期刊
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
卷 20, 期 4, 页码 E69-E82出版社
WILEY
DOI: 10.1002/mpr.353
关键词
depression; anxiety; rating scales; STAR(star)D; measurement-based care
类别
资金
- National Institute of Mental Health (NIMH) [N01MH90003]
- National Institutes of Health (NIH)
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Abbott Laboratories
- Alkermes
- Lichtwer Pharma GmbH
- Lorex Pharmaceuticals
- Aspect Medical Systems
- Astra-Zeneca
- Bristol-Myers Squibb Company
- Cephalon
- Cyberonics
- Eli Lilly Company
- Forest Pharmaceuticals Inc.
- GlaxoSmithkline
- J & J Pharmaceuticals
- Novartis
- Organon Inc.
- PamLab
- LLC
- Pfizer Inc
- Pharmavite
- Roche
- Sanofi/Synthelabo
- Solvay Pharmaceuticals, Inc.
- Wyeth-Ayerst Laboratories
- National Institute of Mental Health
- Stanley Medical Research Institute
- Cyberonics, Inc.
- Neuronetics, Inc.
- Magstim
- Advanced Neuromodulation Systems
- Department of Health and Human Services
- Pfizer, Inc.
- Lilly, Inc.
- Forest Laboratories, Inc.
- GlaxoSmithKline, Inc.
- Mitsubishi-Tokyo
- Merck, Inc.
- Biovail Laboratories, Inc.
- Wyeth, Inc.
- Berlex Laboratories
- Novartis Pharmaceuticals, Inc.
- Sepracor, Inc.
- Boehringer-Ingelheim
- Sanofi-Synthelabo
Both the 17-item Hamilton Rating Scale for Depression (HRSD17) and 30-item Inventory of Depressive Symptomatology - Clinician-rated (IDS-C-30) contain a subscale that assesses anxious symptoms. We used classical test theory and item response theory methods to assess and compare the psychometric properties of the two anxiety subscales (HRSDANX and IDS-C-ANX) in a large sample (N = 3453) of outpatients with non-psychotic major depressive disorder in the Sequenced Treatment Alternatives to Relieve Depression (STAR(star)D) study. Approximately 48% of evaluable participants had at least one concurrent anxiety disorder by the self-report Psychiatric Diagnostic Screening Questionnaire (PDSQ). The HRSDANX and IDS-C-ANX were highly correlated (r = 0.75) and both had moderate internal consistency given their limited number of items (HRSDANX Cronbach's alpha = 0.48; IDS-C-ANX Cronbach's alpha = 0.58). The optimal threshold for ascribing the presence/absence of anxious features was found at a total score of eight or nine for the HRSDANX and seven or eight for the IDS-C-ANX. It would seem beneficial to delete item 17 (loss of insight) from the HRSDANX as it negatively correlated with the scale's total score. Both the HRSDANX and IDS-C-ANX subscales have acceptable psychometric properties and can be used to identify anxious features for clinical or research purposes. Copyright (C) 2011 John Wiley & Sons, Ltd.
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