Article
Rheumatology
Sherri Longobardi, Charmaine Lopez-Davis, Bhuwan Khatri, Constantin Georgescu, Cherilyn Pritchett-Frazee, Christina Lawrence, Astrid Rasmussen, Lida Radfar, Robert Hal Scofield, Alan N. Baer, Susan A. Robinson, Erika Darrah, Robert C. Axtell, Gabriel Pardo, Jonathan D. Wren, Kristi A. Koelsch, Joel M. Guthridge, Judith A. James, Christopher J. Lessard, Amy Darise Farris
Summary: This study identified autoantibodies in anti-Ro/SS-A negative primary Sjogren's syndrome (SS), providing a new approach for diagnosing Ro-negative SS.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Joe Scott Berry, Jessica Tarn, John Casement, Pierre-Marie Duret, Lauren Scott, Karl Wood, Svein-Joar Johnsen, Gunnel Nordmark, Valerie Devauchelle-Pensec, Raphaele Seror, Benjamin Fisher, Fransesca Barone, Simon J. Bowman, Michele Bombardieri, Dennis Lendrem, Renaud Felten, Jacques-Eric Gottenberg, Wan-Fai Ng
Summary: Proteomic and network analysis identified distinct pathobiology and potential therapeutic targets for different subtypes of Sjogren's syndrome (SS). Stratification of patients using the Newcastle Sjogren's Stratification Tool (NSST) revealed an association between high levels of serum IL-6 and improvement in fatigue score. These findings provide insights into the underlying mechanisms and treatment strategies of SS subtypes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Michelle L. Joachims, Bhuwan Khatri, Chuang Li, Kandice L. Tessneer, John A. Ice, Anna M. Stolarczyk, Nicolas Means, Kiely M. Grundahl, Stuart B. Glenn, Jennifer A. Kelly, David M. Lewis, Lida Radfar, Donald U. Stone, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Graham B. Wiley, Jonathan D. Wren, Patrick M. Gaffney, Courtney G. Montgomery, Kathy L. Sivils, Astrid Rasmussen, A. Darise Farris, Indra Adrianto, Christopher J. Lessard
Summary: The study identified specific transcription profiles in Sjögren's disease (SjD) cases, with downregulation of differentially expressed (DE) transcripts compared to healthy controls. Certain lncRNAs exhibited correlated expression with interferon (IFN)-regulated genes in SjD patients.
Article
Immunology
Giacomo Cafaro, Carlo Perricone, Francesco Carubbi, Chiara Baldini, Luca Quartuccio, Roberta Priori, Onorina Berardicurti, Francesco Ferro, Saviana Gandolfo, Angelica Gattamelata, Roberto Giacomelli, Salvatore De Vita, Roberto Gerli, Elena Bartoloni
Summary: The prevalence of PNS involvement in pSS is relatively rare but prognostically relevant. Patients with SMP exhibit main adverse prognostic features, while those with pure sensory neuropathies typically have a milder clinical picture.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Qi An, Jingwen Zhao, Xueqing Zhu, Baoqi Yang, Zewen Wu, Yazhen Su, Liyun Zhang, Ke Xu, Dan Ma
Summary: This article explores the pathogenesis of Sjogrens syndrome caused by autoantibodies attacking salivary and lacrimal gland tissues, focusing on the role of T cells and therapeutic targeting of T cells for treatment of patients with SS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Yunjin Lee, Hyun Sun Jeon, Joon Young Hyon
Summary: This study aimed to investigate the impact of serum anti-La antibodies on clinical parameters of dry eye disease (DED) and evaluate the correlation between antibody titers and DED parameters. The results showed a significant correlation between anti-Ro titers and conjunctival staining score, while no statistical correlation was found between anti-La and clinical DED parameters. Additionally, anti-Ro titers and focus score were significantly higher in patients positive for both anti-Ro and anti-La.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Review
Immunology
Ana Merino-Vico, Giulia Frazzei, Jan Piet van Hamburg, Sander W. Tas
Summary: Autoimmune diseases are characterized by inflammation and tissue damage caused by the immune system recognizing self-antigens. B cells play a critical role in autoimmunity and have been identified as therapeutic targets. This review article provides an overview of novel strategies to target B cells in autoimmune diseases, with a focus on rheumatic diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Rheumatology
Valentina Pucino, Jason D. Turner, Saba Nayar, Florian Kollert, Saaeha Rauz, Andrea Richards, Jon Higham, Ana Poveda-Gallego, Simon J. Bowman, Francesca Barone, Benjamin A. Fisher
Summary: This study aimed to compare clinical and proteomic predictors of primary Sjogren's syndrome (SjS) and non-SjS sicca syndrome (sicca), and identify the key predictors of symptoms. The results showed that obesity-related metabolic factors may regulate symptoms in sicca, while further research is needed to explore the non-inflammatory drivers of high symptom burden in SjS.
