Review
Cell Biology
Christian Johann Lerche, Franziska Schwartz, Marie Theut, Emil Loldrup Fosbol, Kasper Iversen, Henning Bundgaard, Niels Hoiby, Claus Moser
Summary: Infective endocarditis is a life-threatening infectious disease, where high-dose and long-term antibiotic therapy can improve outcomes, but microbial biofilm formation on affected heart valves can lead to persistent or recurrent cases of infection. Non-antibiotic, antimicrobial approaches targeting biofilm formation may offer potential novel strategies for the treatment of IE caused by Staphylococcus aureus.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Medicinal
Norbert Jost, Torsten Christ, Janos Magyar
Summary: Atrial fibrillation is a common cardiac arrhythmia that significantly impacts the health of the elderly population. Intense effort in basic research over the past few decades has advanced understanding of the relationship between atrial remodelling and the development of AF.
Article
Biochemistry & Molecular Biology
Ibrahim S. Al Nasr, Angela Corona, Waleed S. Koko, Tariq A. Khan, Ridha Ben Said, Ismail Daoud, Seyfeddine Rahali, Enzo Tramontano, Rainer Schobert, Noureddine Amdouni, Bernhard Biersack
Summary: A series of 1H-indeno[2',1'-5,6]dihydropyrido[2,3-d]pyrimidine and 1H-indeno[2',1'-5,6]pyrido[2,3-d]pyrimidine derivatives were synthesized and screened for their activity against parasites and viral RNase H. Some compounds exhibited significant activity against Toxoplasma gondii parasites and Leishmania major amastigotes, suggesting further investigation is warranted. A HIV-1 RNase H assay was used to study the RNase H inhibition of selected compounds, and docking simulations were performed to investigate their binding to the active site of the HIV-1 RNase H enzyme. Compound 2a, which was inactive against parasites, showed distinct HIV-1 RNase H inhibitory activity, suggesting that ring substitution determines the antiparasitic or HIV-1 RNase H inhibitory activity of this compound class.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jose I. Bueso-Bordils, Pedro A. Aleman-Lopez, Rafael Martin-Algarra, Maria J. Duart, Antonio Falco, Gerardo M. Anton-Fos
Summary: In this study, discriminant equations were developed using molecular topology and linear discriminant analysis (LDA) to reliably predict the anti-MRSA activity of organic compounds. The results demonstrated the high efficiency of combining molecular topology with LDA for predicting anti-MRSA activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Chunyu Zhang, Chao Xu, Xueyun Gao, Qingqiang Yao
Summary: This article discusses the application and development of platinum-based drugs in cancer treatment, particularly the targeted modification of platinum nanoclusters. The new platinum drugs provide a promising prospect for improving anti-cancer treatments.
Review
Biotechnology & Applied Microbiology
Faseela Hamza, Smita Zinjarde
Summary: Aquaculture, an important food production sector, is facing the challenge of disease occurrences. Marine microorganisms have the potential to provide alternative solutions to antibiotics for treating bacterial diseases in aquaculture. Furthermore, these microorganisms can also act as feed supplements to improve the overall health of aquaculture species and water quality. This review summarizes the studies on marine microorganisms and their potential as agents for tackling bacterial diseases in aquaculture.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Robert Richter, Claus-Michael Lehr
Summary: Extracellular vesicles (EVs) are cell-specific biogenic transport systems that are gaining popularity as diagnostic markers or drug delivery systems, with emerging possibilities for studying drug penetration, drug-membrane interactions, and pathogen-membrane interactions. However, the potential of EVs for these applications has not been fully exploited yet.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Geosciences, Multidisciplinary
Navid Hooshangi, Ali Asghar Alesheikh, Mahdi Panahi, Saro Lee
Summary: This paper investigates task allocation in urban search and rescue (USAR) operations using an agent-based simulation, proposing a method based on the contract net protocol (CNP) to manage uncertainty through the application of different allocation strategies. Simulations conducted in Tehran demonstrate that considering allocation strategies can significantly improve the efficiency of rescue operations.
NATURAL HAZARDS AND EARTH SYSTEM SCIENCES
(2021)
Review
Microbiology
Muriel Billamboz, Zeeshan Fatima, Saif Hameed, Samir Jawhara
Summary: Invasive fungal infections, particularly Candida auris, pose an expanding threat to public health. Over the past decade, new strategies and results in antifungal drug design have emerged to combat this emerging pathogen.
Review
Materials Science, Biomaterials
Mingwan Shi, Xiaohan Liu, Wei Pan, Na Li, Bo Tang
Summary: High temperature generated by photothermal therapy (PTT) can cause inflammation at the tumor site, which limits the efficacy of PTT and increases the risk of tumor metastasis and recurrence. Inhibiting PTT-induced inflammation has been found to significantly improve the effectiveness of cancer treatment. This review summarizes the research progress in combining anti-inflammatory strategies with PTT to enhance its efficacy, providing valuable insights for developing better-designed photothermal agents in clinical cancer therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Analytical
Xinqi Zheng, Yue Zhang, Jingwei Xu, Jian Sun, Yongqian Lei
Summary: A novel surface-enhanced Raman scattering (SERS) strategy based on vortex aggregation of AgNPs was proposed for the rapid detection of anti-infective drugs in environmental water. The method showed enhanced Raman signal and low detection limits, with potential applications in water pollution monitoring.
ANALYTICA CHIMICA ACTA
(2022)
Review
Medicine, Research & Experimental
Reda Ben Mrid, Najat Bouchmaa, Hassan Ainani, Rachid El Fatimy, Gabriel Malka, Loubna Mazini
Summary: Rheumatoid arthritis is a chronic autoimmune disorder that affects the joints and can cause deformity and disability. Recent advancements in understanding the disease, early diagnosis, and new treatment options have been significant. Although non-steroidal antiinflammatory drugs, corticosteroids, and disease-modifying antirheumatic drugs are commonly used, not all patients respond well to them, highlighting the need for new solutions to improve outcomes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Microbiology
Yogavel Manickam, Nipun Malhotra, Siddhartha Mishra, Palak Babbar, Abhishek Dusane, Benoit Laleu, Valeria Bellini, Mohamed-Ali Hakimi, Alexandre Bougdour, Amit Sharma
Summary: This study describes the simultaneous targeting of multiple binding sites of the enzyme prolyl-tRNA synthetase (PRS) in Toxoplasma gondii using two potent inhibitors, halofuginone (HFG) and L95. The inhibitors form a ternary complex with the enzyme, inhibiting its activity and showing additive effects in parasite inhibition assays. This novel approach validates the potential of targeting multiple pockets to inhibit druggable proteins, providing a structural framework for further drug development.
Review
Chemistry, Medicinal
Michail S. Kukharsky, Veronika Skvortsova, Sergey O. Bachurin, Vladimir L. Buchman
Summary: Recent progress in understanding pathological changes in the nervous system and other body systems, such as the immune system, has revealed potential therapeutic targets for the development and progression of ALS. Many drugs have been developed to restore functionality compromised in ALS and other diseases. Current research is focused on repurposing these old drugs for the treatment of ALS patients.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Chemistry, Applied
Mark Wainwright
Summary: The global fight against SARS-CoV-2 has led to rapid advancements in science and healthcare, but prior to this, global infection control research was primarily focused on increasing rates of antimicrobial resistance. Antimicrobial dyes may be a promising avenue for infection control as they possess pan-microbial activity.