Article
Immunology
Pranita D. Tamma, Lauren Komarow, Lizhao Ge, Julia Garcia-Diaz, Erica S. Herc, Yohei Doi, Cesar A. Arias, Owen Albin, Elie Saade, Loren G. Miller, Jesse T. Jacob, Michael J. Satlin, Martin Krsak, W. Charles Huskins, Sorabh Dhar, Samuel A. Shelburne, Carol Hill, Keri R. Baum, Minal Bhojani, Kerryl E. Greenwood-Quaintance, Suzannah M. Schmidt-Malan, Robin Patel, Scott R. Evans, Henry F. Chambers, Vance G. Fowler, David van Duin
Summary: This prospective cohort study investigated the outcomes of patients with ceftriaxone-resistant (CRO-R) Escherichia coli bloodstream infections (BSIs). The study found that patients with CRO-R infections had poorer clinical outcomes compared to those with ceftriaxone-susceptible (CRO-S) infections. The analysis revealed that the CRO-R group had a higher proportion of Pitt bacteremia score >= 4 and a longer time to receive active antibiotic therapy. However, after adjusting for confounding factors using inverse probability weighting, there was no significant difference in the desired outcomes between the two groups. Secondary outcomes showed higher 30-day mortality, longer length of stay, and increased incidence of admission to long-term care facilities in the CRO-R group.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Milena Tocut, Iris Zohar, Orna Schwartz, Orit Yossepowitch, Yasmin Maor
Summary: This study compares the short- and long-term mortality of patients with urosepsis caused by Escherichia coli, comparing those susceptible and resistant to third-generation cephalosporins. The results show that mortality in urosepsis patients is influenced by age and comorbidities, and appropriate antibiotic therapy is not independently associated with 30-day mortality.
BMC INFECTIOUS DISEASES
(2022)
Article
Microbiology
Christian M. Gill, Kamilia Abdelraouf, David P. Nicolau
Summary: WCK 4282 demonstrated clinical exposure efficacies against various Enterobacterales and Pseudomonas aeruginosa isolates in animal experiments. It showed potential activity against cefepime-resistant strains, particularly those producing extended-spectrum beta-lactamase and cephalosporinase.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Camille Bouchand, Anais Andreo, Florence Le Gallou, Stephane Corvec, Celine Bourigault, Didier Lepelletier
Summary: The retrospective study conducted from 2005 to 2019 showed a significant increase in the incidence density of E-ESBL infections over a 17-year period in the university hospital. Patients with E-ESBL bacteremia had a higher mortality rate, highlighting the importance of continued efforts to control the spread of these multidrug-resistant bacteria in the institution.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Nick Daneman, Daniel Fridman, Jennie Johnstone, Bradley J. Langford, Samantha M. Lee, Derek M. MacFadden, Kwadwo Mponponsuo, Samir N. Patel, Kevin L. Schwartz, Kevin A. Brown
Summary: This study investigated patients with E.coli bloodstream infections in Ontario, Canada from 2017 to 2020, and found that resistance to multiple antibiotics is associated with a significant increase in mortality risk among patients.
Article
Infectious Diseases
Antonio Mandujano, Diana Veronica Cortes-Espinosa, Jose Vasquez-Villanueva, Paulina Guel, Gildardo Rivera, Karina Juarez-Rendon, Wendy Lizeth Cruz-Pulido, Guadalupe Aguilera-Arreola, Abraham Guerrero, Virgilio Bocanegra-Garcia, Ana Veronica Martinez-Vazquez
Summary: This study investigated the antimicrobial resistance profile of ESBL-producing E. coli among food-producing animals in Tamaulipas, Mexico. A total of 200 fecal samples were collected and 5.0% of the strains were confirmed as ESBL producers. High percentage of antimicrobial resistance was observed against gentamicin, tetracycline, and streptomycin. The study suggests that food-producing animals may serve as reservoirs and contribute to the spread of ESBL-producing bacteria.
Article
Infectious Diseases
Samanta Freire, Teresa Grilo, Laurent Poirel, Marta Aires-de-Sousa
Summary: This study investigated the potential role of urban pigeons in the dissemination of multidrug-resistant bacteria. The results showed that these pigeons can carry ESBL-producing Escherichia coli strains, which may contribute to the spread of antimicrobial resistance in the environment.