Article
Immunology
Peng Qu, Todd Wuest, Yongfen Min, Ilias Alevizos, Howard A. Young, P. Charles Lin
Summary: This study reveals NK4 as a novel regulator that promotes the development of autoimmune disorders by its roles on B cells. NK4 was significantly elevated in samples from patients with Sjogren's Syndrome, and transgenic expression of NK4 in a mouse model led to autoimmune phenotypes similar to those in patients. NK4 may be a novel therapeutic target for the treatment of autoimmune diseases.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Rheumatology
L. Deroo, H. Achten, K. De Boeck, E. Genbrugge, W. Bauters, D. Roels, F. Dochy, D. Creytens, J. Deprez, F. Van den Bosch, D. Elewaut, I. Peene
Summary: This study aimed to explore the disease characteristics of anti-SSA/Ro positive, suspected, and definite pSS patients, in relation to serological profiles based on anti-Ro52, anti-Ro60, and anti-SSB/La reactivity. The results indicate that separate detection of these antibodies is not only relevant for pSS diagnosis but also aids in patient stratification and evaluation of disease burden. Furthermore, the study suggests a stepwise model where patients with triple reactivity against Ro60, Ro52, and SSB/La display the most glandular abnormalities and signs of B-cell hyperactivity.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Review
Rheumatology
Nazariy Koval, Mariana Alves, Rui Placido, Ana G. Almeida, Joao Eurico Fonseca, Joaquim J. Ferreira, Fausto J. Pinto, Daniel Caldeira
Summary: The use of DOACs, particularly rivaroxaban, among patients with APS is associated with a 69% increased risk of thromboembolic events compared to VKA, while the risks of major bleeding, all bleeding events, and mortality are not significantly different. The certainty of these results is very low.
Review
Immunology
Hiroyuki Yoshitomi, Hideki Ueno
Summary: The interactions between CD4(+)T cells and B cells are crucial for antibody responses and autoimmune diseases. Recent studies identified a new subset of CD4(+)B helper T cells called peripheral helper T (Tph) cells, which provide help to B cells in inflamed tissues and share some functions with Tfh cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Ke Rui, Yue Hong, Qiugang Zhu, Xiaofei Shi, Fan Xiao, Hailong Fu, Qing Yin, Yida Xing, Xinfeng Wu, Xiaodan Kong, Huaxi Xu, Jie Tian, Shengjun Wang, Liwei Lu
Summary: The study demonstrated that murine olfactory ecto-mesenchymal stem cell-derived exosomes can effectively attenuate the progression of experimental Sjogren's syndrome (ESS) by enhancing the immunosuppressive function of myeloid-derived suppressor cells (MDSCs). These exosomes activated the Jak2/Stat3 pathway in MDSCs through IL-6 secretion, and promoted the endogenous production of IL-6 via TLR4 signaling, indicating a potential autocrine pathway for MDSC functional modulation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Rheumatology
Mathijs G. A. Broeren, Jing J. Wang, Giulia Balzaretti, Patricia J. T. A. Groenen, Barbera D. C. van Schaik, Tim Chataway, Charlotte Kaffa, Sander Bervoets, Konnie M. Hebeda, Gergana Bounova, Ger J. M. Pruijn, Thomas P. Gordon, Niek De Vries, Rogier M. Thurlings
Summary: This study comparatively analysed the aberrant affinity maturation of the antinuclear and rheumatoid factor (RF) B cell repertoires in Sjogren's syndrome (SjS) patients. The results showed that the ANA and RF clones in SjS patients displayed tissue-restricted, antigen-dependent and divergent affinity maturation. The affinity maturation of RF clones deviated further during RF clone derived lymphomagenesis and during the regeneration of the autoreactive repertoire after temporary disruption by rituximab.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Alexandra Kachaner, Elisabeth Berge, Frederic Desmoulins, Christine Le Pajolec, Antoine Rousseau, Marc Labetoulle, Gaetane Nocturne, Xavier Mariette, Raphaele Seror
Summary: This study describes primary Sjogren's disease patients who do not have or have a low level of dryness, and compares them with Sjogren's disease patients who have oral or ocular dryness features.
