Article
Multidisciplinary Sciences
I-M Launonen, N. Lyytikainen, J. Casado, E. A. Anttila, A. Szabo, U-M Haltia, C. A. Jacobson, J. R. Lin, Z. Maliga, B. E. Howitt, K. C. Strickland, S. Santagata, K. Elias, A. D. D'Andrea, P. A. Konstantinopoulos, P. K. Sorger, A. Farkkila
Summary: In this study, the authors used highly multiplexed imaging to analyze the immune microenvironment of high-grade serous ovarian cancers (HGSOC) and identified phenotypic characteristics and spatial interactions associated with BRCA1/2 gene mutations. These findings have important implications for improving immunotherapeutic strategies and patient stratification.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Dong Yang, Mei-Han Duan, Qiu-Er Yuan, Zhi-Ling Li, Chuang-Hua Luo, Lan-Yue Cui, Li-Chao Li, Ying Xiao, Xian-Ying Zhu, Hai-Liang Zhang, Gong-Kan Feng, Guo-Chen Liu, Rong Deng, Jun-Dong Li, Xiao-Feng Zhu
Summary: A generalized stroma-immune prognostic signature (SIPS) was proposed to identify ovarian cancer (OV) patients who may benefit from immunotherapy. The SIPS was positively correlated with stroma components and immunosuppressive cells in the tumor microenvironment, indicating their critical role in suppressing the immune response. Targeting stromal components, such as CAFs, in combination with PARP inhibitors, could inhibit tumor growth and improve survival in OV-bearing mice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Beata Gasowska-Bajger, Agnieszka Gasowska-Bodnar, Pawel Knapp, Lubomir Bodnar
Summary: The meta-analysis suggests that survivin expression may serve as an indicator of poor prognosis in ovarian cancer, and is associated with clinicopathological parameters of greater aggressiveness in the disease. Prospective studies are necessary to validate survivin expression as a potential biomarker for ovarian cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Olga Kovaleva, Polina Podlesnaya, Madina Rashidova, Daria Samoilova, Anatoly Petrenko, Valeria Mochalnikova, Vladimir Kataev, Yuri Khlopko, Andrey Plotnikov, Alexei Gratchev
Summary: Esophageal cancer, especially squamous cell carcinoma, shows significant correlations between microbiome composition and tumor infiltrating phenotypes. Specific types of tumors have higher bacterial burdens, with different microbial components associated with disease prognosis.
Article
Dentistry, Oral Surgery & Medicine
Zhengjun Shang, Jingjian Qiu, Erhui Jiang
Summary: This study confirms the prognostic value of TSR in oral squamous cell carcinoma (OSCC) and demonstrates the contribution of cancer-associated fibroblasts (CAFs)-stroma ratio (CSR) to the prognostic value of TSR.
Review
Biochemistry & Molecular Biology
Nicole E. James, Morgan Woodman, Jennifer R. Ribeiro
Summary: EOC patients have low response rates to immunotherapies, but evidence suggests ovarian tumors are immunogenic and immune-related genomic profiles can serve as prognostic markers. Specific research areas that need to be addressed include developing immune-based prognostic signatures and driving advancements in this field.
Article
Oncology
Chiho Miyagawa, Hidekatsu Nakai, Tomoyuki Otani, Ryusuke Murakami, Shiki Takamura, Hisamitsu Takaya, Kosuke Murakami, Masaki Mandai, Noriomi Matsumura
Summary: We modified the histopathologic subtyping algorithm to achieve high interobserver agreement in whole slide imaging and characterized the tumor biology of MT type for treatment individualization. The results showed that MT type had a worse prognosis and genes related to angiogenesis and immune response were highly expressed in the MT type. The findings of this study may be useful for treatment individualization of HGSOC, including angiogenesis inhibitors and immunotherapy.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Pathology
Alhadi Almangush, Lauri Jouhi, Caj Haglund, Jaana Hagstrom, Antti A. Makitie, Ilmo Leivo
Summary: This study analyzed the tumor-stroma ratio (TSR) in 182 patients with oropharyngeal squamous cell carcinoma (OPSCC) and found that patients with a high TSR had lower survival rates. TSR was shown to be a powerful prognostic indicator in OPSCC and could be implemented in routine pathology diagnostics and reporting.
