期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 93, 期 4, 页码 494-501出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12185-011-0824-9
关键词
Leukemia; Acute lymphoblastic leukemia; beta-Arrestin1; Notch1
类别
资金
- National Natural Science Foundation of China [90919013, 30871103]
- Natural Science Foundation of Chongqing [2008BB5072, 2010BA5008]
- Ministry of Chinese Education [NCET-2008]
Acute lymphoblastic leukemia (ALL) is the main subtype of childhood leukemia. Risk stratification is pivotal for ALL prognosis and individualized therapy. The current factors for risk stratification include clinical and laboratory features, cytogenetic characteristics of the blast, early response to chemotherapy, and genetic factors. Analyses of gene expression are becoming increasingly important in ALL risk stratification. beta-Arrestin1, a multifunctional scaffold protein mediating many intracellular signaling networks, has been shown to be involved in many tumors. However, little is known of beta-arrestin1 in leukemia. In this study, we found that beta-arrestin1 was significantly elevated in 155 newly diagnosed ALL patients, compared with 51 controls. Further analysis showed that beta-arrestin1 expression was positively related with risk classification and white blood cell count in ALL. Moreover, expression of Notch1, an essential gene for developing hematological cells and T-ALL, was found to be negatively correlated with beta-arrestin1 in ALL. In conclusion, beta-arrestin1 may be a useful predictor of risk stratification and prognosis of ALL, and thus of potential use in the design of individualized therapy strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据