Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner

AMPK activity is regulated by calcium-mediated protein phosphatase 2A activity

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Nrf2-ARE pathway regulates induction of Sestrin-2 expression

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Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells

(2012) Toran Sanli et al.   PLoS One

Global cancer statistics

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The role of LKB1 and AMPK in cellular responses to stress and damage

(2011) Angela Alexander et al.   FEBS LETTERS

The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53

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Induction of apoptosis by quercetin is mediated through AMPKα1/ASK1/p38 pathway

(2010) Yun-Kyoung Lee et al.   CANCER LETTERS

Stressin' Sestrins take an aging fight

(2010) Andrei V. Budanov et al.   EMBO Molecular Medicine

Quercetin and Cancer Chemoprevention

(2010) Lara Gibellini et al.   Evidence-based Complementary and Alternative Medicine

CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle

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International Trends in Colorectal Cancer Incidence Rates

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AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin

(2009) Yun-Kyoung Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells

(2009) Su-Yu Chien et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Stabilization of p53 Is Involved in Quercetin-Induced Cell Cycle Arrest and Apoptosis in HepG2 Cells

(2008) Shunsuke TANIGAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

AMP-activated Protein Kinase Contributes to UV- and H2O2-induced Apoptosis in Human Skin Keratinocytes

(2008) Cong Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY