these mice. Increasing muscle mass can compensate for the inactivation of beige fat, suggesting that targeting muscle mass may be a therapeutic approach to mitigate the effects of adipose tissue dysfunction in obesity and metabolic syndrome.
MOLECULAR METABOLISM
(2021)
Article
Medicine, Research & Experimental
Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacos, Fatima Crispi, Gregory Duncombe, Martha Lappas, H. David McIntyre, Gregory Rice, Carlos Salomon
Summary: Gestational diabetes mellitus (GDM) poses a significant public health concern, affecting 9-15% of pregnancies worldwide. This study found that EV-associated miRNAs in GDM patients undergo significant changes during gestation and can be effectively used for classification. A set of proteins associated with JAK-STAT signaling in skeletal muscle biopsies from GDM patients was identified, which may be targeted by the miRNA-92a-3p carried by circulating EVs. Overexpression of miRNA-92a-3p was shown to increase insulin sensitivity in primary skeletal muscle cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biology
Anna F. Sheptulina, Karina Yu Antyukh, Anton R. Kiselev, Natalia P. Mitkovskaya, Oxana M. Drapkina
Summary: Increasing evidence suggests that skeletal muscles may play a role in the pathogenesis of obesity and associated conditions. Skeletal muscles, along with adipose tissue, are recognized as endocrine organs, producing biologically active substances. The amount and location of adipose tissue in relation to skeletal muscles is important for metabolic health.
Article
Biochemistry & Molecular Biology
Henver S. Brunetta, Heather L. Petrick, Iman Momken, Rachel M. Handy, Christopher Pignanelli, Everson A. Nunes, Jerome Piquereau, Mathias Mericskay, Graham P. Holloway
Summary: Dietary nitrate supplementation improves glucose homeostasis and mitochondrial bioenergetics through AMPK and SIRT1 signaling in obesity and insulin resistance models.
Article
Nutrition & Dietetics
Beegum Noorjahan Shijina, Achuthan Radhika, Sainulabdeen Sherin, Prabath Gopalakrishnan Biju
Summary: The indole alkaloid vindoline from Catharanthus roseus was found to have significant improvements in insulin resistance, oxidative stress, and inflammatory responses. It enhanced glucose metabolism and increased the expression of insulin receptors, alleviating symptoms of insulin resistance.
Article
Gastroenterology & Hepatology
Cecile Vors, Laurie Joumard-Cubizolles, Manon Lecomte, Emmanuel Combe, Lemlih Ouchchane, Jocelyne Drai, Ketsia Raynal, Florent Joffre, Laure Meiller, Melanie Le Barz, Patrice Gaborit, Aurelie Caille, Monique Sothier, Carla Domingues-Faria, Adeline Blot, Aurelie Wauquier, Emilie Blond, Valerie Sauvinet, Genevieve Gesan-Guiziou, Jean-Pierre Bodin, Philippe Moulin, David Cheillan, Hubert Vidal, Beatrice Morio, Eddy Cotte, Francoise Morel-Laporte, Martine Laville, Annick Bernalier-Donadille, Stephanie Lambert-Porcheron, Corinne Malpuech-Brugere, Marie-Caroline Michalski
Article
Nutrition & Dietetics
Fabienne Laugerette, Cecile Vors, Maud Alligier, Gaelle Pineau, Jocelyne Drai, Carole Knibbe, Beatrice Morio, Stephanie Lambert-Porcheron, Martine Laville, Hubert Vidal, Marie-Caroline Michalski
Article
Endocrinology & Metabolism
Allan de Oliveira Lira, Jose Luiz de Brito Alves, Mariana Pinheiro Fernandes, Diogo Vasconcelos, David Filipe Santana, Joao Henrique da Costa-Silva, Beatrice Morio, Carol Gois Leandro, Luciano Pirola
WORLD JOURNAL OF DIABETES
(2020)
Article
Nutrition & Dietetics
Karla Fabiola Corral-Jara, Laura Cantini, Nathalie Poupin, Tao Ye, Jean Paul Rigaudiere, Sarah De Saint Vincent, Alexandre Pinel, Beatrice Morio, Frederic Capel
Article
Cell Biology
Beatrice Morio, Baptiste Panthu, Arthur Bassot, Jennifer Rieusset
Summary: The liver plays a crucial role in coordinating the metabolic flexibility of the body, with hepatocyte mitochondria being key partners in this process. This review covers the metabolic and signaling pathways carried by liver mitochondria, as well as their role in health and metabolic disorders associated with obesity.
