Review
Immunology
Makoto Murata, Takanori Teshima
Summary: This article discusses the potential of MSC therapy in the treatment of acute GVHD, along with a comparison of studies on the two products, Remestemcel-L and Temcell. While Temcell's real-world efficacy was found to be equivalent to that observed in a prospective study, the precise position of Remestemcel-L/Temcell therapy in the treatment of acute GVHD remains to be determined.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sanaz Keshavarz Shahbaz, Amir Hossein Mansourabadi, Davood Jafari
Summary: Mesenchymal stem cells (MSCs) have the potential to differentiate into different cell subtypes and have attracted attention in clinical investigations. They can ameliorate immune-related disorders such as graft-versus-host diseases (GVHD) through immunomodulatory effects. Genetic engineering can be used to improve MSC immunosuppressive characteristics and enhance their therapeutic applications.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Review
Hematology
Boaz Nachmias, Eran Zimran, Batia Avni
Summary: This paper reviews the clinical experience with the use of MSCs in HSCT and discusses contradictory evidence regarding their effects in hematologic malignancies.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Robert Maximilian Rusch, Yoko Ogawa, Shinri Sato, Satoru Morikawa, Emi Inagaki, Eisuke Shimizu, Kazuo Tsubota, Shigeto Shimmura
Summary: This study explores the different behaviors of allogeneic and syngeneic MSCs in lacrimal glands after transplantation, showing that allogeneic MSCs engraft differently and produce collagen type I more significantly, potentially leading to pathogenic fibrosis. These findings emphasize the importance of understanding the precise mechanisms behind MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Mayela Mendt, May Daher, Rafet Basar, Mayra Shanley, Bijender Kumar, Francesca Lim Wei Inng, Sunil Acharya, Hila Shaim, Natalie Fowlkes, Jamie P. Tran, Elif Gokdemir, Nadima Uprety, Ana K. Nunez-Cortes, Emily Ensley, Thao Mai, Lucila N. Kerbauy, Luciana Melo-Garcia, Paul Lin, Yifei Shen, Vakul Mohanty, JunJun Lu, Sufang Li, Vandana Nandivada, Jing Wang, Pinaki Banerjee, Francia Reyes-Silva, Enli Liu, Sonny Ang, April Gilbert, Ye Li, Xinhai Wan, Jun Gu, Ming Zhao, Natalia Baran, Luis Muniz-Feliciano, Jeffrey Wilson, Indreshpal Kaur, Mihai Gagea, Marina Konopleva, David Marin, Guilin Tang, Ken Chen, Richard Champlin, Katayoun Rezvani, Elizabeth J. Shpall
Summary: This study optimized cord blood tissue derived MSCs (CBti MSCs) by priming them with inflammatory cytokines, leading to their metabolic reprogramming and enhanced glycolytic capacity. The metabolically reprogrammed CBti MSCs showed superior immunosuppressive potential, immunomodulatory properties, and homing capabilities, even after cryopreservation and thawing. These primed CBti MSCs significantly improved outcomes in a xenogenic mouse model of GVHD and could serve as a promising therapeutic option for GVHD and other autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Kilian Kelly, John E. J. Rasko
Summary: GvHD is a life-threatening complication of hematopoietic stem cell transplantation, often requiring high-dose corticosteroid treatment. MSCs show promise as a potential therapy due to their immunosuppressive and immunoregulatory effects, but their efficacy may be influenced by donor variability and manufacturing processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Gerard Socie, Dietger Niederwieser, Nikolas von Bubnoff, Mohamad Mohty, Jeff Szer, Reuven Or, James Garrett, Anirudh Prahallad, Celine Wilke, Robert Zeiser
Summary: Systemic steroids are the first-line treatment for acute graft-versus-host disease, but about 50% of patients become steroid-refractory or dependent. Ruxolitinib is the only approved therapy for these patients and has shown superior efficacy compared with the best available therapy in a clinical trial.
