期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 97, 期 3, 页码 430-432出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12185-013-1278-z
关键词
Diffuse panbronchiolitis; Humanized anti-CCR4 monoclonal antibody; Adult T-cell leukemia/lymphoma
类别
资金
- Grants-in-Aid for Scientific Research [22591063, 25461453] Funding Source: KAKEN
We present the case of a 62-year-old Japanese woman with relapsed adult T-cell leukemia/lymphoma (ATLL) who was treated with humanized anti-CCR4 monoclonal antibody (KW-0761). Although this antibody was highly effective against refractory ATLL, 6 months after the final KW-0761 infusion, the patient complained of hypoxia due to diffuse panbronchiolitis. Physicians should remain vigilant to the possibility of such previously unreported late-onset adverse effects associated with KW-0761 therapy.
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