Article
Biochemistry & Molecular Biology
Richard Van Krieken, Yuan-Li Tsai, Anthony J. Carlos, Dat P. Ha, Amy S. Lee
Summary: Recent research has revealed that ER chaperones such as GRP78 can escape from the ER and traffic to the cell surface in colon and lung cancer via a non-traditional endosomal transport pathway mediated by Rab GTPases. This unconventional translocation mechanism is driven by membrane fusion between ER-derived vesicles and endosomes, requiring specific SNARE proteins and co-chaperones regulated by ER stress-induced signaling pathways.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Environmental Sciences
Lin Zhao, Liyuan Wang, Han Wang, Tao Xi, Sijia Liu, Yang Li, Jianping Ruan, Yongqing Huang
Summary: Fluoride-induced endoplasmic reticulum (ER) stress is responsible for enamel mineralization disorder. This study investigated the mechanisms of fluoride-induced ER stress and autophagy in ameloblasts, and the regulatory role of ER molecular chaperone GRP78 in fluoride-induced autophagy.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Feng Wang, Lili Han
Summary: SGK1 alleviates doxorubicin-induced cardiotoxicity and cardiomyopathy by repressing endoplasmic reticulum stress (ERS).
Article
Pharmacology & Pharmacy
Libo Chuan, Xin Huang, Chuming Fan, Shiyuan Wen, Xiaohua Yang, Jingrong Wang, Jingyu Ren, Jin Ru, Li Ding
Summary: The study found that endoplasmic reticulum stress-related proteins increase in the brains of rats after cardiac arrest and cardiopulmonary resuscitation in a time-dependent manner. Treatment with metformin can alleviate neurological deficits, improve survival rate, reduce cell apoptosis and oxidative stress, and inhibit the expression of related proteins in the brain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ramazan Sabirli, Aylin Koseler, Tarik Goren, Ibrahim Turkcuer, Ozgur Kurt
Summary: This study reveals that GRP78 protein levels were significantly higher in Covid-19 infection patients compared to both Covid-19(-) pneumonia and control group, indicating a potential therapeutic target. There was no significant difference in GRP78 levels among different categories of Covid-19 related pneumonia.
Article
Biology
Sahar Askari, Pegah Javadpour, Fatemeh Sadat Rashidi, Leila Dargahi, Khosrow Kashfi, Rasoul Ghasemi
Summary: This study investigates the role and mechanism of endoplasmic reticulum (ER) stress in memory impairment. By using the ER stress activator thapsigargin, researchers found that ER stress impairs spatial cognition and hippocampal insulin signaling in rats, leading to increased apoptosis and pro-inflammatory response. This study establishes a reliable animal model for memory loss and reveals the underlying mechanisms of ER stress in memory impairment.
Article
Biochemistry & Molecular Biology
Mohammad Reza Aslani, Mojtaba Amani, Neghin Masrori, Mohammad Hossein Boskabady, Hossein Ali Ebrahimi, Leila Chodari
Summary: The study revealed that crocin and dexamethasone can alleviate airway inflammation and suppress ER stress markers. In the OVA-Cr100 group, the inhibitory effects on ER stress apoptotic markers were comparable to the OVA-Dexa group.
Article
Pharmacology & Pharmacy
Jialin Li, Kan Chen, Jianhua Huang, Dongqing Chu, Miaomiao Tian, Keqiang Huang, Chunyu Ma
Summary: Asiatic acid (AA) is shown to induce apoptotic death in tongue cancer cells in vitro and in vivo, potentially through mechanisms involving increased calcium levels and endoplasmic reticulum stress. This suggests that AA could be a promising therapeutic tool for tongue cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Anja Batel, Mirjana Polovic, Mateo Glumac, Oliver Suman, Stipislav Jadrijevic, Bernarda Lozic, Marija Petrovic, Bobana Samardzija, Nicholas J. Bradshaw, Karlo Skube, Vinko Palada, Mislav Acman, Ivana Marinovic Terzic
Summary: This study reveals the role of the SPRTN gene in hepatocellular carcinoma (HCC) and its association with endoplasmic reticulum (ER) stress, providing new insights into the pathogenesis of HCC.
CANCER GENE THERAPY
(2023)
Article
Immunology
Lei Huang, Qi Liu, Tongtong Zhou, Jing Zhang, Qianwen Tian, Qiaolin Zhang, Wei Wei, Huaxun Wu
Summary: This study investigated the molecular mechanisms of beta-arrestin2 in primary Sjogren's syndrome, finding that beta-arrestin2 downregulates GRP78-ATF6-CHOP apoptosis signaling to improve symptoms and tissue integrity in an experimental Sjogren's syndrome mouse model. The research suggests that excessive activation of GRP78-ATF6-CHOP apoptosis signaling is involved in the pathogenesis of primary Sjogren's syndrome, and beta-arrestin2 encourages inflammation-induced epithelial apoptosis through GRP78-ATF6-CHOP apoptosis signaling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Chengjie Wu, Guanglu Yang, Yalan Pan, Lei Wang, Pengcheng Tu, Suyang Zheng, Yang Guo, Yong Ma
Summary: The study demonstrates that icariin can inhibit ERS by down-regulating the expression of CHOP and Grp78, thereby reducing apoptosis of PC12 cells. This research provides potential evidence for icariin to promote the repair of PC12 cells and recovery of spinal cord injury.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Chemistry, Medicinal
Li-juan Gao, Ping Li, Tengyun Ma, Zhan-qiong Zhong, Shi-jun Xu
Summary: This study demonstrated that Ligustilide has neuroprotective effects on Alzheimer's disease cell models through regulating endoplasmic reticulum stress (ERS) and autophagy. Ligustilide decreased apoptosis rate, improved cell viability, and effectively modulated ERS by inhibiting the over-activation of the GRP78/PERK/CHOP signaling pathway. Additionally, Ligustilide alleviated the accumulation of autophagy vacuoles, reduced the ratio of LC3B-II/I, and up-regulated lysosomal acidity and Cathepsin D expression.
PHYTOTHERAPY RESEARCH
(2021)
Article
Clinical Neurology
Kohkichi Hosoda, Taichiro Imahori, Kazuhiro Tanaka, Takiko Uno, Tomoaki Nakai, Masaaki Kohta, Atsushi Fujita, Takashi Sasayama
Summary: The study revealed a close association between endoplasmic reticulum (ER) stress and clinical instability of carotid plaque, indicating that the ER stress pathway may be a potential therapeutic target in the prevention of stroke.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Neurosciences
Nan Zhang, Yangping Shentu, Min Zhu, Hui Wang, Xianghong Yin, Congkuo Du, Feng Xue, Junming Fan, Yongsheng Gong, Xiaofang Fan
Summary: This study investigates the role of Ero1 alpha in hypoxia-induced cognitive impairment and its involvement in neuronal apoptosis through the endoplasmic reticulum stress-associated pathway. The findings suggest that Ero1 alpha may serve as a promising therapeutic target for hypoxia-induced cognitive deficits.
Article
Biochemistry & Molecular Biology
Alicia Otero, Marina Betancor, Hasier Erana, Natalia Fernandez Borges, Jose J. Lucas, Juan Jose Badiola, Joaquin Castilla, Rosa Bolea
Summary: Prion diseases are a group of neurodegenerative disorders caused by the conversion of prion protein to its abnormal isoform. Studies have shown that ER stress and proteasome impairment occur early in spontaneous prion diseases, contributing to the accumulation of misfolded proteins. The findings suggest a strong correlation between ER stress, proteasome impairment and the neuropathological markers of prion diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)