Article
Clinical Neurology
Rebecca C. Thurston, Minjie Wu, Yue-Fang Chang, Howard J. Aizenstein, Carol A. Derby, Emma A. Barinas-Mitchell, Pauline Maki
Summary: Research shows that more severe menopausal symptoms may be associated with greater white matter hyperintensity volume, especially for symptoms occurring during sleep. This finding is important for early intervention and prevention of brain health issues related to middle-aged women.
Article
Geriatrics & Gerontology
Cynthia A. Stuenkel
Summary: VMS in older women may persist into advanced age and increase cardiovascular disease risks. Nonhormonal treatment options are available for those who elect not to use, or are advised not to use, menopausal hormone therapies.
Review
Obstetrics & Gynecology
Bijal Patel, Waljit S. Dhillo
Summary: Vasomotor symptoms (VMS) during menopause have a significant impact on women's physical and mental well-being. Hormone therapy is the gold-standard treatment, but it has limitations. Recent development of neurokinin 3 receptor (NK3R) antagonists has shown promising results in reducing VMS and improving patients' quality of life.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rebecca C. Thurston, Helen E. Aslanidou Vlachos, Carol A. Derby, Elizabeth A. Jackson, Maria Mori Brooks, Karen A. Matthews, Sioban Harlow, Hadine Joffe, Samar R. El Khoudary
Summary: The study found that frequent and persistent vasomotor symptoms (VMS) are associated with increased risk of cardiovascular disease events in women.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Rochelle Zak, Jennifer Zitser, Holly J. Jones, Catherine L. Gilliss, Kathryn A. Lee
Summary: This study examines changes in sleep quality and associated symptoms as women enter menopausal transition. The results show that women in the transition group experience a decline in sleep quality and an increase in trouble sleeping due to feeling too hot. This may indicate the onset of menopausal transition.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Oncology
F. Gernier, A. Gompel, C. Rousset-Jablonski, E. Kalbacher, A. Floquet, D. Berton-Rigaud, O. Tredan, J. Alexandre, P. Follana, A. Zannetti, N. Dohollou, J-M Grellard, B. Clarisse, I Licaj, D. Ahmed-Lecheheb, R. Fauvet, P. Pautier, F. Joly
Summary: The study found that menopausal symptoms and sexual disorders are frequently reported by epithelial ovarian cancer survivors, especially among those who underwent surgical menopause. Most survivors with menopausal symptoms could benefit from hormone replacement therapy.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Medicine, General & Internal
Erin R. Duralde, Talia H. Sobel, JoAnn E. Manson
Summary: Most women worldwide experience menopausal symptoms such as hot flashes, disrupted sleep, and genitourinary discomfort during the menopause transition or postmenopause. These symptoms can persist for many years and may also include mood fluctuations, cognitive changes, low sexual desire, bone loss, increase in abdominal fat, and adverse changes in metabolic health. Hormonal therapies, especially estrogen based, are the most effective treatments, while non-hormonal options are also available. However, menopausal symptoms remain undertreated by healthcare providers.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Obstetrics & Gynecology
Rebecca C. Thurston, Yuefang Chang
Summary: This study found that physiologically assessed vasomotor symptoms (VMS) were associated with lower levels of adiponectin, independent of factors such as age, race/ethnicity, education, insulin resistance, and waist circumference. However, adiponectin did not explain the relationship between VMS and carotid atherosclerosis.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Obstetrics & Gynecology
Angelo Cagnacci, Anjeza Xholli, Francesca Fontanesi, Isabella Neri, Fabio Facchinetti, Federica Palma
Summary: This study aimed to evaluate the relationship between changes in menopausal symptoms and modification of 24-hour urinary cortisol levels. The results showed that a larger decrease in cortisol levels was associated with a greater reduction in menopausal symptoms.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Obstetrics & Gynecology
L. Baquedano, P. Coronado, E. De la Viuda, S. Sanchez, B. Otero, I Ramirez, P. Llaneza, N. Mendoza
Summary: Despite the high prevalence of symptoms, the use of menopausal hormone therapy (MHT) among Spanish perimenopausal and postmenopausal women is very low. The fear of side effects, especially cancer, is the most common reason for women's rejection of MHT. Gynecologists are the most frequently used source of information.
Review
Biochemistry & Molecular Biology
Ivan K. Domingo, Asna Latif, Amit P. Bhavsar
Summary: Cisplatin, a widely used chemotherapeutic drug, is effective against various solid cancers but limited by its adverse drug reactions. The most common reactions include nephrotoxicity, peripheral neuropathy, and ototoxicity. Previous studies focused on oxidative stress as the cause of these toxicities, but recent evidence suggests that inflammation may be the main driving force. This review summarizes the common and distinct inflammation characteristics among different adverse reactions, as well as current treatments targeting pro-inflammatory signaling pathways to improve the use of cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Alanna De Mello, Augustine Chavez, Mahnoor Mukarram, Matthew R. Buras, Juliana M. Kling
Summary: Menopausal symptoms in women from different socioeconomic areas in Arizona showed significant differences, with uninsured or homeless women experiencing higher psychological and somatic symptoms.
