Article
Geriatrics & Gerontology
Mengmeng Feng, Yue Zhang, Yuanqing Liu, Zhiwei Wu, Ziyang Song, Mengya Ma, Yueju Wang, Hui Dai
Summary: The white matter structural network analysis may be a potential and promising method in differentiating AD and SIVD patients, especially with valuable topological changes, such as the BC change in the right putamen.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Min-Chien Tu, Hsiao-Wen Chung, Yen-Hsuan Hsu, Jir-Jei Yang, Wen-Chau Wu
Summary: This study found a stage-dependent coupling between cerebral blood flow (CBF) and white matter hyperintensities (WMHs) in Alzheimer's disease (AD) and subcortical ischemic vascular disease (SIVD). The extent of cortical WMHs correlated with subcortical CBF for CDR = 0.5, whereas the extent of subcortical WMHs correlated with cortical CBF for CDR = 1-2.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Lin Tan, Jian Xing, Zhenqi Wang, Xiao Du, Ruidi Luo, Jianhang Wang, Jinyi Zhao, Weina Zhao, Changhao Yin
Summary: This study investigates the structural imaging changes in patients with subcortical ischemic vascular disease (SIVD)-vascular cognitive impairment no dementia (VCIND) and their correlation with cognitive impairment, aiming to provide new targets for early diagnosis and treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Xiaoshuang Liu, Runtian Cheng, Li Chen, Junwei Gong, Tianyou Luo, Fajin Lv
Summary: Patients with subcortical ischemic vascular disease (SIVD) demonstrate abnormal neurovascular coupling at the early stage of the disease and during disease development, which may be associated with disease severity and cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Runtian Cheng, Li Chen, Xiaoshuang Liu, Tianyou Luo, Junwei Gong, Peiling Jiang
Summary: This study investigated changes in gray matter asymmetry and their relationship with cognitive impairment in patients with subcortical ischemic vascular disease (SIVD) using voxel-based morphological measurements. Results showed that patients with cognitive impairment displayed significant rightward asymmetry in the fusiform and parahippocampal gyruses, while healthy controls and patients without cognitive decline exhibited marked leftward asymmetry in the same areas. The findings suggest the potential use of gray matter asymmetry as a biomarker for disease progression in SIVD patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Xiao-Jiao Liu, Ping Che, Mengya Xing, Xiao-Bing Tian, Chunli Gao, Xiuyan Li, Nan Zhang
Summary: The study found that patients with SIVD had lower blood flow velocity and higher pulsatility index in cerebral arteries compared to those with AD, along with increased lumen diameter, number of arteries with plaque, and total carotid plaque score. The Mini-Mental State Examination score was positively correlated with most major cerebral arteries' blood flow velocity and negatively correlated with common carotid artery lumen diameter, number of arteries with plaque, and total carotid plaque score in dementia patients. These findings suggest that macrovascular structural and functional changes are associated with cognitive impairment in SIVD patients, as well as with AD to a lesser extent.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Roey Schurr, Aviv A. Mezer
Summary: The study developed a method based on Nissl staining technique to quantify the structure and orientation of axons, applicable to various datasets. Utilizing structure tensor analysis, fine details of axonal architecture can be extracted effectively.
Article
Neurosciences
Min-Chien Tu, Sheng-Min Huang, Yen-Hsuan Hsu, Jir-Jei Yang, Chien-Yuan Lin, Li-Wei Kuo
Summary: The study found that DKI metrics may be more sensitive than DTI metrics in reflecting microstructural changes within the gray matter, providing complementary information for the pathogenesis of SIVD and AD.
HUMAN BRAIN MAPPING
(2021)
Article
Psychology, Multidisciplinary
Lidon Marin-Marin, Victor Costumero, Cesar avila, Christos Pliatsikas
Summary: This study investigates the non-linear effects of bilingual experiences on regional grey matter volume in the brain. The results show a non-linear relationship between bilingualism score and inferior frontal gyrus volume, as well as linear increases in putamen and cerebellum volumes as a function of bilingualism score.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Pediatrics
Lilian M. N. Kebaya, Bhavya Kapoor, Paula Camila Mayorga, Paige Meyerink, Kathryn Foglton, Talal Altamimi, Emily S. Nichols, Sandrine de Ribaupierre, Soume Bhattacharya, Leandro Tristao, Michael T. Jurkiewicz, Emma G. Duerden
Summary: Despite therapeutic hypothermia, HIE is still associated with adverse developmental outcomes. This study found significant alterations in subcortical brain macrostructure in neonates with HIE compared to healthy neonates. Smaller subcortical volumes were associated with HIE severity.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Wenhao Zhu, Hao Huang, Shiqi Yang, Xiang Luo, Wenzhen Zhu, Shabei Xu, Qi Meng, Chengchao Zuo, Yong Liu, Wei Wang
Summary: The study found that gray matter atrophy in white matter hyperintensities patients may lead to cognitive decline, especially in those with mild cognitive impairment. The reduction in gray matter volume in the thalamus and fronto-insular cortices is associated with cognitive decline, and these results were further validated.
