Article
Chemistry, Medicinal
Micaela Giani, Luigia Gervasi, Monica Rosa Loizzo, Rosa Maria Martinez-Espinosa
Summary: This study investigates the impact of different concentrations of carbon sources on the production of haloarchaeal carotenoids and their antioxidant activity. The findings suggest that altering the nutritional conditions can optimize carotenoid production and modify their composition, resulting in more active carotenoid extracts with potential applications in the food and nutraceutical industries.
Article
Fisheries
Soohwan Kim, Hyuncheol Jeon, Sungchul C. Bai, Jun Wook Hur, HyonSob Han
Summary: The addition of A. bussei powder to shrimp diets can improve growth performance, immune response, and antioxidant capacity, while reducing liver enzyme levels. This has potential implications for industrial applications.
AQUACULTURE REPORTS
(2022)
Review
Chemistry, Medicinal
Micaela Giani, Yoel Genaro Montoyo-Pujol, Gloria Peiro, Rosa Maria Martinez-Espinosa
Summary: Breast cancer is the primary cause of death in women worldwide, and new alternative therapies are urgently needed. Carotenoids from natural sources have attracted interest as potential anticancer agents, but clinical trial results remain inconclusive.
Article
Chemistry, Medicinal
Micaela Giani, Zaida Montero-Lobato, Ines Garbayo, Carlos Vilchez, Jose M. Vega, Rosa Maria Martinez-Espinosa
Summary: This study found that different environmental and nutritional conditions have a significant impact on the growth and carotenoid accumulation dynamics in Haloferax mediterranei. The use of a two-step process was evaluated for optimal carotenoid yield.
Article
Spectroscopy
Howell G. M. Edwards, Jan Jehlic, Katerina Nemeckova, Adam Culka
Summary: Microbial colonisations of gypsum from Eastern Poland were investigated using Raman microspectrometry with 445 nm excitation. The presence of scytonin in cyanobacterial colonisation of gypsum was observed for the first time, adding a new biomolecular signature to the library of biological pigments for the detection of traces of life in planetary missions.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Microbiology
Shivangi Mishra, Chandan Singh Chanotiya, Karuna Shanker, Anil Kumar Tripathi
Summary: Azospirillum brasilense is a non-photosynthetic bacterium that produces bacterioruberin type of carotenoids. While genes involved in spirilloxanthin pathway were absent, this bacterium contains genes (crtC and crtF) responsible for the biosynthesis of bacterioruberins. Characterization of carotenoids in A. brasilense Cd using chromatography and mass spectrometry revealed the presence of unique carotenoids such as 19'-hydroxyfucoxanthinol and 8'-apoalloxanthinal.
FEMS MICROBIOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Javier Avila-Roman, Patricia Gomez-Villegas, Carla C. C. R. de Carvalho, Javier Vigara, Virginia Motilva, Rosa Leon, Elena Talero
Summary: The production of reactive oxygen species (ROS) is important in the progression of inflammatory diseases. Antioxidants that can scavenge free radicals and reduce oxidative damage are crucial for prevention and treatment of these diseases. Haloarchaea, extremely halophilic microorganisms that live in high-salt environments, have unique compounds with bioactive properties that have not been fully explored. This study aims to assess the potential of haloarchaea as a new source of natural antioxidant and anti-inflammatory agents.
Article
Chemistry, Analytical
Basseem Radwan, Amrutha Prabhakaran, Stefano Rocchetti, Ewelina Matuszyk, Tia E. Keyes, Malgorzata Baranska
Summary: The cellular uptake and bioavailability of anti-inflammatory antioxidant astaxanthin (AXT) can be improved via liposomal encapsulation. Endothelial cells (EC), which line blood vessels, play important roles in maintaining cardiovascular homeostasis. Dysfunction of EC is associated with various diseases and is closely related to oxidative stress and inflammation. Liposomal encapsulation of AXT showed enhanced uptake and anti-inflammatory effects, especially in reducing lipid unsaturation, lipid droplets, and intercellular adhesion molecule 1 (ICAM-1) overexpression in EC.
