Article
Engineering, Electrical & Electronic
Tran Anh Nguyet Dau, Van Manh Hung Le, Thi Kim Hong Pham, Van Hieu Le, Somi Kim Cho, Thai Ngoc Uyen Nguyen, Thi Kieu Hanh Ta, Thi Thanh Van Tran
Summary: In this study, MCM-41 mesoporous silica nanoparticles were successfully synthesized with hexagonal structures and sizes ranging from 100-120 nm. The nanoparticles showed a high specific surface area of 987 m(2).g(-1) and pore sizes from 2 nm to 4 nm. Functionalization with APTES allowed the nanoparticles to be safe for normal cells and toxic to cancer cells in vitro.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Chemistry, Applied
Ruoshi Zhang, Xin Wang, Na Fan, Jing Li
Summary: The Fe(III) loaded porous silica nanoparticles have shown promising potential for establishing an anticancer drug delivery system. Through pH-triggered release and high anti-cancer activity, DOX loaded MM-SN-NH2-Fe demonstrated superior efficacy in both in vitro and in vivo experiments.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Carmen Racles, Mirela-Fernanda Zaltariov, Dragos Peptanariu, Tudor Vasiliu, Maria Cazacu
Summary: Mesoporous silica nanoparticles (MSNs) with different functional groups were synthesized and investigated for the encapsulation and release of anticancer drug Doxorubicin (Dox). The results showed that MSNs with thiol and glucose groups had high loading efficiency and high release rates at pH 5. In vitro experiments demonstrated strong cytotoxic effects of these loaded silica nanoparticles on cancer cells.
Article
Chemistry, Applied
Shiyuan Peng, Baihao Huang, Yizhen Lin, Gongcui Pei, Lijuan Zhang
Summary: This study investigated the application of mesoporous silica nanoparticles (MSN) in drug delivery. The results showed that the structure and surface modification of MSN affect the drug loading and release properties. Hexagonal pore MSN-NH2 and MSN-PDA demonstrated better combined release performance in terms of pH-responsive performance and sustained release effect.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Soraia Fernandes, Tamara Fernandez, Sabrina Metze, Preethi B. Balakrishnan, Binh T. Mai, John Conteh, Claudia De Mei, Alice Turdo, Simone Di Franco, Giorgio Stassi, Matilde Todaro, Teresa Pellegrino
Summary: The combination therapy of magnetic hyperthermia and local chemotherapy shows efficacy in inhibiting dormant cancer stem cells in colorectal cancer, with promising results in colony-forming assays and tumor formation studies. These findings highlight the potential of this treatment approach as an effective personalized cancer treatment against quiescent cancer stem cells.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Noemi Bognanni, Maurizio Viale, Alessia Distefano, Rita Tosto, Nadia Bertola, Fabrizio Loiacono, Marco Ponassi, Domenico Spinelli, Giuseppe Pappalardo, Graziella Vecchio
Summary: Cyclodextrin polymers can serve as carriers to enhance the antitumor activity of Dox and Oxa, especially showing significant effects on HepG2 cells.
Article
Chemistry, Multidisciplinary
Candace M. Day, Martin J. Sweetman, Yunmei Song, Sally E. Plush, Sanjay Garg
Summary: Functionalized nanoparticles have shown promising potential in targeted therapy through studies on loading capacity and release kinetics, contributing to the development of future stimuli-responsive nano-drug delivery systems.
APPLIED SCIENCES-BASEL
(2021)
Article
Pharmacology & Pharmacy
Min-Ki Kim, Do-Hyung Ki, Young-Guk Na, Hae-Soo Lee, Jong-Suep Baek, Jae-Young Lee, Hong-Ki Lee, Cheong-Weon Cho
Summary: By utilizing statistical experimental methods, nano-sized mesoporous silica nanoparticles (MSNs) with excellent physicochemical properties were successfully synthesized. The optimized MSNs exhibited potential as a drug delivery system and showed negligible toxicity in cytotoxicity tests.
Article
Chemistry, Multidisciplinary
Yi-Ping Chen, Chih-Ming Chou, Tsu-Yuan Chang, Hao Ting, Julien Dembele, You-Tai Chu, Tsang-Pai Liu, Chun A. Changou, Chien-Wei Liu, Chien-Tsu Chen
Summary: This study developed a simple method to modify the surface properties of mesoporous silica nanoparticles, allowing them to cross the blood-brain barrier for the treatment of brain diseases. The modified nanoparticles showed no significant cytotoxicity and could release drugs in a pH-responsive manner.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Applied
Mohsen Akbarian, Mohammad Gholinejad, Soliman Mohammadi-Samani, Fatemeh Farjadian
Summary: Mesoporous silica nanoparticles were synthesized and used as a fluorescence-based delivery system for the anticancer drug doxorubicin. The nanoparticles showed no cytotoxicity alone, but exhibited significant drug release and cytotoxicity against breast cancer cells when loaded with doxorubicin. The safety and biocompatibility of the particles were confirmed, making them suitable for therapeutic and imaging applications.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Wenhua Zhan, Hanrui Li, Yingying Guo, Lu Yang, Liaojun Pang, Chaolin Zhang
Summary: Chemotherapy is limited by drug toxicity and side effects in treating breast cancer, but the combination of photothermal therapy with chemotherapy shows promise. A biodegradable mesoporous silica nanoparticle (bMSN NPs) system for loading doxorubicin (DOX) and IR780 has shown excellent therapeutic effects on breast cancer cells in vitro and in vivo.
Article
Chemistry, Multidisciplinary
Tianyu Li, Efrain E. Rodriguez
Summary: This study demonstrated the hydrothermal conversion of mesoporous TiO2 to mesoporous SrTiO3, with controlled pore size distribution and potential for high-temperature applications due to thermal stability.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Chun Xu, Chang Lei, Yue Wang, Chengzhong Yu
Summary: Dendritic mesoporous silica nanoparticles have attracted attention due to their wide applications, but the terminology used is ambiguous. This review provides a critical analysis of reported dendritic silica nanoparticles according to their structural classification, updating the understanding of their formation mechanisms and the control of structural parameters. The review also focuses on the applications of dendritic mesoporous nanoparticles in the biomedical field, offering new insights into the structure-property relationship.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Materials Science, Ceramics
Mehdi Talaei, S. A. Hassanzadeh-Tabrizi, Ali Saffar-Teluri
Summary: Magnetic CuFe2O4 nanoparticles were synthesized via a sol-gel combustion and coated with mesoporous SiO2. The CuFe2O4@SiO2 nanocomposite showed high ibuprofen loading and controlled drug release, with potential applications in biomedicine. Coating CuFe2O4 nanoparticles with mesoporous silica reduced cytotoxicity and improved drug release properties, although it decreased hyperthermia ability.
CERAMICS INTERNATIONAL
(2021)
Article
Nanoscience & Nanotechnology
Nora Igaz, Peter Belteky, David Kovacs, Csaba Papp, Andrea Ronavari, Diana Szabo, Attila Gacser, Zoltan Konya, Monika Kiricsi
Summary: The efficient delivery of Rhodamine 123 and Mitomycin C to multidrug-resistant cells via mesoporous silica nanoparticles (MSNs), resulting in increased intracellular drug concentration and enhanced cytotoxic effects, demonstrates the enormous potential of MSNs in overcoming multidrug-resistant cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)