Article
Medicine, Research & Experimental
Yihan Ding, Chang Liu, Yiming Cai, Chang Hou, Guanghua Chen, Yang Xu, Shaoyan Hu, Depei Wu
Summary: Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have shown to be an effective treatment for steroid-refractory acute graft-versus-host disease (SR-aGVHD) with a high response rate and good survival rate.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Meiling Zhou, Jiaoya Xi, Yaofeng Cheng, Denglong Sun, Peng Shu, Shuiqing Chi, Shuo Tian, Shunan Ye
Summary: The study demonstrated that reprogramming ONFH-BMSCs to iPSC-MSCs could reverse abnormal proliferation, differentiation, and DNA methylation patterns, and transplantation of iPSC-MSCs effectively promoted bone repair and angiogenesis in the necrosis area of the femoral head.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Ying Qu, Zhengxu Sun, Yan Yuan, Zifeng Li, Fen Wang, Kunpeng Wu, Huihui Yu, Qiwang Lin, He Fei, Jian Chen, Maoxiang Qian, Yunfeng Cheng, Hua Jiang, Tong Chen
Summary: This study found a connection between immune imbalance and adipogenic abnormality in the bone marrow (BM) microenvironment of patients with aplastic anemia (AA). Activated CD8(+) T cells and interferon-gamma (IFN-gamma) were found to stimulate adipogenesis of BM mesenchymal stroma cells (MSCs). Additionally, monocytic myeloid-derived suppressive cells (mMDSCs) inhibited T cell proliferation and IFN-gamma production through the inducible nitric oxide synthetase (iNOS) pathway. Transfusing mMDSCs reconstituted BM hematopoietic progenitors, restored immune balance, and prevented pancytopenia and hypo-hematopoiesis.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Lina N. Zaripova, Angela Midgley, Stephen E. Christmas, Michael W. Beresford, Clare Pain, Eileen M. Baildam, Rachel A. Oldershaw
Summary: Mesenchymal stem cells (MSCs) have potential as immunosuppressants for treating autoimmune and autoinflammatory diseases. They can reduce inflammation and promote tissue regeneration. However, during the inflammatory process, MSCs become impaired and lose their immunomodulatory activity. Despite challenges and risks, MSCs show promise in the treatment of severe diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Bing Dong, Chao Wang, Jing Zhang, Jinrong Zhang, Yinuo Gu, Xiaoping Guo, Xu Zuo, He Pan, Alan Chen-Yu Hsu, Guoqiang Wang, Fang Wang
Summary: In this study, it was found that exosomes derived from human umbilical cord mesenchymal stem cells can ameliorate severe, steroid-resistant asthma by modulating macrophage polarization through inhibition of TRAF1.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Sanshiro Kanazawa, Hiroyuki Okada, Dan Riu, Yo Mabuchi, Chihiro Akazawa, Junichi Iwata, Kazuto Hoshi, Atsuhiko Hikita
Summary: This study demonstrates the important role of c-Mpl signal in the proliferation and differentiation ability of mesenchymal stem cells (MSCs), which are maintained through co-culture with hematopoietic stem cells (HSCs). Furthermore, the study suggests the existence of a hematopoietic-mesenchymal signal and highlights the significance of HSC state in the stability of MSC properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hengwei Wu, Jimin Shi, Yi Luo, Yamin Tan, Mingming Zhang, Xiaoyu Lai, Jian Yu, Lizhen Liu, Huarui Fu, He Huang, Yanmin Zhao
Summary: In this study, the clinical response to ruxolitinib in patients with steroid-refractory chronic graft-vs-host disease after allogeneic hematopoietic stem cell transplantation was investigated, and its safety profile was evaluated during the treatment course. The majority of patients treated with ruxolitinib showed significant treatment responses with a relatively well-tolerated safety profile, with lung involvement and matched related donors being associated with less favorable treatment response.