Article
Microbiology
Houda Baati, Mariem Siala, Chafai Azri, Emna Ammar, Mohamed Trigui
Summary: This study aimed to screen enzymatic activities and evaluate carotenoid production levels of halophilic archaea strains. The results showed that all strains have a high similarity with Halobacterium salinarum NRC-1 and exhibited different enzymatic activities. The highest carotenoid producing strain (AS17) was identified and optimized conditions for growth and carotenoid production were determined, resulting in a maximum carotenoid yield of 16.490 mg/l.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Engineering, Environmental
Yunlong Luo, Olalekan Simon Awoyemi, Ravi Naidu, Cheng Fang
Summary: Microplastics and nanoplastics have been found in our daily lives, but there is still uncertainty about the extent of the problem, especially with regards to nanoplastics. Through testing a blender used in the kitchen, researchers discovered a significant amount of microplastics and nanoplastics being released from the plastic container. They advanced the characterisation of microplastics and nanoplastics using Raman imaging, which allowed for direct visualisation and increased sensitivity. By improving imaging resolution and using image reconstruction techniques, the researchers were able to effectively characterise nanoplastics and enhance the signal-to-noise ratio of microplastics.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Cheng Fang, Saianand Gopalan, Jingxian Yu, Ravi Naidu
Summary: Microplastics released from plastic zippers commonly found in clothes and textiles are identified and visualized using scanning electron microscope (SEM) and Raman imaging techniques. The study highlights the potential contamination from such microplastic sources in our daily lives.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Cheng Fang, Saianand Gopalan, Xian Zhang, Lei Xu, Junfeng Niu, Ravi Naidu
Summary: This study examines the release of microplastics from toothbrushes using Raman imaging technique and algorithms. It confirms the release of microplastics in daily lives and provides an imaging analysis approach to identify the chemical elements of microplastics.
ENVIRONMENTAL POLLUTION
(2023)
Article
Microbiology
Yifan He, Takashi L. Suyama, Hyunwoo Kim, Evgenia Glukhov, William H. Gerwick
Summary: The study focused on discovering new MNP tyrosinase inhibitors from marine cyanobacterial and algal origins. The pure compound ScyM showed promising results as a potential candidate for applications such as skin-whitening agent or adjuvant therapy for melanoma cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Fevziye Isil Kesbic, Nejdet Gultepe
Summary: The study characterized a halophilic and thermophilic archaeon, Haloterrigena thermotolerans K15, and investigated its carotenoid contents. The carotenoid extract from this archaeon showed significantly higher antioxidant activity compared to reference compounds such as ascorbic acid and butylated hydroxytoluene.
FOLIA MICROBIOLOGICA
(2022)
Article
Limnology
Miriam Colls, Xisca Timoner, Carme Font, Vicenc Acuna, Sergi Sabater
Summary: The study found that the duration of nonflow periods significantly affects the pigment composition of stream biofilms, with longer and more severe nonflow periods leading to increased differences in pigment composition. The composition of pigments showed distinct differences under different flow conditions, and pigment fingerprints can reflect the biofilm's ability to resist water flow interruption and recover after water flow resumes.
LIMNOLOGY AND OCEANOGRAPHY
(2021)
Article
Chemistry, Analytical
J. M. Madariaga, J. Aramendia, G. Arana, K. Castro, L. Gomez-Nubla, S. Fdez-Ortiz de Vallejuelo, C. Garcia-Florentino, M. Maguregui, J. A. Manrique, G. Lopez-Reyes, J. Moros, A. Cousin, S. Maurice, A. M. Ollila, R. C. Wiens, F. Rull, J. Laserna, V. Garcia-Baonza, M. B. Madsen, O. Forni, J. Lasue, S. M. Clegg, S. Robinson, P. Bernardi, A. J. Brown, P. Cais, J. Martinez-Frias, P. Beck, S. Bernard, M. H. Bernt, O. Beyssac, E. Cloutis, C. Drouet, G. Dromart, B. Dubois, C. Fabre, O. Gasnault, I. Gontijo, J. R. Johnson, J. Medina, P. -Y. Meslin, G. Montagnac, V. Sautter, S. K. Sharma, M. Veneranda, P. A. Willis
Summary: The aim of this study is to analyze and verify the homogeneity of major mineral samples in the SuperCam calibration targets for proper calibration on Mars. Surface analysis of the targets was conducted using micro-EDXRF imaging and micro-Raman spectroscopy imaging to identify elements with homogeneous distribution and provide uncertainty values for further calibration.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Jennifer Huidobro, Julene Aramendia, Gorka Arana, Juan Manuel Madariaga
Summary: This article reviews the adaptation of traditional analytical techniques to in situ space exploration, specifically focusing on the geochemical study of Martian surface. Both elemental and molecular analysis techniques used in Mars missions are described. The challenges faced by analytical chemistry in terms of miniaturization, real-time measurements, automation, and reliability under extreme conditions are emphasized.
ANALYTICA CHIMICA ACTA
(2022)
Article
Environmental Sciences
Jose Maria Esbri, Carmelo M. Minang, Sofia Rivera, Mercedes Madrid-Illescas, Eva Garcia-Noguero, Ana Gonzalez-Valoys, Maite Maguregui, Hugues Thouin, Fabienne Battaglia-Brunet, Eric Gloaguen, Pablo Leon Higueras
Summary: This study focuses on Sb mobility, its transfer to biota, and its impact on soil health in a semi-arid climate. The research identifies stibnite (Sb2S3) as the primary Sb compound and observes high Sb contents in mining materials and soils. The soil-to-plant transfer of Sb is very low, and most of it remains in a residual fraction, with a negligible amount being leachable. The study suggests that the low annual rainfall rates and the scarcity of oxidized Sb compounds explain the limited Sb mobility and dispersion in the mining area, indicating a low toxicological risk associated with past mining activities.
Article
Environmental Sciences
Euler Gallego-Cartagena, Hector Morillas, Wendy Morgado-Gamero, Fabio Fuentes-Gandara, Victor Vacca-Jimeno, Isabel Salcedo, Juan Manuel Madariaga, Maite Maguregui
Summary: Concerns about air pollution have increased significantly in recent decades, especially in urban areas. The use of biological systems as passive samplers provides information about air pollution to assist decision-making in environmental health and urban planning. This study developed a method using naturally growing subaerial biofilms on building facades as natural passive biomonitors for atmospheric heavy metals pollution. The study employed multianalytical approaches to identify the composition of particulate matter accumulated on the biofilms, distinguishing between metals from the original structure and those from anthropogenic emissions. This methodology can be used as an alternative for rapid screening of atmospheric heavy metals pollution.
Article
Spectroscopy
Imanol Torre-Fdez, Cristina Garcia-Florentino, Jennifer Huidobro, Leire Coloma, Patricia Ruiz-Galende, Julene Aramendia, Kepa Castro, Gorka Arana, Juan Manuel Madariaga
Summary: The presence and geochemical composition of olivine on Mars are important for studying the planet. Raman spectrometers, used in Mars 2020 and future missions, provide new possibilities to determine the Mg/Fe ratios in olivine-bearing rocks. Olivine's presence indicates past volcanic activity on Mars, and its forsterite/fayalite ratio can reveal information about the origin and evolution of the parent magma. This study proposes a new calibration model using Raman spectroscopy, greatly improving the accuracy and uncertainty associated with the forsterite/fayalite ratios compared to previous literature.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Crystallography
Silvia Perez-Diez, Cheyenne Bernier, Javier G. Inanez, Maite Maguregui
Summary: This study presents a non-invasive in situ methodology using portable elemental and molecular spectroscopic-based instrumentation to assist provenance studies of archaeological cinnabar pigments. Six cinnabar ores and a pigment from Pompeii were analyzed, and a comparative study of in-situ and laboratory results was conducted. Chemometric data treatment was performed, revealing the need for additional methodologies in the laboratory. However, this methodology was useful for classifying the ores based on mineralogical differences.
Article
Materials Science, Multidisciplinary
Ingrid Fitje Apneseth, Maite Maguregui, Alessandra Vichi, Francesco Caruso
Summary: This study investigates the effect of three commercial cleaning products (Baolin, Centurio, Fulgentin) on shellac-coated mahogany furniture in the Royal Palace of Norway. Non-invasive techniques, such as portable ER-FTIR spectroscopy and colorimetry, are used to assess the chemical composition and color changes of fresh and aged mahogany wood mock-ups. The results suggest that one of the cleaning products may negatively impact the long-term preservation of this furniture collection.
Article
Geography, Physical
Jennifer Huidobro, Julene Aramendia, Gorka Arana, Elisabeth M. Hausrath, Juan Manuel Madariaga
Summary: Raman spectra of gypsum, syngenite, and gorgeyite powders were analyzed at different temperatures. The main bands of the three sulfates shifted towards higher wavenumbers with decreasing temperature, indicating stronger bonds and higher energy. However, the behavior of -OH bands varied depending on the crystal structure acquired at different temperatures. The -OH bands of gypsum became narrower and sharper with decreasing temperature, indicating a more ordered crystalline structure.
