Article
Chemistry, Analytical
Maria L. Souto, Christian Hertweck, Jose J. Fernandez, Adrian Morales-Amador, Maria Garcia-Altares
Summary: Dinoflagellate-derived polyketides are complex molecules with high toxicities and potent bio-activities, but their discovery is hindered by multiple limitations. This study uses a combination of liquid chromatography and mass spectrometry, as well as molecular networking analysis, to screen polyol polyketides and discover nine novel amphidinols in Amphidinium carterae. This strategy enables rapid monitoring of toxin production and differentiation of strains based on their toxin profiles.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Meihan Fang, Jialu Wang, Sheng Fang, Xiaobo Zuo
Summary: Gliadin-carboxymethyl chitosan composite nanoparticles (GC NPs) co-encapsulated with natamycin (Nata) and theaflavins (TFs) were added to carboxymethyl chitosan (CMCS) films as an antioxidant, antifungal, and structural enhancer. The stability of GC NPs dispersion was maintained by electrostatic repulsion. Coencapsulation of TFs improved the photostability of Nata and the antioxidant activity of the NPs dispersion. The addition of Nata/TFs-GC NPs improved the properties and activities of CMCS films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Organic
Badrinath N. Kakde, Emanuela Capota, Jennifer J. Kohler, Uttam K. Tambar
Summary: We reported a robust and stereoselective synthesis of cell-permeable GIcNAc-1-phosphate esters based on commercially available bis(diisopropylamino)-chlorophosphine, applying this method to two diazirine-containing GlcNAc analogues and demonstrating successful cellular incorporation of these compounds to support photo-cross-linking applications.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Lin-Jing Gou, Tian-Tian Liu, Qi Zeng, Wan-Rong Dong, Lu Wang, Sha Long, Jiang-Tao Su, Yu-Xin Chen, Gao Zhou
Summary: This research aimed to investigate the antifungal effect and mechanism of natamycin against Neofusicoccum parvum, the chestnut pathogen. The study evaluated the inhibitory effects of natamycin using drug-containing plates and in vivo assays in chestnuts. The mechanism of action was explored through staining experiments of the fungal cell wall and membrane. Natamycin exhibited strong antifungal properties against N. parvum, primarily by disrupting the fungal cell membranes and causing leakage of intracellular macromolecules.
Article
Chemistry, Multidisciplinary
Shichao Ren, Qiuyan Sun, Liang Zhang, Wentao Sun, Yongxing Li, Xudong Feng, Chun Li
Summary: In this study, an artificial pathway for the de novo biosynthesis of Ro in Saccharomyces cerevisiae was successfully constructed through the selection of key enzymes and metabolic engineering strategies. The Ro titer was significantly increased, reaching a level more than 374,000-fold higher than reported data.
Article
Multidisciplinary Sciences
Finn P. Maloney, Jeremi Kuklewicz, Robin A. Corey, Yunchen Bi, Ruoya Ho, Lukasz Mateusiak, Els Pardon, Jan Steyaert, Phillip J. Stansfeld, Jochen Zimmer
Summary: In this study, we investigated the substrate binding and polymer synthesis of hyaluronan synthase (HAS) using cryo-electron microscopy structures, biochemical analyses, and molecular dynamics simulations. Our findings provide detailed insights into the transmembrane process of HAS, including substrate selection, polymerization, and regulation of hyaluronan synthesis. This research is important for understanding the biosynthesis of acidic extracellular polysaccharides and one of the most abundant glycosaminoglycans in the human body.
