Article
Physiology
Isaie Sibomana, Daniel P. Foose, Michael L. Raymer, Nicholas V. Reo, J. Philip Karl, Claire E. Berryman, Andrew J. Young, Stefan M. Pasiakos, Camilla A. Mauzy
Summary: The study utilized untargeted metabolomics to investigate AMS severity during high altitude sojourn, revealing significant differences in urinary metabolites between AMS and non-AMS individuals prior to altitude exposure. These differentially expressed metabolites primarily related to energy metabolism, suggesting that alterations in energy metabolism before high altitude exposure may influence AMS susceptibility.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
E. Garrido, J. Botella de Maglia, O. Castillo
Summary: More than 100 million people ascend to high mountainous areas worldwide annually, with 10-85% affected by acute mountain sickness at nonextreme altitudes. Proper prevention, diagnosis, treatment and management of these conditions in a hostile environment such as high mountains are essential, as they can be incapacitating and life-threatening.
REVISTA CLINICA ESPANOLA
(2021)
Article
Immunology
Haoran Guo, Qi Wang, Tao Li, Jingwen Chen, Chao Zhang, Ying Xu, Qing Chang, Hangyi Li, Weiqiang Sun, Ruidi Han, Chi Wang, Chengbin Wang
Summary: This study discovered that ascending to high altitude can lead to physiological and molecular changes, resulting in some individuals being unable to acclimatize. Predicting acute mountain sickness (AMS) prior to ascent remains a challenge. Proteomic analysis revealed significant differences in inflammatory and immune-related processes between AMS-susceptible and AMS-resistant groups. Potential biomarkers, such as SAP, AAT, LTF, and HSP90-alpha, were identified for the prediction of AMS at low altitudes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Xiaoyan Pu, Fuxin Li, Xue Lin, Rong Wang, Zhi Chen
Summary: The present study investigated the changes in lung histomorphology and oxidative stress, as well as the expression of IL-17C and other inflammatory factors during acute mountain sickness (AMS) in male rats. The results showed that under hypoxic stress, lung tissue suffered from varying degrees of injury, and oxidative stress and expression of inflammatory factors increased significantly, potentially leading to the occurrence of AMS.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biology
Yuan Xie, Diya Yang, Alex S. Huang, Yiquan Yang, Ying Han, Yunxiao Sun, Kai Cao, Huaizhou Wang, Shizheng Wu, Qiang Zhu, Guozhong Wang, Tianyi Wu, Ningli Wang
Summary: Increased cerebral blood flow at high altitudes leads to capillary overperfusion and vasogenic cerebral edema, the leading hypothesis of acute mountain sickness (AMS). This study aimed to investigate the ocular microcirculation changes during early-stage AMS. The results showed that optic nerve thickening, increased subarachnoid space, and increased retinal capillary flow density were associated with AMS. OCTA increase in retinal capillary flow density could serve as a potential biomarker for CNS microvascular changes and AMS development.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Medicine, General & Internal
Elan Small, Caleb Phillips, James Marvel, Grant Lipman
Summary: This study aimed to investigate the relationship between increasing age and acute mountain sickness. The results showed no significant correlation between age and the occurrence or severity of acute mountain sickness. However, a history of altitude illness increased the odds of developing acute mountain sickness.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Johannes Burtscher, Erik R. Swenson, Peter Hackett, Gregoire P. Millet, Martin Burtscher
Summary: Background altitude sojourns attract individuals of all ages and different health statuses, but the risk of acute mountain sickness (AMS) when flying to high altitude destinations is often overlooked. This mini-review evaluates the altitude-dependent AMS incidence depending on the mode of ascending, such as air travel or terrestrial travel.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Jingbin Ke, Jie Yang, Chuan Liu, Zhexue Qin, Jihang Zhang, Jun Jin, Shiyong Yu, Hu Tan, Yuanqi Yang, Chen Zhang, Jiabei Li, Jie Yu, Shizhu Bian, Xiaohan Ding, Chunyan He, Fangzhengyuan Yuan, Jingdu Tian, Chun Li, Rongsheng Rao, Lan Huang
