期刊
INTERNATIONAL JOURNAL OF MODERN PHYSICS B
卷 23, 期 6-7, 页码 1566-1571出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0217979209061275
关键词
ZnO; biocompatibility; cell proliferation; apoptosis
The in vitro and in vivo biocompatibility of the ZnO nanoparticles were evaluated using cell model and animal model, by MTT assay, flow cell cytometry, pathological optical and electron microscopy examinations. Both the L929 cell and Hela cell proliferative activity were strongly inhibited by the presence of ZnO nanoparticles, no matter cultured with low dose and high dose suspension. AnnexinV-FITC/PI-FCM assay showed that the number of necrotic cell and apoptotic cell increased significantly. Feeding the ZnO nanoparticle suspension through digestive tract would lead to the damage to some primary organs (heart, lung, liver and kidney). Further investigation by TEM showed the expanded sarcoplasmic reticulum and organelle vacuolation features.
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