Article
Genetics & Heredity
Zain Al Yafei, Steven J. Mack, Marion Alvares, Bassam R. Ali, Bachar Afandi, Salem A. Beshyah, Charu Sharma, Wael Osman, Rajaa Mirghani, Amre Nasr, Sareea Al Remithi, Jamal Al Jubeh, Wasim Y. Almawi, Juma AlKaabi, Gehad ElGhazali
Summary: This study found associations of DRB1 and DQB1 alleles, genotypes, and haplotypes with T1D in Emiratis, showing similarities to Caucasian and non-Caucasian populations. However, certain alleles and haplotypes associated with T1D in European, African, and Asian populations were not observed in Emiratis, highlighting the contribution of ethnic diversity in the diverse associations between DRB1 and DQB1 and T1D across different populations.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Adil Ahmed Ali, Khalid Eltahir Khalid, Somaya Elhaj Mohammed, Mohammed Salman Akhtar, Osman Khalafalla Saeed
Summary: The aim of this study was to determine the frequency of HLA class II alleles and haplotypes in Sudanese patients with Rheumatoid Arthritis (RA). The study found that HLA-DRB1*04 and *10 alleles were more common in RA patients, while HLA-DRB1*07 allele was significantly less common. HLA-DQB1*03 allele was strongly associated with RA risk, whereas HLA-DQB1*02 and *06 showed protective effects against RA. Several specific HLA haplotypes were also found to be significantly associated with RA risk or protection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Abdelhafidh Hajjej, Saniya Abdrakhmanova, Aida Turganbekova, Wassim Y. Almawi
Summary: The study found that the HLA profile of Ukrainian population in Kazakhstan is closely related to Eastern Europeans (including Ukrainians) and European Russians but distant from Asian populations. This supports the idea that the Kazakhstani Ukrainians originated from Ukraine and migrated to Central Asia in the 18th-20th centuries.
Article
Multidisciplinary Sciences
Leidy Pedraza, Milena Camargo, Darwin A. Moreno-Perez, Ricardo Sanchez, Luisa Del Rio-Ospina, Indira M. Baez-Murcia, Manuel E. Patarroyo, Manuel A. Patarroyo
Summary: This study identified 16 HLA-DRB1 alleles in Colombian women that significantly influence the outcome of Chlamydia trachomatis infection. DRB1*08:02:01G and DRB1*12:01:01G were related to infection-promoting events, while only the DQB1*05:03:01G allele related to clearance/persistence events. Women homozygous for HLA-DRB1 alleles were associated with lower clearance probability and/or early occurrence of persistence.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Paulin Sonon, Maria Lucia Brito Ferreira, Renata Santos Almeida, Neifi Hassan Saloum Deghaide, Glauco Henrique Willcox, Elizabeth Lima Guimaraes, Antonio Fernando da Purificacao Junior, Marli Tenorio Cordeiro, Carlos Alexandre Antunes de Brito, Maria de Fatima Militao de Albuquerque, Roberto D. Lins, Eduardo A. Donadi, Norma Lucena-Silva
Summary: The study found that specific HLA-DRB1/DQA1/DQB1 genotypes/haplotypes were overrepresented in patients exhibiting neurological complications during the Brazilian 2015-2016 arbovirus outbreak. Certain allele groups were also identified to have a protective effect against arbovirus neurological manifestation, being underrepresented in both the whole group of patients and in patients with peripheral neurological spectrum disorders (PSD) or encephalitis spectrum disorders (ESD).
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Wen-Chang Wang, Yu-Shiang Lin, Yin-Fan Chang, Chih-Ching Yeh, Chien-Tien Su, Jin-Shang Wu, Fu-Hsiung Su
Summary: In this study, HLA-DPA1 was primarily associated with the long-term response of primary infantile HBVac, while HLA-DPB1 and HLA-DQB1 exhibited associations with the HBV booster vaccination.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Maria Loginova, Daria Smirnova, Svetlana Kutyavina, Igor Paramonov
Summary: The two novel HLA alleles, DRB1*12:90 and DQB1*03:458, have non-synonymous mutations in exon 3.
