Article
Microbiology
Dhanapal Senthilkumar, Diwakar D. Kulkarni, Govindarajulu Venkatesh, Vandana Gupta, Priyanka Patel, Manu Dixit, Bharti Singh, Sandeep Bhatia, Chakradhar Tosh, Shiv Chandra Dubey, Vijendra Pal Singh
Summary: The serological survey on pigs in different states of India revealed varying seroprevalence rates of H1N1 virus, with widespread antibody circulation observed in pigs from eastern Uttar Pradesh. The co-circulation of seasonal H1N1 virus and pandemic H1N1 virus in pigs suggests potential spill-over transmission of influenza from humans to pigs. Continuous and systematic molecular surveillance in pig populations is recommended to mitigate the risk and emergence of pandemic influenza.
CURRENT MICROBIOLOGY
(2021)
Article
Virology
Hechao Zhu, Xiangmin Li, Huanchun Chen, Ping Qian
Summary: A/swine/Heilongjiang/GN/2020 (EA-H1N1) virus was isolated from pregnant sows with miscarriage and respiratory disease in Heilongjiang province, China. The virus exhibited high pathogenicity and could cause severe respiratory tract damage in mice, with the potential of systemic spread.
Article
Multidisciplinary Sciences
Fei Meng, Huanliang Yang, Zhiyuan Qu, Yan Chen, Yijie Zhang, Yaping Zhang, Liling Liu, Xianying Zeng, Chengjun Li, Yoshihiro Kawaoka, Hualan Chen
Summary: This study found that the EA H1N1 swine influenza virus became lethal in mice and transmissible in ferrets by acquiring key mutations in the PA protein. These mutations enhanced the messenger RNA transcription of viral proteins and provide important insights for monitoring field strains with pandemic potential.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Bo Meng, Hailing Li, Chong Feng, Weiwei Guo, Yali Feng, Dawei Zhu, Hualan Chen, Ying Zhang
Summary: A study has found that canine influenza viruses (CIVs) in Liaoning, China are undergoing a rapid evolution process, with increased mammalian adaptation ability. The CIVs are likely generated from a reassortment case between H3 CIVs and H5N6 avian influenza viruses (AIVs).
FRONTIERS IN MICROBIOLOGY
(2023)
Letter
Immunology
Jakob N. Nissen, Sophie J. George, Charlotte K. Hjulsager, Jesper S. Krog, Xiaohui C. Nielsen, Tina V. Madsen, Klara M. Andersen, Tyra G. Krause, Lasse S. Vestergaard, Lars E. Larsen, Ramona Trebbien
Summary: In January 2021, a case of human infection with influenza A(H1N1)pdm09 virus containing a nonstructural gene highly similar to Eurasian avian-like H1Nx swine influenza virus was detected in Denmark. The clinical case and testing results of the genetic and antigenic characterizations of the virus were described.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Virology
Yan-Na Xiao, Fei-Yuan Yu, Qian Xu, Jiang Gu
Summary: This study investigated the expression of influenza virus receptors in the human placenta and found that it is susceptible to 2009 influenza A virus (H1N1/09) infection. The study highlights the importance of protecting pregnant women from infection during influenza season.
Article
Virology
Ji-Rong Yang, Chuan-Yi Kuo, I-Ling Yu, Fang-Yen Kung, Fang-Tzy Wu, Jen-Shiou Lin, Ming-Tsan Liu
Summary: A novel reassortant virus, A/Taiwan/1/2021(H1N2)v, containing gene segments from swine influenza A(H1N2) viruses and human A(H1N1)pdm09 viruses, was isolated in Taiwan for the first time. Bidirectional transmission between humans and swine contributes to influenza virus diversity and poses a potential pandemic threat.
Article
Microbiology
Junda Zhu, Zhimin Jiang, Jinhua Liu
Summary: The study found that the pdm/09-M gene influences the virulence, transmission efficiency, and gene transcription level of SIVs, and promotes the release of largely filamentous virions.
