期刊
MICROBIOLOGY AND IMMUNOLOGY
卷 59, 期 9, 页码 567-571出版社
WILEY-BLACKWELL
DOI: 10.1111/1348-0421.12288
关键词
complementarity; human rotavirus; packaging signal; secondary structure
资金
- JSPS KAKENHI [26650134]
- Grants-in-Aid for Scientific Research [26650134] Funding Source: KAKEN
RotavirusA (RVA) possesses a genome of 11 segmented RNAs. In human RVA, two major genomic constellations are represented by prototype strains Wa and DS-1. Here packaging signals differentiating Wa-like and DS-1-like genomic constellations were searched for by analyzing genomic sequences of Wa-like and DS-1-like strains. One pair of 11 nucleotide sites in the coding regions of viral structural protein (VP) 2 and VP6 was found to be complementary specifically among Wa-like strains. These sites tended to be free from base-pairing in secondary structures of genomic segments, suggesting that they may serve as a packaging signal in Wa-like strains.
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