Article
Medical Laboratory Technology
Ji Won In, Kiwook Jung, Sue Shin, Kyoung Un Park, Hajeong Lee, Eun Young Song
Summary: This study investigated the association of HLA-DRB1 and -DQB1 alleles with the susceptibility to IgA nephropathy (IgAN) and its progression to end-stage kidney disease (ESKD) in Korean patients. The findings revealed novel associations between certain HLA alleles and IgAN, as well as a significant difference in the frequency of an HLA allele between ESKD and non-ESKD groups.
ANNALS OF LABORATORY MEDICINE
(2022)
Editorial Material
Cell Biology
Luis Alberto Marin Rubio, Ramon Rada, Jesus Ontanon
Summary: Four novel HLA alleles, HLA-B*40:02:01:26, HLA-DQB1*03:01:01:29, HLA-DQB1*04:02:01:12 and HLA-DPB1*1195:01, have been detected in Spanish individuals.
Article
Neurosciences
Sasiharan Pandi, Rathika Chinniah, Vandit Sevak, Padma Malini Ravi, Muthuppandi Raju, Neethi Arasu Vellaiappan, Balakrishnan Karuppiah
Summary: The study identified specific HLA alleles that may be associated with susceptibility and protection against Parkinson's disease.
NEUROSCIENCE LETTERS
(2021)
Article
Immunology
David G. Hernandez-Mejia, Ivan Aurelio Paez-Gutierrez, Valerie Dorsant Ardon, Nathalie Camacho Ramirez, Melissa Mosquera, Paola Andrea Cendales, Bernardo Armando Camacho
Summary: The main limitation in finding compatible donors is the HLA compatibility, especially if no identical match is found within the patient's family group. Bone marrow registries have allowed the identification of 10/10 compatible unrelated donors, but the availability and frequency of haplotypes and HLA alleles vary among ethnic groups and geographical areas, making it difficult to find identical matches in international registries.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sigrid Le Clerc, Laura Lombardi, Bernhard T. Baune, Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott R. Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Rafaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hofmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John R. Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, SusanG Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Urban Osby, Andrea Pfennig, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofeld, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Claudia Pisanu, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Wahid Boukouaci, Jean-Romain Richard, Philippe Le Corvoisier, Caroline Barrau, Jean-Francois Zagury, Marion Leboyer, Ryad Tamouza
Summary: The study revealed that certain amino acid variants within the HLA-DRB1*11:01 classical allele are associated with different responses to lithium treatment in bipolar affective disorder patients. This suggests that the inflammatory background mediated by HLA genes may impact the efficacy of lithium treatment in BD.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Meena A. Kanikannan, Rakesh Kathgave, Sireesha Yareeda, Shiva K. Katkam, Konda Kumaraswamy, Vijay K. Kutala
Summary: This study found that HLA-DRB1*10, DRB1*10-DQB1*05, and HLA-DRB1*15-DQB1*03 alleles may influence the susceptibility to NMO among South Indians, while the DRB1*14 allele and DRB1*14-DQB1*05 haplotype showed a protective role against NMO.
Article
Cell Biology
Maria Loginova, Svetlana Druzhinina, Igor Paramonov
Summary: Three novel HLA-DRB1 alleles, HLA-DRB1*07:150, HLA-DRB1*13:345 and HLA-DRB1*14:256, were identified.
Article
Immunology
Amber Barton, Athumani Ramadhani, Elias Mafuru, Tara Mtuy, Patrick Massae, Aiweda Malissa, Tamsyn Derrick, Joanna Houghton, Anna Harte, Thomas Payne, Harry Pickering, Matthew J. Burton, Chrissy H. Roberts, Martin J. Holland
Summary: HLA typing was performed on 336 Maasai participants using locus-specific amplicon sequencing at the HLA-A,-B,-C,-DRB1,-DQB1 and-DPB1 loci. The participants were recruited from three villages in North Tanzania for a study on risk factors for trachomatous scarring in children. Apart from the HLA-A locus, all other loci significantly deviated from Hardy-Weinberg equilibrium, possibly due to high relatedness among individuals: 238 individuals shared a household with at least one other participant. The most frequent alleles at each locus were A*68:02 (14.3%), B*53:01 (8.4%), C*06:02 (19.2%), DRB1*13:02 (17.7%), DQB1*02:01 (16.9%), and DPB1*01:01 (15.7%), while the most common inferred haplotype was A*68:02 B*18:01 C*07:04 DRB1*08:04 DQB1*04:02 DPB1*04:01 (1.3%).
