Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Agata Gabryelska, Szymon Turkiewicz, Filip Franciszek Karuga, Marcin Sochal, Dominik Strzelecki, Piotr Bialasiewicz
Summary: Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent pauses in breathing, leading to intermittent hypoxia and arousals during the night. It is associated with comorbidities in various systems, including cardiovascular, metabolic, psychiatric, and neurological complications. The disruption of the circadian clock may play a significant role in the development and progression of OSA-related complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Yuntao Lu, Bing Liu, Junjie Ma, Shuo Yang, Ju Huang
Summary: Short-term sleep deprivation causes changes in the circadian gene expression of approximately 3,000 genes in the mouse lung, particularly in genes associated with metabolism and signaling pathways regulating protein phosphorylation. The positive correlation between mean expression and amplitude of cycling genes is maintained under sleep deprivation conditions, supporting the energetic cost optimization model of circadian gene expression.
FRONTIERS IN GENETICS
(2021)
Review
Nutrition & Dietetics
Lauren N. Woodie, Kaan T. Oral, Brianna M. Krusen, Mitchell A. Lazar
Summary: Obesity and metabolic diseases are common in industrialized societies due to circadian disruption caused by shift work, jet lag, and social obligations. The circadian rhythm of the hypothalamic suprachiasmatic nucleus (SCN) plays a critical role in regulating physiological, metabolic, and behavioral processes. However, disruptions in external cues or metabolic flexibility can lead to the development of obesity and metabolic disease. This review explores the circadian rhythm of nutrient metabolism and discusses obesity as a circadian disease.
Review
Endocrinology & Metabolism
Xuemin Peng, Yong Chen
Summary: The relationship between circadian rhythms and thermogenic fat and its potential in treating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Weiyun Zhang, Chi-Tang Ho, Muwen Lu
Summary: This study found that piperine improves lipid metabolism disorders in HepG2 cells by regulating the Bmal1 and Clock genes, reducing circadian desynchrony, ROS overproduction, and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Shuai Wang, Yanke Lin, Lu Gao, Zemin Yang, Jingpan Lin, Shujing Ren, Feng Li, Jing Chen, Zhigang Wang, Zhiyong Dong, Pinghua Sun, Baojian Wu
Summary: Growing evidence suggests that circadian clock and obesity are intertwined, but the underlying mechanism is poorly understood. This study investigated the link between circadian clock and obesity, and found that obesity causes perturbance of the circadian clock in white adipose tissue (WAT). Reduced levels of glutamine and methionine in obese WAT were associated with decreased histone acetylation and methylation at the Bmal1 promoter. It was also found that impaired expression of PPAR-gamma in obesity led to downregulation of SLC1A5, resulting in reduced uptake of glutamine and methionine. These findings suggest that PPAR-gamma integrates obesity and adipocyte clock, promoting a vicious cycle between circadian disruption and obesity development.
Review
Physiology
Melissa L. Erickson, Karyn A. Esser, William E. Kraus, Thomas W. Buford, Leanne M. Redman
Summary: Disruption of the skeletal muscle circadian clock leads to a shift towards lipid oxidation and decrease in carbohydrate oxidation at the whole-body level, resulting in metabolic disturbances. Exercise is hypothesized to counter these disturbances by modifying the skeletal muscle clock and restoring optimal substrate balance.
EXERCISE AND SPORT SCIENCES REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Tingting Li, Shihua Zhang, Yuxuan Yang, Lingli Zhang, Yu Yuan, Jun Zou
Summary: This paper reviews the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Multidisciplinary Sciences
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam J. Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.
