Article
Plant Sciences
Linfeng Dai, Li Zhu, Shiyu Ma, Jingya Liu, Minyi Zhang, Jieyi Li, Yong Luo, Xing Zhou, Qiuxiong Chen, Lei Wang, Yi Huang, Yang Chen
Summary: This study aimed to investigate the regulatory effect of berberine (BBR) on endothelial junction function in inflammatory vascular injury. The results showed that BBR restored the expression of junction proteins and inhibited the activation of NLRP3 inflammasomes in endothelial cells. Additionally, BBR exhibited a similar effect to eliminating extracellular calcium. These findings suggest that BBR has therapeutic potential in inflammatory vascular injury by targeting calcium signals and the NLRP3 inflammasome.
Article
Pharmacology & Pharmacy
Ji Hu, Ru Chen, Jie An, Yilong Wang, Minglu Liang, Kai Huang
Summary: The study demonstrates that dauricine can alleviate endothelial inflammation by suppressing the NF-κB pathway, leading to a decrease in adhesion of THP-1 cells to HUVECs and protection against acute lung injury in mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wenjia Tian, Huifeng Hao, Ming Chu, Jingjing Gong, Wenzhe Li, Yuan Fang, Jindong Zhang, Cunzheng Zhang, Yonghui Huang, Fei Pei, Liping Duan
Summary: This study found that berberine can reduce lung metastasis in pancreatic cancer by improving the endothelial barrier and reducing the infiltration of circulating tumor cells. The results showed that berberine effectively inhibits the enzyme activities of TGFBR1, which plays a key role in the protective effect on endothelial barrier disruption by tumor cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Du Lei-lei, Liu Ying, Wan Li, Chen Chu, Fan Gang
Summary: The study showed that SBE could maintain the integrity of alveolar-capillary barrier under endotoxin challenge in mice, significantly alleviating lung injury induced by LPS.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Urology & Nephrology
Takashi Kitani, Kengo Kidokoro, Tomohiro Nakata, Yuhei Kirita, Itaru Nakamura, Kunihiro Nakai, Aya Yagi-Tomita, Tomoharu Ida, Noriko Uehara-Watanabe, Kisho Ikeda, Noriyuki Yamashita, Benjamin D. Humphreys, Naoki Kashihara, Satoaki Matoba, Keiichi Tamagaki, Tetsuro Kusaba
Summary: Heart failure patients with kidney failure have increased kidney venous pressure and upregulated endothelial NF-kappa B signaling, which synergistically worsen kidney injury.
KIDNEY INTERNATIONAL
(2022)
Article
Environmental Sciences
Yizhuo Gao, Na Wang, Dong Jia
Summary: JMJD3 aggravates the severity of lipopolysaccharide-induced acute lung injury by affecting epigenetic modification and macrophage phenotype. JMJD3 induces H3K27me3 and H3K4me3 demethylation, which inhibits IL4i1 transcription and increases the M1/M2 ratio of macrophages, exacerbating LPS-induced lung injury. Inhibiting JMJD3 with GSK-J4 may be a potential treatment for LPS-induced acute lung injury.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Immunology
Qianqian Guo, Kunimaro Furuta, Shahidul Islam, Nunzia Caporarello, Enis Kostallari, Kobe Dielis, Daniel J. J. Tschumperlin, Petra Hirsova, Samar H. H. Ibrahim
Summary: The study reveals that VCAM1 not only functions as a scaffold for leukocyte adhesion during liver injury, but also modulates LSEC capillarization and liver fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jing Guo, Qiao-Zhou Liu, Fang-Juan Zhu, Min Li, Jiao Li, Li Guo, Qian-Yun Sun, Qing-Xiong Yang
Summary: This study demonstrates the strong anti-inflammatory activity of acteoside in the CVF-induced acute lung inflammation model, suggesting it as a potential therapeutic agent for complement-related inflammatory diseases.
Article
Critical Care Medicine
Jingjing Cao, Chengjia Ding, Jieen Huang, Yanzhu Chen, Yi Chen
Summary: This study investigated the role of pulmonary vascular glycocalyx degradation in acute lung injury in rats with severe heatstroke. The shedding of glycocalyx aggravated lung injuries, increased vascular permeability, and aggravated vascular endothelial dysfunction, leading to apoptosis, inflammation, and oxidation in the pulmonary tissues.
Article
Biochemistry & Molecular Biology
Taichi Matsumoto, Junichi Matsumoto, Yuka Matsushita, Moeno Arimura, Kentaro Aono, Mikiko Aoki, Kazuki Terada, Masayoshi Mori, Yutaka Haramaki, Takuya Imatoh, Atsushi Yamauchi, Keisuke Migita
Summary: This study investigated the effect of bortezomib (BTZ) on vascular permeability and expression of cell-cell junction molecules in human pulmonary microvascular endothelial cells. The findings showed that clinically relevant concentrations of BTZ increased the permeability of endothelial cell monolayers and downregulated the expression of claudin-5, occludin, and VE-cadherin at both protein and mRNA levels. This suggests that BTZ-induced pulmonary toxicity may be mediated by increased vascular permeability caused by the downregulation of these cell-cell junction molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ram Kuwar, Xuejun Wen, Ning Zhang, Dong Sun
Summary: This study investigated the role of integrins in promoting adhesion, growth, development, and vascular-like network formation of rat primary brain microvascular endothelial cells. By using an integrin-binding array platform, specific types of integrins and their binding peptides were identified. Furthermore, a 3D hydrogel culture system functionalized with these binding peptides promoted robust growth and lumenized microvascular-like network formation of brain microvascular endothelial cells.