Review
Immunology
Peishan Li, Qianmin Ou, Songtao Shi, Changshun Shao
Summary: Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and can be used for the treatment of autoimmune diseases and other chronic disorders. Dental stem cells (DSCs) have remarkable immunomodulatory properties and have therapeutic effects on systemic inflammatory diseases. MSCs derived from nondental tissues, such as the umbilical cord, also show benefits in the management of periodontitis in preclinical studies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Hematology
Shinsuke Iida, Tadao Ishida, Katsuhisa Horimoto, Hirotaka Kazama, Hyunchung Kim, Bruce Crawford, Takanori Teshima
Summary: The study examined the burden and medical costs associated with stem cell mobilization in MM patients receiving ASCT, comparing between G-CSF alone and G-CSF + CPA groups. More patients were treated with G-CSF + CPA combination therapy. The direct costs were higher in the combination group, with hospitalization basic fee being the main cost driver in both groups and phases.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2021)
Editorial Material
Hematology
Takanori Teshima
Summary: The study demonstrated that cannabinoids can modulate the immune responses involved in the regulation of acute and chronic graft-versus-host disease after allogeneic stem cell transplantation.
Review
Hematology
Robert Zeiser, Takanori Teshima
Summary: Acute graft-versus-host disease can target organs beyond the classical intestines, liver, and skin, with potential involvement of the central nervous system, lungs, ovaries and testis, thymus, bone marrow, and kidney. Understanding these nonclassical target organs may contribute to better patient outcomes post allo-HCT.
Article
Hematology
Ronjon Chakraverty, Takanori Teshima
Summary: In summary, regenerative failure at barrier surfaces and maladaptive repair leading to fibrosis are hallmarks of graft-versus-host disease (GVHD). While immunosuppressive treatment can control inflammation, impaired tissue homeostasis results in prolonged organ damage and impaired quality of life. Current interventions aim to address these critical failures in tissue regeneration and repair to improve therapeutic outcomes in GVHD.
Article
Public, Environmental & Occupational Health
Isao Yokota, Peter Y. Shane, Takanori Teshima
Summary: This study conducted testing on travelers at three international airports in Japan using self-collected saliva samples, with a screening strategy of initial CLEIA followed by confirmatory NAAT for intermediate antigen concentrations. This two-step strategy effectively reduced the need for confirmatory NAAT testing without significantly increasing false negatives.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Public, Environmental & Occupational Health
Takako Shimura, Kodai Abe, Toshiki Takenouchi, Mamiko Yamada, Hisato Suzuki, Makoto Suematsu, Sho Nakakubo, Keisuke Kamada, Satoshi Konno, Takanori Teshima, Kenjiro Kosaki
Summary: The study identified at least eight sub-lineages of the B.1.1.214 lineage introduced from Honshu to Hokkaido between July and November 2020, with five sub-lineages originating from the Greater Tokyo Area. The person-nights of travelers from the Greater Tokyo Area to Hokkaido in 2020, especially in October, were significantly higher compared to 2019.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Hematology
Shinsuke Iida, Tadao Ishida, Toshihiro Miyamoto, Satoshi Teramukai, Heigoroh Shirai, Rie Kanamori, Yuki Tajima, Bruce Crawford, Jingbo Yi, Takanori Teshima
Summary: This study examined the healthcare resource use and medical costs associated with the use of plerixafor in Japanese multiple myeloma patients. The results showed that although plerixafor is associated with higher medical costs, the patients using this drug received fewer concomitant medications and spent less time in apheresis.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2022)
Article
Hematology
Hideki Goto, Koji Izutsu, Daisuke Ennishi, Yuko Mishima, Shinichi Makita, Koji Kato, Miyoko Hanaya, Satoshi Hirano, Kazuya Narushima, Takanori Teshima, Hirokazu Nagai, Kenichi Ishizawa
Summary: The selective phosphatidylinositol 3-kinase delta inhibitor zandelisib showed favorable safety and efficacy in Japanese patients with relapsed/refractory indolent non-Hodgkin's lymphoma, achieving an objective response rate of 79%.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2022)
Article
Medical Laboratory Technology
Keiichi Nakano, Satoshi Sugawa, Masanori Seimiya, Satoshi Murakami, Keiko Yasuda, Chiaki Watanabe, Hideki Goto, Takanori Teshima
Summary: This study found that autoantibodies against cTnI were more frequent than those against cTnT. However, the presence of these antibodies did not significantly affect the measurement of cTnI and cTnT.