Article
Multidisciplinary Sciences
Nisha Misra, Manohar Damara, Pierre Chambon
Summary: This article investigates the role of transcriptional regulators RevErbα, E4BP4, and CRY1/PER1 in generating circadian rhythms. Molecular and genetic analyses reveal that the chromatin protein HP1α plays a crucial role in transcriptional repressions of circadian clock genes and their output genes. The presence of HP1α is critical for chromatin compaction, formation of repressed biomolecular hydrophobic condensates, and recruitment and methylation of DNA methylating enzymes on the intronic deoxyCpG islands within the circadian output genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli
Summary: This article investigates the relationship between heme biosynthesis disorders and altered expression of circadian genes, finding that changes in circadian gene expression may be associated with the symptoms and signs of porphyria patients.
Review
Food Science & Technology
Mamali Das, Kasi Pandima Devi, Tarun Belwal, Hari Prasad Devkota, Devesh Tewari, Adeleh Sahebnasagh, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Mahsa Rasekhian, Suowen Xu, Mehran Amirizadeh, Kiumarth Amini, Maciej Banach, Jianbo Xiao, Safieh Aghaabdollahian, Seyed Mohammad Nabavi
Summary: Vascular diseases are caused by abnormal endothelial response, resulting in atherosclerosis, hypercholesterolemia, etc. Polyphenols have antioxidative, anti-inflammatory, and anti-hypertensive properties, beneficial for preventing endothelial dysfunction.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemical Research Methods
Prabina Kumar Meher, Ansuman Mohapatra, Subhrajit Satpathy, Anuj Sharma, Isha Saini, Sukanta Kumar Pradhan, Anil Rai
Summary: A computational method based on Support Vector Machine (SVM) was developed to identify circadian genes, achieving an accuracy of 62.48%. The method was also applied for proteome-wide identification of circadian proteins in two cereal crops and functional annotation with Gene Ontology terms.
Review
Biochemistry & Molecular Biology
Sara M. Ortega-Campos, Eva M. Verdugo-Sivianes, Ana Amiama-Roig, Jose R. Blanco, Amancio Carnero
Summary: The molecular machinery of the circadian clock regulates gene expression and cellular activities to adapt to daily light-dark cycles. Disruption of the circadian rhythm is an independent risk factor for cancer and circadian genes may play dual roles as tumor suppressors and oncogenes. Understanding the molecular basis of the circadian clock can help identify new markers and targets for cancer prognosis and therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Peripheral Vascular Disease
Paramita Pati, David J. R. Fulton, Zsolt Bagi, Feng Chen, Yusi Wang, Julia Kitchens, Lisa A. Cassis, David W. Stepp, R. Daniel Rudic
Article
Physiology
Xia Shang, Paramita Pati, Ciprian B. Anea, David J. R. Fulton, R. Daniel Rudic
JOURNAL OF VASCULAR RESEARCH
(2016)
Article
Multidisciplinary Sciences
Yusi Wang, Paramita Pati, Yiming Xu, Feng Chen, David W. Stepp, Yuqing Huo, R. Daniel Rudic, David J. R. Fulton
Article
Immunology
Xueyi Li, Yanfang Yu, Boris Gorshkov, Stephen Haigh, Zsuzsanna Bordan, Daniel Weintraub, Radu Daniel Rudic, Trinad Chakraborty, Scott A. Barman, Alexander D. Verin, Yunchao Su, Rudolf Lucas, David W. Stepp, Feng Chen, David J. R. Fulton
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
David J. R. Fulton, Xueyi Li, Zsuzsanna Bordan, Yusi Wang, Keyvan Mahboubi, R. Daniel Rudic, Stephen Haigh, Feng Chen, Scott A. Barman
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Multidisciplinary Sciences
Ahmed Elmarakby, Jessica Faulkner, Paramita Pati, R. Dan Rudic, Clare Bergson
Article
Biology
