Article
Biochemistry & Molecular Biology
Daria Trifonova, Mirela Curin, Ksenja Riabova, Antonina Karsonova, Walter Keller, Hans Groenlund, Ulrika Kaeck, Jon R. Konradsen, Marianne van Hage, Alexander Karaulov, Rudolf Valenta, Kurt A. Jellinger
Summary: More than 10% of the world's population suffers from an IgE-mediated allergy to cats, which mainly manifests as respiratory symptoms. Several cat allergens have been identified, and Fel d 1, Fel d 4, and Fel d 7 show high allergenic activity in patients with respiratory allergies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ksenja Riabova, Antonina Karsonova, Marianne van Hage, Ulrika Kack, Jon R. Konradsen, Hans Gronlund, Daria Fomina, Evgeny Beltyukov, Polina A. Glazkova, Dmitry Yu Semenov, Rudolf Valenta, Alexander Karaulov, Mirela Curin
Summary: Cat allergies are triggered by immunoglobulin E (IgE) sensitization and can result in respiratory reactions. This study investigated the associations between different cat allergen molecules and various phenotypes of cat allergy. The findings showed that in addition to the main cat allergen, rFel d 1, other allergen molecules such as rFel d 3, rFel d 4, and rFel d 7 are also important. Cumulative IgE levels specific to cat allergen molecules can serve as a biomarker for identifying patients with complex phenotypes of cat allergy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Lina Hoerner-Schmid, Jelena Palic, Ralf S. Mueller, Bianka Schulz
Summary: The etiology of feline inflammatory bronchial disease is poorly understood. This study compared the degree of allergen-specific serum IgE responses between cats with different types of inflammatory bronchial disease and clinically healthy cats. The results showed that cats with mixed inflammation had significantly more positive reactions against mite allergens compared to healthy cats. Blood eosinophils were inversely correlated with the amount of allergen-specific serum IgE. Sensitization to dust mites seems to be more prevalent in cats with mixed inflammation. However, positive IgE reactions can be observed in both healthy and diseased cats, and should be interpreted in the context of clinical findings and environmental conditions.
Article
Agriculture, Dairy & Animal Science
Rachel Kinsman, Rachel Casey, Jane Murray
Summary: This study investigated the types of materials targeted by cats exhibiting pica at different ages, as reported by owners. Factors such as moving house, renting rather than owning a home, and living in a household without dogs were found to increase the odds of a cat displaying chronic pica. The study provides novel data on pica in UK pet cats and aims to contribute towards a better understanding of this behavior for future research.
Article
Allergy
Francisca Vilchez-Sanchez, Rosa Rodriguez-Perez, Carmen Gomez-Traseira, Javier Dominguez-Ortega, Lucia Hernandez-Rivas, Itsaso Losantos Garcia, Santiago Quirce, Maria Pedrosa
Summary: This study found that 16.3% of patients were sensitised to Pru p 7, which was associated with severe reactions, upper airway symptoms, anaphylaxis, and the presence of an eliciting cofactor.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Zongjie Li, Di Di, Qing Sun, Xiaohui Yao, Jianchao Wei, Beibei Li, Ke Liu, Donghua Shao, Yafeng Qiu, Haixia Liu, Zhanjun Cheng, Zhiyong Ma
Summary: Accumulating studies have shown that the gut microbiota is closely associated with gastrointestinal diseases in animals, and it can directly influence the host's intestinal function by regulating the development of the host's intestinal immune system. In this study, the gut microbiota of Ragdoll cats and Felinae cats were compared, revealing differences in microbial communities between the two groups. The Ragdoll cats had higher richness and diversity of beneficial microbes compared to the Felinae cats. These findings have implications for the treatment of gastrointestinal diseases and provide important insights into the domestication and gut microbial communities of different cat breeds.
