Article
Medicine, General & Internal
Yingying Jiang, Chunlei Fan, Yan Dang, Wenmin Zhao, Lingna Lv, Jinli Lou, Lei Li, Huiguo Ding
Summary: This study aimed to determine the characteristics, prognosis, and risk factors of cirrhotic patients with spontaneous fungal peritonitis (SFP) and fungiascites, as well as to develop a predictive model for early differentiation of SFP/fungiascites from spontaneous bacterial peritonitis (SBP).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Dina Leth Moller, Soren Schwartz Sorensen, Neval Ete Wareham, Omid Rezahosseini, Andreas Dehlbeak Knudsen, Jenny Dahl Knudsen, Allan Rasmussen, Susanne Dam Nielsen
Summary: This study investigates the pattern of bacterial and fungal bloodstream infections in pediatric liver and kidney transplant recipients, finding a high incidence of BSI with different pathogen compositions depending on the type of transplanted organ. Recommendations for antibiotic therapy should take into account the specific organ transplant and local resistance patterns.
BMC INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Yu Sawada, Ayako Setoyama, Yumiko Sakuragi, Natsuko Saito-Sasaki, Haruna Yoshioka, Motonobu Nakamura
Summary: The skin is exposed to various environmental stimuli, leading to inflammatory immune responses, especially towards cutaneous fungal infections. IL-17 producing cells play a crucial role in anti-fungal action, but their actual impact remains unclear. Research focuses on the role of IL-17-producing cells in cutaneous fungal infections and characteristics of infectious fungi on the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Rene Staritzbichler, Pascal Hunold, Irina Estrela-Lopis, Peter Werner Hildebrand, Berend Isermann, Thorsten Kaiser
Summary: The study evaluated the potential application of Raman spectroscopy in medical laboratories for a variety of biomarkers, using serum samples from patients with liver disease. By combining Raman spectroscopy with routine diagnostics and utilizing complex mathematical algorithms, the study demonstrated the high potential of Raman spectroscopy to quantify multiple biomarkers simultaneously in medical laboratory diagnostics.
Article
Gastroenterology & Hepatology
Branden D. Tarlow, W. Ray Kim, Ajitha Mannalithara, Paul Y. Kwo, C. Andrew Bonham, Allison Kwong
Summary: This study found that MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting posttransplant outcomes. Uncapping the MELD score for waitlist candidates may lead to greater survival benefits from liver transplantation.
Article
Medicine, General & Internal
Silvia Wuerstle, Alexander Hapfelmeier, Siranush Karapetyan, Fabian Studen, Andriana Isaakidou, Tillman Schneider, Roland M. Schmid, Stefan von Delius, Felix Gundling, Rainer Burgkart, Andreas Obermeier, Ulrich Mayr, Marc Ringelhan, Sebastian Rasch, Tobias Lahmer, Fabian Geisler, Paul E. Turner, Benjamin K. Chan, Christoph D. Spinner, Jochen Schneider
Summary: Ascitic fluid infection is a serious complication of liver cirrhosis, and it is crucial to distinguish between spontaneous bacterial peritonitis (SBP) and secondary peritonitis in these patients due to different treatment approaches. This study analyzed 532 SBP episodes and 37 secondary peritonitis episodes to identify key differentiation criteria. Microbiological characteristics, severity of illness, and clinicopathological parameters were identified as the most important predictors to distinguish between SBP and secondary peritonitis. A point-score model with ten discriminatory features was established, and two cut-off scores were defined to divide patients into low-risk and high-risk groups for secondary peritonitis based on a sensitivity of 95% to rule out or rule in SBP episodes. Overall, the discrimination between secondary peritonitis and SBP remains challenging, but the findings of this study may help clinicians with the crucial differentiation.
Article
Infectious Diseases
Beiling Li, Chao Yang, Zhiping Qian, Yan Huang, Xianbo Wang, Guotao Zhong, Jinjun Chen
Summary: Spontaneous fungal ascites infection is a rare but devastating complication in patients with cirrhosis, leading to high incidence of acute kidney injury and 28-day mortality. It is recommended to conduct fungal cultures of ascitic fluid in this patient population for optimal clinical management. Future studies should focus on early diagnosis of fungal infection in patients with cirrhosis.
INFECTIOUS DISEASES AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Yan Li, Lungen Lu, Xiaobo Cai
Summary: Liver transplantation is the only curative option for end-stage liver disease, but limitations exist, prompting the need for research into alternative options. Liver regeneration, divided into hepatocyte-driven and liver progenitor cell-driven categories, shows promise as a therapeutic strategy for end-stage liver disease.
Article
Biochemistry & Molecular Biology
Matanis Lobna, Eiza Nasren, Sabag Adi, Bejar Jacob, Gimenez-Arnau Ana Maria, Maurer Marcus, Vadasz Zahava
Summary: Sema5A is highly expressed in the skin of patients with chronic spontaneous urticaria (CSU), which may drive the expression and effects of IL-17A. Further studies are needed to confirm the role of Sema5A in the pathogenesis of CSU.