Article
Rheumatology
Raphaele Seror, Gabriel Baron, Marine Camus, Divi Cornec, Elodie Perrodeau, Simon J. Bowman, Michele Bombardieri, Hendrika Bootsma, Jacques-Eric Gottenberg, Benjamin Fisher, Wolfgang Hueber, Joel A. van Roon, Valerie Devauchelle-Pensec, Peter Gergely, Xavier Mariette, Raphael Porcher
Summary: An composite responder index, called Sjogren's Tool for Assessing Response (STAR), was developed in this study to evaluate the treatment response in primary Sjogren's syndrome (pSS). Through data analysis and consensus techniques, the researchers identified five core domains and developed 227 STAR options for sensitivity testing. The candidate STAR showed good sensitivity to change and will be further validated in a dedicated randomized controlled trial.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Marie Pean De Ponfilly-Sotier, Florent L. Besson, Lea Gomez, Sebastien Ottaviani, Philippe Dieude, Stephane Pavy, Xavier Mariette, Raphaele Seror, Gaetane Nocturne
Summary: This study evaluated the relevance of 18F-FDG PET-CT in discriminating polymyalgia rheumatica (PMR) and spondylarthritis (SpA) with atypical presentations. The results showed significant overlap in PET-CT patterns between the two conditions, making differentiation challenging. The use of a validated PET-CT composite score could improve diagnostic performance.
Letter
Rheumatology
Samuel Bitoun, Jerome Avouac, Julien Henry, Roba Ghossan, Omar Al Tabaa, Rakiba Belkhir, Gaetane Nocturne, Alice Andree Mariaggi, Flore Rozenberg, Christelle Vauloup-Fellous, Xavier Mariette, Raphaele Seror
Meeting Abstract
Rheumatology
R. Seror, G. Baron, M. Camus, D. Cornec, E. Perrodeau, S. J. Bowman, M. Bombardieri, H. Bootsma, J. E. Gottenberg, B. Fisher, W. Hueber, J. van Roon, V. Devauchelle-Pensec, P. Gergely, X. Mariette, R. Porcher
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Hematology
Fanny Urbain, Sophie Ferlicot, Laurence Rocher, Florent L. Besson, Lea Gomez, Jean-Marie Michot, Thierry Lazure, Xavier Mariette, Gaetane Nocturne, Olivier Lambotte, Mohamad Zaidan, Nicolas Noel
Summary: This study analyzed data from 10 patients with renal involvement of lymphoma and compared them with cases reported in the literature. The results showed that diffuse large B-cell lymphoma was the most common subtype in these patients. Interestingly, some patients presented with urological symptoms, while others presented with systemic symptoms. The study found that patients with urological symptoms were more likely to have renal masses and low-grade B-cell lymphomas.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2022)
Article
Allergy
Bilal Alashkar Alhamwe, Zhan Gao, Fahd Alhamdan, Hani Harb, Matthieu Pichene, Abel Garnier, Jihad El Andari, Andreas Kaufmann, Peter L. Graumann, Dorthe Kesper, Christian Daviaud, Holger Garn, Joerg Tost, Daniel P. Potaczek, Martin J. Blaser, Harald Renz
Summary: This research identifies a novel mechanism by which early-life exposure to Acinetobacter lwoffii (AL) can prevent chronic inflammatory diseases such as asthma. The study found that AL triggers a proinflammatory immune response characterized by elevated levels of IL-6 and subsequent IL-10 production in CD4(+) T-cells. This immune response, along with changes in the gastrointestinal microbiome, contribute to the protection against asthma.