ANNALS OF GLACIOLOGY
(2023)
Article
Archaeology
P. Irizar, O. Gomez-Laserna, G. Arana, J. M. Madariaga, I. Martinez-Arkarazo
Summary: This research investigates the potential of agar hydrogels loaded with ionic liquids (ILs) as a sustainable and gentle cleaning method for built heritage conservation. The results demonstrate that ILs can effectively remove iron and copper stains while also inhibiting microbial growth. This study showcases the potential of IL-loaded agar hydrogels as an innovative approach in the field of built heritage conservation.
JOURNAL OF CULTURAL HERITAGE
(2023)
Article
Archaeology
Eugenia Tomasini, Ilaria Costantini, Valeria Careaga, Carlos Rua Landa, Kepa Castro, Juan Manuel Madariaga, Marta Maier, Gabriela Siracusano
Summary: Research on the materiality of Andean Colonial artistic heritage provides insights into the cultural and social history of the region. This study examines a hidden mural painting in a church in Bolivia using interdisciplinary and multi-analytical approaches. The identification of pigments and painting techniques revealed the use of local materials by Andean painters, as well as their adaptation of traditional European practices. This knowledge contributes to the conservation and preservation of similar artworks in the Andean region.
JOURNAL OF CULTURAL HERITAGE
(2023)
Review
Geosciences, Multidisciplinary
Mark A. Sephton, Jonathan S. W. Tan, Jonathan S. Watson, Keyron Hickman-Lewis, Juan M. Madariaga
Summary: The search for organic biomarkers on Mars is a high-priority goal for past, present, and future missions. Thermal extraction is the most popular in situ analysis technique, but it faces challenges when analyzing mineral-organic mixtures. Potential mitigations are suggested for future experiments, which can be used both on Mars and on returned samples on Earth.
JOURNAL OF THE GEOLOGICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Ilaria Costantini, Julene Aramendia, Nagore Prieto-Taboada, Gorka Arana, Juan Manuel Madariaga, Juan Francisco Ruiz
Summary: In this study, micro-samples from a rock art site in Spain were analyzed to understand the conservation state of the painted panel and to confirm the efficacy of a desalination treatment. Various techniques were used for characterization, revealing the presence of dolomitic limestone, silicon aggregates, aluminosilicates, iron oxides, and sulfate compounds. The analysis also showed evidence of biological activity and the presence of calcium oxalates, which likely contribute to the preservation of the pictographs. The presence of carotenoid pigments and the intentional use of hematite for painting were also identified.
Article
Plant Sciences
Ireneia Melo, Isabel Salcedo, Cesar A. Garcia, Ibai Olariaga
Summary: Two new species, Megasporia insularis and Porogramme principes, were identified based on morphological and molecular data from specimens collected on Principe Island. Phylogenetic analyses supported the placement of M. insularis within the redefined Megasporia clade. P. principes was placed in a supported clade sister to P. subargentea, and it is proposed to combine the species G. taiwanensis as Porogramme taiwanensis.
Article
Chemistry, Analytical
Michel Rocha Baqueta, Augusto Cesar Costa-Santos, Ana Paula Rebellato, Gisele Marcondes Luz, Juliana Azevedo Lima Pallone, Federico Marini, Alexsandro Lara Teixeira, Douglas N. Rutledge, Patricia Valderrama
Summary: This study reports the essential element composition of new Brazilian Canephora coffees and applies chemometric tools for analysis. The results demonstrate the suitability of this method for origin and species discrimination based on the inorganic fraction of coffee.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mohamed A. Korany, Rasha M. Youssef, Marwa A. A. Ragab, Mostafa A. Afify
Summary: A stability-indicating fit-for-purpose method was developed for the determination of HC, TL, and PS in syrup dosage form. The method successfully separated CL from THY and quantified the analytes using HPLC-DAD. The robustness of the method was assessed through statistical analysis and self-validation.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Lingling Lin, Minyu Li, Ping Li, Chenqing Ye, Huanglong Zhuang, Shaohuang Weng, Feng Chen
Summary: This study developed a highly sensitive and selective electrochemical sensor for simultaneous detection of dopamine and uric acid. The sensor exhibited excellent anti-interference and stability, and could accurately measure dopamine and uric acid in human urine samples.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma
Summary: In this study, a high-performance SERS-active aptasensor was successfully developed for the quantitative analysis of AFB1 in cereal grains, which is of great significance in the field of food safety.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