Article
Microbiology
Sien De Koster, Moniek Ringenier, Basil Britto Xavier, Christine Lammens, Dieter De Coninck, Katrien De Bruyne, Klaas Mensaert, Marjolein Kluytmans-van den Bergh, Jan Kluytmans, Jeroen Dewulf, Herman Goossens
Summary: This study characterized and traced ESBL-producing and ciprofloxacin-resistant Escherichia coli in Belgian food-producing animals. Multiple sequence types, resistance genes, and virulence profiles were detected. Transmission pathways within and between farms were identified, highlighting the importance of plasmid transmission in the spread of resistance.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Gizem Levent, Ashlynn Schlochtermeier, Javier Vinasco, Jenny Jennings, John Richeson, Samuel E. Ives, Keri N. Norman, Sara D. Lawhon, Guy H. Loneragan, H. Morgan Scott
Summary: Extended-spectrum-beta-lactamase (ESBL) and AmpC-lactamase-producing Enterobacteriaceae pose serious health risks. A controlled feedlot trial on cattle revealed that the use of certain antibiotics resulted in the emergence of drug-resistant E. coli, with a high prevalence of multidrug-resistant ESBL/AmpC E. coli in cattle feces.
Article
Veterinary Sciences
Ana V. Martinez-Vazquez, Jose Vazquez-Villanueva, Luis M. Leyva-Zapata, Hugo Barrios-Garcia, Gildardo Rivera, Virgilio Bocanegra-Garcia
Summary: The study evaluated the antimicrobial resistance profile of Escherichia coli strains isolated from bovine feces and carcass samples in Tamaulipas, Mexico, finding that a majority of strains exhibited resistance to multiple antibiotics, with the highest resistance rates observed for ampicillin, cephalothin, and tetracyclines. Additionally, a significant portion of the strains displayed a multidrug-resistant phenotype.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Mayo Yasugi, Shingo Hatoya, Daisuke Motooka, Daisuke Kondo, Hideo Akiyoshi, Masayuki Horie, Shota Nakamura, Terumasa Shimada
Summary: The presence of mcr plasmid-mediated colistin-resistant ESBL-producing Enterobacterales in companion dogs and cats in Japan was identified. The isolates from a dog and a cat carried different mcr genes and bla genes on plasmids. This suggests that companion dogs and cats may serve as important reservoirs for cross-species transmission of the mcr gene.
VETERINARY MICROBIOLOGY
(2023)
Article
Infectious Diseases
Delveen R. Ibrahim, Christine E. R. Dodd, Dov J. Stekel, Remilekun T. Meshioye, Mathew Diggle, Michelle Lister, Jon L. Hobman
Summary: Cephalosporin therapy failure is a serious problem worldwide for infection control. Cephalosporin-resistant infections are often caused by multidrug-resistant E. coli producing ESBLs and/or pAmpC beta-lactamases. Analysis of MDR E. coli isolates from a UK hospital revealed a high prevalence of ESBL/pAmpC genetic determinants and significant correlations between resistance genes and specific antibiotics. The findings emphasize the importance of improved antibiotic therapy guidelines, including reduced usage and enhanced surveillance.
Article
Infectious Diseases
Toyotaka Sato, Shin-ichi Yokota, Tooru Tachibana, Satoshi Tamai, Shigeki Maetani, Yutaka Tamura, Motohiro Horiuchi
Summary: The study found that companion animals can carry fluoroquinolone-resistant Escherichia coli, which may be associated with human clinical infections and can potentially be transmitted to their owners.