Ramon C. Hermida, Michael H. Smolensky, Horia Balan, Richard J. Castriotta, Juan J. Crespo, Yaron Dagan, Sherine El-Toukhy, Jose R. Fernandez, Garret A. FitzGerald, Akio Fujimura, Yong-Jian Geng, Ramon G. Hermida-Ayala, Antonio P. Machado, Luiz Menna-Barreto, Artemio Mojon, Alfonso Otero, R. Daniel Rudic, Eva Schernhammer, Carsten Skarke, Tomoko Y. Steen, Martin E. Young, Xiaoyun Zhao
Summary: Current hypertension guidelines lack recommendations on treatment timing, overlooking the impact of circadian rhythms on medication effects. Studies on ingestion-time trials for hypertension should adhere to strict guidelines including recruitment of participants based on ABPM diagnosis, selecting treatment times based on internal biological time, and using ABPM as the primary method for blood pressure assessment.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Qimei Han, Zyare J. Orr, Godfrey K. Desouza, Zsolt Bagi, R. Daniel Rudic
CIRCULATION RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Qimei Han, Zsolt Bagi, Raducu Daniel Rudic
Summary: The progression of vascular disease is influenced by various factors including arterial circadian rhythms and their interaction with different variables. Research has shown that circadian rhythms and their molecular components cycle in different vascular cells, revealing a complexity that is specific to blood vessels, cell types, and even individual cells. Further studies continue to shed light on how circadian clocks act in the vasculature, with implications for blood vessel disease.
CURRENT OPINION IN PHARMACOLOGY
(2021)
Article
Neurosciences
Alvin V. Terry Jr, Wayne D. Beck, Ping-Chang Lin, Patrick M. Callahan, R. Daniel Rudic, Mark W. Hamrick
Summary: In this study, a new method using manganese-enhanced magnetic resonance imaging (MEMRI) was developed to measure axonal transport rates in real time in mice. The study evaluated the effects of age and a microtubule-stabilizing agent called Epothilone D on axonal transport rates. The results showed that aging led to decreased axonal transport rates, and treatment with Epothilone D increased axonal transport rates in aged mice. This study provides further evidence for the potential of microtubule-based therapeutic strategies in age-related neurological disorders.
Review
Peripheral Vascular Disease
Michelle L. Gumz, Daichi Shimbo, Marwah Abdalla, Ravi C. Balijepalli, Christian Benedict, Yabing Chen, David J. Earnest, Karen L. Gamble, Scott R. Garrison, Ming C. Gong, John B. Hogenesch, Yuling Hong, Jessica R. Ivy, Bina Joe, Aaron D. Laposky, Mingyu Liang, Eric J. MacLaughlin, Tami A. Martino, David M. Pollock, Susan Redline, Amy Rogers, R. Dan Rudic, Eva S. Schernhammer, George S. Stergiou, Marie-Pierre St-Onge, Xiaoling Wang, Jacqueline Wright, Young S. Oh
Summary: Healthy individuals experience variation in blood pressure over a 24-hour period, with higher levels during wakefulness and lower levels during sleep. Disruption of the blood pressure circadian rhythm has been associated with negative health outcomes such as cardiovascular disease, dementia, and chronic kidney disease. Current approaches to diagnosis and treatment do not adequately consider the circadian rhythmicity of blood pressure. This review summarizes findings from a workshop held by the National Heart, Lung, and Blood Institute to identify knowledge gaps and research opportunities related to the study of blood pressure circadian rhythm and chronotherapy for hypertension.
Correction
Cardiac & Cardiovascular Systems
Qimei Han, Zyare J. Orr, Godfrey K. Desouza, Zsolt Bagi, R. Daniel Rudic
CIRCULATION RESEARCH
(2021)
Review
Biology
Yanyan Xu, Wenhu Pi, R. D. Rudic
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2019)
Article
Hematology
Huijuan Dou, Attila Feher, Alec C. Davila, Maritza J. Romero, Vijay S. Patel, Vinayak M. Kamath, Monika Beck Gooz, R. Daniel Rudic, Rudolf Lucas, David J. Fulton, Neal L. Weintraub, Zsolt Bagi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2017)