Article
Immunology
Ta-hsin Tsung, Ke-Hao Huang, Wu-Chien Chien, Yi-Hao Chen, I-Chuan Yen, Chi-Hsiang Chung, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that uveitis is a risk factor for stroke development in patients with AS, and both anterior uveitis and posterior segment involvement increase the risk of stroke.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Oh Chan Kwon, Kyungdo Han, Jaeyoung Chun, Ryul Kim, Seung Wook Hong, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Min-Chan Park
Summary: The presence of immune-mediated inflammatory diseases in patients with type 2 diabetes increases their risk of cardiovascular morbidity and mortality, including stroke, myocardial infarction, cardiovascular mortality, and all-cause mortality.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Ting-Yi Lin, Yi-Fen Lai, Wu-Chien Chien, Yi-Hao Chen, Chien-An Sun, Chi-Hsiang Chung, Jiann-Torng Chen, Ching-Long Chen
Summary: Endophthalmitis was found to be an independent risk factor for ACS in patients with AS, especially in AS patients with comorbidities such as diabetes mellitus, hyperlipidemia, and in those aged 60 years or older.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Shuo-Yan Gau, Yung-Heng Lee, Hsi-Kai Tsou, Jing-Yang Huang, Xinpeng Chen, Zhizhong Ye, James Cheng-Chung Wei
Summary: The main objective of this retrospective cohort study was to evaluate the risk of fibromyalgia in Ankylosing spondylitis (AS) patients in different age and sex subgroups. The study found that AS patients had a higher risk of developing fibromyalgia, especially those over 65 years old. Clinicians should be aware of this association in managing patients with AS.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Abdulla Watad, Dennis McGonagle, Saar Anis, Reut Carmeli, Arnon D. Cohen, Avishai M. Tsur, Niv Ben-Shabat, Nicola Luigi Bragazzi, Merav Lidar, Howard Amital
Summary: Ankylosing spondylitis (AS) is associated with an increased risk of Alzheimer's disease (AD), Parkinson's disease (PD), and epilepsy, but not multiple sclerosis (MS). Treatment with tumor necrosis factor inhibitors (TNFi) is associated with a reduced risk of developing AD in AS patients.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Zhihua Yin, Hui-Ying Low, Brian Shiian Chen, Kuo-Shu Huang, Yue Zhang, Yu-Hsun Wang, Zhizhong Ye, James Cheng-Chung Wei
Summary: This study found a higher risk of ankylosing spondylitis (AS) in patients with endometriosis, suggesting clinicians should be aware of the occurrence of AS in patients with endometriosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Seo Yeon Yoon, Seok-Jae Heo, Yong Wook Kim, Seung Nam Yang, Hyun Im Moon
Summary: This study found that ankylosing spondylitis is associated with an increased risk of Parkinson's disease and atypical parkinsonism. The use of non-steroidal anti-inflammatory drugs may have a protective effect against Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Medicine, General & Internal
Kevin Sheng-Kai Ma, Chee-Ming Lee, Po-Hung Chen, Yan Yang, Yi Wei Dong, Yu-Hsun Wang, James Cheng-Chung Wei, Wen Jie Zheng
Summary: This study found that patients with optic neuritis have a higher risk of developing autoimmune diseases, especially those who are young or female. The use of corticosteroids reduced the link between optic neuritis and subsequent autoimmune diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Haseeb Chaudhary, Clementina Lopez-Medina, Muhammad Asim Khan, Maxime Dougados, Marina Magrey
Summary: In a global axSpA cohort, HLA-B*27 (-) patients had a longer delay in diagnosis, more frequently had peripheral arthritis, enthesitis, IBD, and psoriasis, and were more often treated with csDMARDs compared to the HLA-B*27 (+) subgroup.
Article
Rheumatology
Matilda Morin, Karin Hellgren, Ulf Lindstroem, Thomas Frisell
Summary: This study aims to identify the risk factors for ankylosing spondylitis (AS) during perinatal and early life, while controlling for family-shared confounding using a sibling comparison design. The study found that having older siblings and a history of tonsillectomy in childhood were independently associated with the development of AS, even after adjusting for family-shared factors in a sibling comparison analysis.
Article
Rheumatology
Marta Arevalo Salaet, Clementina Lopez-Medina, Mireia Moreno, Victoria Navarro-Compan, Joan Calvet Fontova, Maria Llop, Maxime Dougados, Jordi Gratacos
Summary: This study analyzed the influence of HLA-B27 in the phenotypical expression of pSpA. The results showed that HLA-B27-positive patients had an earlier disease onset and higher axial involvement, tarsitis, and uveitis, but no association with other EMM, fibromyalgia, or peripheral structural damage was observed.