Article
Otorhinolaryngology
Young-Ha Lee, Minheon Kim, Cheol Hyo Ku, Hyun Su Lee, Joo Hyung Lee, Dong Hwan Kwon, Eun Jung Lee
Summary: This study aimed to assess the association between staphylococcal enterotoxins (SEs) and allergic diseases and the degree of allergen sensitisation in children. The results showed that patients sensitised to SEs had higher IgE levels and eosinophil counts, and were more likely to have polysensitisation and allergic multimorbidity. When the SE-IgE value was 0.35 or higher, the likelihood of allergen polysensitisation was significantly higher.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Allergy
Chrysanthi Skevaki, Pavel Tafo, Kathrin Eiringhaus, Nina Timmesfeld, Markus Weckmann, Christine Happle, Philipp P. Nelson, Nicole Maison, Bianca Schaub, Isabell Ricklefs, Oliver Fuchs, Erika von Mutius, Matthias Volkmar Kopp, Harald Renz, Gesine Hansen, Anna-Maria Dittrich
Summary: In this study, analytical and diagnostic concordance of three commonly used technologies for sIgE detection among young children was found to be good. Despite differences in positive concordance for common sensitizations, extending the number of allergens did not significantly change the overall performance of the three assay systems. These results suggest that more comprehensive multiplex approaches may not improve the clinical utility of sIgE testing in this age group.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Allergy
Wei Chern Gavin Fong, Adrian Chan, Hongmei Zhang, John W. Holloway, Graham Roberts, Ramesh Kurukulaaratchy, Syed Hasan Arshad
Summary: The study found a strong association between childhood food allergy and adult asthma, while the link between childhood food allergen sensitization and adult rhinitis was weaker. It is recommended to closely monitor children with food allergies/sensitizations during childhood to detect and intervene early in subsequent allergic airway diseases, particularly asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Paul L. P. Brand, Richard M. Brohet, Olof Schwantje, Lambert D. Dikkeschei
Summary: This study aimed to evaluate the relationship between sensitisation and symptoms of allergic disease in children. The results showed that inhalant and food allergen sensitisation was common in children with allergic symptoms. However, adding allergen component test results did not contribute to distinguishing phenotypes of allergic disease in children.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Review
Biology
Cristiana Indolfi, Elisabetta D'Addio, Chiara Lucia Bencivenga, Giulio Rivetti, Irene Bettini, Amelia Licari, Sara Manti, Francesca Mori, Michele Miraglia del Giudice, Angela Klain
Summary: The review presents evidence suggesting a potential protective effect of early exposure to pets, particularly dogs, in preventing food allergies and reducing the risk of allergy and asthma in children. The likelihood of a child developing allergy and asthma seems to be influenced by various factors, including genetic background and early exposure to environmental factors that may interact with the gut microbiota and immune system.
Article
Veterinary Sciences
Gretchen K. Carlisle, Rebecca A. Johnson, Colleen S. Koch, Leslie A. Lyons, Ze Wang, Jessica Bibbo, Nancy Cheak-Zamora
Summary: The study explored the welfare of cats adopted by families of children with ASD after being screened for ideal temperament. Results showed that the adopted cats' stress levels did not increase postadoption, but the small sample size limited the analytical power and generalizability, warranting further research.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Nutrition & Dietetics
Vincenzo Fierro, Valeria Marzano, Linda Monaci, Pamela Vernocchi, Maurizio Mennini, Rocco Valluzzi, Stefano Levi Mortera, Rosa Pilolli, Lamia Dahdah, Veronica Calandrelli, Giorgia Bracaglia, Stefania Arasi, Carla Riccardi, Alessandro Fiocchi, Lorenza Putignani
Summary: Through oral food challenge and proteomic methods, traces of milk and egg allergens were found to be undetectable in PAL-labelled milk- and egg-free biscuits, with no reactions observed in patients. This study suggests that the allergen content in these biscuits is far below the minimal doses considered theoretically capable of causing reactions.
Review
Immunology
Nishelle D'souza, Milena Weber, Eszter Sarzsinszky, Susanne Vrtala, Mirela Curin, Mirjam Schaar, Victoria Garib, Margarete Focke-Tejkl, Yanqiu Li, Richard Jones, Hao Chen, Rudolf Valenta, Baoqing Sun
Summary: Approximately 30% of the global population suffers from IgE-mediated allergy, with China having the largest population and over 400 million allergic patients. Allergy prevention and treatment strategies include allergen avoidance, vaccination, and tolerance induction, requiring a detailed understanding of relevant allergen molecules affecting specific populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Nina Hoeyrup, Thomas Spillmann, Linda Toresson
Summary: Cyclosporine is suggested as an immunosuppressive treatment for cats with chronic pancreatitis (CP). This study found that cyclosporine treatment significantly reduces serum Spec fPL concentrations, indicating an improvement in pancreatic inflammation.