Article
Medicine, General & Internal
Lingling Liu, Kehang Xie, Mengmeng Yin, Xiaoqiu Chen, Binhuan Chen, Jianting Ke, Cheng Wang
Summary: This study found that serum potassium, albumin, and vitamin B-12 levels were lower in patients with fungal peritonitis compared to bacterial peritonitis patients. Additionally, lower levels of potassium and B-12 were independently associated with higher rates of technique failure in peritonitis cases. These findings suggest that serum potassium, albumin, and B-12 may serve as potential oxidative stress markers for fungal peritonitis.
ANNALS OF MEDICINE
(2021)
Review
Allergy
Stuart G. Tangye, Anne Puel
Summary: Chronic mucocutaneous candidiasis (CMC) is recognized as a primary immunodeficiency, and recent studies have identified the genetic etiology of CMC linked to impaired IL-17-mediated immunity. The IL-17 axis plays a crucial role in mucocutaneous immunity to Candida spp and Staphylococcus aureus in humans, while it seems to be redundant against other common microbes. This review provides an overview of the current understanding of IL-17A/F-mediated immunity and its relevance in human immunity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Multidisciplinary Sciences
Renata Glowczynska, Sonia Borodzicz-Jazdzyk, Michal Peller, Joanna Raszeja-Wyszomirska, Piotr Milkiewicz, Krzysztof Zieniewicz, Grzegorz Opolski
Summary: This study assessed the role of cardiac exercise stress test in the diagnosis of cirrhotic cardiomyopathy (CCM). The results showed a higher prevalence of chronotropic incompetence (CI) among liver transplant candidates with chronic liver disease, which correlated with the severity of liver disease. However, CI did not seem to influence the long-term survival post liver transplantation (OLT).
Article
Gastroenterology & Hepatology
Ezequiel Mauro, Lucrecia Garcia-Olveira, Adrian Gadano
Summary: Hepatorenal syndrome is a serious complication of cirrhosis with high mortality rates. The updated definition of HRS as HRS-AKI reduces the risk of delayed treatment, while vasoconstrictive agents combined with albumin are commonly used in HRS treatment. MELD/MELD-Na scores are utilized to prioritize patients on the waiting list for liver transplant.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Zhiyong Guo, Qiang Zhao, Zehua Jia, Changjun Huang, Dongping Wang, Weiqiang Ju, Jian Zhang, Lu Yang, Shanzhou Huang, Maogen Chen, Xiaofeng Zhu, Anbin Hu, Yi Ma, Linwei Wu, Yinghua Chen, Ming Han, Yunhua Tang, Guodong Wang, Linhe Wang, Lifen Li, Wei Xiong, Zhiheng Zhang, Yuekun Shen, Zhaoxia Tang, Caihui Zhu, Xiaoxiang Chen, Xiaoguang Hu, Yiwen Guo, Honghui Chen, Yihao Ma, Tao Zhang, Shunwei Huang, Ping Zeng, Simei Lai, Tielong Wang, Zhitao Chen, Jinlong Gong, Jia Yu, Canhui Sun, Chang Li, Haiyi Tan, Yao Liu, Yuqi Dong, Chengjun Sun, Bing Liao, Jun Ren, Zhenhai Zhou, Schlegel Andrea, Nashan Bjorn, Changjie Cai, Fengqiu Gong, Jian Rong, Wenqi Huang, Xiangdong Guan, Pierre-Alain Clavien, Tullius G. Stefan, Jiefu Huang, Xiaoshun He
Summary: Ischemia-reperfusion injury (IRI) is a significant concern in organ transplantation, but ischemia-free organ transplantation may provide a solution by avoiding IRI and improving outcomes.