VETERINARY MICROBIOLOGY
(2021)
Article
Immunology
Anna Parys, Elien Vandoorn, Jacqueline King, Annika Graaf, Anne Pohlmann, Martin Beer, Timm Harder, Kristien Van Reeth
Summary: A pig farmer in the Netherlands was infected with a Eurasian avian-like swine influenza A(H1N1) virus that was also found in the farmed pigs. Antigenic and genetic characterization of both viruses was conducted. Continued surveillance of swine influenza A viruses is necessary for assessing risks in humans and pigs.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Virology
Min Zhu, Hao Zeng, Jianqiao He, Yaohui Zhu, Pingping Wang, Jianing Guo, Jinfan Guo, Huabo Zhou, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Ying Chen
Summary: The reassortment between avian H9N2 and Eurasian avian-like (EA) H1N1 viruses may have potentially changed from avian-to-mammals adaptation. This study found that the introduction of EA H1N1 internal genes into H9N2 virus restored the replication capability and resulted in extreme virulence in some cases. This raises new concerns for public health due to the possible coexistence of H9N2 and EA H1N1 viruses in dogs.
Article
Immunology
Shuai-Yong Wang, Feng Wen, Ling-Xue Yu, Juan Wang, Man-Zhu Wang, Jie-Cong Yan, Yan-Jun Zhou, Wu Tong, Tong-Ling Shan, Guo-Xin Li, Hao Zheng, Chang-Long Liu, Ning Kong, Guang-Zhi Tong, Hai Yu
Summary: During 2018-2020, 32 Eurasian avian-like swine influenza A(H1N1) viruses and their reassortant viruses were isolated from pigs in China. In late 2020, a novel reassortant H3N1 virus, derived from G4 Eurasian H1N1 and H3N2 swine influenza viruses, emerged and posed a zoonotic infection risk.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Virology
Haoran Sun, Jiyu Liu, Yihong Xiao, Yuhong Duan, Jizhe Yang, Yu Chen, Yinghui Yu, Han Li, Yuzhong Zhao, Juan Pu, Yipeng Sun, Jinhua Liu, Honglei Sun
Summary: The reassortant G4 Eurasian avian-like H1N1 virus, with genes from the 2009 pandemic and triple-reassortant origin, has replaced the G1 genotype as the predominant strain in swine populations in China. G4 virus shows enhanced replication, longer virus shedding duration, and causes more severe respiratory lesions in pigs compared to G1 virus. The G4 virus, with vRNP complex genes from pdm/09 origin, exhibits higher levels of nuclear accumulation and polymerase activity, posing a great threat to both swine industry and public health.
Article
Microbiology
Jin Zhao, Wanting He, Meng Lu, Haijian He, Alexander Lai
Summary: Cats are susceptible to various influenza A viruses, including a novel reassortant virus (FIV-HWT-2017) isolated from a symptomatic cat in China. This reassortant virus has genetic characteristics from avian, canine, and human influenza viruses. Enhanced surveillance for novel influenza viruses in pet and stray cats is necessary.
Article
Public, Environmental & Occupational Health
Moegi Kuroda, Tatsufumi Usui, Chiharu Shibata, Haruka Nishigaki, Tsuyoshi Yamaguchi
Summary: In 2019, a case of bidirectional infection between humans and pigs occurred in a swine farm in Japan. An employee with influenza-like illness transmitted the infection to sows, which subsequently infected a veterinarian and her family. Whole-genome analysis confirmed that the viruses isolated from all individuals belonged to the same lineage. Unique mutations in the influenza A virus genomes corresponding to the host species were also identified.
