Review
Endocrinology & Metabolism
Akira Iwase, Yuko Hasegawa, Yumiko Tsukui, Mio Kobayashi, Hikaru Hiraishi, Tomoko Nakazato, Yoshikazu Kitahara
Summary: Anti-Mullerian hormone (AMH) is an indirect indicator of ovarian reserve and fertility. It is used to test the number of remaining follicles. A decline in AMH suggests a decrease in follicles, while polycystic ovary syndrome patients often have elevated AMH levels. AMH varies with folliculogenesis and changes in the follicle cohort, which play a crucial role in ovarian activity throughout a woman's lifetime.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ghazal Mansouri, Maryam Safinataj, Armita Shahesmaeili, Leila Allahqoli, Hamid Salehiniya, Ibrahim Alkatout
Summary: This study evaluated the effect of laparoscopic cystectomy on ovarian reserve in patients with ovarian cysts. The results showed that the surgery reduced serum AMH levels and the number of cauterizations used, cyst type, and bilaterality had a significant impact on postoperative AMH levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Laurie Denis-Laroque, Youenn Drouet, Ingrid Plotton, Nicolas Chopin, Valerie Bonadona, Jacqueline Lornage, Bruno Salle, Christine Lasset, Christine Rousset-Jablonski
Summary: This study found a tendency towards premature decrease in ovarian reserve among BRCA1/2 pathogenic variant carriers, with a higher risk of low ovarian reserve indicated by extreme levels of AMH and AFC.
Article
Obstetrics & Gynecology
Drechsel C. E. Katja, Van Tilborg C. Theodora, Eijkemans J. C. Marinus, Lentjes G. W. M. Eef, Homminga Irene, Goddijn Mariette, Van Golde J. T. Ron, Verpoest Willem, Lichtenbelt D. Klaske, Broekmans J. M. Frank, Bos M. E. Anna
Summary: This study aimed to investigate whether female BRCA1- and BRCA2 mutation carriers have a reduced ovarian reserve status. The results showed no meaningful differences in ovarian reserve status between BRCA mutation carriers and controls.
REPRODUCTIVE SCIENCES
(2023)
Article
Medicine, General & Internal
Besim Haluk Bacanakgil, Gulsah Ilhan, Karolin Ohanoglu
Summary: This study evaluated the effects of vitamin D supplementation on ovarian reserve markers and found that it significantly increased AMH level, AFC, 25(OH)D and calcium levels, while decreasing FSH level and alkaline phosphatase level.
Article
Endocrinology & Metabolism
Laura Melado, Raquel Vitorino, Carol Coughlan, Leyla Depret Bixio, Ana Arnanz, Ibrahim Elkhatib, Neelke De Munck, Human M. Fatemi, Barbara Lawrenz
Summary: This study aimed to describe age-specific serum AMH and AFC values for women native to the Arabian Peninsula. The results showed that AMH and AFC were significantly associated with age, as well as with different styles of head covering among women on the Arabian Peninsula.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Obstetrics & Gynecology
Richard A. Anderson, David Cameron, Florian Clatot, Isabelle Demeestere, Matteo Lambertini, Scott M. Nelson, Fedro Peccatori
Summary: Female patients undergoing anticancer treatment are at risk of adverse ovarian outcomes, and AMH can be used as a biomarker to assess ovarian reserve and POI. Chemotherapy or radiotherapy consistently led to reduced/undetectable AMH levels, but partial recovery was observed during follow-up. Oligo/amenorrhea was associated with post-treatment AMH decline, suggesting impending POI. Long-term follow-up of pediatric patients showed significantly lower AMH levels compared to control groups. AMH can identify the damaging effect of cancer treatments on ovarian function, but further studies are needed to determine its diagnostic and predictive value.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Medicine, General & Internal
Juhun Lee, Dae Gy Hong
Summary: This study analyzed the factors related to the recovery of serum anti-Mullerian hormone (sAMH) from the lowest level after surgery in Korean women with ovarian endometriosis. The study found that preoperative cancer antigen 125 level and postoperative C-reactive protein level were related to sAMH recovery. Postoperative serum CRP level could be used as a marker to predict sAMH nadir after surgery.