Article
Geriatrics & Gerontology
Ye He, Jing Tian, Wendy H. Oddy, Leigh Blizzard, Terence Dwyer, Martha Hickey, Alison J. Venn
Summary: The study found that childhood adiposity, especially abdominal obesity, was associated with more severe total, somatic, psychological, and urogenital symptoms in women aged 45-49 years. However, there were no significant associations between childhood overweight/obesity or abdominal obesity and vasomotor symptoms or vaginal dryness.
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Article
Immunology
Nicholas D. Leigh, Kathleen M. Kokolus, Rachel E. O'Neill, Wei Du, Jason W. -L. Eng, Jingxin Qiu, George L. Chen, Philip L. McCarthy, J. David Farrar, Xuefang Cao, Elizabeth A. Repasky
JOURNAL OF IMMUNOLOGY
(2015)
Article
Multidisciplinary Sciences
Jason W. -L. Eng, Chelsey B. Reed, Kathleen M. Kokolus, Rosemarie Pitoniak, Adam Utley, Mark J. Bucsek, Wen Wee Ma, Elizabeth A. Repasky, Bonnie L. Hylander
NATURE COMMUNICATIONS
(2015)
Meeting Abstract
Oncology
Nicholas D. Leigh, Kathleen M. Kokolus, Jason W-L Eng, Jingxin Qiu, George L. Chen, Philip L. McCarthy, Xuefang Cao, Elizabeth A. Repasky
CANCER IMMUNOLOGY RESEARCH
(2015)
Meeting Abstract
Oncology
Jason W-L Eng, Chelsey B. Reed, Kathleen Kokolus, Mark Bucsek, Rose Pitoniak, Adam T. Utley, WenWee Ma, Elizabeth A. Repasky, Bonnie L. Hylander
CANCER IMMUNOLOGY RESEARCH
(2015)
Article
Oncology
Kristian M. Koller, Heath B. Mackley, Jason Liu, Henry Wagner, Giampaolo Talamo, Todd D. Schell, Colette Pameijer, Rogerio I. Neves, Bryan Anderson, Kathleen M. Kokolus, Carol A. Mallon, Joseph J. Drabick
CANCER BIOLOGY & THERAPY
(2017)
Review
Oncology
Kristian M. Koller, Wenge Wanga, Todd D. Schell, Eugene M. Cozza, Kathleen M. Kokolus, Rogerio I. Neves, Heath B. Mackley, Colette Pameijer, Anna Leung, Bryan Anderson, Carol A. Mallon, Gavin Robertson, Joseph J. Drabick
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2016)
Article
Oncology
Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd. D. Schell
Article
Oncology
Lindsay K. Ward-Kavanagh, Kathleen M. Kokolus, Timothy K. Cooper, Aron E. Lukacher, Todd D. Schell
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Meeting Abstract
Oncology
Megan Wheelden, Jeremy Haley, Todd Schell, Kathleen M. Kokolus, Diane Hershock, Carol Mallon, Heath B. Mackley, Jeffrey Michael Sivik, Joseph J. Drabick
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Oncology
Kathleen M. Kokolus, Jeremy S. Haley, Emily J. Koubek, Raghavendra Gowda, Saketh S. Dinavahi, Arati Sharma, David F. Claxton, Klaus F. Helm, Joseph J. Drabick, Gavin P. Robertson, Jeffrey D. Neighbors, Raymond J. Hohl, Todd D. Schell
Meeting Abstract
Oncology
Kathleen Kokolus, Natasa Obermajer, Per Basse, Pawel Kalinski
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Oncology
Mark J. Bucsek, Guanxi Qiao, Cameron R. MacDonald, Thejaswini Giridharan, Lauren Evans, Brian Niedzwecki, Haichao Liu, Kathleen M. Kokolus, Jason W. -L. Eng, Michelle N. Messmer, Kristopher Attwood, Scott I. Abrams, Bonnie L. Hylander, Elizabeth A. Repasky
Article
Oncology
Heath B. Mackley, Jason Liu, Junjia Zhu, Henry Wagner, Giampaolo Talamo, Todd D. Schell, Colette Pameijer, Rogerio I. Neves, Bryan Anderson, Kathleen M. Kokolus, Jeffrey Sivik, Carol A. Mallon, Kristian M. Koller, Joseph J. Drabick
JOURNAL OF RADIATION ONCOLOGY
(2017)
Meeting Abstract
Oncology
Kristian Michael Koller, Heath B. Mackley, Henry Wagner, Giampaolo Talamo, Todd Schell, Colette Pameijer, Rogerio Izar Neves, Bryan Anderson, Kathleen M. Kokolus, Carol Mallon, Joseph J. Drabick
JOURNAL OF CLINICAL ONCOLOGY
(2016)
Meeting Abstract
Immunology
Matthew Alexander, Kathleen Kokolus, Amanda Costa, Eleanor Clancy-Thompson, Elizabeth Repasky, David Mullins
JOURNAL OF IMMUNOLOGY
(2015)