Article
Endocrinology & Metabolism
Nele Warmke, Fiona Platt, Alexander F. Bruns, Claire H. Ozber, Natalie J. Haywood, Yilizila Abudushalamu, Charles Slater, Victoria Palin, Piruthivi Sukumar, Stephen B. Wheatcroft, Nadira Y. Yuldasheva, Mark T. Kearney, Kathryn J. Griffin, Richard M. Cubbon
Summary: In this study, pericyte insulin signaling was found to promote angiopoietin-1 secretion and endothelial Tie2 signaling. Disruption of this pathway led to excessive vascular sprouting and venous plexus abnormalities, mimicking diabetic retinopathy characteristics. Future research should focus on evaluating the role of pericyte insulin signaling in this disease.
Article
Endocrinology & Metabolism
Nele Warmke, Fiona Platt, Alexander F. Bruns, Claire H. Ozber, Natalie J. Haywood, Yilizila Abudushalamu, Charles Slater, Victoria Palin, Piruthivi Sukumar, Stephen B. Wheatcroft, Nadira Y. Yuldasheva, Mark T. Kearney, Kathryn J. Griffin, Richard M. Cubbon
Summary: Pericytes play a crucial role in regulating vascular development and stability, with dysfunction potentially contributing to diabetic retinopathy. Knockout of insulin receptors in pericytes resulted in abnormal vascular development, indicating the importance of insulin signaling in promoting angiopoietin-1 secretion and endothelial Tie2 signaling.
Article
Chemistry, Multidisciplinary
Yue Hao, Guimin Xu, Xiangni Wang, Yixin Cui, Na Liu, Xingmin Shi, Guanjun Zhang
Summary: The study found that PAM treatment had dual effects on the angiogenesis of HUVECs, with short-term treatment promoting and long-term treatment inhibiting. This may be achieved by changing the content of RONS, affecting the VEGF-VEGFR-2 signaling pathway.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Haiyan Zhou, Tangting Chen, Yongjie Li, Jingcan You, Xin Deng, Ni Chen, Tian Li, Youkun Zheng, Rong Li, Mao Luo, Jianbo Wu, Liqun Wang
Summary: This study found that Tie-2 is modified by AGEs in diabetes, leading to the inhibition of Ang-1 signaling activation and angiogenesis. This finding provides a novel mechanism for Ang-1/Tie-2 signal dysfunction and angiogenesis failure in diabetic ischemic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ha -Ram Park, Anahita Shiva, Portia Cummings, Seoyeon Kim, Sungsoo Kim, Eunhyeong Lee, Alessandra Leong, Subrata Chowdhury, Carrie Shawber, Richard Carvajal, Gavin Thurston, Joon-Yong An, Amanda W. Lund, Hee Won Yang, Minah Kim
Summary: The position of T-cells in the tumor microenvironment affects their ability to encounter the tumor and kill it. The vascular destabilizing factor ANGPT2 causes vascular integrity issues in the tumor periphery, leading to a lack of T-cell infiltration in the tumor core, which is associated with a poor response to immunotherapy.
Article
Food Science & Technology
Wenhui Li, Yijing He, Hongyu Zhao, Lei Peng, Jia Li, Rong Rui, Shiqiang Ju
Summary: The study demonstrated that 200 μM GSP cotreatment effectively alleviated the toxic effects of FB1 exposure, promoting first polar body extrusion and improving subsequent cleavage and blastocyst development rates.