Article
Clinical Neurology
Mahmud Omar, Niv Ben-Shabat, Avishai M. Tsur, Arnon D. Cohen, Abdulla Watad, Howard Amital, Kassem Sharif
Summary: A large retrospective, population-based, cross-sectional study shows that patients with AS have a higher prevalence of psychiatric disorders, particularly depression, and a lower prevalence of schizophrenia. Disease modifying drugs used for the management of AS are not predictors of psychiatric disorders in AS patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Kathy Ming Feng, Wu-Chien Chien, Yi-Hao Chen, Chien-An Sun, Chi-Hsiang Chung, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that uveitis could be a predictor of ACS in patients with AS. Both anterior uveitis and posterior segment involvement were associated with an increased risk of ACS in AS patients. Age, diabetes mellitus, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, asthma, and systemic steroids were significant risk factors for ACS. The all-cause mortality was higher in the uveitis group compared to the non-uveitis group.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Soo Min Ahn, Minju Kim, Ye-Jee Kim, Yusun Lee, Yong-Gil Kim
Summary: This study evaluated the risk of acute anterior uveitis (AAU) in patients with ankylosing spondylitis (AS) during treatment with tumor necrosis factor-alpha inhibitors (TNFis). The data showed that compared to adalimumab, the use of etanercept increased the risk of AAU, and this risk was not influenced by the history of AAU.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Yi-Fen Lai, Ting-Yi Lin, Wu-Chien Chien, Chien-An Sun, Chi-Hsiang Chung, Yi-Hao Chen, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that patients with AS who have uveitis are at a significantly higher risk of developing acute myocardial infarction (AMI) compared to those without uveitis. Regardless of gender or age group, patients with uveitis in the AS population have an increased risk for AMI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Bente Glintborg, Ulf Lindstrom, Daniela Di Giuseppe, Sella Aarrestad Provan, Bjorn Gudbjornsson, Merete Lund Hetland, Brigitte Michelsen, Johan K. Wallman, Kalle Aaltonen, Anna-Mari Hokkanen, Dan Nordstrom, Tanja Schjodt Jorgensen, Rebekka Lund Hansen, Arni Jon Geirsson, Kathrine Lederballe Gron, Niels Steen Krogh, Johan Askling, Lars Erik Kristensen, Lennart T. H. Jacobsson
Summary: This study compares the effectiveness of secukinumab with tumor necrosis factor inhibitors (TNFi) in treating patients with spondyloarthritis (SpA), using adalimumab as the main comparator. The findings show that secukinumab has similar treatment retention as adalimumab in the first or second line of therapy, but poorer outcomes in the third-plus line. Secukinumab also has lower response rates than adalimumab, particularly in the third-plus line of treatment.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Daniela Di Giuseppe, Ulf Lindstrom, Kalle Aaltonen, Heikki Relas, Sella Provan, Bjorn Gudbjornsson, Merete Lund Hetland, Johan Askling, Markku Kauppi, Arni Jon Geirsson, Katerina Chatzidionysiou, Tanja Schjodt Jorgensen, Lene Dreyer, Brigitte Michelsen, Lennart Jacobsson, Bente Glintborg
Summary: This study aimed to explore the occurrence of multiple switching in routine care axSpA patients and identify associated clinical characteristics. The results showed that multiple switching was relatively common and associated with gender, previous comorbidities, and extra-articular manifestations.
Letter
Rheumatology
Karin Bengtsson, Helena Forsblad-d'Elia, Anna Deminger, Eva Klingberg, Mats Dehlin, Sofia Exarchou, Ulf Lindstrom, Johan Askling, Lennart T. H. Jacobsson
Article
Rheumatology
Daniela Di Giuseppe, Ulf Lindstrom, Hannah Bower, Benedicte Delcoigne, Thomas Frisell, Katerina Chatzidionysiou, Christopher Sjowall, Elisabet Lindqvist, Johan Askling
Summary: This large observational study supports the equivalence of biologic DMARD biosimilar products and originators when used in routine rheumatology care.