JOURNAL OF HEPATOLOGY
(2023)
Review
Cell & Tissue Engineering
Xin-Hao Hu, Lan Chen, Hao Wu, Yang-Bo Tang, Qiu-Min Zheng, Xu-Yong Wei, Qiang Wei, Qi Huang, Jian Chen, Xiao Xu
Summary: This article discusses the application of cell therapy in the treatment of end-stage liver disease, with a focus on various cell types used for cell transplantation and the processes involved. Furthermore, the practical obstacles of cell therapy are summarized, and potential solutions are offered.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Oncology
Asmaa M. Zahran, Mona H. Abdel-Rahim, Ahmed Refaat, Mona Sayed, Mostafa M. Othman, Lamiaa M. R. Khalak, Helal F. Hetta
Article
Oncology
Asmaa M. Zahran, Sawsan M. Moeen, Ahmad F. Thabet, Amal Rayan, Mona Hussein Abdel-Rahim, Wael M. Y. Mohamed, Helal F. Hetta
LEUKEMIA & LYMPHOMA
(2020)
Article
Virology
Mohamed Ahmed El-Mokhtar, Sherein G. Elgendy, Abeer Sharaf Eldin, Elham Ahmed Hassan, Ali Abdel Azeem Hasan, Muhamad R. Abdel Hameed, Douaa Sayed, Eman H. Salama
Article
Immunology
Asmaa M. Zahran, Omnia El-Badawy, Khalid Elsayh, Wael M. Y. Mohamed, Khalid F. Riad, Mona H. Abdel-Rahim, Amal Rayan
JOURNAL OF IMMUNOLOGY RESEARCH
(2020)
Article
Oncology
Asmaa M. Zahran, Helal F. Hetta, Amal Rayan, Abeer Sharaf Eldin, Elham Ahmed Hassan, Hussein Fakhry, Ahmed Soliman, Omnia El-Badawy
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Respiratory System
Sahar Farghly Youssif, Elham Ahmed Hassan, Ahmed Mohamed Moharram, Mohammed Ameen Farhan, Dalia M. Badary, Ali Adel Azeem Hasan
CLINICAL RESPIRATORY JOURNAL
(2020)
Article
Immunology
Omnia El-Badawy, Amany S. Helmy, Ahmed M. Abbas, Asmaa M. Zahran, Noha A. Afifi, Mona H. Abdel-Rahim
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2020)
Article
Immunology
Mohamed A. El-Mokhtar, Nahla M. Elsherbiny, Douaa Sayed, Duaa M. Raafat, Eman Askar, Almontaser Hussein, Mohamed A. Y. Abdel-Malek, Amira M. Shalaby
JOURNAL OF IMMUNOLOGY RESEARCH
(2020)
Article
Microbiology
Nahla M. Elsherbiny, Mohammed Rammadan, Elham A. Hassan, Mohamed E. Ali, Abeer S. Abd El-Rehim, Wael A. Abbas, Mohamed A. A. Abozaid, Ebtisam Hassanin, Helal F. Hetta
Article
Multidisciplinary Sciences
Sultan F. Alnomasy, Bader S. Alotaibi, Ahmed H. Mujamammi, Elham A. Hassan, Mohamed E. Ali
Summary: Differentiating between viral and bacterial meningitis is crucial in determining the appropriate treatment. This study found that using serum PCT and CSF-parameters can effectively discriminate between the two types of meningitis, with the combination of PCT and CSF-protein significantly improving predictive accuracy for bacterial meningitis.
Article
Oncology
Asmaa M. Zahran, Omnia El-Badawy, Lamiaa M. Kamel, Amal Rayan, Khalid Rezk, Mona H. Abdel-Rahim
Summary: The study found that the levels of CD4(+)CD25(+high)T cells and Tregs were higher in TNBC peripheral blood and malignant tissue compared to healthy controls and normal tissue. Tumor-infiltrating Tregs increased with tumor size and were higher in patients with local recurrences. Tregs also showed a significant inverse relation with DFS and a direct relation with peripheral Tregs levels.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Multidisciplinary Sciences
Asmaa M. Zahran, Amal Rayan, Zeinab Albadry M. Zahran, Wael M. Y. Mohamed, Dalia O. Mohamed, Mona H. Abdel-Rahim, Omnia El-Badawy
Summary: The study found that the expression of PD-1 and CD39 on CD4(+) and CD8(+) cells infiltrating tumor tissue was significantly increased and associated with poor prognosis in TNBC patients. The disease-free survival was inversely related to the expression of PD1 and CD39 on CD8(+) T lymphocytes in cancer tissue.
Article
Medicine, General & Internal
Nahla M. Elsherbiny, Mohammed Ramadan, Nagla H. Abu Faddan, Elham Ahmed Hassan, Mohamed E. Ali, Abeer Sharaf El-Din Abd El-Rehim, Wael A. Abbas, Mohamed A. A. Abozaid, Ebtisam Hassanin, Ghada A. Mohamed, Helal F. Hetta, Mohammed Salah
Summary: This study investigates the compositional and functional characteristics of gut microbiota in patients with type 1 diabetes in two Egyptian cities and explores the influence of geographical locality. The results show consistent changes in the microbiota profile of diabetic patients, including lower alpha diversity and Firmicutes/Bacteroidetes (F/B) ratio, as well as enriched representations of specific bacteria. Significant differences are also observed between the two diabetic groups at the functional level.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Medicine, General & Internal
Wael Abd Elgwad Elsewify, Elham Ahmed Hassan, Mohamed A. Mekky, Abeer Sharaf El-Din Abd El-Rehim, Zain El-Abdeen Ahmed Sayed, Mohamed Omar Abdel Malek, Tarek T. H. ElMelegy, Abeer Sabry
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2020)