Article
Physiology
Michael Thompson, Masahide Sakabe, Mark Verba, Jiukuan Hao, Stryder M. Meadows, Q. Richard Lu, Mei Xin
Summary: Proper vascular formation is regulated by multiple signaling pathways. The expression of PRDM16 in arterial endothelial cells (ECs) but not venous ECs plays a crucial role in maintaining arterial characteristics. Deletion of Prdm16 in ECs leads to abnormal venous marker expression in the artery and reduced recruitment of vascular smooth muscle cells. The ectopic expression of ANGIOPOIETIN2 in Prdm16 knockout ECs further suggests the role of PRDM16 in suppressing venous characteristics.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Oncology
Yuxian Wu, Jinghai Gao, Xiaojun Liu
Summary: The study showed that upregulation of ANGPTL4 in ovarian cancer cells led to increased tumor angiogenesis, growth, and metastasis inhibition. Inactivation of VEGFR2 Y949 phosphorylation eliminated the tumor-suppressive effects of ANGPTL4 inhibition in spontaneous ovarian carcinoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Thomas Jansen, Miroslava Kvandova, Isabella Schmal, Sanela Kalinovic, Paul Stamm, Marin Kuntic, Marc Foretz, Benoit Viollet, Andreas Daiber, Matthias Oelze, John F. Keaney Jr, Thomas Muenzel, Eberhard Schulz, Swenja Kroeller-Schoen
Summary: The study demonstrates that mice with endothelial-specific deletion of alpha 1AMPK have detrimental effects during voluntary exercise training, including increased reactive oxygen species production, eNOS uncoupling, and endothelial dysfunction. These results suggest that endothelial alpha 1AMPK plays a critical role in vascular protection and determines whether the effects of exercise on the vasculature are beneficial or harmful.
Article
Pharmacology & Pharmacy
Yiyun Song, Hui Yu, Qiaoling Sun, Fei Pei, Qing Xia, Zhaoli Gao, Xianhua Li
Summary: Grape seed proanthocyanidin extract (GSPE) can maintain the balance between mitochondrial biogenesis and dynamics by negatively regulating p66Shc expression, and it has a renal protective effect in diabetic kidney disease (DKD).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Kangliang Sheng, Guanghui Zhang, Xiaowei Kong, Jingmin Wang, Wanmeng Mu, Yongzhong Wang
Summary: Encapsulating grape seed proanthocyanidin extract (GSPE) using materials such as sodium alginate (SA) can improve stability and release efficiency, effectively immobilizing GSPE in polymeric microcapsules for controlled release. Research has shown that microcapsules made with SA-methyl cellulose (MC) and SA-hydroxypropyl methylcellulose (HPMC) exhibit higher thermal stability, making them suitable for maintaining GSPE content and release efficiency.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Oncology
Emmi Kapiainen, Minna K. Kihlstrom, Riikka Pietila, Mika Kaakinen, Veli-Pekka Ronkainen, Hongmin Tu, Anne Heikkinen, Raman Devarajan, Ilkka Miinalainen, Anna Laitakari, Mohammadhassan Ansarizadeh, Qin Zhang, Gong-Hong Wei, Lloyd Ruddock, Taina Pihlajaniemi, Harri Elamaa, Lauri Eklund
Summary: The study investigates the role of different forms of ANGPT2 in cancer, revealing that ANGPT2(443) plays a crucial role in vascular remodeling, tumor growth, and metastasis.
Article
Fisheries
Yaser Mohammadi, Barzan Bahrami Kamangar, Mohammad Ali Zarei
Summary: The study evaluated the effects of grape seed proanthocyanidin extract on growth performance, serum biochemical properties, fillet proximate composition, and liver antioxidant enzyme activity in common carp fingerlings. The results showed dose-dependent effects of GSPE on various parameters, with low levels showing positive impacts.
Article
Biochemistry & Molecular Biology
Changhong Li, Linli Zhang, Chengmei Liu, Xuemei He, Mingshun Chen, Jun Chen
Summary: This study investigates the anti-cervical cancer activity of lipophilic grape seed proanthocyanidin (LGSP). LGSP showed a significant anti-proliferative effect on HeLa cells by increasing reactive oxygen species, inducing cell apoptosis, and blocking cell cycle progression. It also effectively suppressed the growth of a HeLa xenograft tumor in a zebrafish model.
Article
Food Science & Technology
Tong Jiang, Hong Wang, Peihua Xu, Yifan Yao, Yilong Ma, Zhaojun Wei, Xiangli Niu, Yafang Shang, Dong Zhao
Summary: Bread made with wheat flour containing grape seed proanthocyanidin (GSP) (0.4%) showed improved textural properties, including hardness, cohesiveness, gumminess, and chewiness. GSP enhanced the-gluten microstructure during the final fermentation stage, with increased disulfide bonds, hydrophobic interactions, and α-helix content in secondary structures. Additionally, GSP addition significantly increased the phenolic content and antioxidative activity of the bread. The degree of fermentation also had a strong impact on dough forces, and properly controlling the fermentation time was beneficial for improving bread quality, providing valuable guidance for the bread processing industry.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)