NEUROSCIENCE BULLETIN
(2021)
Article
Clinical Neurology
Yair Mina, Tianxia Wu, Hsing-Chuan Hsieh, Dima A. Hammoud, Swati Shah, Chuen-Yen Lau, Lillian Ham, Joseph Snow, Elizabeth Horne, Anuradha Ganesan, Stanley I. Rapoport, Edmund C. Tramont, Daniel S. Reich, Brian K. Agan, Avindra Nath, Bryan R. Smith
Summary: The study found that HIV infection is associated with a higher incidence of brain white matter hyperintensities (WMH), primarily due to aging and modifiable comorbidities.
Article
Oncology
Bo Liu, Shan Meng, Jie Cheng, Yan Zeng, Daiquan Zhou, Xiaojuan Deng, Lianqin Kuang, Xiaojia Wu, Lin Tang, Haolin Wang, Huan Liu, Chen Liu, Chuanming Li
Summary: The combination of radiomics derived from brain high-resolution T1-weighted imaging and automatic machine learning can accurately diagnose SIVCIND. The optimal radiomics features are mostly located in the right amygdala, left caudate nucleus, left putamen, and left thalamus.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Neus Falgas, Ignacio Illan-Gala, Isabel E. Allen, Paige Mumford, Youssef M. Essanaa, Michael M. Le, Michelle You, Lea T. Grinberg, Howard J. Rosen, Thomas C. Neylan, Joel H. Kramer, Christine M. Walsh
Summary: This study aimed to investigate the association between insomnia severity and brain health in healthy older adults, considering the potential effects of depression and sleep apnea. The results showed a relationship between insomnia severity and brain health, even with mild insomnia, independent of depression and likelihood of sleep apnea. Specific GM areas (such as the orbitofrontal, insular and temporo-parietal junction) were associated not only with the presence of insomnia, but also with its severity.
Article
Clinical Neurology
Sung Hoon Kang, Monica Eunseo Kim, Hyemin Jang, Hojeong Kwon, Hyejoo Lee, Hee Jin Kim, Sang Won Seo, Duk L. Na
Summary: The study found that the prevalence of Aβ positivity increased with the severity of cognitive impairment, but decreased with the severity of white matter hyperintensities. Aβ positivity was associated with higher education, absence of diabetes, and presence of APOE ε4.
Article
Clinical Neurology
Mingzhe Zheng, Hanjian Du, Wei Ni, Lauren G. Koch, Steven L. Britton, Richard F. Keep, Guohua Xi, Ya Hua
TRANSLATIONAL STROKE RESEARCH
(2015)
Article
Ophthalmology
Changying Li, Ping Cai, Linping Shi, Yun Lin, Jiuquan Zhang, Suqing Liu, Bing Xie, Yanshu Shi, Hong Yang, Sha Li, Hanjian Du, Jian Wang
CURRENT EYE RESEARCH
(2012)
Article
Neurosciences
Chuanming Li, Jian Wang, Li Gui, Jian Zheng, Chen Liu, Hanjian Du
JOURNAL OF ALZHEIMERS DISEASE
(2011)
Article
Endocrinology & Metabolism
Chao Gao, Hanjian Du, Ya Hua, Richard F. Keep, Jennifer Strahle, Guohua Xi
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2014)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanjian Du, Yuanchao Zhang, Bing Xie, Nan Wu, Guocai Wu, Jian Wang, Tianzi Jiang, Hua Feng
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2011)
Article
Clinical Neurology
Peigang Lu, Linping Shi, Hanjian Du, Bing Xie, Changying Li, Sha Li, Ting Liu, Hua Feng, Jian Wang
JOURNAL OF NEURORADIOLOGY
(2013)
Article
Clinical Neurology
Hanjian Du, Bing Xie, Peigang Lu, Hua Feng, Jian Wang, Shaoji Yuan
JOURNAL OF NEURORADIOLOGY
(2014)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanjian Du, Bing Xie, Qiongwu Yu, Jian Wang
MAGNETIC RESONANCE IMAGING
(2009)
Article
Multidisciplinary Sciences
Yonghe Li, Wenyan Lu, Taj D. King, Chia-Chen Liu, Gautam N. Bijur, Guojun Bu
Article
Multidisciplinary Sciences
Yonghui Li, Hanjian Du, Bing Xie, Nan Wu, Jian Wang, Guocai Wu, Hua Feng, Tianzi Jiang
Article
Multidisciplinary Sciences
Ming Song, Hanjian Du, Nan Wu, Bing Hou, Guocai Wu, Jian Wang, Hua Feng, Tianzi Jiang
Proceedings Paper
Clinical Neurology
Mingzhe Zheng, Hanjian Du, Feng Gao, Lauren G. Koch, Steven L. Britton, Richard F. Keep, Guohua Xi, Ya Hua
BRAIN EDEMA XVI: TRANSLATE BASIC SCIENCE INTO CLINICAL PRACTICE
(2016)