Article
Rheumatology
J. K. Wallman, G-M Alenius, E. Klingberg, V Sigurdardottir, S. Wedren, S. Exarchou, U. Lindstrom, D. Di Giuseppe, J. Askling, L. T. H. Jacobsson
Summary: The validity of clinical ICD-10 diagnoses for PsA in the Swedish NPR is good, with positive predictive values (PPVs) of 69-82% for CASPAR fulfilment and 86% for meeting any established PsA classification criteria.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Kristina Lejon, Urban Hellman, Anjani Kumar, Helena Forsblad-d'Elia
Summary: The purpose of this study was to investigate the changes in different cell types and disease-related factors in patients with ankylosing spondylitis (AS) from northern Sweden. The study found a significant reduction in the number of TFH cells, plasmablasts, and B memory cells in AS patients, which may be related to an aberrant humoral immune response associated with inflammation. Some cell types in female patients were negatively correlated with inflammation markers.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Rheumatology
Thomas Frisell, Hannah Bower, Matilda Morin, Eva Baecklund, Daniela Di Giuseppe, Benedicte Delcoigne, Nils Feltelius, Helena Forsblad-d'Elia, Elisabet Lindqvist, Ulf Lindstroem, Johan Askling
Summary: The objective of this study was to assess and compare the incidence rates of key safety outcomes for individual targeted synthetic or biological disease-modifying antirheumatic drugs (b/ts DMARDs) in rheumatoid arthritis (RA). The study found that the b/tsDMARDs currently used to treat RA have acceptable and largely similar safety profiles, but differences exist in particular concerning tolerability and specific infection risks.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Sofia Exarchou, Johan K. Wallman, Daniela Di Giuseppe, Eva Klingberg, Valgerdur Sigurdardottir, Sara Wedren, Ulf Lindstrom, Carl Turesson, Lennart T. H. Jacobsson, Johan Askling
Summary: This study aimed to estimate the prevalence of clinically diagnosed Psoriatic Arthritis (PsA) in Sweden in 2017 and assess the use of disease-modifying antirheumatic drugs (DMARDs) among PsA patients in contact with specialized rheumatology care. The prevalence of PsA in Sweden was approximately 0.35% among adults aged 18 to 79 years in 2017, and nearly three-fourths of PsA patients in recent contact with specialized rheumatology care received DMARD therapy in 2017.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Louise Linde, Lykke M. Ornbjerg, Stylianos Georgiadis, Simon H. Rasmussen, Ulf Lindstrom, Johan Askling, Brigitte Michelsen, Daniela Di Giuseppe, Johan K. Wallman, Bjorn Gudbjornsson, Thorvardur Jon Love, Dan C. Nordstrom, Timo Yli-Kerttula, Lucie Nekvindova, Jiri Vencovsky, Florenzo Iannone, Alberto Cauli, Anne Gitte Loft, Bente Glintborg, Karin Laas, Ziga Rotar, Matija Tomsic, Gary J. Macfarlane, Burkhard Moller, Marleen van de Sande, Catalin Codreanu, Michael J. Nissen, Merih Birlik, Sukran Erten, Maria J. Santos, Elsa Vieira-Sousa, Merete L. Hetland, Mikkel Ostergaard
Summary: In bio-naive patients with PsA initiating a TNF inhibitor (TNFi), baseline predictors of Disease Activity index for PsA in 28 joints (DAPSA28) remission and moderate response at 6 months, as well as drug retention at 12 months were identified, indicating potential generalizability from country to disease level.
Article
Rheumatology
Ulf Lindstrom, Daniela di Giuseppe, Sofia Exarchou, Gerd-Marie Alenius, Tor Olofsson, Eva Klingberg, Lennart Jacobsson, Johan Askling, Johan K. Wallman
Summary: This study aimed to compare the treatment outcomes of patients with newly diagnosed psoriatic arthritis (PsA) and rheumatoid arthritis (RA) using methotrexate (MTX) monotherapy. The results showed that PsA patients were less likely to continue the use of MTX compared to RA patients, and the effectiveness of MTX was also lower in PsA.
Article
Rheumatology
C. Feldthusen, M. Hallstrom, A. d'Elia, A. Deminger, U. Kiltz, H. Forsblad-d'Elia
Summary: The objective of this study was to translate the ASAS HI EFIS into Swedish and culturally adapt it for a Swedish context, and to assess the construct validity of the Swedish version of ASAS HI and test-retest reliability in ASAS HI and EFIS in Swedish patients with AS. The results showed that the Swedish version of ASAS HI is valid and reliable, and recommended for assessing the impact of AS on global functioning and health.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Matilda Morin, Karin Hellgren, Ulf Lindstroem, Thomas Frisell
Summary: This study aims to identify the risk factors for ankylosing spondylitis (AS) during perinatal and early life, while controlling for family-shared confounding using a sibling comparison design. The study found that having older siblings and a history of tonsillectomy in childhood were independently associated with the development of AS, even after adjusting for family-shared factors in a sibling comparison analysis.
Article
Rheumatology
Erik Hulander, Tatiana Zverkova Sandstrom, Jeannette Beckman Rehnman, Lucy Law, Stefan Soderberg, Helena Forsblad-d'Elia
Summary: This study assessed the dietary nutrient intake in patients with r-axSpA and compared it to persons without r-axSpA. The results showed that the patients had impaired dietary intake, particularly in nutrients with anti-inflammatory properties. Therefore, it is suggested to incorporate nutrition screening into the management of r-axSpA patients.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Magnus Hallstrom, Eva Klingberg, Anna Deminger, Jeannette Beckman Rehnman, Mats Geijer, Helena Forsblad-d'Elia
Summary: This study examined the factors that influence BASFI scores in r-axSpA patients, both overall and stratified by sex. The results showed that age, body mass index, disease activity, fatigue, and tenderness were independently associated with BASFI. There were no significant differences in BASFI scores between males and females, but certain individual questions showed gender differences, such as worse ability to look over shoulder in males and worse ability to climb stairs in females.
ARTHRITIS RESEARCH & THERAPY
(2023)