Article
Oncology
Sojung Park, Sung Yong Lee, Dojin Kim, Yun Su Sim, Jeong-Seon Ryu, Juwhan Choi, Su Hwan Lee, Yon Ju Ryu, Jin Hwa Lee, Jung Hyun Chang
Summary: This study investigated 363 patients with advanced lung adenocarcinoma harboring EGFR mutations and evaluated the efficacy of afatinib, erlotinib, and gefitinib according to mutation type. E19del and L858R mutations were associated with superior progression-free survival and overall survival compared to uncommon mutations. Afatinib showed significantly longer progression-free survival across all EGFR mutation types.
Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Article
Multidisciplinary Sciences
Brendan Sullivan, Taylor Light, Vinh Vu, Adrian Kapustka, Kalina Hristova, Deborah Leckband
Summary: This study reveals a force-transduction mechanism that connects mechanical perturbations of E-cadherin to the activation of EGFR, a key regulator of cell proliferation. The results demonstrate that E-cadherin and EGFR form complexes at the plasma membrane, which are disrupted by the application of force or the presence of EGF. The findings provide insights into the initial steps of E-cadherin-mediated force transduction and the activation of growth regulatory signaling cascades.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Theresa Nauth, Farhad Bazgir, Hannah Voss, Laura Brandenstein, Niloufar Mosaddeghzadeh, Verena Rickassel, Sophia Deden, Christian Gorzelanny, Hartmut Schlueter, Mohammad R. Ahmadian, Georg Rosenberger
Summary: This study investigated the molecular mechanism underlying the skin manifestations in patients with Costello syndrome caused by mutations in the HRAS gene. The findings suggested that HRAS signaling pathways are involved in the regulation of integrin trafficking and cell adhesion, which are crucial for the pathobiology of Costello syndrome.
HUMAN MOLECULAR GENETICS
(2023)
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Sho Shiino, Graham Ball, Binafsha M. Syed, Sasagu Kurozumi, Andrew R. Green, Hitoshi Tsuda, Shin Takayama, Akihiko Suto, Emad A. Rakha
Summary: This meta-analysis revealed that loss of ER or PR in recurrent tumors was significantly associated with shorter overall survival. Similar trends were observed in groups with distant metastasis. Gain of ER was a significant predictor of longer post-recurrence survival.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Review
Cell Biology
Joanne L. Peterson, Brian P. Ceresa
Summary: Maintaining proper structure and function of the cornea is essential for clear vision. The epidermal growth factor receptor (EGFR) plays a crucial role in maintaining and restoring the corneal epithelium. Recent advances in understanding EGFR signaling and trafficking offer new strategies to overcome receptor desensitization and optimize receptor signaling for corneal health.
Article
Gastroenterology & Hepatology
Juhoon So, Minwook Kim, Seung-Hoon Lee, Sungjin Ko, Daniel A. Lee, Hyewon Park, Mizuki Azuma, Michael J. Parsons, David Prober, Donghun Shin
Summary: The differentiation of liver progenitor cells (LPCs) into hepatocytes is crucial for reducing inflammation and fibrosis in chronic liver diseases. Inhibition of the epidermal growth factor receptor (EGFR) signaling pathway promotes LPC-to-hepatocyte differentiation and may serve as a proregenerative therapeutic approach for patients with advanced liver disease. This study provides insights into the mechanisms underlying LPC-mediated liver regeneration and suggests the potential of EGFR inhibitors as a treatment option.
Article
Biochemical Research Methods
Rizwan Qureshi, Avirup Ghosh, Hong Yan
Summary: This study examines the complete structure of the multi-domain EGFR protein and its mutants using molecular dynamics simulations and normal mode analysis. The findings reveal different patterns of correlated motions in each domain of EGFR mutants compared to the wildtype, and the mutant structures have fewer hydrogen bonds. These findings are important for understanding the dynamics and communications in EGFR domains.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2022)
Article
Clinical Neurology
Maria Diaz, Jasmin Jo, Mark Smolkin, Sarah Jane Ratcliffe, David Schiff
Summary: The study found that patients with lower-grade gliomas have a higher VTE risk, which is decreased in the presence of an IDH mutation. The incidence of VTE in glioblastoma patients is not affected by MGMT promoter methylation status.