Article
Endocrinology & Metabolism
Wisanee Wisanwattana, Kanjana Wongkrajang, Dong-yi Cao, Xiao-ke Shi, Zhong-hui Zhang, Zong-yuan Zhou, Fu Li, Qing-gang Mei, Chun Wang, Apichart Suksamrarn, Guo-lin Zhang, Fei Wang
Summary: The study showed that compounds synthesized using icariin analogs can promote estrogen biosynthesis in osteoblastic cells, enhancing bone growth and remodeling. Compound 14 activates PKG to stimulate SHP2, Src, and ERK signaling pathways, leading to increased estrogen biosynthesis, suggesting its potential for treating osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Applied
Xiepeng Mo, Xinling Peng, Xianrui Liang, Sheng Fang, Hujun Xie, Jie Chen, Yuecheng Meng
Summary: This study demonstrated the fabrication and application of natamycin-loaded zein/casein composite nanoparticles to enhance the properties of gelatin films. The nanocomposite films showed significant improvements in physicochemical properties and antifungal activities, making them promising as innovative additives for food packaging materials.
FOOD HYDROCOLLOIDS
(2021)
Article
Pharmacology & Pharmacy
Zhuang Li, Na Liu, Wanzhen Yang, Jie Tu, Yahui Huang, Wei Wang, Chunquan Sheng
Summary: The first light-responsive antifungal agents were designed by controlling the fungal ergosterol biosynthesis pathway with photocaged triazole lanosterol 14α-demethylase inhibitors. The light-activated compound showed efficient recovery of antifungal activity after shielding and activation. These new chemical tools enable precise regulation of fungal growth, morphology, and biofilm formation. In vivo models demonstrated the efficacy of these light-activated compounds in prolonging survival and reducing fungal burden.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biotechnology & Applied Microbiology
Kuan Chen, Meng Zhang, Baihan Gao, Aobulikasimu Hasan, Junhao Li, Yang'oujie Bao, Jingjing Fan, Rong Yu, Yang Yi, Hans Agren, Zilong Wang, Haiyang Liu, Min Ye, Xue Qiao
Summary: In this study, glycosyltransferases (GT) from Astragalus membranaceus were studied to synthesize structurally diverse astragalosides, providing new biocatalytic tools for saponin biosynthesis.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Sajad Azhdari, Mehran Moradi
Summary: The use of carboxymethyl cellulose-natamycin coating can effectively extend the shelf life of high moisture mozzarella cheese and have inhibitory effects on certain microorganisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Organic
Junfeng Zhao, Tianlu Mo, Xinhui Li, Wei Ding, Qi Zhang
Summary: This study focuses on the glycosylation pathway in the biosynthesis of saccharomicin A (SA-A), an oligosaccharide antibiotic with 17 sugar moieties. Through extensive gene-knockout studies and comparative metabolic profile analysis, a complete pathway in assembling the heptadecasaccharide chain of SA-A was established, which is the longest saccharide chain found in natural products.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Food Science & Technology
Zhaojun Ban, Fangyuan Chen, Lingling Liu, Shuang Zhang, Lijun Wang, Hongpeng Wang, Luyin Wang, Yi Zhu
Summary: This work developed nanoparticles composed of natamycin and gliadin, which enhanced the water dispersibility and stability of natamycin. The addition of sodium carboxymethylcellulose further improved the structure and homogeneity of the nanoparticles. In vitro and in vivo tests confirmed the bacteriostatic activity of the natamycin/carboxymethylcellulose nanoparticles against Penicillium expansum. These findings provide a new approach and reference for developing post-harvest colloidal delivery systems.
Article
Chemistry, Multidisciplinary
Xinkun Ren, Ajay L. Chandgude, Daniela M. Carminati, Zhuofan Shen, Sagar D. Khare, Rudi Fasan
Summary: This study reports a highly stereoselective strategy for olefin cyclopropanation using a phosphonyl diazo reagent as the carbene precursor, and develops efficient biocatalysts using a "substrate walking" protein engineering strategy. This method enables the efficient transformation of a broad range of vinylarene substrates, with high diastereomeric and enantiomeric selectivity.
