Article
Biochemistry & Molecular Biology
Ishfaq Ahmad Sheikh, Mohd Amin Beg, Taha Abo-Almagd Abdel-Meguid Hamoda, Hammam Mahmoud Siraj Mandourah, Erdogan Memili
Summary: Polybrominated diphenyl ethers (PBDEs) are widely used fire-retardant chemicals in consumer products and have the potential to bioaccumulate in the environment, including wildlife and humans, leading to adverse health effects such as neurodevelopmental deficits and reproductive dysfunction. In this study, the structural interactions of four PBDEs with the thyroid hormone receptor (TR alpha) were investigated. The results showed that all four PBDEs bound tightly to TR alpha and disrupted the thyroid signaling, which could have implications in reproductive function and infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Engineering, Environmental
Chinemerem Ruth Ohoro, Abiodun Olagoke Adeniji, Anthony Ifeanyi Okoh, Omobola Oluranti Okoh
Summary: PBDEs are human-influenced chemicals commonly used as flame retardants, with environmental persistence and bioaccumulation potential. They can travel long distances through air and water, primarily residing in sediments in aquatic environments. Different congeners prevail in environmental samples compared to human tissues.
JOURNAL OF ENVIRONMENTAL HEALTH SCIENCE AND ENGINEERING
(2021)
Article
Environmental Sciences
Qian Zhang, Mingjun Hu, Huabing Wu, Qingshan Niu, Xuelei Lu, Jialiu He, Fen Huang
Summary: The study found that exposure to PBDEs, As, and Hg may be associated with the development of thyroid cancer, with high levels of exposure to As and Hg being linked to an increased risk of thyroid cancer. There is a positive interaction effect between some PBDE congeners and Hg, while a negative interaction effect was observed between BDE-209 and Pb. Further prospective research with large samples is needed to confirm these findings.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Anita A. Thambirajah, Michael G. Wade, Jonathan Verreault, Nicolas Buisine, Veronica A. Alves, Valerie S. Langlois, Caren C. Helbing
Summary: This critical review highlights the complexity of Endocrine Disrupting Chemicals interfering with Thyroid Hormone function through interactions with other hormonal axes, and emphasizes the lack of data generated in non-mammalian vertebrate classes. With the availability of more genomics-based resources, better identification and delineation of EDC effects, modes of action, and identification of effective biomarkers suitable for HPT disruption is possible. The effects of EDCs are likely to cascade into a plurality of complex physiological effects, beyond the few variables tested within research studies.
ENVIRONMENTAL RESEARCH
(2022)
Review
Environmental Sciences
ZhiChao Dang
Summary: Both AMA and LAGDA are used to detect thyroid-mediated modality and adversity based on morphological changes during thyroid hormone-dependent metamorphosis. The EU Guidance recommends their use for investigating the effects of thyroid hormone system disrupting chemicals. However, there is debate over the necessity of using LAGDA as a follow-up to positive AMA results. This study analyzes the similarities, differences, and sensitivity of these two assays in detecting TDCs.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Qi Xu, Jian Li, Shang Cao, Guangcai Ma, Xianglong Zhao, Qiuyi Wang, Xiaoxuan Wei, Haiying Yu, Zhiguo Wang
Summary: In this study, 18 OH-PBDEs with neutral and anionic forms were selected to estimate their binding interactions with the ligand binding domain (LBD) of thyroid hormone receptor O (TRO) through molecular dynamics simulations. The results indicate that most OH-PBDEs have stronger binding affinities to TRO-LBD compared to their anionic counterparts, and the hydroxyl dissociation of ligands plays a major role in their binding. Additionally, 5 hydrophobic residues (Met313, Leu330, Ile276, Leu346, and Phe272) are identified to have important contributions to binding OH-PBDEs. These findings provide a solid theoretical basis for accurately assessing the thyroid hormone disrupting effects of these chemicals.