Article
Medicine, General & Internal
Shuang Ye, Shuling Zhou, Yutuan Wu, Xuan Pei, Wei Jiang, Wanling Shi, Wentao Yang, Xiaoyan Zhou, Boer Shan, Huijuan Yang
Summary: We conducted genomic profiling on Chinese ovarian clear cell carcinoma (OCCC) patients and discovered the mutation landscape and genetic prognostic biomarkers of OCCC. The most frequent genetic alterations were the simultaneous mutations in ARID1A and PIK3CA genes, and most patients had potentially targetable driver mutations. These findings provide important insights for understanding OCCC and exploring potential therapeutic strategies.
ANNALS OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jennifer E. Russ, Mary E. Haywood, Sydney L. Lane, William B. Schoolcraft, Mandy G. Katz-Jaffe
Summary: This study used spatial transcriptomics to analyze the transcriptomic landscape of ovaries from young and aged mice. Significant transcriptomic changes were observed between young and aged samples, including distinct granulosa cell populations and the absence of an oocyte sub-cluster in aged mouse ovaries.
Article
Cell Biology
Tong Su, Panpan Zhang, Fujun Zhao, Shu Zhang
Summary: This study investigated the roles of infiltrated immune cells and immune-related genes (IRGs) in epithelial ovarian cancer, and established an immune-based prognostic risk model using nine IRGs. The model classified EOC patients into low-risk and high-risk groups, and revealed different immune landscapes between the two groups, providing insights into the immune status in the tumor microenvironment for prognosis.
Article
Oncology
Jing Feng Hu, Xin Song, Kan Zhong, Xue Ke Zhao, Fu You Zhou, Rui Hua Xu, Ji Lin Li, Xian Zeng Wang, Xue Min Li, Pan Pan Wang, Ling Ling Lei, Meng Xia Wei, Ran Wang, Zong Min Fan, Xue Na Han, Yao Chen, Liu Yu Li, Jia Jia Ji, Yuan Ze Yang, Bei Li, Miao Miao Yang, Hai Jun Yang, Fu Bao Chang, Jing Li Ren, Sheng Li Zhou, Li Dong Wang
Summary: A brand new prognostic nomogram was constructed by combining clinical and pathological characteristics to increase prognostic value in patients with esophageal squamous cell carcinoma.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Shuna Liu, Ming Wu, Fang Wang
Summary: Ovarian cancer presents a serious threat to women's health due to its low early diagnosis rate and tendency for metastasis and recurrence. Conventional treatment involving platinum and paclitaxel chemotherapy based on surgery may not effectively address the recurrence and progression of the disease. By understanding the molecular pathways involved in ovarian cancer recurrence and progression, biomarker-guided treatment options have the potential to significantly improve patient prognosis and lead to personalized treatment strategies.
Article
Biochemistry & Molecular Biology
Katharina Doetzer, Friederike Schlueter, Franz Edler von Koch, Christine E. Brambs, Sabine Anthuber, Sergio Frangini, Bastian Czogalla, Alexander Burges, Jens Werner, Sven Mahner, Barbara Mayer
Summary: Integrin alpha 2 beta 1 has been identified as a prognostic and predictive marker in primary ovarian cancer, showing significant correlations with ERα, EGFR, immune cell infiltration, and PD-L1 expression. High alpha 2 beta 1 expression is associated with shorter survival, serving as an independent prognostic factor for patients' progression-free and platinum-free intervals. It has the potential to stratify patients for chemotherapy and immunotherapy and design new targeted treatment strategies.
Article
Oncology
Ching-Yu Cheng, Heng-Cheng Hsu, Yi-Jou Tai, Ying-Cheng Chiang, Yu-Li Chen, Wen-Fang Cheng
Summary: The study found that the prognosis of unexpected ovarian cancer is independent of the primary surgical procedure. Prognostic factors included the FIGO stage, histological type, tumor grade, and timing of surgery and chemotherapy. Comprehensive staging surgery should be performed promptly after diagnosis to improve outcomes.
Article
Engineering, Environmental
Ilham Benjelloun, David Garon, Natacha Heutte, Lydia Leleyter, Fabienne Baraud
Summary: This study developed a new soil microcosm for evaluating fungal biosorption of metals in solid medium, focusing on bioaugmentation with Absidia cylindrospora in artificially contaminated soil. A separation technique involving centrifugation was shown to effectively separate the mycelium from the soil, allowing for accurate evaluation of metal accumulation by the fungus. Results demonstrated the viability of Absidia cylindrospora for biosorption of considerable amounts of Cd, Cu, and Pb from contaminated soil, supporting its potential use in bioremediation studies.