Article
Multidisciplinary Sciences
Mutasim E. Ibrahim
Summary: This study investigated the prevalence and risk factors for multidrug-resistant Klebsiella pneumoniae infection among hospitalized patients in southern Saudi Arabia. The study found that 66.8% of patients were infected with multidrug-resistant K. pneumoniae strains. Factors such as gender, age, intensive care unit admission, invasive medical devices, and chronic illness were significantly associated with the infection.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Meril Massot, Pierre Chatre, Benedicte Condamine, Veronique Metayer, Olivier Clermont, Jean-Yves Madec, Erick Denamur, Marisa Haenni
Summary: The study revealed a high prevalence of ESBL-producing E. coli in veal calves, with calves being successively colonized by different clones leading to a decreasing carriage trend. The persistence of a clone in a farm was significantly associated with the number of colonized calves. Despite high diversity, few dominant bla(CTX-M) gene/plasmid/chromosomal backgrounds were identified, with the spread scenario depending on the farm. Interactions between resistance genes, plasmids, and bacterial clones contribute to fitness optimization in specific environments.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Review
Nursing
Chia-Te Chen, Heng-Hsin Tung, Yen-Chin Chen, Jiun-Ling Wang, Sheng-Han Tsai, Yen-Ta Huang, Teh-Fu Hsu
Summary: This study conducted a systematic review and meta-analysis to evaluate the effects of cold application on pain and anxiety reduction after chest tube removal (CTR). The findings showed that cold application is a safe and easy-to-administer nonpharmacological method with immediate and persistent effects on pain and anxiety relief after CTR. The subgroup analysis further revealed that a skin temperature drop to 13 degrees C of cold application was significantly more effective for immediate reduction in pain intensity after CTR.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Infectious Diseases
Szu-Ting Huang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Hang, Jann-Tay Wang, Yu-Chung Chuang, Yee-Chun Chen, Shan-Chwen Chang
Summary: This study analyzed the risk factors affecting the treatment outcome of linezolid for vancomycin-resistant Enterococcus bloodstream infection. The study found that the linezolid minimum inhibitory concentration and concentration-time curve/MIC were not associated with mortality, while the linezolid dose per body weight, body height, and the interaction between them were independent risks for mortality. In conclusion, the clinical outcomes of linezolid treatment for vancomycin-resistant Enterococcus bloodstream infection are associated with the dose and body height.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Wen -Kai Chu, Un-In Wu, Tai-Fen Lee, Aristine Cheng, Kai -Hsiang Chen, Kuan-Yin Lin, Yee-Chun Chen
Summary: Amphotericin B and itraconazole are the primary agents for treating histoplasmosis. Newer azoles are alternatives for patients refractory to or intolerant of standard therapy.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Aristine Cheng, Ming-Ju Hsieh, Sui-Yuan Chang, Si-Man Ieong, Chien-Yu Cheng, Wang-Huei Sheng, Shan-Chwen Chang
Summary: This study investigated whether adverse reactions to different COVID-19 vaccines reliably predict immune responses. The results showed that participants who reported local erythema, swelling, pain, as well as systemic fever, chills, headache, myalgia, arthralgia, and fatigue had significantly higher antibody levels at days 14 and 28 compared to those who did not report local or systemic reactogenicity.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Wang-Huei Sheng, Hao-Chun Chang, Sui-Yuan Chang, Ming-Ju Hsieh, Yu-Cheng Chen, Yu-Yun Wu, Sung-Ching Pan, Jann-Tay Wang, Yee -Chun Chen
Summary: We aimed to investigate the prevalence and risk factors of SARS-CoV-2 infection among healthcare workers (HCWs) during the omicron variant outbreak in Taiwan. The study found that recent contact with a SARS-CoV-2 infected household and underlying autoimmune diseases were significant risk factors for acquiring SARS-CoV-2 infection among HCWs. It is recommended to maintain appropriate infection control measures to reduce the risk of SARS-CoV-2 infection among HCWs.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
L. Huang, J-W Hou, H-Y Fan, M-C Tsai, C. Yang, J. B. Hsu, Y. C. Chen
Summary: This study found an association between the timing of puberty onset and body fat percentage (BFP), and identified the critical periods of BFP transition before and after puberty. The BFP of girls first decreases and then increases before puberty onset.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Genetics & Heredity
Hsien-Yu Fan, Wan-Yu Lin, Tzu-Pin Lu, Yun-Yu Chen, Justin BoKai Hsu, Sung-Liang Yu, Ta-Chen Su, Hung-Ju Lin, Yang-Ching Chen, Kuo-Liong Chien
Summary: This study used targeted next-generation sequencing to investigate the association between genetic variants and left ventricular mass, and identified candidate genes including CASQ2, COL5A1, and FXN. These findings provide important insights into the functional mechanisms of these genes and variants.