Article
Environmental Sciences
Pauline Frenoy, Chloe Marques, Thibault Fiolet, German Cano-Sancho, Gianluca Severi, Francesca Romana Mancini
Summary: The study aimed to assess the association between dietary intake of PBDEs and breast cancer risk, and investigate the potential modification of this association by vegetable oil consumption. The results showed a positive linear trend between dietary intake of PBDEs and breast cancer risk, with potential modification by vegetable oil consumption.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Marija Dvorscak, Karla Jagic, Lucija Besednik, Iva Simic, Darija Klincic
Summary: Microwave-assisted extraction (MAE) is an effective method for extracting organic pollutants from human milk samples. By optimizing extraction conditions such as solvent type and volume, extraction temperature, etc., high-quality extracts can be obtained.
MICROCHEMICAL JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Ming-Jun Hu, Jin-Liang Zhu, Qian Zhang, Jia-Liu He, Wan-Jun Yang, Zhen-Yu Zhu, Jia-Hu Hao, Fen Huang
Summary: Exposure to PBDEs and metals among rural adult residents along the Yangtze River in China may influence thyroid function, with some PBDE congeners and metals showing associations with thyroid hormones. However, there was no statistically significant association observed between PBDEs, metals, and thyroid-stimulating hormone. Bayesian Kernel Machine Regression analysis suggested similar trends in the relationship between PBDEs, metals mixtures, and thyroid hormones. Additional studies are needed to confirm these findings and identify potential mechanisms.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Qiong Zhang, Jiajun Peng, Anyan Huang, Shukai Zheng, Xiaoling Shi, Boyu Li, Wenlong Huang, Wei Tan, Xin Wang, Kusheng Wu
Summary: Animal studies have shown that exposure to PBDEs can affect lipid balance, and this study investigated the relationship between PBDEs in adipose tissues and blood lipid metabolism in female patients undergoing plastic surgery. The results indicated that certain PBDE congeners were associated with dyslipidemia and blood pressure alteration, and a non-linear relationship was observed between PBDEs and blood lipid levels.
ENVIRONMENTAL RESEARCH
(2022)
Article
Engineering, Environmental
Yue Wang, Yongtao Yu, Hongbo Zhang, Yuze Huo, Xiaoqian Liu, Yanhui Che, Jiechen Wang, Guangyu Sun, Huihui Zhang
Summary: The study investigated the effects of exposure to BDE47 and BDE209 on tobacco plant growth and physiological function using physiological and transcriptomic techniques. Both pollutants inhibited tobacco plant growth and primarily affected photosynthesis and plant hormone signal transduction pathways.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Aalekhya Reddam, Andreas Sjodin, Whitney Cowell, Richard Jones, Shuang Wang, Frederica Perera, Julie B. Herbstman, Allison Kupsco
Summary: This study found associations between exposure to polybrominated diphenyl ethers (PBDEs) and birth outcomes in a cohort of Dominican and African American newborns, mainly affecting birth weight and length.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Juan P. Munoz, Tammy C. Bleak, Gloria M. Calaf
Summary: Glyphosate, a broad-spectrum herbicide introduced in 1974, has had a significant impact on the crop industry and is considered one of the most successful herbicides in history. However, recent studies have raised concerns about its safety, with conflicting opinions from international agencies regarding its effects on human health, particularly as an endocrine-disrupting chemical and carcinogen.