Article
Endocrinology & Metabolism
Benjamin S. Harris, Anne Z. Steiner, Anne Marie Jukic
Summary: This study investigated the association between biomarkers of ovarian reserve and menstrual cycle length, indicating that higher AMH levels are associated with longer menstrual cycles, independent of age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Benjamin S. Harris, Anne Z. Steiner, Anne Marie Jukic
Summary: This study analyzed data from 632 women aged 30-44 without infertility history who were attempting to conceive for less than 3 months, and found that increasing AMH levels were associated with longer menstrual cycle lengths.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Elif Yildiz, Burcu Timur, Gurhan Guney, Hakan Timur
Summary: This study investigated the effect of SARS-CoV-2 mRNA vaccine on the fertility of women at the 6th month using AMH as an ovarian reserve test. The study included 104 women, with 74 in the vaccinated group and 30 in the control group. The results showed that vaccination did not adversely affect ovarian reserve.
Article
Environmental Sciences
Xinyan Wang, Shuai Zhang, Huihui Yan, Zhao Ma, Yunshan Zhang, Haining Luo, Xueli Yang
Summary: This study investigated the association between ambient PM2.5, O3 pollution, and ovarian reserve in reproductive-aged Chinese women. The results showed that increased exposure to PM2.5 and O3 was associated with decreased AMH levels, indicating reduced ovarian reserve. Notably, the effects of O3 exposure on ovarian reserve were different from those of PM2.5 exposure.
ENVIRONMENTAL POLLUTION
(2024)
Article
Endocrinology & Metabolism
Ayako Muraoka, Satoko Osuka, Atsushi Yabuki, Bayasula, Masato Yoshihara, Hideaki Tanaka, Reina Sonehara, Natsuki Miyake, Mayuko Murakami, Sayako Yoshita, Natsuki Nakanishi, Tomoko Nakamura, Maki Goto, Akira Iwase, Hiroaki Kajiyama
Summary: This study found that DNG is more effective than GnRHa in preserving ovarian reserve after cystectomy for ovarian endometrioma. This is achieved through reducing the inflammatory response during the perioperative period and other endometriosis-related inflammatory reactions.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Peng Xiang, Jia-yin Yao, Xiao-lan Li, Min Zhang, Pin-jin Hu, Min Zhi
Summary: This study evaluated the ovarian reserve in women with CD using AMH levels and identified age, CD activity, and thalidomide use as risk factors associated with decreased ovarian reserve. CD women have lower ovarian reserve compared to healthy women.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Kristen Upson, Clarice R. Weinberg, Hazel B. Nichols, Gregg E. Dinse, Aimee A. D'Aloisio, Dale P. Sandler, Donna D. Baird
Summary: The study found that prenatal exposure to farm environments is associated with lower ovarian reserve biomarker concentrations in adulthood, while childhood farm exposure has weaker associations. These findings suggest that prenatal farm exposure may result in reduced ovarian reserve in adulthood.