BIOREMEDIATION JOURNAL
(2022)
Article
Oncology
Brent J. Small, Marie Lange, Wanting Zhai, Jaeil Ahn, Tim A. Ahles, Judith E. Carroll, Harvey J. Cohen, Deena Graham, Martine Extermann, Natacha Heutte, Heather S. L. Jim, Brenna C. McDonald, Sunita K. Patel, James C. Root, Andrew J. Saykin, Kathleen Van Dyk, Xingtao Zhou, Jeanne Mandelblatt, Florence Joly
Summary: Pooled individual-level data from two large prospective studies of older breast cancer survivors showed that older women who received taxane-based chemotherapy did not experience greater declines in cognitive performance or well-being compared to women receiving other chemotherapy regimens. Despite being at greater risk for negative outcomes, treatment with taxane-based chemotherapies did not exacerbate these health consequences for older cancer survivors.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Reproductive Biology
Hemily Batista-Silva, Keyla Rodrigues, Kieiv Resende Sousa de Moura, Nicolas Elie, Glen Van der Kraak, Christelle Delalande, Fatima Regina Mena Barreto Silva
Summary: The study investigated the effects of Bisphenol A (BPA) on testicular energy metabolism and morphology in zebrafish through in vitro and short-term in vivo experiments. Results showed that BPA exposure decreased lactate and glycogen content, altered enzyme activity, induced apoptosis in testicular cells, and affected spermatogenesis in male zebrafish. Overall, short-term BPA exposure was found to impact energy metabolism and spermatogenesis in zebrafish.
REPRODUCTIVE TOXICOLOGY
(2022)
Letter
Otorhinolaryngology
E. Babin, N. Heutte, C. Bethuel-Kamga, M. Perreard
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Floriane Maillard, Nicolas Elie, Nadege Villain-Naud, Melanie Lepoittevin, Anne-Sophie Martinez, Christophe Lelong
Summary: The reduced reproductive ability of triploid oysters is likely due to impaired spermatogenesis, disrupted mitosis and meiosis, and abnormalities in germ cell nuclei and the gonadal tract. This study provides insight into the cellular and molecular events underlying the lower fertility of triploid oysters.
Article
Otorhinolaryngology
Mathieu Cesaire, Audrey Rambeau, Florian Clatot, Alisson Johnson, Natacha Heutte, Juliette Thariat
Summary: This study evaluated the impact of lymphopenia on the efficacy of nivolumab immunotherapy in patients with head and neck cancer. The results showed that lymphopenia upon initiation of nivolumab did not affect patients' survival, but persistent lymphopenia during immunotherapy might be a prognostic marker of patient survival.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lethicia Magno Massuia de Almeida, Maelle Coquemont-Guyot, Nicolas Elie, Annette Morvan-Bertrand, Jean-Christophe Avice, Alain Mollier, Sophie Brunel-Muguet
Summary: Many studies have shown that high temperature events during the crop reproductive phase have adverse effects on seed yield and quality. However, the plant responses to repeated stressing events are still not well understood, despite the increasing frequency of extreme abiotic constraints, such as heat waves, due to climate change. This study investigated the responses of oilseed rape plants to three different sequences of heat stress events, including their intensity, timing, duration, and frequency. The results showed that while total seed yield was not significantly affected, there were differences in seed number and weight, indicating the strong compensatory capacity of indeterminate growth species. Heat stress led to significant decreases and increases in seed oil and protein content respectively, depending on the age of the pods. Soluble sugars concentrations were impacted by heat during seed development but not at physiological maturity, suggesting the presence of compensatory mechanisms. The study concludes that the effects of repeated heat stresses on seed yield and quality are determined by the optimal temperature for compound biosynthesis and the timing of biosynthesis. These findings highlight the complexity of designing thermo-sensitizing protocols to maintain or improve seed quality in species with indeterminate growth.