Article
Food Science & Technology
Jong H. Kim, Christina C. Tam, Kathleen L. Chan, Luisa W. Cheng, Kirkwood M. Land, Mendel Friedman, Perng-Kuang Chang
Summary: The fungal antioxidant system is targeted by redox-active polyene antifungal drugs like NAT, and its efficacy is influenced by pH and food ingredients. While NAT shows higher activity against human pathogens at pH 5.6, it is more effective against foodborne fungi at acidic pH, with food ingredients playing a greater role in impacting NAT efficacy in commercial food matrices.
Article
Oncology
Ming Xu, Jing Zhu, Shuiping Liu, Chan Wang, Qinglan Shi, Yeye Kuang, Xiao Fang, Xiaotong Hu
Article
Biotechnology & Applied Microbiology
Ruonan Zhang, Ting Pan, Yu Xiang, Mingming Zhang, Jiao Feng, Shuiping Liu, Ting Duan, Peng Chen, Bingtao Zhai, Xiaying Chen, Wengang Wang, Bi Chen, Xuemeng Han, Liuxi Chen, Lili Yan, Ting Jin, Ying Liu, Guohua Li, Xingxing Huang, Wenzheng Zhang, Yitian Sun, Qiujie Li, Qin Zhang, Lvjia Zhuo, Tian Xie, Qibiao Wu, Xinbing Sui
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Review
Medicine, Research & Experimental
Shuiping Liu, Qiujie Li, Ke Chen, Qin Zhang, Guohua Li, Lvjia Zhuo, Bingtao Zhai, Xinbing Sui, Xiaotong Hu, Tian Xie
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Review
Biochemistry & Molecular Biology
Jianzhong Gu, Yu Zhan, Lvjia Zhuo, Qin Zhang, Guohua Li, Qiujie Li, Shasha Qi, Jinyu Zhu, Qun Lv, Yingying Shen, Yong Guo, Shuiping Liu, Tian Xie, Xinbing Sui
Summary: M(6)A methyltransferases, as writers in N6-methyladenosine, play essential roles in dynamically regulating life processes. They are involved in various biological functions such as cell growth, nerve development, metabolism, and are potential targets for future disease treatment strategies. Although there are unresolved issues in this field, expectations are high for the future potential of m(6)A methyltransferases.
CELL AND BIOSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Na Kong, Xiaying Chen, Jiao Feng, Ting Duan, Shuiping Liu, Xueni Sun, Peng Chen, Ting Pan, Lili Yan, Ting Jin, Yu Xiang, Quan Gao, Chengyong Wen, Weirui Ma, Wencheng Liu, Mingming Zhang, Zuyi Yang, Wengang Wang, Ruonan Zhang, Bi Chen, Tian Xie, Xinbing Sui, Wei Tao
Summary: Baicalin, an active component in Scutellaria baicalensis Georgi, shows anticancer activity in bladder cancer cells by inducing ferroptosis, suggesting a potential novel therapeutic approach for bladder cancer treatment.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Cell Biology
Binyue Xu, Lu Chen, Yu Zhan, Karl Nelson S. Marquez, Lvjia Zhuo, Shasha Qi, Jinyu Zhu, Ying He, Xudong Chen, Hao Zhang, Yingying Shen, Gongxing Chen, Jianzhong Gu, Yong Guo, Shuiping Liu, Tian Xie
Summary: This review summarizes the recent advances in the research of FABP5, highlighting its crucial role in modulating cellular processes and participating in the pathogenesis of various diseases. Furthermore, the potential of using FABP5 as a diagnostic biomarker and therapeutic target is discussed, shedding light on future research challenges.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuiping Liu, Lu Chen, Yintao Zhang, Ying Zhou, Ying He, Zhen Chen, Shasha Qi, Jinyu Zhu, Xudong Chen, Hao Zhang, Yongchao Luo, Yunqing Qiu, Lin Tao, Feng Zhu