E. Abas, C. Marina-Montes, C. Perez-Marin, J. Puimedon, J. Anzano
Summary: This study conducted a comprehensive measurement of natural and anthropogenic radionuclides in soil, water, and air in different locations around Deception Island in Antarctica. The results revealed significant levels of 210Pb and anthropogenic 137Cs in soil samples near old human settlements and facilities, as well as detectable levels of 137Cs and 60Co in water samples from old hunting areas. The findings also suggested potential resuspension processes based on higher-than-expected air quality results.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Joao Franciso Allochio, Nayara A. dos Santos, Nathalia dos S. Conceicao, Clara S. D. Baptista, Keyller B. Borges, Valdemar Lacerda Jr, Wanderson Roma
Summary: This study developed a fiber spray ionization mass spectrometry (FSI-MS) method, which shows great potential in detecting illicit drugs. Compared with paper spray ionization mass spectrometry (PSI-MS), FSI-MS demonstrates higher sensitivity in COC detection.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Dina A. Ahmed, Ola G. Hussein, Mamdouh R. Rezk, Mohamed Abdelkawy, Yasmin Rostom
Summary: The main goal of this study was to develop two green chromatographic techniques, HPLC and TLC, for the determination of alcaftadine (ALF) in pharmaceutical formulation and biological samples. The developed HPLC technique showed high efficiency and minimal environmental impact, successfully identifying ALF in the presence of its degradate. The TLC method provided a stability indicating study for ALF and was determined to be safe, green, and eco-friendly.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Abdullah Taner Bisgin
Summary: A green, speedy, and handy method for separation and determination of four commonly used food colorants was established using vortex assisted sequential-simultaneous liquid phase micro-extraction (VA-SS-LPME). The method does not require any instrumental chromatographic techniques. The procedure includes sequential separation steps using different extractants and simultaneous UV-vis spectrophotometric determination steps. The method is environmentally friendly and applicable for determination of colorants in food and pharmaceuticals.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Yifan Zhang, Tong Zhang, Wenjing Ba, Li Liu, Yuan Rao, Xiaodan Zhang, Hanhan Zhang, Xiu Jin
Summary: This paper proposes a novel spectral transfer modelling method based on neural network architecture searching for the asymptomatic prediction of Akizuki pear cork spot disorder. The experiments show that the model by this method is more effective, achieving an accuracy of 82.61%.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
P. K. Fathima Anjila, G. R. Tharani, Anand Sundaramoorthy, Venkat Kumar Shanmugam, Karthikeyan Subramani, Shanmugavel Chinnathambi, Ganesh N. Pandian, Vimala Raghavan, Andrews Nirmala Grace, Singaravelu Ganesan, Mangaiyarkarasi Rajendiran
Summary: This work proposes a rapid and sensitive spectroscopic method for detecting melamine in food products using rare-earth Terbium-doped Graphene Quantum Dots (Tb-GQDs) synthesized by microwave and simple chemical conjugation methods. The synthesized Tb-GQDs show a spherical shape with a size of approximately 6 nm and a quantum yield of 52%. The maximum detection limit for melamine concentration in milk and milk products is found to be 0.31 μM. The dual emitting Tb-GQDs provide a sensitive and effective platform for real-time detection of melamine in food samples, particularly in milk, and show promising potential in the food industry.
MICROCHEMICAL JOURNAL
(2024)
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Sa Dong, Qiuyun Shi, Lingjun Guan, Yulong Wang, Pengyan Liu, Cunzheng Zhang, Jianguo Feng
Summary: In this study, a highly sensitive indirect competitive chemiluminescence enzyme immunoassay (icCLEIA) method was developed for the determination of sodium pentachlorophenolate (PCP-Na) and its metabolite pentachlorophenol (PCP). The method showed high specificity and affinity with a detection limit of 0.0032 ng/mL for PCP-Na and 0.0192 ng/mL for PCP. The method had no cross reaction with other chlorophenols compounds except for PCP. The average recoveries in chicken, pork and fish samples were 81.3-105.8% with low coefficient of variation (CV).
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Palaniappan Ilayaraja, Murugan Manivannan, Paramasivam Parthiban
Summary: Nirmatrelvir, an antiviral drug used for the treatment of COVID-19, has been recommended by the World Health Organization. We developed an optimized analytical method for the quantification of Nirmatrelvir and its products, with high sensitivity and a wide linear range. The method also meets the requirements for greenness evaluation.
MICROCHEMICAL JOURNAL
(2024)