LABORATORY MEDICINE
(2023)
Review
Hematology
Nataliya P. Buxbaum, Gerard Socie, Geoffrey R. Hill, Kelli P. A. Macdonald, Victor Tkachev, Takanori Teshima, Stephanie J. Lee, Jerome Ritz, Stefanie Sarantopoulos, Leo Luznik, Defu Zeng, Sophie Paczesny, Paul J. Martin, Steven Z. Pavletic, Kirk R. Schultz, Bruce R. Blazar
Summary: Chronic graft-versus-host disease (cGvHD) remains a significant problem in allogeneic hematopoietic stem cell transplantation. Recent research has provided valuable insights into the pathophysiology of cGvHD, leading to the development of personalized treatment approaches.
Review
Oncology
Yutaka Tsutsumi, Shinichi Ito, Souichi Shiratori, Takanori Teshima
Summary: The hepatitis C virus (HCV) can lead to liver cancer and is associated with lymphoma. Advances in drug treatment have improved outcomes, with the potential for HCV eradication using direct acting antivirals (DAA). HCV reactivation during lymphoma treatment and the role of HCV-RNA as a biomarker are also explored in this review.
Article
Hematology
Takaya Ichikawa, Tomokazu Tamura, Mutsumi Takahata, Takashi Ishio, Makoto Ibata, Ikumi Kasahara, Koichiro Minauchi, Satoshi Yamamoto, Takanori Teshima, Takasuke Fukuhara
Summary: This study found that some COVID-19 patients with haematological malignancies had prolonged viral shedding. The prolonged shedding was associated with lower CD4(+) T-cell counts and the use of specific chemotherapy drugs.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Infectious Diseases
Suguru Kurosawa, Keisuke Imafuku, Sho Nakakubo, Sumio Iwasaki, Takanori Teshima, Hideki Goto, Hideyuki Ujiie
Summary: In this case report, a pseudotumor caused by M. genavense infection was observed only in a cutaneous lesion. The pathogen was identified through genetic testing. Combination therapy was recommended for treatment, based on previous literature.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Hematology
Kotaro Miyao, Yachiyo Kuwatsuka, Makoto Murata, Koji Nagafuji, Takanori Teshima, Yuki Takeuchi, Souichi Shiratori, Yuho Najima, Naoyuki Uchida, Masatsugu Tanaka, Masashi Sawa, Shuichi Ota, Takahiro Fukuda, Yukiyasu Ozawa, Shinichi Kako, Toshiro Kawakita, Takahide Ara, Junji Tanaka, Yoshinobu Kanda, Yoshiko Atsuta, Junya Kanda, Seitaro Terakura
Summary: This study compares the outcomes of bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) and evaluates the impact of antithymocyte globulin (ATG) on PBSCT recipients. It finds that PBSCT recipients have higher nonrelapse mortality and more severe graft-versus-host disease (GVHD) compared to BMT recipients. ATG administration shows promising results in improving the outcomes of PBSCT recipients.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Infectious Diseases
Isao Yokota, Takayo Sakurazawa, Junichi Sugita, Sumio Iwasaki, Keiko Yasuda, Naoki Yamashita, Shinichi Fujisawa, Mutsumi Nishida, Satoshi Konno, Takanori Teshima
Summary: The study found that CLEIA is more sensitive than ICA in detecting SARS-CoV-2, especially in situations where quick results are needed, while ICA is suitable for the early period after symptom onset.
INFECTIOUS DISEASE REPORTS
(2021)