Summary: As the most prevalent internal modification in eukaryotic RNAs, N-6-methyladenosine (m(6)A) has been discovered to play an essential role in cellular proliferation, metabolic homeostasis, embryonic development, etc. A new database named 'M6AREG' is developed to systematically cover, for the first time, data on the effects of m(6)A-centered regulation on both disease development and drug response, and explicitly describe the molecular mechanism underlying each type of regulation.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Chemistry, Medicinal
Hongquan Xu, Wei Zhang, Ying Zhou, Zixuan Yue, Tianci Yan, Yuanyuan Zhang, Yuhong Liu, Yanfeng Hong, Shuiping Liu, Feng Zhu, Lin Tao
Summary: In this study, an online platform, NPcVar, was developed to systematically describe the variations in natural product (NP) content and their corresponding mechanisms. The platform includes 2201 NPs and 694 biological resources, and provides detailed information about species, NPs, factors involved, NP content data, and experimental details. It also offers cross-links to well-established databases and visualizations of NP content under different experimental conditions. NPcVar is a valuable resource for understanding the relationship between species, factors, and NP contents and can facilitate the development of new therapeutics.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Hongquan Xu, Wei Zhang, Ying Zhou, Zixuan Yue, Tianci Yan, Yuanyuan Zhang, Yuhong Liu, Yanfeng Hong, Shuiping Liu, Feng Zhu, Lin Tao
Summary: In this study, a publicly accessible online platform called NPcVar was developed to systematically describe the variations in natural product (NP) content and their corresponding mechanisms. The platform includes 2201 NPs and 694 biological resources, categorized using 126 factors and containing 26,425 records. Each record provides information on species, NP, factors involved, NP content data, plant parts responsible for NP production, experimental location, and reference information. The platform also provides cross-links to well-established databases and visualizes NP content under different experimental conditions. NPcVar is a valuable resource for understanding the relationship between species, factors, and NP contents, and it is expected to enhance the production of high-value NPs and aid in the development of new therapeutics.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Cell Biology
Shuiping Liu, Qiujie Li, Guohua Li, Qin Zhang, Lvjia Zhuo, Xuemeng Han, Mingming Zhang, Xiaying Chen, Ting Pan, Lili Yan, Ting Jin, Jianjun Wang, Qun Lv, Xinbing Sui, Tian Xie
CELL DEATH & DISEASE
(2020)
Review
Oncology
Shuiping Liu, Lvjia Zhuo, Jianjun Wang, Qin Zhang, Qiujie Li, Guohua Li, Lili Yan, Ting Jin, Ting Pan, Xinbing Sui, Qun Lv, Tian Xie
AMERICAN JOURNAL OF CANCER RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Peng Chen, Qibiao Wu, Jiao Feng, Lili Yan, Yitian Sun, Shuiping Liu, Yu Xiang, Mingming Zhang, Ting Pan, Xiaying Chen, Ting Duan, Lijuan Zhai, Bingtao Zhai, Wengang Wang, Ruonan Zhang, Bi Chen, Xuemeng Han, Yicong Li, Liuxi Chen, Ying Liu, Xingxing Huang, Ting Jin, Wenzheng Zhang, Hong Luo, Xiaohui Chen, Yongqiang Li, Qiujie Li, Guohua Li, Qin Zhang, Lvjia Zhuo, Zuyi Yang, Huifen Tang, Tian Xie, Xiaoping Ouyang, Xinbing Sui
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
Review
Oncology
Shuiping Liu, Guohua Li, Qiujie Li, Qin Zhang, Lvjia Zhuo, Xiaying Chen, Bingtao Zhai, Xinbing Sui, Ke Chen, Tian Xie
AMERICAN JOURNAL OF CANCER RESEARCH
(2020)
Article
Oncology
Bingtao Zhai, Qibiao Wu, Wengang Wang, Mingming Zhang, Xuemeng Han, Qiujie Li, Peng Chen, Xiaying Chen, Xingxing Huang, Guohua Li, Qin Zhang, Ruonan Zhang, Yu Xiang, Shuiping Liu, Ting Duan, Jianshu Lou, Tian Xie, Xinbing Sui