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Chun Kwon, Seong-Ho Ok, Seung Hyun Ahn, Sung Il Bae, Ji-Yoon Kim, Yeran Hwang, Kyeong-Eon Park, Mingu Kim, Ju-Tae Sohn
Summary: In this study, the researchers investigated the involvement of aortic contraction induced by dexmedetomidine in the transactivation of EGFR in endothelium-denuded rat aortas. They found that the activation of alpha-2 adrenoceptor, Src kinase, and matrix metalloproteinase mediated the contraction and subsequent JNK phosphorylation and increased calcium levels. These findings provide insights into the cellular mechanisms underlying dexmedetomidine-induced effects on aortic contraction and EGFR transactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Jong Won, Rami Lee, Sun-Hye Choi, Ji-Hun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study aimed to elucidate the involvement of EGFRs in gintonin-induced wound repair in HaCaT keratinocytes. Results showed that gintonin increased EGF receptor activation, as well as promoted proliferation and migration in HaCaT cells. Additionally, gintonin stimulated the expression and release of HB-EGF. These findings suggest a close relationship between gintonin's wound-healing effects and the collaboration of EGF receptor activation and HB-EGF release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Ikbal Esen Aydingoz, Gulsen Tukenmez Demirci, Deniz Agirbasli, Devrim Oz-Arslan, Guven Yenmis
Summary: The study revealed a significant increase in the amount of EGF in acne patients, indicating a potential role of EGF in the pathogenesis of acne.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Oncology
Daichi Fujimoto, Hiroaki Akamatsu, Takeshi Morimoto, Kazushige Wakuda, Yuki Sato, Yoshitaka Kawa, Toshihide Yokoyama, Motohiro Tamiya, Ryota Hiraoka, Naoki Shingu, Hideki Ikeda, Akihiro Tamiya, Masaki Kanazu, Eisaku Miyauchi, Satoru Miura, Masaaki Yanai, Makiko Yomota, Ryotaro Morinaga, Takashi Yokoi, Akito Hata, Hidekazu Suzuki, Hirotaka Matsumoto, Shinya Sakata, Naoki Furuya, Yuhei Harutani, Ichiro Nakachi, Ayumu Otsuki, Shinya Uematsu, Satoshi Hara, Keiki Yokoo, Takeya Sugimoto, Nobuyuki Yamamoto
Summary: This study aimed to determine the incidence and clinical course of histologic transformation (HT) in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. The study found that approximately 3% of EGFR-mutated patients developed HT after acquiring resistance to EGFR-tyrosine kinase inhibitors (TKIs). There was no significant difference in survival between patients with transformation to high-grade neuroendocrine carcinoma and those with transformation to another subtype of non-small cell lung cancer. Cytotoxic agents were likely to be effective in patients with HT, while the effectiveness of immune checkpoint inhibitors was limited.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Engineering, Environmental
Yunpeng Wang, Cuiwei Yu, Haoyu Ji, Zhehan Liu, Xiaotong Wang, Yinghe Ji, Xiaomeng Sun, Yue Zhao, Xiaohong Qiu, Ting Zhang, Jing Li, Xin Liu, Xinpeng Lv, Benzhi Cai, Yingqi Zhao, Jian-An Huang, Yang Li
Summary: This article reports a 3-step method to prepare a SERS system of silver nanoparticle clusters to overcome the interference of complex constituents of serum and achieve quantitative SERS analysis of drugs in serum. The method involves removing proteins from serum, enhancing drug adsorption on the nanoparticles, and suppressing background by using an internal standard in nanoparticle aggregation. The method shows great potential for clinical application in therapeutic drug monitoring and personalized medicine.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Caicun Zhou, Gongyan Chen, Yunchao Huang, Jianying Zhou, LiZhu Lin, Jifeng Feng, Zhehai Wang, YongQian Shu, Jianhua Shi, Yi Hu, QiMing Wang, Ying Cheng, Fengying Wu, Jianhua Chen, Xiaoyan Lin, Yongsheng Wang, Jianan Huang, Jiuwei Cui, Lejie Cao, Yunpeng Liu, Yiping Zhang, Yueyin Pan, Jun Zhao, LiPing Wang, Jianhua Chang, Qun Chen, Xiubao Ren, Wei Zhang, Yun Fan, Zhiyong He, Jian Fang, Kangsheng Gu, XiaoRong Dong, Faguang Jin, Hongjun Gao, Guangyu An, Cuimin Ding, Xiaodong Jiang, Jianping Xiong, Xiangdong Zhou, Sheng Hu, Ping Lu, Anwen Liu, Shuliang Guo, Jianjin Huang, Chengchu Zhu, Jian Zhao, Beili Gao, Yinglan Chen, Chengping Hu, Jian Zhang, Hongmei Zhang, Hui Zhao, Yanfei Tai, Xinjing Ma, Wei Shi, CameL Study Grp