Article
Oncology
Gwenn Le Gall, Sabine Noal, Natacha Heutte, Benedicte Clarisse, Alexandra Leconte, Francois Cherifi, Corinne Delcambre, Florence Joly, Benedicte Clin
Summary: The study aimed to analyze the impact of adjuvant trastuzumab on fatigue, emotional status, and quality of personal and work life in patients with localized breast cancer. The results showed that trastuzumab did not affect fatigue and return to work, but patients treated with trastuzumab may experience a stronger feeling of helplessness in terms of emotional well-being. Therefore, emotional support should be provided for patients receiving trastuzumab.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Environmental Sciences
I. Benjelloun, N. Merlet-Machour, F. Portet-Koltalo, N. Heutte, D. Garon, F. Baraud, L. Leleyter
Summary: Soil contamination is a significant issue due to urbanization and industrialization. This paper introduces the bioaugmentation effect of fungal strain Absidia cylindrospora on co-contaminated industrial soil for the first time. The study investigates the evolution of metals and PAHs content in the soil over time, as well as the adsorption and/or accumulation of metals within the mycelium of Absidia cylindrospora. The results show that the fungal strain can simultaneously accumulate Cd, Co, Cu, Ni, and Zn, even in the presence of high levels of PAHs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Review
Otorhinolaryngology
E. Babin, N. Heutte, M. Humbert, O. Laccourreye
Summary: This study analyzed the impact of total laryngectomy on the quality of sexual life for cancer patients and the methods used to assess it. The results showed that the quality of sexual life was severely affected, including issues like erectile dysfunction, decreased ejaculatory function, and low libido. Lack of postoperative support was also reported. Therefore, these factors should be taken into account before performing total laryngectomy, and there is a need for a common information tool to improve the management of sexuality based on patient demand.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2023)
Article
Oncology
Guenaelle Levallet, Fatemeh Dubois, Nicolas Elie, Christian Creveuil, Solenn Brosseau, Claire Danel, Arnaud Scherpereel, Sylvie Lantuejoul, Julien Mazieres, Laurent Greillier, Clarisse Audigier-Valette, Emmanuel Bergot, Denis Moro-Sibilot, Olivier Molinier, Herve Lena, Isabelle Monnet, Franck Morin, Valerie Gounant, Gerard Zalcman
Summary: This study evaluated the prognostic and predictive values of VEGFR-2 and CD34 in pleural mesothelioma. The results showed that high expression of VEGFR2 or CD34 correlated with longer overall survival and progression-free survival in patients with pleural mesothelioma.
Article
Medicine, General & Internal
Guillaume Rucher, Kevin Prigent, Christophe Simard, Anne-Marie Frelin, Maelle Coquemont-Guyot, Nicolas Elie, Nicolas Delcroix, Nicolas Perzo, Romain Guinamard, Ludovic Berger, Alain Manrique
Summary: This study assessed the effects of targeted radiation therapy on the aortic valve in mice and found that it resulted in remodeling of the aortic valve in ApoE(-/-) mice resembling human lesions. This preclinical model could be a valuable tool for evaluating therapeutic interventions in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Carine Sauger, Jerome Quinquis, Clothilde Berthelin, Melanie Lepoittevin, Nicolas Elie, Laurent Dubroca, Kristell Kellner
Summary: This study used histology and stereology to estimate the sexual maturity phase of the European Plaice and described the oogenesis cycle and size at first maturity. It provides a method for accurately determining a key parameter for fisheries management that may be applicable to other species.
Proceedings Paper
Agronomy
L. Magno, J. -C. Avice, A. Morvan-Bertrand, N. Elie, A. Mollier, S. Brunel-Muguet
Summary: This study aims to explore the detrimental effects of high temperatures on plants and the stress memory effects of repeated stressing events, especially in the context of climate change. It seeks to find thermo-sensitizing protocols to maintain or increase seed yield and quality by monitoring the evolution of seed nutritional quality.
XXXI INTERNATIONAL HORTICULTURAL CONGRESS, IHC2022: INTERNATIONAL SYMPOSIUM ON INTEGRATIVE APPROACHES TO PRODUCT QUALITY IN FRUITS AND VEGETABLES
(2022)
Article
Chemistry, Multidisciplinary
Frederic Justaud, Hippolyte Paysant, Louis Bastien Weiswald, Abdelghani Jebahi, Marie Jouanne, Nicolas Elie, Anne Sophie Voisin-Chiret, Thierry Roisnel, Clement Orione, Nicolas Levoin, Laurent Poulain, Rene Gree
Summary: This paper investigates the development of Mcl-1 inhibitors and their importance in cancer research. By revising the structure of the MIM1 compound, a new compound called FJ-809 was obtained. It was found that FJ-809 had no significant activity on Mcl-1, unlike the previous MIM1.
NEW JOURNAL OF CHEMISTRY
(2022)