NEURAL REGENERATION RESEARCH
(2023)
Article
Plant Sciences
Hui Zhang, Wenwen Dong, Siyuan Li, Yunqian Zhang, Zhou Lv, Lu Yang, Lai Jiang, Tao Wu, Yan Wang
Summary: Salidroside has protective effects on oxidative stress-induced lung endothelial dysfunction, improving lung injury, and may serve as a promising therapeutic agent for treating ventilation-induced lung injury.
PHARMACEUTICAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Alina Grylls, Karin Seidler, James Neil
Summary: High blood pressure is a significant public health challenge with recent evidence suggesting altered microbiota may contribute to hypertension by inducing metabolic endotoxemia through chronic translocation of lipopolysaccharides. Probiotic intervention targeting LPS-induced alterations in vascular endothelium shows potential for improving vasorelaxation, reducing vascular inflammation, and managing hypertension.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Hee-Weon Lee, Min Ji Gu, Guijae Yoo, In-Wook Choi, Sang-Hoon Lee, Yoonsook Kim, Sang Keun Ha
Summary: Glycolaldehyde (GA) stimulates adhesive capacity and induces the expression of VCAM-1 and ICAM-1 in VSMCs through inhibition of MAPK and NF-kappa B signaling pathways, providing new insights into GA-induced inflammation within atherosclerotic lesions.
Article
Nutrition & Dietetics
Jiyu Chen, Yanli Huang, Xiaohong Bian, Yan He
Summary: The study demonstrates that berberine has a suppressive effect on the inflammatory response caused by lipopolysaccharides (LPS) through regulating the NF-kappa B/Nlrp3 signaling pathway, providing a potential therapeutic strategy for acute lung injury (ALI).
FRONTIERS IN NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Eleonora Torre, Martina Arici, Alessandra Maria Lodrini, Mara Ferrandi, Paolo Barassi, Shih-Che Hsu, Gwo-Jyh Chang, Elisabetta Boz, Emanuela Sala, Sara Vagni, Claudia Altomare, Gaspare Mostacciuolo, Claudio Bussadori, Patrizia Ferrari, Giuseppe Bianchi, Marcella Rocchetti
Summary: Istaroxime improves diabetic cardiomyopathy by stimulating SERCA2a and improving intracellular Ca2+ dynamics.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
Chih-Chuan Lin, Kuang-Hung Hsu, Chia-Pang Shih, Gwo-Jyh Chang
Summary: Paraquat ingestion can lead to cardiovascular collapse and death, possibly involving oxidative stress and inflammation. There is limited information on the relationship between hemodynamic and cardiac electrophysiological effects in acute Paraquat poisoning.
Article
Multidisciplinary Sciences
Yen-Huey Chen, Ying-Ju Lai, Ching-Ying Huang, Hui-Ling Lin, Chung-Chi Huang
Summary: The use of high PEEP 15 cmH(2)O in ARDS patients can offset the drawbacks of low VT and improve the predictive performance of PPV, ensuring the accuracy of fluid responsiveness.
SCIENTIFIC REPORTS
(2021)
Article
Orthopedics
Wen-Chung Tsai, Tung-Yang Yu, Gwo-Jyh Chang, Hsiang-Ning Chang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S. Pang
Summary: The study demonstrated that simultaneous use of PRP and suramin promoted myoblast proliferation, reduced fibronectin expression, and decreased fibronectin expression at the site of muscle injury. In the animal study, the group treated with PRP plus suramin showed better muscle healing and contractile strength compared to the group treated with PRP alone.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yen-Lin Huang, Po-Ru Chen, Ying-Ju Lai, Hsao-Hsun Hsu
Summary: This study evaluated the efficacy of sirolimus in LAM patients and its potential impact on lung parenchymal changes and LAM cells, demonstrating that sirolimus effectively reduced the expression of mTOR and phosphorylated cofilin, as well as inhibited the migration and proliferation of LAM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Shang-Hung Chang, Yi-Hsin Chan, Wei-Jan Chen, Gwo-Jyh Chang, Jia-Lin Lee, Yung-Hsin Yeh
Summary: The study investigated the potential role of CD44 and its related signaling in tachypacing-induced downregulation of LTCC, showing that CREB/CD44 signaling contributes to the suppression of LTCC, providing valuable insights into atrial remodeling and AF pathogenesis.
Article
Medical Laboratory Technology
Ying-Ju Lai, Winston W-Y Kao, Yung-Hsin Yeh, Wei-Jan Chen, Pao-Hsien Chu
Summary: Lumican deficiency promotes pulmonary arterial remodeling. Administration of lumikine reverses the PAH pathogenesis caused by hypoxia-induced experimental PAH. Lumican is an antiproliferative target that functions to suppress pAKT activation during pathogenesis.
TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Andrea Luraghi, Mara Ferrandi, Paolo Barassi, Martina Arici, Shih-Che Hsu, Eleonora Torre, Carlotta Ronchi, Alessio Romerio, Gwo-Jyh Chang, Patrizia Ferrari, Giuseppe Bianchi, Antonio Zaza, Marcella Rocchetti, Francesco Peri
Summary: Stimulation of sarcoplasmic reticulum calcium ATPase SERCA2a is a promising therapeutic strategy for heart failure. Istaroxime, a compound with dual mechanisms of action, inhibits Na+/K+ ATPase and stimulates SERCA2a. By synthesizing a series of analogues, we identified a compound that lacks Na+/K+ ATPase inhibitory activity but retains SERCA2a stimulatory action. Further studies in isolated cardiomyocytes and a rat model showed that the compound is safe and improves cardiac performance, making it a potential drug candidate for heart failure treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ying-Chang Tung, Mei-Ling Cheng, Lung-Sheng Wu, Hsiang-Yu Tang, Cheng-Yu Huang, Gwo-Jyh Chang, Chi-Jen Chang
Summary: This study investigates the changes and reversibility of cardiac energetics in a rat model of cardiac volume overload (VO) using transcriptomics and metabolomics analyses. The findings suggest that glycolysis is downregulated and redirected towards the hexosamine biosynthetic pathway (HBP) and O-linked-N-acetylglucosaminylation in the compensated hypertrophy (CH) phase, and further suppressed in the progression to heart failure (HF). Derangements in fatty acid oxidation become prominent only in HF. Correction of VO can reverse the differential expression of genes involved in glycolysis, HBP, and fatty acid oxidation in CH but not in HF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Gwo-Jyh Chang, Yung-Hsin Yeh, Wei-Jan Chen, Yu-Shien Ko, Ying-Ju Lai, Yun-Shien Lee
Summary: Candesartan cilexetil can suppress arrhythmia by attenuating cardiac electrical remodeling and calcium mishandling, and protect the heart from adverse electrical remodeling induced by pressure overload.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Ying-Hao Wen, Chen-Fang Lee, Yu-Ju Chen, Gwo-Jyh Chang, Kowit-Yu Chong
Summary: This study demonstrated in vitro that platelet lysate-induced hypercoagulability could be prevented by fibrinogen depletion or the addition of an anticoagulant.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tzung-Hai Yen, Wan-Jing Ho, Yung-Hsin Yeh, Ying-Ju Lai
Summary: The study established an animal model to evaluate pulmonary arterial remodeling associated with SLE-related PAH, and found that inhibiting Cat S protein can significantly improve SLE and PAH, providing new approaches for the treatment of SLE-PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Chi-Jen Chang, Ying-Ju Lai, Ying-Chang Tung, Lung-Sheng Wu, Lung-An Hsu, Chi-Nan Tseng, Gwo-Jyh Chang, Kai-Chien Yang, Yung-Hsin Yeh
Summary: Our study suggests that disturbed flow in dysfunctional arteriovenous fistulae (AVF) contributes to the development of neointimal hyperplasia (NH) through the induction of endothelial mesenchymal transition (EndMT) via the osteopontin/CD44 axis. We provided evidence from both animal and cell culture experiments to support this hypothesis. We also found that the osteopontin/CD44 axis is involved in AVF dysfunction in patients with uremia. These findings highlight the potential of targeting the osteopontin/CD44 axis as a therapeutic strategy for preventing AVF dysfunction.
KIDNEY INTERNATIONAL
(2023)
Article
Physiology
Yu-Juei Hsu, Gwo-Jyh Chang, Ying-Ju Lai, Yi-Hsin Chan, Wei-Jan Chen, Chi-Tai Kuo, Yung-Hsin Yeh
Summary: This study found that high phosphate intake causes atrial remodeling and increases the risk of atrial fibrillation. In mice with chronic kidney disease, a high phosphate diet increased atrial fibrillation vulnerability, atrial fibrosis, and oxidative stress. Inhibiting STAT3/NF-kappa B signaling and oxidative stress can alleviate the atrial abnormalities caused by high phosphate intake. Therefore, high dietary phosphate intake may have detrimental effects on the atria and increase the risk of atrial fibrillation.
Article
Medicine, Research & Experimental
Ying-Ju Lai, Feng-Chun Tsai, Gwo-Jyh Chang, Shang-Hung Chang, Chung-Chi Huang, Wei-Jan Chen, Yung-Hsin Yeh
Summary: This study reveals a mechanistic link between TGF-β-induced endothelial-mesenchymal transition (EndMT) and atrial fibrosis through the miR-181b/Sema3A/LIMK/p-cofilin signaling pathway, and suggests blocking miR-181b and increasing Sema3A as potential strategies for AF therapeutic intervention.
JOURNAL OF CLINICAL INVESTIGATION
(2022)