Summary: The addition of camrelizumab to first-line chemotherapy significantly improves the progression-free survival of patients with advanced nonsquamous NSCLC. It provides long-term survival benefit with manageable toxicity and durable response. These results support the combination of camrelizumab and chemotherapy as a first-line treatment for advanced nonsquamous NSCLC.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Feng-Xia Liang, Liang-Liang Zhou, Yi Hu, Shi-Fu Li, Zhen-Yu Zhang, Jing-Yue Li, Can Fu, Chun-Yan Wu, Li Wang, Jian-An Huang, Lin-Bao Luo
Summary: In this study, a sensitive narrowband photodetector (NB-PD) with peak response at 580 nm and the full-width at half-maximum of 23 nm was successfully achieved. With the introduction of the back-end circuit, a yellow light intensity meter was constructed with the NB-PD, which showed good capability for yellow light monitoring with low absolute and relative errors.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Marzia Iarossi, Daniel Darvill, Aliaksandr Hubarevich, Jian-An Huang, Yingqi Zhao, Angela Federica De Fazio, Devin B. O'Neill, Francesco Tantussi, Francesco De Angelis
Summary: Solid-state nanopores can sense biomolecules at the single-molecule level, but limitations and challenges exist in current electrical and optical sensing strategies. In contrast, plasmonic nanoassemblies that support high-density nanopores have shown promising results in capturing analytes and discriminating DNA sequences using surface-enhanced Raman scattering.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Lingling Jiang, Jiale Zhang, Hongying Li, Chaoqin He, Ruo Yuan, Yingqi Zhao, Jian-An Huang, Ying Zhuo, Xia Yang
Summary: In this study, a highly efficient SERS substrate Sn1-xCexO2 was synthesized by varying concentrations of Ce ions and introducing oxygen vacancies. The charge transfer pathway and strong interaction between the Sn1-xCexO2 nanoflowers (NFs) and methylene blue (MB) molecules were promoted, resulting in an enhancement factor (EF) as high as 1.80 x 106. This study provides an approach for the preparation of new SERS substrates that can be used in bioanalysis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Respiratory System
Chuan-cai Xu, Zhi-song He, Wei Lei, Jin-zhou Zhu, Da-guo Zhao, Jin-dan Kong, Yao Wei, Ying Xu, Jian-An Huang
Summary: This study found that patients with breakthrough infections after receiving the COVID-19 vaccine had higher lymphocyte counts, anti-SARS-CoV-2 spike IgG and IgM antibody titers within 60 days of receiving the second dose compared to those with a 60-day or longer interval. Additionally, the IL-6 level was significantly lower in the group with a shorter interval.
CLINICAL RESPIRATORY JOURNAL
(2023)
Review
Food Science & Technology
Meng-ge Tang, Sheng Zhang, Li-gui Xiong, Jing-hui Zhou, Jian-an Huang, Ai-qing Zhao, Zhong-hua Liu, Ai-ling Liu
Summary: Polyphenol oxidase (PPO) is a metalloenzyme in tea plants that plays a crucial role in enhancing defensive responses, cultivating high-quality germplasm resources, and producing functional tea products. The oxidative polymerization of PPO in tea manufacturing can provide functional foods for preventing and treating chronic non-communicable diseases. However, more comprehensive research is needed to understand the relationship between PPO and tea. This article provides a comprehensive review of the classification, catalytic mechanism, and utilization of PPO in modulating tea flavors, compositions, and nutrition, as well as the techniques for modifying and applying PPO based on modern enzymology and synthetic biology.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Yingqi Zhao, Aliaksandr Hubarevich, Angela Federica De Fazio, Marzia Iarossi, Jian-An Huang, Francesco De Angelis
Summary: Plasmonic nanopores combined with Raman spectroscopy have been used for label-free single-molecule detection and sequencing. We presented a bowl-shaped plasmonic gold nanopore that enables direct Raman detection of single lambda-DNA molecules. The bowl shape facilitates the generation of a single intense hot spot, allowing for ultrasmall focusing of NIR light and the detection of 7 consecutive bases along the DNA chain in flow-through conditions.
