期刊
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
卷 335, 期 -, 页码 22-32出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijms.2012.10.009
关键词
Low molecular weight compounds; MALDI; Mass spectrometry; Matrix; Matrix-assisted laser desorption-ionization; Matrix-free LDI; Nanoparticles; SALDI
资金
- Ministry of Education and Science, Poland [N N204 226940]
Preparation is described of durable surface of cationic silver nanoparticles (AgNPs), covering commercial and modified MALDI targets, along with characterization of nanoparticles properties and examples of the use in MS analyses of various low molecular weight (LMW) organic compounds, including saccharides, amino acids, nucleosides, glycosides, sulfonic acids, aldehydes and nucleic bases. The new surface allowed higher sensitivity of detection, being attomoles for D-ribose. Examples of application of new Ag nanoparticle-enhanced target for analysis of biological samples, urine and blood serum, are also presented. (C) 2012 Elsevier B.V. All rights reserved.
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