Article
Allergy
Christina Krantz, Simone Accordini, Kjell Alving, Angelo G. Corsico, Pascal Demoly, Diogenes S. Ferreira, Bertil Forsberg, Judith Garcia-Aymerich, Thorarinn Gislason, Joachim Heinrich, Rain Jogi, Ane Johannessen, Benedicte Leynaert, Alessandro Marcon, Jesus Martinez-Moratalla Rovira, Elisabet Nerpin, Dennis Nowak, Anna-Carin Olin, Mario Olivieri, Antonio Pereira-Vega, Chantal Raherison-Semjen, Francisco Gomez Real, Torben Sigsgaard, Guilia Squillacioti, Christer Janson, Andrei Malinovschi
Summary: In a multi-center population-based study, an independent association between upper airway inflammatory disorders (UAID) and elevated fractional exhaled nitric oxide (FeNO) levels was found. There was a significant interaction with perennial sensitization and asthma, highlighting the concept of united airway disease.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Public, Environmental & Occupational Health
Xiang Xiao, Meng Gao, Yang Zhou, Shu-Li Xu, Luke D. Knibbs, Joachim Heinrich, Shyamali C. Dharmage, Lidia Morawska, Shao Lin, Bin Jalaludin, Xubo Shen, Yuanzhong Zhou, Guang-Hui Dong
Summary: This study investigates the associations between greenness and birth outcomes and finds that greenness exposure is associated with increased gestational age, birthweight, and birth length in urban dwellers. The use of nonlinear methods reveals that increasing greenness levels from low to medium may provide greater health benefits.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Shanzina Iasmin Sompa, Anna Zettergren, Sandra Ekstrom, Swapna Upadhyay, Koustav Ganguly, Antonios Georgelis, Petter Ljungman, Goran Pershagen, Inger Kull, Erik Melen, Lena Palmberg, Anna Bergstrom
Summary: Despite the growing popularity of e-cigarettes, limited epidemiological studies have been conducted to investigate their impact on respiratory health in young adults. This study found that e-cigarette use was more common in male smokers and was associated with an increased risk of respiratory symptoms and overweight/obesity. However, the small number of exclusive e-cigarette users hindered firm conclusions.
ENVIRONMENTAL RESEARCH
(2022)
Article
Allergy
Anna Kilanowski, Elisabeth Thiering, Gang Wang, Ashish Kumar, Sara Kress, Claudia Flexeder, Carl-Peter Bauer, Dietrich Berdel, Andrea von Berg, Anna Bergstroem, Monika Gappa, Joachim Heinrich, Gunda Herberth, Sibylle Koletzko, Inger Kull, Erik Melen, Tamara Schikowski, Annette Peters, Marie Standl
Summary: This study identified seven trajectories of allergic diseases and investigated their associations with early-life determinants, genetic factors, and clinical characteristics. The results revealed that family history of allergies, specific polygenic risk scores, and clinical characteristics were associated with these trajectories.
Article
Environmental Sciences
Anne Boudier, Iana Markevych, Benedicte Jacquemin, Michael J. Abramson, Simone Accordini, Bertil Forsberg, Elaine Fuertes, Judith Garcia-Aymerich, Joachim Heinrich, Ane Johannessen, Benedicte Leynaert, Isabelle Pin, Valerie Siroux
Summary: This study found that European adults who resided in areas with higher air pollution and less greenspace were more likely to have lower mental component of health-related quality of life (HRQOL), regardless of their asthma or rhinitis status.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Carla P. Harris, Carlana Ramlochansingh, Olaf Uhl, Hans Demmelmair, Joachim Heinrich, Berthold Koletzko, Marie Standl, Elisabeth Thiering
Summary: This study evaluated the associations between different dietary patterns during pregnancy and cord blood metabolites. The findings showed that a fish and shellfish diet was associated with specific fatty acid levels, while a meat and potato diet was associated with levels of propionylcarnitine. These associations highlight potential metabolic pathways involved in the early programming of health and disease through maternal diet.
Article
Critical Care Medicine
Gang Wang, Jenny Hallberg, Rosa Faner, Hans-Jacob Koefoed, Simon Kebede Merid, Susanna Klevebro, Sophia Bjorkander, Olena Gruzieva, Goran Pershagen, Marianne van Hage, Stefano Guerra, Matteo Bottai, Antonios Georgelis, Ulrike Gehring, Anna Bergstrom, Judith M. Vonk, Inger Kull, Gerard H. Koppelman, Alvar Agusti, Erik Melen
Summary: Recent evidence emphasizes the significance of optimal lung development during childhood for lifelong health. This study explored the plasticity of individual lung function states during childhood and found that catch-up and growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction in adulthood.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Environmental Sciences
Femke Bouma, Gerard Hoek, Gerard H. Koppelman, Judith M. Vonk, Jules Kerckhoffs, Roel Vermeulen, Ulrike Gehring
Summary: This study investigated the association between long-term exposure to ultrafine particles (UFP) and allergic sensitization in children. The findings showed no significant association between UFP exposure and sensitization to inhalant and food allergens. However, NO2, PM2.5, PM2.5 absorbance, and PM10 were found to be associated with sensitization to food allergens.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Pauline Kiss, Myrna M. T. de Rooij, Gerard H. Koppelman, Jolanda Boer, Judith M. Vonk, Roel Vermeulen, Lenny Hogerwerf, Hendrika A. M. Sterk, Anke Huss, Lidwien A. M. Smit, Ulrike Gehring
Summary: This study found that adolescents living closer to livestock farms had lower lung function compared to those living farther away. There is an association between closer proximity to farms and poorer lung function.