Article
Medicine, Research & Experimental
Xiaohui Zhang, Yuhong Qin, Wei Lei, Jian-An Huang
Summary: The diagnostic accuracy of metagenomic next-generation sequencing (mNGS) is superior to conventional microbiological tests (CMTs) for severe community-acquired pneumonia (SCAP) in immunocompromised patients. mNGS has advantages in detecting polymicrobial infections and identifying unexpected pathogens. Therefore, mNGS can be considered as an important diagnostic method for SCAP.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Jie Yuan, Tao Jin Wang, Jian Chen, Jian An Huang
Summary: The study of the creep properties of soils is important for settlement management and building safety. This paper analyzes the influence of mineral composition and content on the structure and creep properties of soft soil at the microscopic level. The energy scale method is proposed and used to analyze the results of direct shear creep test, revealing correlations between viscosity coefficient, adsorbed water, and soft soil creep.
FRONTIERS IN MATERIALS
(2023)
Article
Microbiology
Wei-Tao Gong, Xiao-Jie Zhao, Gao-Ming Wang, Xiao-Lin Ma, Jian-An Huang
Summary: Our study revealed the significant bactericidal effect of the zidovudine-amikacin combination against amikacin-resistant Enterobacteriales, and demonstrated the strong synergistic effect with amikacin. These findings suggest that the zidovudine-amikacin combination could be an effective alternative therapy for multidrug-resistant Enterobacteriales.
MICROBIOLOGY SPECTRUM
(2023)
Article
Materials Science, Ceramics
Wei Huang, Xiaoyu Lu, Dongsheng Jia, Jianan Huang, Zhi Li, Han Xie, Mitang Wang, Ying Li, Dongliang Zhang
Summary: In this experiment, pure α-Fe2O3 and Y-doped Fe2O3 nanoparticles with different concentrations were prepared using a simple hydrothermal method. The photocatalytic performance of the samples for MB dye degradation was studied using various characterization techniques. The results showed that the particle size was around 100 nm, and with the increase of Y ion concentration, the band gap decreased and the degradation rate increased. The doping of 1.0% Y ions significantly affected the photocatalytic performance of α-Fe2O3.
CERAMICS INTERNATIONAL
(2023)
Article
Respiratory System
Yongkang Huang, Shiyuan Gao, Ting Li, Beilei Zhang, Juan Du, Yajuan Qian, Yufei Xing, Tong Zhou, Minhua Shi, Jian-an Huang, Yixin Lian
Summary: This study aimed to identify risk factors and examine the clinical characteristics of lung cancer patients with pulmonary embolism (PE). The study found that 1.08% of lung cancer patients had PE, with the majority being male and adenocarcinoma being the most common histological subtype. The study also found that PE was an independent predictor of poor survival, and a high ECOG score was an independent risk factor for PE in lung cancer patients.
CLINICAL RESPIRATORY JOURNAL
(2023)
Article
Chemistry, Applied
Xuexue Zheng, Tengfei Hu, He Xie, Xingchang Ou, Jianan Huang, Chao Wang, Zhonghua Liu, Qin Li
Summary: In this study, the key odor-active compounds of Fu brick tea were identified using headspace solid phase microextraction combined with gas chromatography-mass spectrometry and gas chromatography-olfactometry. A total of 43 volatile and 38 odor-active compounds were identified, with dihydroactindiolide, (E)-linalool oxide, and benzyl alcohol being the most abundant. Aroma recombination experiments verified that these compounds successfully simulated the overall aroma profile of Fu brick tea. This study provides a theoretical basis for understanding the formation of characteristic aromas in Fu brick tea.
Article
Chemistry, Multidisciplinary
Xiaoyu Lu, Jianan Huang, Han Xie, Wei Huang, Zhigao Sun, Dongliang Zhang, Xiaowei Zhang, Mitang Wang
Summary: A liquid-phase reduction technique was used to obtain praseodymium-doped cuprous oxide photocatalyst. The 3% Pr : Cu2O photocatalyst showed the best photocatalytic performance due to the reduced recombination of photogenerated electron-hole pairs. The functioning mechanism of the Pr : Cu2O photocatalyst was examined.