Modeling and in vitro study on capture efficiency of magnetic nanoparticles transported in an implant-assisted cylindrical tube under magnetic field

A mathematical model is developed to predict the capture efficiency of magnetic nanoparticles flowing in an implant-assisted tube under magnetic field. The ferromagnetic SS-430 coil is implanted as a stent and placed perpendicular to applied magnetic field inside the tube to enhance the capture efficiency. The dominant magnetization and drag forces, which significantly affect the capturing of magnetic particles, are incorporated in the model. Results show that capture efficiency increases from 36 to 81 % as we increase the magnetic field from 0.1 to 0.5 T, respectively. Furthermore, decrease in capture efficiency from 81 to 41 % is observed by increasing the inlet velocity from 2 to 8 mm/s, respectively. In vitro experiments to measure the capture efficiency were also performed to validate the mathematical model. An agreement in trend between experimental and mathematical model results is observed; however, the value of capture efficiency is less in case of experimental as compared to model results. Interestingly, this study shows that capture efficiency can be increased by 1.6 times by using the ferromagnetic stent as compared to without stent geometry.