Review
Biochemistry & Molecular Biology
Jinsong Xue, Qingqing Xiao, Min Zhang, Dan Li, Xiaofei Wang
Summary: Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants found in various materials. They have been detected in soil, air, water, dust, and animal tissues, and are associated with a range of toxic effects on different organ systems. Understanding the mechanisms and potential toxicity of PBDEs is important for developing effective prevention strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Timothy M. Ullmann, Heng Liang, Hector Mora, Jacques Greenberg, Katherine D. Gray, Jessica Limberg, Dessislava Stefanova, Xin Zhu, Brendan Finnerty, Toni Beninato, Rasa Zarnegar, Irene Min, Thomas J. Fahey
Summary: The study investigated the effects of polybrominated diphenyl ethers (PBDEs) and tris(2-chloroethyl) phosphate (TCEP) on thyrocytes. PBDEs demonstrated genotoxicity but not cytotoxicity in follicular thyrocytes in vitro. These findings suggest that PBDEs may have carcinogenic potential in human thyroid cells.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Environmental Sciences
Cheng-Chih Kao, Danielle E. Que, Sayre J. Bongo, Lemmuel L. Tayo, Yi-Hsien Lin, Chun-Wen Lin, Sheng-Lun Lin, Yan-You Gou, Wen-Li Hsu, Cherng-Gueih Shy, Kuo-Lin Huang, Ming-Hsien Tsai, How-Ran Chao
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Chemistry, Multidisciplinary
Hong Thi Thu Nguyen, How-Ran Chao, Kuan-Chung Chen
APPLIED SCIENCES-BASEL
(2019)
Article
Environmental Sciences
Chane-Yu Lai, How-Ran Chao, Ying I. Tsai, Xiang-Yu Huang, Tzu-Hsien Lin
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Environmental Sciences
How-Ran Chao, Danielle E. Que, Alisha C. Aquino, Yan-You Gou, Lemmuel L. Tayo, Yi-Hsien Lin, Ming-Hsien Tsai, Fu-Lin Hsu, I-Cheng Lu, Sheng-Lun Lin, Natwat Srikhao, Cherng-Gueih Shy, Kuo-Lin Huang
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2020)
Article
Biochemistry & Molecular Biology
Tun-Chieh Chen, How-Ran Chao, Ching-Ying Wu, Yun-Ru Lai, Chu-Huang Chen, Tohru Yoshioka, Wen-Li Hsu, Ming-Hsien Tsai
Summary: Human breast milk lipids play a significant role in promoting infant neurodevelopment. Specifically, 9,12-octadecadiynoic acid has been shown to have a positive correlation with infant adaptive behavioral development, which is crucial for managing environmental stress. Further research in C. elegans has revealed the involvement of 9,12-octadecadiynoic acid in regulating serotonin-mediated neuronal activity and antioxidant defense genes, highlighting its importance in governing adaptive behavioral development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Jian-He Lu, Wen-Che Hou, Ming-Hsien Tsai, Yu-Ting Chang, How-Ran Chao
Summary: This study investigated the toxicity of Carboxylated SWCNTs (SWCNTs-COOH) in Caenorhabditis elegans (C. elegans) and human cells. The results showed that exposure to SWCNTs-COOH affected the lifespan, growth, reproduction, and locomotion behavior of C. elegans, and induced reactive oxygen species (ROS) generation and alteration of antioxidant gene expression. Similar nanotoxic effects were observed in human cells.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Cherng-Gueih Shy, Jian-He Lu, Hui-Chen Lin, Min-Nan Hung, Hsiu-Chun Chang, Meng-Lun Lu, How-Ran Chao, Yao-Shen Chen, Pi-Sheng Wang
Summary: The Delta variant of the SARS-CoV-2 virus caused an outbreak in Pingtung, Taiwan. Through rapid epidemiological investigation, gene sequencing, isolation, screening, and vaccination, the outbreak was successfully controlled within one month. Environmental factors may have also contributed to the control of the virus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ming-Hsien Tsai, How-Ran Chao, Wen-Li Hsu, Ching-Chung Tsai, Chu-Wen Lin, Chu-Huang Chen
Summary: The study found significant associations between PBDEs and lipid components in human breast milk (HBM) and infant neurodevelopment, highlighting the importance of these components as predictors for infant neurodevelopment. Despite certain PBDEs potentially playing a role, the findings indicate that the lipid components of HBM are directly important for infant neurodevelopment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
I-Cheng Lu, How-Ran Chao, Wan-Nurdiyana-Wan Mansor, Chun-Wei Peng, Yi-Chyun Hsu, Tai-Yi Yu, Wei-Hsiang Chang, Lung-Ming Fu
Summary: This study investigated the presence of EEDCs and MPs in commonly consumed fish samples from estuaries in northern Taiwan. The analysis found that typical consumption of estuarine fish by Taiwanese people does not pose significant direct health risks from EEDCs, although other sources of exposure should not be ignored.