CANCER BIOLOGY & MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Shuiping Liu, Haoming Lin, Da Wang, Qiang Li, Hong Luo, Guoxiong Li, Xiaohui Chen, Yongqiang Li, Peng Chen, Bingtao Zhai, Wengang Wang, Ruonan Zhang, Bi Chen, Mingming Zhang, Xuemeng Han, Qiujie Li, Liuxi Chen, Ying Liu, Xiaying Chen, Guohua Li, Yu Xiang, Ting Duan, Jiao Feng, Jianshu Lou, Xingxing Huang, Qin Zhang, Ting Pan, Lili Yan, Ting Jin, Wenzheng Zhang, Lvjia Zhuo, Yitian Sun, Tian Xie, Xinbing Sui
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2019)
Article
Microbiology
Vera Analise Schommer, Mateus Torres Nazari, Flavia Melara, Julia Catiane Arenhart Braun, Alan Rempel, Lara Franco dos Santos, Valdecir Ferrari, Luciane Maria Colla, Aline Dettmer, Jeferson Steffanello Piccin
Summary: This review introduces the techniques and mechanisms of bacteria immobilization on biochar, as well as its applications in bioremediation and agriculture. The immobilization characteristics of biochar depend on pyrolysis methods, raw materials, and properties of biochar. Scanning electron microscope and colony forming unit analysis are commonly used to verify the immobilization efficiency. Applying biochar-immobilized bacteria can improve soil quality, plant growth, and crop yield.
MICROBIOLOGICAL RESEARCH
(2024)
Article
Microbiology
Manoj Kumar Solanki, Naveen Chandra Joshi, Prashant Kumar Singh, Sandeep Kumar Singh, Gustavo Santoyo, Lucas Carvalho Basilio de Azevedo, Ajay Kumar
Summary: The rhizosphere microbiome plays a crucial role in plant growth and health. Rhizosphere engineering can be used to modify the microbiome and improve plant productivity and resilience.
MICROBIOLOGICAL RESEARCH
(2024)
Article
Microbiology
Xin Cao, Xing-Wang Cheng, Yin-Ying Liu, Hong-Wei Dai, Ren-You Gan
Summary: Maintaining oral health is crucial for overall well-being. Imbalances in oral microorganisms can lead to various infectious diseases. Exploring alternatives for prevention and management of oral infections is important due to limitations of current treatments. Natural products offer potential as reliable, effective, and affordable therapeutic options for oral infectious diseases.
MICROBIOLOGICAL RESEARCH
(2024)
Article
Microbiology
Jose David Flores-Felix, Ana Carolina Goncalves, Sara Meirinho, Ana Raquel Nunes, Gilberto Alves, Cristina Garcia-Viguera, Diego A. Moreno, Luis R. Silva
Summary: The application of bacterial biofortifiers is increasing and has been shown to improve the nutritional characteristics of blueberries in Portugal.
MICROBIOLOGICAL RESEARCH
(2024)
Review
Microbiology
Asma Sani, Wan-Qi Qin, Jia-Yi Li, Yi-Fan Liu, Lei Zhou, Shi-Zhong Yang, Bo-Zhong Mu
Summary: This article summarizes the structural diversity of microbial lipopeptide biosurfactants and their applications as biocontrol agents in plants. Lipopeptides have low toxicity and wide range of applications, making them important in the pesticide industry.
MICROBIOLOGICAL RESEARCH
(2024)
Article
Microbiology
Xiao-Yu Sun, Jie Deng, Chenhui Zhang, Sin-Yee Fung, Kam-Leung Siu, Ying-Ying Cheng, Liumei Ye, Jiaoxia Qin, Ke Wang, Jiu-Xin Qu, Wenying Gao, Fuxiang Wang, Dong-Yan Jin, Liang Yang
Summary: In this study, a novel c-di-GMP binding protein SodA that regulates oxidative stress tolerance in S. maltophilia was identified. The enzyme activity of SodA was shown to be directly modulated by c-di-GMP through various in vivo and in vitro experiments.
MICROBIOLOGICAL RESEARCH
(2024)