Article
Genetics & Heredity
Sari Lieberman, Ariela Tomer, Avi Ben-Chetrit, Oded Olsha, Shalom Strano, Rachel Beeri, Sivan Koka, Hila Fridman, Karen Djemal, Itzhak Glick, Todd Zalut, Shlomo Segev, Miri Sklair, Bella Kaufman, Amnon Lahad, Aviad Raz, Ephrat Levy-Lahad
GENETICS IN MEDICINE
(2017)
Article
Genetics & Heredity
Sari Lieberman, Amnon Lahad, Ariela Tomer, Carmit Cohen, Ephrat Levy-Lahad, Aviad Raz
GENETICS IN MEDICINE
(2017)
Article
Gastroenterology & Hepatology
Sari Lieberman, Tom Walsh, Menachem Schechter, Tomer Adar, Eran Goldin, Rachel Beeri, Nitzan Sharon, Hagit Baris, Liat Ben Avi, Elizabeth Half, Israela Lerer, Brian H. Shirts, Colin C. Pritchard, Ian Tomlinson, Mary-Claire King, Ephrat Levy-Lahad, Tamar Peretz, Yael Goldberg
Article
Oncology
Suhair Lolas Hamameh, Paul Renbaum, Lara Kamal, Dima Dweik, Mohammad Salahat, Tamara Jaraysa, Amal Abu Rayyan, Silvia Casadei, Jessica B. Mandell, Suleyman Gulsuner, Ming K. Lee, Tom Walsh, Mary-Claire King, Ephrat Levy-Lahad, Moein Kanaan
INTERNATIONAL JOURNAL OF CANCER
(2017)
Editorial Material
Medicine, General & Internal
Satvit A. Shalev, Joel Zlotogora, Adel Shalata, Ephrat Levy-Lahad
Article
Clinical Neurology
Adi Aran, Reeval Segel, Kota Kaneshige, Suleyman Gulsuner, Paul Renbaum, Scott Oliphant, Tomer Meirson, Ariella Weinberg-Shukron, Yair Hershkovitz, Sharon Zeligson, Ming K. Lee, Abraham O. Samson, Stanley M. Parsons, Mary-Claire King, Ephrat Levy-Lahad, Tom Walsh
Article
Genetics & Heredity
Amanda Ewart Toland, Andrea Forman, Fergus J. Couch, Julie O. Culver, Diana M. Eccles, William D. Foulkes, Frans B. L. Hogervorst, Claude Houdayer, Ephrat Levy-Lahad, Alvaro N. Monteiro, Susan L. Neuhausen, Sharon E. Plon, Shyam K. Sharan, Amanda B. Spurdle, Csilla Szabo, Lawrence C. Brody
NPJ GENOMIC MEDICINE
(2018)
Article
Genetics & Heredity
Hila Fridman, Doron M. Behar, Shai Carmi, Ephrat Levy-Lahad
GENETICS IN MEDICINE
(2020)
Editorial Material
Oncology
Sari Lieberman, Hadar Goldvaser, Ephrat Levy-Lahad
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Rachel Michaelson-Cohen, Matan J. Cohen, Carmit Cohen, Dan Greenberg, Amir Shmueli, Sari Lieberman, Ariela Tomer, Ephrat Levy-Lahad, Amnon Lahad
Summary: This study analyzed the cost-effectiveness of BRCA mutation screening in the Ashkenazi Jewish population and found that population screening is both effective and cost-effective for preventing breast and ovarian cancer. BRCA testing should be made available to all Ashkenazi Jewish women, regardless of family history.
Meeting Abstract
Endocrinology & Metabolism
Adi Auerbach, Ariella Weinberg Shokrun, Ephrat Levy-Lahad, David Zangen
HORMONE RESEARCH IN PAEDIATRICS
(2017)
Meeting Abstract
Endocrinology & Metabolism
Eran Lavi, Tehila Klopshtock, Ariella Weinberg-Shukron, Abdulsalam Abu Libdeh, Ephrat Levy-Lahad, David Zangen
HORMONE RESEARCH IN PAEDIATRICS
(2017)
Article
Obstetrics & Gynecology
Ranjit Manchanda, Shreeya Patel, Antonis C. Antoniou, Ephrat Levy-Lahad, Clare Turnbull, Gareth Evans, John L. Hopper, Robert J. Macinnis, Usha Menon, Ian Jacobs, Rosa Legood
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2017)
Article
Genetics & Heredity
Gael Nicolas, Monica Sanchez-Contreras, Eliana Marisa Ramos, Roberta R. Lemos, Joana Ferreira, Denis Moura, Maria J. Sobrido, Anne-Claire Richard, Alma Rosa Lopez, Andrea Legati, Jean-Francois Deleuze, Anne Boland, Olivier Quenez, Pierre Krystkowiak, Pascal Favrole, Daniel H. Geschwind, Adi Aran, Reeval Segel, Ephrat Levy-Lahad, Dennis W. Dickson, Giovanni Coppola, Rosa Rademakers, Joao R. M. de Oliveira
NEUROLOGY-GENETICS
(2017)
Meeting Abstract
Oncology
P. Mor, E. Levy-Lahad, U. Beler, M. Carmon, S. Strano, T. Hadar, O. Olsha, R. Rabinowitz, N. Srebnik, E. Simon, R. Duchin, M. Jackson, R. Rabinovitch