Review
Biochemistry & Molecular Biology
Wei-Shiung Lian, Feng-Sheng Wang, Yu-Shan Chen, Ming-Hsien Tsai, How-Ran Chao, Holger Jahr, Re-Wen Wu, Jih-Yang Ko
Summary: Osteoporosis and osteoarthritis are the leading causes of musculoskeletal dysfunction in older adults. Gut microbiota and metabolites play an important role in maintaining the homeostasis of cartilage and bone tissue. Modulating gut microbiota and supplementing microbiota-derived metabolites may help slow down the development of these skeletal disorders.
Article
Multidisciplinary Sciences
Wan Nurdiyana Wan Mansor, Samsuri Abdullah, Che Wan Mohd Noor Che Wan Othman, Mohamad Nor Khasbi Jarkoni, How-Ran Chao, Sheng-Lun Lin
Article
Environmental Sciences
Shida Chen, Kangping Cui, Tai-Yi Yu, How-Ran Chao, Yi-Chyun Hsu, I-Cheng Lu, Rachelle D. Arcega, Ming-Hsien Tsai, Sheng-Lun Lin, Wan-Chun Chao, Chunneng Chen, Kwong-Leung J. Yu
AEROSOL AND AIR QUALITY RESEARCH
(2019)
Article
Environmental Sciences
Danielle E. Que, How-Ran Chao, Yi-Chyun Hsu, Kangping Cui, Shida Chen, Lemmuel L. Tayo, Rachelle D. Arcega, Ying- Tsai, I-Cheng Lu, Lin-Chi Wang, Li-Hao Young, Kwong-Leung J. Yu, Chane-Yu Lai, Wen-Che Hou, Sheng-Lun Lin
AEROSOL AND AIR QUALITY RESEARCH
(2019)
Article
Engineering, Environmental
Yung-Dun Dai, How-Ran Chao, Pen-Chi Chiang
JOURNAL OF HAZARDOUS TOXIC AND RADIOACTIVE WASTE
(2019)
Article
Environmental Sciences
Meng-Ching Chung, Ming-Hsien Tsai, Danielle E. Que, Sayre J. Bongo, Wen-Li Hsu, Lemmuel L. Tayo, Yi-Hsien Lin, Sheng-Lun Lin, Yan-You Gou, Yi-Chyun Hsu, Wen-Che Hou, Kuo-Lin Huang, How-Ran Chao
AEROSOL AND AIR QUALITY RESEARCH
(2019)
Article
Public, Environmental & Occupational Health
Dewan Muhammad Shoaib, Tanvir Ahmed, Kazy Farhat Tabassum, Mehedi Hasan, Fazle Sharior, Mahbubur Rahman, Makfie Farah, Md Azizur Rahman, Alauddin Ahmed, James B. Tidwell, Mahbub-Ul Alam
Summary: An intervention was implemented in Bangladesh during COVID-19 to reduce occupational health risks for waste and sanitation workers. The intervention involved training and distribution of personal protective equipment (PPE). The study found that the intervention improved workers' knowledge, attitude, and practice regarding PPE usage.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Andreas Kortenkamp, Olwenn Martin, Eleni Iacovidou, Martin Scholze
Summary: The European Food Safety Authority's downward revision of the Health-based Guidance Value for bisphenol A (BPA) has led to disagreements with other regulatory agencies, particularly the German Federal Institute for Risk Assessment. The differing views between EFSA and BfR are driven by their respective selection of endpoints and study evaluation systems, as well as their acceptance or refusal of immunotoxic effects as a basis for establishing a Health-based Guidance Value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Shizhen He, Bjorn Lundberg, Jenny Hallberg, Susanna Klevebro, Goran Pershagen, Kristina Eneroth, Erik Melen, Matteo Bottai, Olena Gruzieva
Summary: Early life air pollution exposure and abnormal inflammation-related protein profiles may interact synergistically towards lower lung function in infants.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Karolina Bralewska
Summary: This review study examines the concentrations of various air pollutants in fire stations, identifies the limitations and strengths of existing research, identifies research gaps and challenges, and suggests potential solutions for reducing firefighter exposure to air pollution at fire stations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)