ENVIRONMENTAL RESEARCH
(2023)
Letter
Respiratory System
Tianyu Zhao, Elisabeth Thiering, Rudolf A. Joerres, Marie Standl, Jan Kuehnisch, Joachim Heinrich
Article
Environmental Sciences
Apolline Saucy, Ulrike Gehring, Sergio Olmos, Cyrille Delpierre, Jeroen de Bont, Olena Gruzieva, Kees de Hoogh, Anke Huss, Petter Ljungman, Erik Melen, Asa Persson, Inka Pieterson, Marjan Tewis, Zhebin Yu, Roel Vermeulen, Jelle Vlaanderen, Cathryn Tonne
Summary: Residential relocation is used as a natural experiment in epidemiological studies to assess the health impact of environmental changes. Predictors of relocation differ between adult and birth cohorts, and movers tend to experience higher levels of air pollution. Higher socioeconomic position is associated with a higher probability of relocation towards healthier levels of the urban exposome. These findings provide valuable insights for reducing bias in epidemiological studies using relocation as a natural experiment.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Femke Bouma, Nicole A. H. Janssen, Joost Wesseling, Sjoerd van Ratingen, Maciek Strak, Jules Kerckhoffs, Ulrike Gehring, Wouter Hendricx, Kees de Hoogh, Roel Vermeulen, Gerard Hoek
Summary: This study investigated the associations between long-term exposure to ultrafine particles and natural and cause-specific mortality in the Netherlands. The results showed that long-term exposure to ultrafine particles was associated with increased respiratory disease and lung cancer mortality, but a weaker association with cardiovascular disease mortality.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Lars Libuda, Birgit Filipiak-Pittroff, Marie Standl, Tamara Schikowski, Andrea von Berg, Sibylle Koletzko, Carl-Peter Bauer, Joachim Heinrich, Dietrich Berdel, Monika Gappa
Summary: A previous study found that breastfeeding can protect against early eczema, but this protection diminishes in adolescence, possibly due to a rebound effect. This study explored the role of early eczema on allergies until young adulthood and whether it modifies the association between breastfeeding and allergies. The results showed that early eczema strongly predicts allergies until young adulthood, but breastfeeding did not have a significant long-term effect on allergies.
Article
Respiratory System
Ana Maria Vicedo-Cabrera, Erik Melen, Francesco Forastiere, Ulrike Gehring, Klea Katsouyanni, Arzu Yorgancioglu, Charlotte Suppli Ulrik, Kjeld Hansen, Pippa Powell, Brian Ward, Barbara Hoffmann, Zorana Jovanovic Andersen
Summary: Climate change poses a major threat to lung patients, leading to more frequent and extreme weather events, prolonged aeroallergen seasons, and deteriorating air quality. Therefore, immediate action is needed from the healthcare community and policymakers to prepare for a complex future.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Peripheral Vascular Disease
Loreen Thuermann, Mario Bauer, Maike Ferland, Marey Messingschlager, Tamara Schikowski, Andrea von Berg, Joachim Heinrich, Gunda Herberth, Irina Lehmann, Marie Standl, Saskia Trump
Summary: This study investigated transcriptional changes of immune modulators associated with hypertension in adolescents, highlighting the importance of early blood pressure monitoring for intervention and prevention of adverse outcomes.
Article
Public, Environmental & Occupational Health
Dewan Muhammad Shoaib, Tanvir Ahmed, Kazy Farhat Tabassum, Mehedi Hasan, Fazle Sharior, Mahbubur Rahman, Makfie Farah, Md Azizur Rahman, Alauddin Ahmed, James B. Tidwell, Mahbub-Ul Alam
Summary: An intervention was implemented in Bangladesh during COVID-19 to reduce occupational health risks for waste and sanitation workers. The intervention involved training and distribution of personal protective equipment (PPE). The study found that the intervention improved workers' knowledge, attitude, and practice regarding PPE usage.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Andreas Kortenkamp, Olwenn Martin, Eleni Iacovidou, Martin Scholze
Summary: The European Food Safety Authority's downward revision of the Health-based Guidance Value for bisphenol A (BPA) has led to disagreements with other regulatory agencies, particularly the German Federal Institute for Risk Assessment. The differing views between EFSA and BfR are driven by their respective selection of endpoints and study evaluation systems, as well as their acceptance or refusal of immunotoxic effects as a basis for establishing a Health-based Guidance Value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Shizhen He, Bjorn Lundberg, Jenny Hallberg, Susanna Klevebro, Goran Pershagen, Kristina Eneroth, Erik Melen, Matteo Bottai, Olena Gruzieva
Summary: Early life air pollution exposure and abnormal inflammation-related protein profiles may interact synergistically towards lower lung function in infants.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Karolina Bralewska
Summary: This review study examines the concentrations of various air pollutants in fire stations, identifies the limitations and strengths of existing research, identifies research gaps and challenges, and suggests potential solutions for reducing firefighter exposure to air pollution at fire stations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)