Summary: Echocardiographic parameter MV TMADlateral at sea level may serve as a potential predictor for the occurrence of AMS, and may be associated with differential alterations of ventricular systolic and diastolic functions in subjects after acute high altitude exposure.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Medicine, Research & Experimental
Yiliyaer Nijiati, Tao Yang, Mutalifu Aimaiti, Dilinuer Maimaitiyiming, Ainiwaer Aikemu
Summary: Irbesartan significantly reduces pulmonary artery pressure and improves pulmonary artery damage in a rat model of CMS, possibly through impacting cholesterol metabolism pathway and inhibiting the expression of important proteins. It also serves as a potential treatment for pulmonary artery disease caused by CMS.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Physiology
Nasenien Nourkami-Tutdibi, Jennifer Kuellmer, Sven Dietrich, Dominik Monz, Michael Zemlin, Erol Tutdibi
Summary: Acute mountain sickness (AMS) is a common disease caused by hypobaric hypoxia in high-altitude. Despite the role of cytokines in the development of AMS, the biological pathways and molecular mechanisms are still unclear. This study aims to measure changes in blood cytokine levels and their association with AMS development.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Health Care Sciences & Services
Xiaowei Ye, Mengjia Sun, Shiyong Yu, Jie Yang, Zhen Liu, Hailin Lv, Boji Wu, Jingyu He, Xuhong Wang, Lan Huang
Summary: Cardiorespiratory fitness is important for coping with high-altitude hypoxic stress, but its association with AMS has not been evaluated. Wearable technology devices, such as smartwatches, can provide a feasible assessment of cardiorespiratory fitness, particularly VO2max, and may contribute to AMS prediction.
JMIR MHEALTH AND UHEALTH
(2023)
Article
Chemistry, Analytical
Yiliyaer Nijiati, Lianlian Shan, Tao Yang, Maiwulanijiang Yizibula, Ainiwaer Aikemu
Summary: Chronic mountain sickness (CMS) is a significant pathology affecting the cardiopulmonary system in high-altitude regions. By using a metabonomic approach, this study found that irbesartan can reverse metabolic disorder induced by CMS through pathways such as energy metabolism, amino acid metabolism, and taurine metabolism, confirming its effectiveness in improving CMS.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Damian M. Bailey, Marcel Culcasi, Teresa Filipponi, Julien V. Brugniaux, Benjamin S. Stacey, Christopher J. Marley, Rodrigo Soria, Stefano F. Rimoldi, David Cerny, Emrush Rexhaj, Lorenza Pratali, Carlos Salinas Salmon, Carla Murillo Jauregui, Mercedes Villena, Francisco Villafuerte, Antal Rockenbauer, Sylvia Pietri, Urs Scherrer, Claudio Sartori
Summary: Chronic mountain sickness (CMS) is a high-altitude maladaptation syndrome characterized by elevated systemic oxidative-nitrosative stress. This study found that highlanders have permanently elevated systemic oxidative-nitrosative stress levels, which are further increased in CMS+ patients, leading to systemic vascular complications and increased morbidity/mortality.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Bao Liu, Gang Xu, Bingda Sun, Gang Wu, Jian Chen, Yuqi Gao
Summary: This study aimed to comprehensively evaluate the changes in clinical characteristics and biochemical indices of high-altitude travelers and determine their association with acute mountain sickness (AMS). The results showed that uric acid (UA) and platelet distribution width (PDW) were significantly higher in AMS-susceptible individuals than in AMS-resistant individuals. Changes in UA and number of neutrophils can be used as indicators for identifying AMS. Therefore, the human body presents compensatory physiological and biochemical responses to high-altitude travel, and UA concentration and its trend with high-altitude experience can effectively identify AMS.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Biochemical Research Methods
Chih-Yuan Wei, Ping-Nan Chen, Shih-Sung Lin, Tsai-Wang Huang, Ling-Chun Sun, Chun-Wei Tseng, Ke-Feng Lin
Summary: This study aims to measure environmental conditions and physiological variables of participants in high-altitude regions in real time to develop an AMS risk evaluation model. The experiment results indicate that machine learning multivariate analysis has higher AMS prediction accuracies than analyses utilizing single variables. The developed AMS evaluation model can serve as a reference for the future development of wearable devices capable of providing timely warnings of AMS risks to hikers.
BMC BIOINFORMATICS
(2022)