Article
Nutrition & Dietetics
Alexandre Pinel, Jean Paul Rigaudiere, Chrystele Jouve, Christophe Montaurier, Celine Jousse, Marie LHomme, Beatrice Morio, Frederic Capel
Summary: Transgenerational and continuous intake of EPA may help reduce cardiovascular and metabolic risks related to an unbalanced diet by modulating insulin sensitivity, fatty acid metabolism, and fibrosis in skeletal muscle.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Multidisciplinary Sciences
G. J. P. Rautureau, B. Morio, S. Guibert, C. Lefevre, J. Perrier, A. Alves, M. A. Chauvin, C. Pinteur, M. A. Monet, M. Godet, A. M. Madec, J. Rieusset, A. Mey, Baptiste Panthu
Summary: Obesity is linked to respiratory diseases, affecting the lung and liver the most. High-fat high-sugar diet induces specific metabolic changes in various organs, with the lung showing the second most severe effects, including decreased one-carbon metabolism and increased lipid accumulation.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Aline Maria Nunes de Lira Gomes Bloise, Aiany Cibelle Simoes-Alves, Alves Debora Santos, Beatrice Morio, Joao Henrique Costa-Silva
Summary: Nutrition transition is a global phenomenon characterized by increased consumption of fat-rich diets and high prevalence of obesity. While reducing saturated fatty acids intake is a consensus in preventing metabolic diseases, fatty acids of different chain lengths may have different cardiometabolic effects. Short and medium-chain SFA may provide beneficial health effects in cardiometabolic prevention.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Jeremy Bellien, Erwan Bozec, Frederic Bounoure, Hakim Khettab, Julie Malloizel-Delaunay, Mohamed Skiba, Michele Iacob, Nathalie Donnadieu, Aude Coquard, Beatrice Morio, Brigitte Laillet, Jean-Paul Rigaudiere, Jean-Michel Chardigny, Christelle Monteil, Cathy Vendeville, Alain Mercier, Anne-Francoise Cailleux, Anne Blanchard, Jacques Amar, Leopold K. Fezeu, Bruno Pannier, Alessandra Bura-Riviere, Pierre Boutouyrie, Robinson Joannides
Summary: This study assessed the cardiovascular and metabolic effects of camelina oil in hypertensive patients with metabolic syndrome. The results showed that camelina oil supplementation did not improve vascular function but adversely affected glucose metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Arthur Bassot, Carina Prip-Buus, Anais Alves, Olivier Berdeaux, Johan Perrier, Veronique Lenoir, Jingwei Ji-Cao, Marie-Agnes Berger, Emmanuelle Loizon, Stephanie Cabaret, Baptiste Panthu, Jennifer Rieusset, Beatrice Morio
Summary: This study demonstrates the impact of Grp75 or Mfn2 silencing and overexpression on triglyceride accumulation and cholesterol storage in MAMs, promoting fatty liver through distinct cellular pathways. Both proteins play crucial roles in hepatic lipid and cholesterol metabolism in obesity and NAFLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Mauricio Castro-Sepulveda, Beatrice Morio, Mauro Tunon-Suarez, Sebastian Jannas-Vela, Francisco Diaz-Castro, Jennifer Rieusset, Hermann Zbinden-Foncea
Summary: This study aimed to investigate the mitochondrial dynamics response in human peripheral blood mononuclear cells during the metabolic transition from fasting to feeding. The results demonstrated that this transition reduces mitochondria-ER interactions, induces mitochondrial fission, and reduces mitochondrial cristae density in human PBMCs.
Review
Physiology
Morgane Couchet, Charlotte Breuillard, Christelle Corne, John Rendu, Beatrice Morio, Uwe Schlattner, Christophe Moinard
Summary: Ornithine transcarbamylase (OTC) is a widely distributed enzyme in organisms, catalyzing the production of L-citrulline and playing a crucial role in the urea cycle. OTC is mainly expressed in the liver and intestine in mammals, influencing amino acid homeostasis significantly.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alexandre Pinel, Jean-Paul Rigaudiere, Beatrice Morio, Frederic Capel
Summary: The study showed that continuous intake of EPA-rich fish oil for three generations could reduce activation of inflammatory processes, maintain metabolic homeostasis, and decrease dysregulation of cholesterol metabolism and mitochondrial functions in response to an obesogenic diet. Continuous intake of long chain n-3 PUFA may be beneficial in preventing the effects of energy-dense, nutrient-poor foods.
Article
Cardiac & Cardiovascular Systems
Vivien Chavanelle, Stephanie Chanon, Claudie Pinteur, Emmanuelle Loizon, Guillaume Vial, Yolanda E. Otero, Florian Le Joubioux, Thierry Maugard, Sebastien L. Peltier, Pascal Sirvent, Beatrice Morio
Summary: The study showed that TOTUM-63 significantly reduced food intake, limited weight gain, and improved glucose homeostasis in animal models of obesity, potentially through modulation of GLP-1 and PYY.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Nutrition & Dietetics
Anais Alves, Frederic Lamarche, Remy Lefebvre, Eva Drevet Mulard, Arthur Bassot, Stephanie Chanon, Emmanuelle Loizon, Claudie Pinteur, Aline Maria Nunes de Lira Gomes Bloise, Murielle Godet, Gilles J. P. Rautureau, Baptiste Panthu, Beatrice Morio
Summary: The interactions between mitochondria and the endoplasmic reticulum, known as MAMs, are altered in the liver in obesity, which leads to disruption of the insulin signaling pathway. The plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance. Glycine supplementation can promote MAM integrity and improve insulin response in hepatocytes, but it does not have a beneficial effect on the overall metabolic profile in obese mice.
