期刊
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
卷 217, 期 4-5, 页码 435-442出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijheh.2013.08.006
关键词
Epidemiology; Asthma; Risk factors; Farming; Pesticides
资金
- Mutualite Sociale Agricole
- Agence nationale de securite sanitaire de l'alimentation, de l'environnement et du travail
- Fondation de France
- Conseil Regional de Basse Normandie
- Ligue Contre le Cancer
Epidemiological studies have reported an increased risk of respiratory diseases in agricultural population, but a protective farm-effect has also been reported for asthma. In the AGRICAN cohort, self-reported doctor-diagnosed asthma was analyzed according to allergy, in relation with history of life-time exposure to 13 crops and 5 livestock, pesticide exposure and early life on a farm, taking into account sex, age, education and body mass index. Among the 1246 asthmatics (8.0%), 505 were allergic (3.3%) and 719 non-allergic (4.6%). In multivariate analysis, a significant excess was observed, only for allergic asthma, in vine-growing (OR= 1.43, p = 0.002), fruit-growing (OR= 1.58, p = 0.001), greenhouses (OR= 1.66, p= 0.02), grasslands (OR= 1.35, p = 0.009), beets (OR= 1.52, p = 0.003) and horses (OR= 1.35, p = 0.04). Pesticide use and history of pesticide poisoning were significantly associated with allergic asthma in grassland, vineyards and fruit-growing and with non-allergic asthma in beets. Living on a farm in the first year of life tended to be protective for childhood allergic asthma in farms with livestock (OR= 0.72, p=0.07) but deleterious in farms with vineyards, fruit or vegetables (OR= 1.44, p = 0.07). In AGRICAN, an increased risk of allergic asthma was observed with crop exposure, pesticide use and early life on a farm, especially in vine-growing, grassland, beets, fruit and vegetable-growing. (C) 2013 Elsevier GmbH. All rights reserved.
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