ZOONOSES AND PUBLIC HEALTH
(2022)
Article
Immunology
Qiuxia Wang, Changbo Ou, Yongxi Dou, Lei Chen, Xuelian Meng, Xingyou Liu, Yan Yu, Jinqing Jiang, Jinyou Ma, Zhidong Zhang, Jianhe Hu, Xuepeng Cai
MICROBIAL PATHOGENESIS
(2017)
Article
Immunology
Changbo Ou, Qiuxia Wang, Yan Yu, Yanhong Zhang, Jinyou Ma, Xianghui Kong, Xingyou Liu
MICROBIAL PATHOGENESIS
(2017)
Article
Virology
Changbo Ou, Qiuxia Wang, Yanhong Zhang, Weili Kong, Shouping Zhang, Yan Yu, Jinyou Ma, Xingyou Liu, Xianghui Kong
Article
Immunology
Changbo Ou, Qiuxia Wang, Xiaobing Wei, Mingcheng Liu, Xingyou Liu, Cheng He
MICROBIAL PATHOGENESIS
(2018)
Article
Agriculture, Dairy & Animal Science
Y. Yu, Y. H. Zhang, Z. Y. Xu, T. Y. Liu, Q. X. Wang, C. B. Ou, J. Y. Ma
Article
Agriculture, Dairy & Animal Science
Qiuxia Wang, Changbo Ou, Xiaobing Wei, Yan Yu, Jinqing Jiang, Yanhong Zhang, Jinyou Ma, Xingyou Liu, Gaiping Zhang
Article
Agriculture, Dairy & Animal Science
Zhi-Yong Xu, Yan Yu, Yan Liu, Chang-Bo Ou, Yan-Hong Zhang, Ting-Yu Liu, Qiu-Xia Wang, Jin-You Ma
Article
Agriculture, Dairy & Animal Science
Yanhong Zhang, Yan Yu, Changbo Ou, Jinyou Ma, Qiuxia Wang, Shouyang Du, Zhiyong Xu, Renfeng Li, Feng Guo
Article
Agriculture, Dairy & Animal Science
Qiuxia Wang, Huilong Hu, Guangli Chen, Hailin Liu, Siyuan Wang, Dasong Xia, Yan Yu, Yanhong Zhang, Jinqing Jiang, Jinyou Ma, Yanzhao Xu, Zhiyong Xu, Changbo Ou, Xingyou Liu
Article
Immunology
Yan Yu, Lingling Cheng, Lili Li, Yanhong Zhang, Qiuxia Wang, Changbo Ou, Zhiyong Xu, Yimin Wang, Jinyou Ma
MICROBIAL PATHOGENESIS
(2019)
Article
Agriculture, Dairy & Animal Science
Yan Yu, Zhiyong Xu, Yanhong Zhang, Qiuxia Wang, Changbo Ou, Yimin Wang, Li Wang, Pei Gao, Shouyang Du, Feng Guo, Jinyou Ma
Article
Endocrinology & Metabolism
Yan Yu, Zhiyong Xu, Changbo Ou, Qiuxia Wang, Yanhong Zhang, Feng Guo, Pei Gao, Jinyou Ma
Summary: The study demonstrated that ghrelin administration reduced inflammatory cell infiltration and fibrosis degree induced by IBDV, as well as decreased the expression of TGF-beta and MMP-9 in infected chickens. This suggests that ghrelin may play a role in attenuating bursal fibrosis by modulating inflammatory responses and fibrotic markers.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Article
Immunology
Yu Yan, Cheng Lingling, Xu Zhiyong, Zhang Yanhong, Ou Changbo, Wang Qiuxia, Gao Pei, Ma Jinyou
Summary: The study investigated the tissue distribution, developmental changes, and response to IBDV infection of IRFs in chickens using qRT-PCR. Results showed tissue-specific expression of different chIRFs and their close association with the development and immune response of BF. Infection with IBDV led to activation or suppression of certain chIRFs, which may provide insights for antiviral gene selection and vaccine adjuvant development.
MICROBIAL PATHOGENESIS
(2021)
Article
Agriculture, Dairy & Animal Science
Yan Yu, Lili Li, Rui Sun, Zhiyong Xu, Qiuxia Wang, Changbo Ou, Yanhong Zhang, Pei Gao, Jinyou Ma
Summary: The study revealed the important roles of PTEN gene in the distribution and development of immune organs in poultry, and the downregulation of PTEN expression in chickens infected with IBDV might be a mechanism for the virus to evade host immunity. Strategies aimed at restoring PTEN expression could potentially be a therapy for preventing IBDV infection.
Article
Microbiology
Qiuxia Wang, Fuming Chu, Xin Zhang, Huilong Hu, Lang Lu, Fang Wang, Yan Yu, Yanhong Zhang, Jinyou Ma, Zhiyong Xu, Fatma Eldemery, Changbo Ou, Xingyou Liu
Summary: This study investigated the impact of CCL19 on IBDV replication. The results showed that CCL19 could decrease the gene and protein levels of IBDV, and overexpression of CCL19 led to a significant reduction in IBDV content. This suggests that CCL19 may play a crucial role in the pathogenesis of IBDV.
FRONTIERS IN MICROBIOLOGY
(2022)