Article
Biochemistry & Molecular Biology
Marta Gerasymchuk, Gregory Ian Robinson, Olga Kovalchuk, Igor Kovalchuk
Summary: Modern understanding of aging is based on the accumulation of cellular damage during one's life span due to the gradual deterioration of regenerative mechanisms in response to the continuous effect of stress, lifestyle, and environmental factors, followed by increased morbidity and mortality. Cell culture models are valuable tools to investigate the mechanisms of aging by inducing cellular senescence in stress-induced premature senescence (SIPS) models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Taihao Quan, Yaping Xiang, Yingchun Liu, Zhaoping Qin, Yan Yang, George Bou-Gharios, John J. Voorhees, Andrzej A. Dlugosz, Gary J. Fisher
Summary: The aging process affects the structure and function of dermal collagen, leading to thinning, fragility, wrinkles, laxity, impaired wound healing, and a microenvironment conducive to cancer. CCN1 protein is elevated in aged human skin, and transgenic mice expressing CCN1 in dermal fibroblasts display accelerated skin dermal aging. This mouse model provides a novel tool for understanding and studying the mechanisms of skin aging.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Nutrition & Dietetics
Visarut Buranasudja, Chawanphat Muangnoi, Kittipong Sanookpan, Hasseri Halim, Boonchoo Sritularak, Pornchai Rojsitthisak
Summary: The study found that eriodictyol can protect human dermal fibroblasts from the harmful effects of hydrogen peroxide by directly neutralizing reactive oxygen species, enhancing detoxifying enzyme activities, and regulating the expression of Nrf2 signaling system.
Article
Environmental Sciences
Faroza Nazir, Qazi Fariduddin, Anjuman Hussain, Tanveer Alam Khan
Summary: This study investigated the effects of brassinosteroids and hydrogen peroxide on tomato plants under copper stress. The results showed that EBL and H2O2 applied through distinct modes could enhance the resilience of tomato plants to copper stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Yue Zhang, Yanhuang An, Ning Yang, Wei Wang, Ruirui Liu, Run Gao, Yaping Zhou
Summary: Oridonin influences the root growth of Arabidopsis thaliana by regulating PLC1 and H2O2, with high concentrations inhibiting root growth.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Biochemistry & Molecular Biology
Marina Alorda-Clara, Margalida Torrens-Mas, Pere Miquel Morla-Barcelo, Pilar Roca, Jorge Sastre-Serra, Daniel Gabriel Pons, Jordi Oliver
Summary: Genistein may increase oxidative stress and inflammation in colon cancer cells, ultimately decreasing cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Ali Eskandari, Evelyn K. F. Yim, D. Moira Glerum, Ting Y. Y. Tsui
Summary: The presence of indium sulfate in the culture media leads to decreased cell viability and increased production of ROS in human dermal fibroblasts. In the presence of indium sulfate, cell morphology becomes more circular and compact, and the ability of cells to align along the surface structure is reduced, especially on structures with larger line/trench widths.
Article
Cell Biology
Shih-Yao Chen, Jeng-Long Hsieh, Po-Ting Wu, Ai-Li Shiau, Chao-Liang Wu
Summary: This study found that decreased expression of miR-133 is associated with aberrant proliferation and migration of RA FLS. Overexpression of miR-133 reduced cell viability and migration of RA FLS, with decreased levels of FSCN1, EGFR, and MET.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yoshie Umehara, Miho Takahashi, Hainan Yue, Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Ko Okumura, Hideoki Ogawa, Francois Niyonsaba
Summary: The skin produces antimicrobial peptides that not only fight against pathogens but also have immunomodulatory functions. This study found that human beta-defensins promote the secretion of angiogenin, a potent angiogenic factor, by fibroblasts, suggesting a novel role of these peptides in angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Natasha Masub, Evan Austin, Alisen Huang, Jared Jagdeo
Summary: High-fluence LED-RL may decrease fibroblast proliferation by inducing G(0)/G(1) arrest, providing insight into the molecular mechanism underlying LED-RL as an anti-fibrotic therapeutic.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Chemistry, Analytical
Meng-Meng Liu, Hui Liu, Shan-Hong Li, Yu Zhong, Yao Chen, Zi-Zhen Guo, Wei Chen, Xin-Hua Lin, Yun Lei, Ai-Lin Liu
Summary: A paper-based 3D platform was developed for constructing an AD cell model and monitoring cell activity through H2O2, where curcumin showed significant cytoprotective effects in reducing H2O2 production and improving cell viability.
Article
Cell Biology
Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Silke Kowar, Manching Ku, Tilman Brummer, Melanie Boerries
Summary: Vemurafenib induces paradoxical changes in human dermal fibroblast (HDF) due to a permissive chromatin landscape, leading to compensatory effects during combination therapies with less specific MAPK/ERK inhibitors. The importance of evaluating the effects of drugs on non-transformed stromal components, especially in combination therapies, is highlighted.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Chemistry, Physical
Ali Eskandari, D. Moira Glerum, Ting Y. Tsui
Summary: This study demonstrates that exposure to indium chloride has detrimental effects on the behavior of human fibroblasts and adversely impacts their mitochondrial morphology.
Article
Biochemistry & Molecular Biology
Dabin Choi, Wesuk Kang, Soyoon Park, Bomin Son, Taesun Park
Summary: For several decades, excessive glucocorticoids (GCs) have been known to inhibit collagen synthesis and accelerate skin aging, but the molecular mechanisms involved are not well understood. In this study, the researchers identified potential glucocorticoid receptor (GR) target genes that may contribute to the inhibition of collagen synthesis. They confirmed that dexamethasone, a synthetic GC, activates canonical GR signaling in dermal fibroblasts and identified six candidate genes involved in the GC-mediated inhibition of collagen synthesis. This study provides insights into the molecular mechanisms of GC-mediated skin aging and lays the foundation for further research on the biological characteristics of individual GR target genes.
Article
Multidisciplinary Sciences
Richard Francis
Summary: The study found that nebulization of hydrogen peroxide (H2O2) for respiratory disease treatment negatively impacts respiratory cilia motility and flow. Low concentrations of H2O2 immediately depress cilia motility, while higher concentrations completely cease cilia motility and flow. The use of nebulized H2O2 for respiratory diseases should be approached with caution.