FRONTIERS IN GENETICS
(2023)
Article
Infectious Diseases
Tai-Chung Tseng, Yu-Chung Chuang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Huang, Jann-Tay Wang, Yee-Chun Chen, Shan-Chwen Chang
Summary: In this study, combination therapy with high-dose daptomycin and fosfomycin was found to improve the survival rate of patients with vancomycin-resistant enterococcus bloodstream infection compared to daptomycin monotherapy. The survival benefit was most pronounced for patients with fosfomycin MIC ≤64 mg/L and a low Pitt bacteremia score.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Shih-Yi Huang, Rong Sun, Yang-Ching Chen, Lin Kang, Chung-Teng Wang, Ching-Feng Chiu, Hung-Tsung Wu
Summary: The prevalence of obesity and adverse obesity-associated pregnancy outcomes has increased. Aspartame, commonly used as an artificial sweetener, may reduce calorie content in food and drinks, but its effects on pregnancy are largely unknown. In this study, pregnant mice treated with aspartame showed decreased fasting blood glucose level and increased systolic blood pressure. The treated animals had lower placenta and fetus weights, as well as reduced thickness of the placenta decidua layer. Aspartame also affected the expression of certain proteins involved in placental function. In trophoblast cells, aspartame induced cell cycle arrest, reduced proliferation rate and migration activity, and increased oxidative stress. These effects were reversed by antioxidants or sweet taste receptor inhibitors. A metabolite of aspartame, phenylalanine, had similar effects on trophoblasts. Overall, our data suggest that aspartame consumption during pregnancy may impact placental structure, growth, and function through oxidative stress mediated by sweet taste receptors.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Immunology
Clea Melenotte, Vishukumar Aimanianda, Monica Slavin, Jose Maria Aguado, Darius Armstrong-James, Yee-Chun Chen, Shahid Husain, Christian Van Delden, Faouzi Saliba, Agnes Lefort, Francoise Botterel, Olivier Lortholary
Summary: Invasive aspergillosis is a rare but serious infection in liver transplant recipients, with a high mortality rate. Risk factors before, during, and after transplantation have been identified, and accurate diagnosis requires collaboration between radiology and clinical biology. It is recommended to reduce the dose of tacrolimus and closely monitor blood levels when using certain drugs, and surgery should be considered on a case-by-case basis. Antifungal prophylaxis and environmental measures should be implemented to prevent outbreaks.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Nutrition & Dietetics
Yu-Hsin Chien, Chia-Yuan Lin, Shih-Yuan Hsu, Yue-Hwa Chen, Hung-Tsung Wu, Shiu-Wen Huang, Yang-Ching Chen
Summary: This study investigated the effects of consuming different types of nonnutritive sweeteners (NNSs) on adiposity changes during pubertal growth. The results showed that the consumption of aspartame, sucralose, glycyrrhizin, stevioside, and sorbitol was associated with decreased fat mass and increased fat-free mass. These effects were more prominent in girls and normal-weight children.
Article
Allergy
Linh Ba Phuong Huynh, Nam Nhat Nguyen, Hsien-Yu Fan, Shih-Yi Huang, Chung-Hsiung Huang, Yang -Ching Chen
Summary: A meta-analysis study found that maternal omega-3 supplementation during pregnancy and lactation can reduce the risk of infant food allergy and sensitization, while childhood intake of omega-3 supplements does not appear to have a significant protective effect against food allergies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Correction
Cardiac & Cardiovascular Systems
Hsien Yu Fan, Yen-Tsung Huang, Yun-Yu Chen, Justin Bokai Hsu, Hung-Yuan Li, Ta-Chen Su, Hung-Ju Lin, Kuo-Liong Chien, Yang Ching Chen
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yaa-Hui Dong, Jiun-Ling Wang, Chia-Hsuin Chang, Jou-Wei Lin, Yu-An Chen, Chun-Yu Chen, Sengwee Toh
Summary: This large-scale cohort study found no increased risk of mitral valve regurgitation or aortic valve regurgitation in the adult population associated with the use of different types of fluoroquinolones.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Environmental Sciences
Jung-Sheng Chen, Bing-Mu Hsu, Wen-Chien Ko, Jiun-Ling Wang
Summary: This study focused on the distribution of antimicrobial-resistant E. coli in two rivers with different urbanization levels. It found that E. coli from Kaoping River, with drainage mainly from livestock farming, had higher resistance to antibiotics and more positive detection of antibiotic-resistance genes compared to Tamsui River. The study provides insights into the specific management of different waste streams across urban areas and highlights the need for periodic surveillance of the effects of wastewater treatment plants and livestock waste on river contamination.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)