Article
Rheumatology
Loic Meudec, Pauline Richebe, Juliette Pascaud, Xavier Mariette, Gaetane Nocturne
Summary: Janus kinase inhibitors have a negative impact on the activation and antitumor activity of NK cells, with TOFA and UPA showing the most significant effects.
Article
Rheumatology
Gaetane Nocturne, Xavier Mariette
Summary: The management of Sjogren's disease is challenging due to the heterogeneous clinical presentations and lack of validated treatment. However, international experts have been working on establishing recommendations for management. With active research in this field, we expect the development of effective treatments in the near future, benefiting patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Allergy
Fahd Alhamdan, Timm Greulich, Christian Daviaud, Leigh M. Marsh, Frauke Pedersen, Clemens Thoelken, Petra Ina Pfefferle, Thomas Bahmer, Daniel P. Potaczek, Joerg Tost, Holger Garn
Summary: This study aimed to use EV miRNA signatures to uncover the molecular mechanisms of obesity-associated low type-2 asthma. EV miRNA profiles were able to clearly distinguish between obese low type-2 asthma, non-obese low type-2 asthma, and healthy control groups. Pathway analysis revealed inflammatory cytokines and metabolic factors signaling pathways to be specifically associated with obesity-associated low type-2 asthma. Additionally, miR-17-92 and miR-106a-363 clusters were significantly enriched in obesity-associated low type-2 asthma and exhibited correlations with key laboratory and lung function parameters.
Article
Environmental Sciences
Paulina Jedynak, Lucile Broseus, Jorg Tost, Florence Busato, Stephan Gabet, Cathrine Thomsen, Amrit K. Sakhi, Isabelle Pin, Remy Slama, Johanna Lepeule, Claire Philippat
Summary: A previous study found positive associations between maternal urinary concentrations of triclosan and placental DNA methylation in male fetuses. This study aimed to validate and expand on these findings by examining triclosan exposure and placental DNA methylation in a cohort of male and female fetuses. The results confirmed associations between triclosan and certain genes in both sexes, with the majority of associations being positive and mapping to imprinted genes. The study also identified mediation effects of placental tissue heterogeneity on the associations. In conclusion, triclosan exposure is associated with placental DNA methylation, particularly in imprinted genes.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Aurelie Nakamura, Lucile Broseus, Joerg Tost, Daniel Vaiman, Silvia Martins, Katherine Keyes, Kim Bonello, Mathilde Fekom, Katrine Strandberg-Larsen, Anne-Laure Sutter-Dallay, Barbara Heude, Maria Melchior, Johanna Lepeule
Summary: The placenta plays a crucial role in fetal and brain development, and its epigenome reflects the prenatal environment and can be linked to the future health of the fetus. This study investigated the association between placental DNA methylation and child behavioral and emotional difficulties. The results revealed sex-specific associations and provided insights into the mechanisms of neurodevelopment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jorg Tost
Summary: Epigenetic modifications, particularly DNA methylation, play a crucial role in influencing phenotype, morphology, and behavioral traits. They provide a molecular record of exposure to environmental factors and contribute significantly to evolutionary dynamics. However, studies on DNA methylation in ecology are still limited, mainly due to the complexity of analysis and data interpretation.
MOLECULAR ECOLOGY RESOURCES
(2023)
Article
Rheumatology
Alexandra Kachaner, Elisabeth Berge, Frederic Desmoulins, Christine Le Pajolec, Antoine Rousseau, Marc Labetoulle, Gaetane Nocturne, Xavier Mariette, Raphaele Seror
Summary: This study describes primary Sjogren's disease patients who do not have or have a low level of dryness, and compares them with Sjogren's disease patients who have oral or ocular dryness features.
Letter
Rheumatology
Gaetane Nocturne, Oriane Marmontel, Mathilde di Filippo, Pascale Chretien, Roman Krzysiek, Francois Lifermann, Nawal Rahal, Rakiba Belkhir, Philippe Moulin, Xavier Mariette
Letter
Rheumatology
Mathilde Pezot, Gaetane Nocturne, Rakiba Belkhir, Julien Henry, Stephan Pavy, Raphaele Seror, Xavier Mariette, Samuel Bitoun
ANNALS OF THE RHEUMATIC DISEASES
(2023)